Tag: M.W=300-350

Ishida, Hideharu published the artcileSynthetic studies on sialoglycoconjugates. 94. Synthesis of 6′-GM2, a regioisomer of ganglioside GM2, for studying the mechanism of action of GM2 activator, HPLC of Formula: 10378-06-0, the publication is Carbohydrate Research (1997), 302(3-4), 223-227, database is CAplus and MEDLINE.

GM2 activator is a protein cofactor that assists β-hexosaminidase (HexA) in hydrolyzing the β-linked N-acetylgalactosamine (GalNAc) in ganglioside GM2. We report a synthesis of the regioisomer of ganglioside GM2, 6′-GM2, in which the GalNAc residue is linked, not to the 4-OH, but to the 6-OH of Gal to show that the resistance of GalNAc in GM2 to HexA is due to the specific structure of the GM2-epitope, β-D-GalNAc-(1→4)-α-Neu5Ac-(2→3)-β-D-Gal→.

Carbohydrate Research published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, HPLC of Formula: 10378-06-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Vijayakumar, B. published the artcileAn eco-friendly method for the synthesis of aryl and alkyl esters of carboxylic acids using acid activated Indian bentonite, Application of Isobutyl palmitate, the publication is Journal of the Indian Chemical Society (2005), 82(10), 922-925, database is CAplus.

Esterification of various carboxylic acids with phenol and alcs. was achieved using acid activated Indian bentonite (AAIB) as catalyst. The catalyst is versatile, and the reaction is found to work well for primary, secondary and tertiary alcs. The yields are very good under specific reaction conditions.

Journal of the Indian Chemical Society published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C5H10OS, Application of Isobutyl palmitate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hofmeister, Armin published the artcileSyntheses of Morpholine-Based Nucleotide Analogs for Hepatic siRNA Targeting and Stabilization, Category: esters-buliding-blocks, the publication is Journal of Medicinal Chemistry (2021), 64(10), 6838-6855, database is CAplus and MEDLINE.

A morpholine-based nucleotide analog was developed as a building block for hepatic siRNA targeting and stabilization. Attachment of an asialoglycoprotein-binding GalNAc ligand at the morpholine nitrogen was realized with different linkers. The obtained morpholino GalNAc scaffolds were coupled to the sense strand of a transthyretin-targeting siRNA and tested for their knockdown potency in vitro and in vivo. A clear structure-activity relationship was developed with regard to the linker type and length as well as the attachment site of the morpholino GalNAc moieties at the siRNA sense strand. Further, simple alkylation of the morpholine nitrogen led to a nucleotide analog, which increased siRNA stability, when used as a double 3′-overhang at the sense strand sequence. Combination of the best morpholino GalNAc building blocks as targeting nucleotides with an optimized stabilizing alkyl-substituted morpholine as 3′-overhangs resulted in siRNAs without any phosphorothioate stabilization in the sense strand and clearly improved the duration of action in vivo.

Journal of Medicinal Chemistry published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ohiri, Reginald C. published the artcileSolvent based variations in yield of bioactive extracts from the sclerotium of Pleurotus tuber-regium, Synthetic Route of 110-34-9, the publication is Chemica Sinica (2019), 10(1), 773-791, database is CAplus.

Background: The therapeutic effectiveness of herbs and fungi used for medicinal purposes is not only a factor of their bioactive constituents but also a factor of both the extraction solvent and extraction method. Objective: The objective of this study is to extract and analyze the bioactive components in the sclerotum of Pleurotus tuber-regium using different solvents, as to ascertain the solvent that gives a better yield. Method: A quantity of 10.0 kg of fresh sclerotia of P. tuber-regium purchased at Zarama Market in Southern Nigeria was washed, peeled and the white inner parts were sliced using a sterilized knife. The sliced samples were dried at room temperature for fourteen days. After grinding, the bioactive components were extracted by weighing 10 g of sample into three well stopper bottles and each was extracted in 20 mL of specific extraction solvent (methanol, hexane and dichloromethane), while that of soxleth extraction was done in a soxleth apparatus, using ethanol as the solvent. The process was repeated twice and the combined aliquot obtained were concentrated to 5.0 mL and purified. Two milliliters of the extracts were used for gas chromatog. and mass spectroscopy anal. Result: The highest peak on the chromatogram for the methanol extract was observed at 32.644 min., while hexane, dichloromethane and soxhlet extracts had their highest peaks at 31.459 min., 14.254 min. and 18.060 min. resp. The highest bioactive component in methanol extract was (3aR,4R,7R)-1,4,9,9-Tetramethyl-3, 4,5,6,7,8-hexahydro2H-3a,7-methane with a value of 62.856%, while hexane, dichloromethane and soxhlet extracts had Hexasiloxane, tetradecamethyl-, Bis(2-ethylhexyl) phthalate and Phthalic acid, 3-chlorobenzyl Bu ester with values of 29.170%, 5.092% and 25.490% resp. Conclusion: Hexane and dichloromethane extracts yielded more bioactive components with better nutriceutical and medicinal properties and may be regarded as better solvents for mushroom and fungi extractions.

Chemica Sinica published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Synthetic Route of 110-34-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kurkcuoglu, M. published the artcileComposition and antimicrobial activity of the essential oils of Calamintha betulifolia Boiss. et Bal, Recommanded Product: Isobutyl palmitate, the publication is Journal of Essential Oil Research (2007), 19(3), 285-287, database is CAplus.

The water distilled essentials oil from the aerial parts of Calamintha betulifolia Boiss. et Bal. collected from three different localities in Turkey were analyzed by GC and GC/MS. Fifty six to seventy nine components representing 80.6-93.0% of the oils were characterized. Pulegone (26-54%) was found as the main constituent. The antimicrobial effects of C. betulifolia essential oil are reported here for the first time.

Journal of Essential Oil Research published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, Recommanded Product: Isobutyl palmitate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ishiyama, Tatsuo published the artcileOrtho-C-H borylation of benzoate esters with bis(pinacolato)diboron catalyzed by iridium-phosphine complexes, Quality Control of 1146214-86-9, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(1), 159-161, database is CAplus and MEDLINE.

Iridium complexes generated from [Ir(OMe)(COD)]₂ and tris[3,5-bis(trifluoromethyl)phenyl]phosphine efficiently catalyzed the ortho-C-H borylation of benzoate esters with bis(pinacolato)diboron in octane at 80 °C to produce the corresponding arylboronates in high yields with excellent regioselectivities.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1146214-86-9. 1146214-86-9 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester, name is Methyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzoate, and the molecular formula is C15H18BF3O4, Quality Control of 1146214-86-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Yu-yu published the artcileVolatile component analysis of traditional fermented flour paste by GC-MS, COA of Formula: C20H40O2, the publication is Shipin Kexue (Beijing, China) (2012), 33(16), 100-105, database is CAplus.

The volatile composition of traditional fermented flour paste was analyzed by simultaneous distillation extraction (SDE) and gas chromatog. and mass spectrometry (GC-MS). The volatile compounds separated from traditional fermented flour paste were identified by comparing their retention indexes with those of reference compounds Their relative contents were determined by peak area normalization method and their contents in traditional fermented flour paste were measured by internal standard method. A total of 113 compounds were identified accounting for 95.368% of the total peak area. Their total content in traditional fermented flour paste was 263.049 μg/g. These compounds included 10 aldehydes (11.862 μg/g), 25 esters (6.955 μg/g), 20 acids (140.596 μg/g), 14 hydrocarbons (1.934 μg/g), 9 alcs. (5.666 μg/g), 19 heterocycles (53.938 μg/g), 7 ketones (1.406 μg/g) and 9 other compounds (40.692 μg/g).

Shipin Kexue (Beijing, China) published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C9H6FNO, COA of Formula: C20H40O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cui, Jingrong published the artcileStereocontrolled allylation of 2-amino-2-deoxy sugar derivatives by a free-radical procedure, Safety of (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, the publication is Carbohydrate Research (1998), 309(4), 319-330, database is CAplus.

Preparative routes for anomerically specific 1-C-allylation of 2-amino-2-deoxy sugars have been evaluated in a comparative study of various N-substituents and aglycons as precursors for glycosyl radicals that effectively capture an allyl group from allyltributyltin. The crystalline triacetate of 3-(2-acetamido-2-deoxy-α-D-glucopyranosyl)-1-propene was obtained in 70% yield when 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl chloride was treated with allyltributyltin under free-radical conditions, whereas the corresponding bromide led only to an oxazolidine derivative The 2-trifluoroacetamido 1-bromide analog of 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl chloride was also an effective radical source, giving the 2-trifluoroacetamido analog in 60% yield. The free amino analog was conveniently obtained via the 2-p-methoxybenzylideneamino 1-bromide analog of 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl chloride. Use of 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl bromide as radical precursor allowed stereospecific access to β-1-C-allyl derivatives of the amino sugar. The crystalline galactosamine analog was obtained by using the galacto analog of 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl chloride, but the corresponding manno chloride gave only an oxazoline product. The 1-C-allylated amino sugar derivatives are conformationally more mobile than derivatives not having a 1-C-linked substituent.

Carbohydrate Research published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C14H19NO8, Safety of (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Boeve, Jean-Luc published the artcileSecretion of the ventral glands in Craesus sawfly larvae, HPLC of Formula: 110-34-9, the publication is Biochemical Systematics and Ecology (2008), 36(11), 836-841, database is CAplus.

The secretion from ventral glands of Craesus alniastri, Craesus septentrionalis, and Craesus latipes (Hymenoptera, Tenthredinidae, Nematinae) was analyzed by GC-MS. The terpenoid dolichodial was the major compound in the 3 species. A few other terpenoids, several hydrocarbons, esters, aldehydes, and the aromatic compound benzaldehyde were also detected. Among the Nematinae the occurrence of dolichodial is restricted to Craesus and several species of the closely related genus Nematus. Craesus comprises ∼20 species. Their larvae are generally gregarious and brightly colored, and they possess highly developed ventral glands. Field tests show that the gregarious habit of C. septentrionalis larvae is an active process. This manuscript covers the chemotaxonomy, biosynthesis, and bioactivity of dolichodial, and the interactions between glandular secretion and appearance of larvae.

Biochemical Systematics and Ecology published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C20H40O2, HPLC of Formula: 110-34-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wu, Jian published the artcileImproving the Antigenicity of sTn Antigen by Modification of Its Sialic Acid Residue for Development of Glycoconjugate Cancer Vaccines, Application of (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, the publication is Bioconjugate Chemistry (2006), 17(6), 1537-1544, database is CAplus and MEDLINE.

Sialyl Tn (sTn) antigen is a sialylated disaccharide abundantly expressed by many tumors. To search for effective cancer immunotherapies based on sTn antigen, the authors designed and synthesized a series of unnatural N-acyl derivatives of sTn and studied their immunol. properties. For this purpose, an efficient method was developed to synthesize the natural and unnatural forms of sTn antigen and their protein conjugates. The resultant glycoconjugates were used to immunize C57BL/6 mice, and the immune response was assessed by ELISA. Whereas the keyhole limpet hemocyanin (KLH) conjugate of sTn elicited low levels of IgM antibodies, the KLH conjugates of N-iso-butanoyl sTn and N-phenylacetyl sTn, especially the latter, induced high titers of antigen-specific IgG antibodies, showing a T-cell-dependent response that is critical for the antitumor activity. The results suggest that the modified forms of sTn, especially N-phenylacetyl sTn, have improved antigenicity and promising immunol. properties for use as cancer vaccines.

Bioconjugate Chemistry published new progress about 10378-06-0. 10378-06-0 belongs to esters-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Ester,Inhibitor,Inhibitor, name is (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate, and the molecular formula is C13H11NO, Application of (3aR,5R,6R,7R,7aR)-5-(Acetoxymethyl)-2-methyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]oxazole-6,7-diyl diacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics