M.W=300-350 Archives - Page 6 of 12 - Esters-buliding-blocks

Knothe, Gerhard’s team published research in Fuel in 82 | CAS: 110-34-9

Fuel published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Quality Control of 110-34-9.

Knothe, Gerhard published the artcileCetane numbers of branched and straight-chain fatty esters determined in an ignition quality tester, Quality Control of 110-34-9, the publication is Fuel (2003), 82(8), 971-975, database is CAplus.

The cetane number, a widely used diesel fuel quality parameter related to the ignition delay time (and combustion quality) of a fuel, has been applied to alternative diesel fuels such as biodiesel and its components. In this work, the cetane numbers of 29 samples of straight-chain and branched C₁-C₄ esters as well as 2-ethylhexyl esters of various common fatty acids were determined The cetane numbers of these esters are not significantly affected by branching in the alc. moiety. Therefore, branched esters, which improve the cold-flow properties of biodiesel, can be employed without greatly influencing ignition properties compared to the more common Me esters. Unsaturation in the fatty acid chain was again the most significant factor causing lower cetane numbers Cetane numbers were determined in an ignition quality tester (IQT) which is a newly developed, automated rapid method using only small amounts of material. The IQT is as applicable to biodiesel and its components as previous cetane-testing methods.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Auvil, Tyler J.’s team published research in Synthesis in 44 | CAS: 1146214-86-9

Synthesis published new progress about 1146214-86-9. 1146214-86-9 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester, name is Methyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzoate, and the molecular formula is C15H18BF3O4, Name: Methyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzoate.

Auvil, Tyler J. published the artcileInternal lewis acid assisted benzoic acid catalysis, Name: Methyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzoate, the publication is Synthesis (2012), 44(14), 2173-2180, database is CAplus.

Internal Lewis acid assisted benzoic acid derivatives are introduced as new low-mol.-weight single-hydrogen-bond donor catalysts for the activation of nitroalkenes. Selected 2-borylbenzoic acid derivatives gave good yields of products in the addition of indoles to nitroalkenes. Control experiments suggest that both the internal Lewis acid coordination and the carboxylic acid functionalities are critical to the optimal performance of these catalysts.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sern, Cheah Han’s team published research in Journal of Oil Palm Research in 20 | CAS: 110-34-9

Journal of Oil Palm Research published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C14H19NO8, COA of Formula: C20H40O2.

Sern, Cheah Han published the artcileSynthesis of palmitic acid-based esters and their effect on the pour point of palm oil methyl esters, COA of Formula: C20H40O2, the publication is Journal of Oil Palm Research (2008), 542-547, database is CAplus.

The objectives of this research were to synthesis palmitic acid-based esters and to study their effects on the pour point of palm oil Me esters. Palmitic acid was esterified with six different branched-chain alcs., namely 2-propanol, 2-butanol, 2-ethyl-1-hexanol, 2-methyl-1-butanol, 2-methyl-1-propanol and 2,2-dimethylpropane-1,3-diol. The purified products were characterized by FT-IR, ¹H-NMR and ¹³C-NMR. The effect of the six synthesized palmitic acid-based esters on palm oil Me esters (biodiesel) was later evaluated. The compounds under study were iso-Pr palmitate (1), sec-Bu palmitate (2), 2-ethylhexyl palmitate (3), 2-methylbutyl palmitate (4), iso-Bu palmitate (5) and 2,2-dimethylpropane-1,3-diyl daipalmitate (6). All of the synthesized compounds were miscible in palm oil Me esters due to similar polarity of the solute and the biodiesel. The blends of the resultant six ester compounds in palm oil Me esters were evaluated resp. for their effect on pour point property. The 2,2-dimethylpropane-1,3-diyl dipalmitate was able to improve the pour point of palm oil Me esters from 12°C to 9°C when 5 wt % was added.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Villa, C.’s team published research in Green Chemistry in 5 | CAS: 110-34-9

Green Chemistry published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C22H18O2, Computed Properties of 110-34-9.

Villa, C. published the artcileSolvent-free reactions as green chemistry procedures for the synthesis of cosmetic fatty esters, Computed Properties of 110-34-9, the publication is Green Chemistry (2003), 5(5), 623-626, database is CAplus.

Solid-liquid solvent-free phase transfer catalysis (PTC) and acidic catalysis in dry media were applied, as green chem. procedures, to the synthesis under mild conditions of long chain aliphatic esters of interest in the cosmetic field. The reactions were performed under conventional heating and microwave activation, analyzing the profiles of the temperature increases during the reactions and studying the yields at different reaction times. The selected esters were obtained with very good yields within short reaction times. Using Aliquat 336 as phase transfer agent, the results showed lower yields under classical heating for very short reaction times (5 min), but usually comparable to the yields obtained under microwave heating extending the reaction time up to 15 min. The simple heterogeneous mixture of reagents with catalytic amount of neat p-toluenesulfonic acid (PTSA) under classical heating leads to good results, similar to those obtained under microwave activation with regards to yields and reaction times (10 min for microwave activation/15 min for oil bath).

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ivanenkov, Yan A.’s team published research in Bioorganic & Medicinal Chemistry Letters in 28 | CAS: 10378-06-0

Bioorganic & Medicinal Chemistry Letters published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, HPLC of Formula: 10378-06-0.

Ivanenkov, Yan A. published the artcileSynthesis and biological evaluation of novel doxorubicin-containing ASGP-R-targeted drug-conjugates, HPLC of Formula: 10378-06-0, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(3), 503-508, database is CAplus and MEDLINE.

Asialoglycoprotein receptor (ASGP-R) belongs to a wide family of C-type lectins and it is currently regarded as an attractive protein in the field of targeted drug delivery (TDD). It is abundantly expressed in hepatocytes and can be found predominantly on the sinusoidal surface especially of HepG2 cells. Therefore, ASGP-R can be used for the TDD of anticancer therapeutics against HCC and mol. diagnostic tools. To date, a variety of mono- and multivalent selective ASGP-R ligands have been discovered. Although many of these compounds have demonstrated a relatively high binding affinity towards the target, the reported synthetic schemes are not handled, complicated and include many non-trivial steps. In the current study, we describe a convenient and versatile synthetic approach to novel monovalent drug-conjugates containing N-acetyl-2-deoxy-2-aminogalactopyranose fragment as an ASGP-R-recognition “core-head” and well-known nonselective cytostatic – Doxorubicin (Dox). This is the first example of the direct conjugation of a drug mol. to the ASGP-targeted warhead by a really convenient manner via a simple linker sequence. The performed MTS-based biol. evaluation in HepG2 cells revealed the novel conjugates as having anticancer activity. Confocal microscopy showed that the mols. readily penetrated HepG2 membrane and were mainly localized within the cytoplasm instead of the nucleus. Per contra, Dox under the same conditions demonstrated good anticancer activity and was predominantly concentrated in the nucleus. Therefore, we speculate that the amide “trigger” that we have used in this study for linker attachment is a sufficiently stable inside the cells to be enzymically or spontaneously degraded. As a consequence, we did not observe the release of the drug. Ligands containing triggers that are more liable towards endogenous hydrolysis within the tissue of targeting are strongly required.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Petrov, Rostislav A.’s team published research in Bioorganic & Medicinal Chemistry Letters in 28 | CAS: 10378-06-0

Petrov, Rostislav A. published the artcileSynthesis and biological evaluation of novel mono- and bivalent ASGP-R-targeted drug-conjugates, Safety of (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(3), 382-387, database is CAplus and MEDLINE.

Asialoglycoprotein receptor (ASGP-R) is a promising biol. target for drug delivery into hepatoma cells. Nevertheless, there are only few examples of small-mol. conjugates of ASGP-R selective ligand equipped by a therapeutic agent for the treatment of hepatocellular carcinoma (HCC). In the present work, we describe a convenient and versatile synthetic approach to novel mono- and multivalent drug-conjugates containing N-acetyl-2-deoxy-2-aminogalactopyranose and anticancer drug – paclitaxel (PTX). Several mols. have demonstrated high affinity towards ASGP-R and good stability under physiol. conditions, significant in vitro anticancer activity comparable to PTX, as well as good internalization via ASGP-R-mediated endocytosis. Therefore, the conjugates with the highest potency can be regarded as a promising therapeutic option against HCC.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nan, Lijun’s team published research in Scientia Horticulturae (Amsterdam, Netherlands) in 162 | CAS: 110-34-9

Scientia Horticulturae (Amsterdam, Netherlands) published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Formula: C20H40O2.

Nan, Lijun published the artcileEffect of alternative new pruning system and harvesting times on aroma compounds of young wines from Ecolly (Vitis vinifera) in a new grape growing region of the Weibei Plateau in China, Formula: C20H40O2, the publication is Scientia Horticulturae (Amsterdam, Netherlands) (2013), 181-187, database is CAplus.

Each training system affecting the volatile concentration of wine is closely related to the specific growing conditions of grape. The aim of this work is to evaluate the influence of different training systems, such as crawled cordon training (CCT) and independent long-stem pruning (ILSP), on the volatile composition of Ecolly wine in Weibei Plateau region in three periods (July 31, August 10 and 24). Total aroma concentration (271.15 mg L^-1) and Et octanoate concentration (84.60 mg L^-1) were the highest for ILSP in August 24 in aroma compounds However, total aroma concentration of CCT exceeded the ILSP in July 31 and August 10, resp. ILSP could lead to higher acetate esters compared with CCT except for August 10. Ethanol esters were also strongly influenced by training systems in July 31 (CCT > ILSP) and August 24 (ILSP > CCT), except for slight influence in August 10. But other esters were not strongly impacted by training system. Despite the highest higher alcs. in ILSP in August 24, CCT still displayed significant higher concentration in the first two harvesting times than ILSP. Organic acids showed the same trend as higher alcs. in the experiment Odor activity values (OAVs) of the 16 aromas compounds showed similar results. Results have shown that CCT improved the accumulation of aroma compounds in early wine, if harvesting time need to be postponed, ILSP was also a suitable select. Whereas, a strongly suggestion of CCT was made because stabilization of yield and quality could be guaranteed by CCT annually.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wan, Yiqian’s team published research in Redai Haiyang in 16 | CAS: 110-34-9

Redai Haiyang published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C7H11N, Quality Control of 110-34-9.

Wan, Yiqian published the artcileChemical studies on soft coral Lobophytum catelai. II., Quality Control of 110-34-9, the publication is Redai Haiyang (1997), 16(3), 78-82, database is CAplus.

The chem. constituents of the soft coral Lobophytum catelai collected from Xisha Islands were studied by spectroscopies and GC/MS. Eight compounds were isolated and identified, which were palmitic acid, iso-Bu palmicate, Bu alc., Pr palmitate, 2,3-dihydroxypropyloctadecaicate, 2β,3β-epoxy-5α-androsta-17-ol, 14-methyl-5α-cholesta-8-ene-3-one, and 2α,3α-epoxy-5α-androsta- 17-β-ol.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nan, Lijun’s team published research in Scientia Horticulturae (Amsterdam, Netherlands) in 162 | CAS: 110-34-9

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nan, Lijun’s team published research in Scientia Horticulturae (Amsterdam, Netherlands) in 162 | CAS: 110-34-9

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics