Tag: M.W=300-350

Zhang, Yueqi published the artcileAnalysis of volatile flavor compounds in blue cheese, COA of Formula: C20H40O2, the publication is Shipin Kexue (Beijing, China) (2015), 36(16), 132-136, database is CAplus.

The volatile flavor components of blue cheese were extracted by solid-phase micro extraction (SPME) or simultaneous distillation extraction (SDE), and analyzed by gas chromatog.-mass spectrometry (GC-MS). A total of 111 volatile compounds were identified in blue cheese, including 2 hydrocarbons, 6 aldehydes, 12 ketones, 20 acids, 49 esters, 13 alcs. and phenols, and 9 sulfur-containing compounds or nitrogen-containing compounds or heterocyclic compounds 2-Heptanone, 2-nonanone, butanoic acid, hexanoic acid, n-decanoic acid, decanoic acid Et ester, 3-(methylthio)-1-propanol, and 6-heptyltetrahydro-2H-pyran-2-one may have impacts on the flavor of blue cheese.

Shipin Kexue (Beijing, China) published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C9H9F5Si, COA of Formula: C20H40O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tao, Hui published the artcileMetabolic engineering of microbes for branched-chain biodiesel production with low-temperature property, Category: esters-buliding-blocks, the publication is Biotechnology for Biofuels (2015), 1-11, database is CAplus and MEDLINE.

Background: The steadily increasing demand for diesel fuels calls for renewable energy sources. This has attracted a growing amount of research to develop advanced, alternative biodiesel worldwide. Several major disadvantages of current biodiesels are the undesirable phys. properties such as high viscosity and poor low-temperature operability. Therefore, there is an urgent need to develop novel and advanced biodiesels. Results: Inspired by the proven capability of wax ester synthase/acyl-CoA, diacylglycerol acyltransferase (WS/DGAT) to generate fatty acid esters, de novo biosynthesis of fatty acid branched-chain esters (FABCEs) and branched fatty acid branched-chain esters (BFABCEs) was performed in engineered Escherichia coli through combination of the (branched) fatty acid biosynthetic pathway and the branched-chain amino acid biosynthetic pathway. Furthermore, by modifying the fatty acid pathway, we improved FABCE production to 273 mg/L and achieved a high proportion of FABCEs at 99.3 % of total fatty acid esters. In order to investigate the universality of this strategy, Pichia pastoris yeast was engineered and produced desirable levels of FABCEs for the first time with a good starting point of 169 mg/L. Conclusions: We propose new pathways of fatty acid ester biosynthesis and establish proof of concept through metabolic engineering of E. coli and P. pastoris yeast. We were able to produce advanced biodiesels with high proportions FABCEs and BFABCEs. Furthermore, this new strategy promises to achieve advanced biodiesels with beneficial low-temperature properties.

Biotechnology for Biofuels published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C13H18N2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Prakash, Thazha P. published the artcileTargeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice, Computed Properties of 10378-06-0, the publication is Nucleic Acids Research (2014), 42(13), 8796-8807, database is CAplus and MEDLINE.

Triantennary N-acetyl galactosamine (GalNAc, GN3), a high-affinity ligand for the hepatocyte-specific asialoglycoprotein receptor (ASGPR), enhances the potency of second-generation gapmer antisense oligonucleotides (ASOs) 6-10-fold in mouse liver. When combined with next-generation ASO designs comprised of short S-cEt (S-2′-O-Et-2′,4′-bridged nucleic acid) gapmer ASOs, ∼60-fold enhancement in potency relative to the parent MOE (2′-O-methoxyethyl RNA) ASO was observed GN3-conjugated ASOs showed high affinity for mouse ASGPR, which results in enhanced ASO delivery to hepatocytes vs. nonparenchymal cells. After internalization into cells, the GN3-ASO conjugate is metabolized to liberate the parent ASO in the liver. No metabolism of the GN3-ASO conjugate was detected in plasma suggesting that GN3 acts as a hepatocyte targeting prodrug that is detached from the ASO by metabolism after internalization into the liver. GalNAc conjugation also enhanced potency and duration of the effect of two ASOs targeting human apolipoprotein C-III and human transthyretin in transgenic mice. The unconjugated ASOs are currently in late stage clin. trials for the treatment of familial chylomicronemia and TTR-mediated polyneuropathy. The ability to translate these observations in humans offers the potential to improve therapeutic index, reduce cost of therapy and support a monthly dosing schedule for therapeutic suppression of gene expression in the liver using ASOs.

Nucleic Acids Research published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, Computed Properties of 10378-06-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sun, Jingcan published the artcileDetermination of Flavor Esters in Enzymatically Transformed Coconut Oil, Safety of Isobutyl palmitate, the publication is Journal of Food Biochemistry (2013), 37(6), 654-660, database is CAplus.

The lipase-catalyzed transesterification of coconut oil with fusel oil was investigated in this study. Various aroma-active octanoic acid esters, such as ethyl-, butyl-, propyl-, isobutyl- and (iso)amyl octanoate, were synthesized in addition to other esters. To determine the amount of flavor esters, a simple yet effective sample preparation method through refrigeration was developed to sep. valuable fatty acid esters from monoglycerides, diglycerides and triglycerides. With this sample preparation method, gas chromatog. coupled with mass spectrometry and flame ionization detector was applied to determine flavor esters in transesterified coconut oil with a total run time of 51 min. The levels of coefficient of variation were within 2% and the recovery rates were in the range of 89.5-100.0%, indicating good accuracy and high precision. The sample preparation and quantification method established appears to be useful for the determination of a wide range of fatty acid esters in oil samples. PRACTICAL APPLICATIONS : Fatty acid esters, especially short-chain fatty acid esters, are important flavoring agents applied in the food industry. Using lipase as the biocatalyst to synthesize desirable flavor fatty acid esters from lipids and alcs. is gaining the interest of researchers, since the esters formed by this method are deemed as natural. The reaction equilibrium was achieved at around 20 h. For industrial production of flavor fatty acid esters, it is essential to monitor the amount of these target compounds in the reaction solutions In this study we developed a simple and effective quantification method to determine the esters in transesterified coconut oil which may also be applicable for the anal. of esters in other oil samples such as lipid-derived biofuels.

Journal of Food Biochemistry published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C2H8Cl2N4S2, Safety of Isobutyl palmitate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tateo, F. published the artcileIdentification of organic contaminants in disposable aluminium foil containers, Category: esters-buliding-blocks, the publication is Food Additives & Contaminants (2006), 23(10), 1030-1037, database is CAplus and MEDLINE.

A series of disposable aluminum foil containers designed for cooking and packaging foods and available on the Italian market were investigated. Using different anal. techniques (near IR (NIR), High Resolution Gas Chromatog. (HR-GC), gas chromatog./mass spectrometry (GC/MS)), organic substances used as lubricants in the manufacturing of the containers were detected on the aluminum layer in contact with the food. These contaminants were not mineral hydrocarbon fractions used for the shaping of can lids and bodies, but had an organic structure identifiable as esters derived by synthesis between fatty acids C8 and C10 with glycerin, and between C16 and C18 with Bu alc. Mixtures of higher esters were also identified as contaminants. Twelve samples were analyzed, and the total amount of contaminant substances was found to range from 900 to 1200 μg/dm². It is recommended, for safety and compliance with European Community (EC) Regulation Number 1935/2004 (27 Oct. 2004), that the use of aluminum foil containers be subject to appropriate regulation concerning substances adopted for technol. purposes.

Food Additives & Contaminants published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C4H6O3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mevel, Mathieu published the artcileChemical modification of the adeno-associated virus capsid to improve gene delivery, Product Details of C14H19NO8, the publication is Chemical Science (2020), 11(4), 1122-1131, database is CAplus and MEDLINE.

Gene delivery vectors based on adeno-associated virus (AAV) are highly promising due to several desirable features of this parent virus, including a lack of pathogenicity, efficient infection of dividing and non-dividing cells and sustained maintenance of the viral genome. However, the conclusion from clin. data using these vectors is that there is a need to develop new AAVs with a higher transduction efficiency and specificity for relevant target tissues. To overcome these limitations, we chem. modified the surface of the capsid of AAV vectors. These modifications were achieved by chem. coupling of a ligand by the formation of a thiourea functionality between the amino group of the capsid proteins and the reactive isothiocyanate motif incorporated into the ligand. This strategy does not require genetic engineering of the capsid sequence. The proof of concept was first evidenced using a fluorophore (FITC). Next, we coupled the N-acetylgalactosamine ligand onto the surface of the AAV capsid for asialoglycoprotein receptor-mediated hepatocyte-targeted delivery. Chem.-modified capsids also showed reduced interactions with neutralizing antibodies. Taken together, our findings reveal the possibility of creating a specific engineered platform for targeting AAVs via chem. coupling.

Chemical Science published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, Product Details of C14H19NO8.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Prakash, Thazha P. published the artcileSolid-phase synthesis of 5′-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry, Formula: C14H19NO8, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(19), 4127-4130, database is CAplus and MEDLINE.

A convenient solid-phase synthetic method was developed for assembling a triantennary N-acetylgalactosamine (GalNAc) cluster on the 5′-end of antisense oligonucleotide using phosphoramidite chem. Conjugation of the 5′-triantennary GalNAc cluster improved potency of the 14 mer ASO 7-fold in mice and more than 50 fold in hepatocytes. The synthetic approach described in this letter simplifies the synthesis of 5′-triantennary GalNAc cluster conjugated ASOs and helps understand the structure-activity relationship for targeting hepatocytes with oligonucleotide therapeutics.

Bioorganic & Medicinal Chemistry Letters published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, Formula: C14H19NO8.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Hong-Lei published the artcileIdentification and Biosynthesis of Novel Male Specific Esters in the Wings of the Tropical Butterfly, Bicyclus martius sanaos, Computed Properties of 110-34-9, the publication is Journal of Chemical Ecology (2014), 40(6), 549-559, database is CAplus and MEDLINE.

Representatives of the highly speciose tropical butterfly genus Bicyclus (Lepidoptera: Nymphalidae) are characterized by morphol. differences in the male androconia, a set of scales and hair pencils located on the surface of the wings. These androconia are assumed to be associated with the release of courtship pheromones. In the present study, the authors report the identification and biosynthetic pathways of several novel esters from the wings of male B. martius sanaos. The authors found that the volatile compounds in this male butterfly were similar to female-produced moth sex pheromones. Components associated with the male wing androconial areas were identified as Et, iso-Bu and 2-phenylethyl hexadecanoates and (11Z)-11-hexadecenoates, among which the latter are novel natural products. By topical application of deuterium-labeled fatty acid and amino acid precursors, the authors found these pheromone candidates to be produced in patches located on the forewings of the males. Deuterium labels from hexadecanoic acid were incorporated into (11Z)-11-hexadecenoic acid, providing exptl. evidence of a Δ11-desaturase being active in butterflies. This unusual desaturase was found previously to be involved in the biosynthesis of female-produced sex pheromones of moths. In the male butterflies, both hexadecanoic acid and (11Z)-11-hexadecenoic acid were then enzymically esterified to form the Et, iso-Bu and 2-phenylethyl esters, incorporating ethanol, isobutanol, and 2-phenylethanol, derived from the corresponding amino acids L-alanine, L-valine, and L-phenylalanine.

Journal of Chemical Ecology published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C6H16OSi, Computed Properties of 110-34-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Uranga, Carla C. published the artcileFatty acid esters produced by Lasiodiplodia theobromae function as growth regulators in tobacco seedlings, Name: Isobutyl palmitate, the publication is Biochemical and Biophysical Research Communications (2016), 472(2), 339-345, database is CAplus and MEDLINE.

The Botryosphaeriaceae are a family of trunk disease fungi that cause dieback and death of various plant hosts. This work sought to characterize fatty acid derivatives in a highly virulent member of this family, Lasiodiplodia theobromae. NMR and gas chromatog.-mass spectrometry of an isolated compound revealed (Z, Z)-9,12-Et octadecadienoate, (trivial name Et linoleate), as one of the most abundant fatty acid esters produced by L. theobromae. A variety of naturally produced esters of fatty acids were identified in Botryosphaeriaceae. In comparison, the production of fatty acid esters in the soil-borne tomato pathogen Fusarium oxysporum, and the non-phytopathogenic fungus Trichoderma asperellum was found to be limited. Et linoleate, Et hexadecanoate (trivial name Et palmitate), and Et octadecanoate, (trivial name Et stearate), significantly inhibited tobacco seed germination and altered seedling leaf growth patterns and morphol. at the highest concentration (0.2 mg/mL) tested, while Et linoleate and Et stearate significantly enhanced growth at low concentrations, with both still inducing growth at 98 ng/mL. This work provides new insights into the role of naturally esterified fatty acids from L. theobromae as plant growth regulators with similar activity to the well-known plant growth regulator gibberellic acid.

Biochemical and Biophysical Research Communications published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C13H9FO, Name: Isobutyl palmitate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bouvet, Vincent R. published the artcileA Short and Economical Synthesis of Orthogonally Protected C-Linked 2-Deoxy-2-acetamido-α-D-galactopyranose Derivatives, Recommanded Product: (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, the publication is Journal of Organic Chemistry (2006), 71(9), 3619-3622, database is CAplus and MEDLINE.

A short and high-yielding synthesis has been devised to prepare C-linked 2-deoxy-2-acetamido-α-D-galactopyranose derivative (I). One of the main advantages of this approach is that it employs com. available and inexpensive D-glucosamine as the starting material. The key steps include a highly stereoselective C-allylation followed by epimerization of the C-4 hydroxyl group. Building block I and orthogonally protected C-linked 2-deoxy-2-acetamido-α-D-galactopyranose derivative were obtained in 44% overall yield (six steps) and 29% overall yield (eight steps), resp. This represents a significant improvement over previously reported syntheses.

Journal of Organic Chemistry published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, Recommanded Product: (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics