Tag: M.W=250-300

Dodgson, K. S. published the artcileSulfatases. IX. The arylsulfatases of mammalian livers, Related Products of esters-buliding-blocks, the publication is Biochemical Journal (1955), 29-37, database is CAplus and MEDLINE.

cf. C.A. 49, 1228a. The presence of 2 arylsulfatases in the livers of rat, ox, rabbit, and mouse has been shown. The enzymes can be distinguished by the ready solubility of one of them (“soluble”) after disruption of the mitochondria by acetone-drying, incubation in hyper- and hypo-tonic solutions, or alternate freezing and thawing. In the rat the “insoluble” enzyme is localized in the microsomes of the liver cell and the soluble enzyme is found mainly in the mitochondria. The insoluble enzyme has a high affinity for p-nitrophenyl and p-acetylphenyl sulfates, while the soluble enzyme has a low affinity for these substrates but a high activity towards nitrocatechol sulfate. The soluble enzyme of rat liver has been further separated into 2 enzymes which are comparable to sulfatases A and B of ox liver.

Biochemical Journal published new progress about 6217-68-1. 6217-68-1 belongs to esters-buliding-blocks, auxiliary class Salt,Nitro Compound,Sulfonate,Benzene, name is Potassium 4-nitrophenyl sulfate, and the molecular formula is C6H4KNO6S, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dodgson, K. S. published the artcileSulfatases. XV. The arylsulfatases of human serum and urine, Category: esters-buliding-blocks, the publication is Biochemical Journal (1957), 668-73, database is CAplus and MEDLINE.

cf. C.A. 51, 5895e. Human serum and urine exhibit little arylsulfatase (I) activity towards K p-acetylphenyl and p-nitrophenyl sulfates. In certain circumstances urine does show activity towards these substrates, but the activity resides in sedimentable material such as cellular debris and bacteria. Both serum and urine exhibit appreciable I activity towards nitrocatechol sulfate. The activity in urine is a feature of the urine per se and probably arises only in part from cellular debris. Two enzymes, corresponding to I A and I B of human tissues, are responsible for the bulk of the I activity of urine. Some observations on the nonenzymic catalysis by serum of the alk. hydrolysis of p-nitrophenyl sulfate are reported.

Biochemical Journal published new progress about 6217-68-1. 6217-68-1 belongs to esters-buliding-blocks, auxiliary class Salt,Nitro Compound,Sulfonate,Benzene, name is Potassium 4-nitrophenyl sulfate, and the molecular formula is C6H4KNO6S, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chen, Jian published the artcileA direct HPLC method for the determination of enantiomeric excess of some highly enantiomerically enriched derivatives of chiral glycidols, COA of Formula: C9H9NO6S, the publication is Tetrahedron Letters (1993), 34(48), 7663-6, database is CAplus.

A newly developed HPLC method which requires no derivatization is used to determine accurately the enantiomeric purity of some glycidol-based derivatives that were enantiomerically enriched by recrystallization or lipase-catalyzed kinetic resolution after the Sharpless asym. epoxidation

Tetrahedron Letters published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, COA of Formula: C9H9NO6S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

McComsey, David F. published the artcileNovel, Broad-Spectrum Anticonvulsants Containing a Sulfamide Group: Pharmacological Properties of (S)-N-[(6-Chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112), Quality Control of 115314-17-5, the publication is Journal of Medicinal Chemistry (2013), 56(22), 9019-9030, database is CAplus and MEDLINE.

Broad-spectrum anticonvulsants are of considerable interest as antiepileptic drugs, especially because of their potential for treating refractory patients. Such “neurostabilizers” have also been used to treat other neurol. disorders, including migraine, bipolar disorder, and neuropathic pain. A series of sulfamide derivatives was synthesized and their anticonvulsant activity evaluted. Thus, the authors identified promising sulfamide I (JNJ-26489112) and explored its pharmacol. properties. Compound I exhibited excellent anticonvulsant activity in rodents against audiogenic, elec. induced, and chem. induced seizures. Mechanistically, I inhibited voltage-gated Na⁺ channels and N-type Ca²⁺ channels and was effective as a K⁺ channel opener. The anticonvulsant profile of I suggests that it may be useful for treating multiple forms of epilepsy (generalized tonic-clonic, complex partial, absence seizures), including refractory (or pharmacoresistant) epilepsy, at dose levels that confer a good safety margin. On the basis of its pharmacol. and other favorable characteristics, I was advanced into human clin. studies.

Journal of Medicinal Chemistry published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Quality Control of 115314-17-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wright, Jay S. published the artcileSequential Ir/Cu-Mediated Method for the Meta-Selective C-H Radiofluorination of (Hetero)Arenes, Name: Methyl 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, the publication is Journal of the American Chemical Society (2021), 143(18), 6915-6921, database is CAplus and MEDLINE.

This article describes a sequential Ir/Cu-mediated process for the meta-selective C-H radiofluorination of (hetero)arene substrates. In the first step, Ir-catalyzed C(sp²)-H borylation affords (hetero)aryl pinacolboronate (BPin) esters. The intermediate organoboronates are then directly subjected to copper-mediated radiofluorination with [¹⁸F]tetrabutylammonium fluoride to afford fluorine-18 labeled (hetero)arenes in high radiochem. yield and radiochem. purity. This entire process is performed on a bench top without Schlenk or glove box techniques and circumvents the need to isolate (hetero)aryl boronate esters. The reaction was automated on a TracerLab FX_FN module with 1,3-dimethoxybenzene and a meta-tyrosine derivative The products, [¹⁸F]1-fluoro-3,5-dimethoxybenzene and an ¹⁸F-labeled meta-tyrosine derivative, were obtained in 37 ± 5% isolated radiochem. yield and >99% radiochem. purity and 25% isolated radiochem. yield and 99% radiochem. purity, and 0.52 Ci/μmol (19.24 GBq/μmol) molar activity (A_m), resp.

Journal of the American Chemical Society published new progress about 757982-31-3. 757982-31-3 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester,Boronic acid and ester, name is Methyl 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, and the molecular formula is C21H26Br4S2, Name: Methyl 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mori-Quiroz, Luis M. published the artcileCopper-Catalyzed Amidation of Primary and Secondary Alkyl Boronic Esters, Recommanded Product: tert-Butyl N-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]carbamate, the publication is Chemistry – A European Journal (2016), 22(44), 15654-15658, database is CAplus and MEDLINE.

The oxidative copper-catalyzed cross-coupling of functionalized alkyl boronic esters with primary amides is reported. Through the identification of appropriate diketimine ligands, conditions for efficient coupling of both primary and secondary alkyl boronic esters with diverse primary amides, including acetamide, have been developed.

Chemistry – A European Journal published new progress about 1850305-80-4. 1850305-80-4 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is tert-Butyl N-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]carbamate, and the molecular formula is C14H28BNO4, Recommanded Product: tert-Butyl N-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]carbamate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yao, Xinle published the artcile3D printing of PTFE-filled polyimide for programmable lubricating in the region where lubrication is needed, Safety of Trimethylolpropane triacrylate, the publication is Tribology International (2022), 107405, database is CAplus.

Three-dimensional (3D) target-region-lubrication printing of photosensitive polyimide (PSPI) filled with polytetrafluoroethylene (PTFE), i.e., PSPI-PTFE, with excellent tribol. properties for self-lubricating devices was realized by digital light processing of PSPI-PTFE ink and thermal post-treatment. The 3D-printed PSPI-PTFE composites exhibited the friction coefficients and wear rates sharply reduced by 88% and 98%, resp., and good mech. properties, thermal stability and interlayer bonding as well. Importantly, the surfaces with lubricating only in regions where needed were readily realized due to the layer-by-layer manufacturing manner of 3D printing. As proof-of-concept, a target-region-lubricating bearing was demonstrated successfully, which run stably with a speed ranged from 60 to 180 rpm/min, indicating that the 3D-printed PSPI-PTFE composites are suitable for fabricating devices with complex and special shapes.

Tribology International published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C6H10F3NO, Safety of Trimethylolpropane triacrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gardner, Terrence G. published the artcileEnzymatic hydrolysis of an organic sulfur compound, Synthetic Route of 6217-68-1, the publication is Advances in Enzyme Research (2019), 7(1), 1-13, database is CAplus.

Sulfatases which cleave sulfate esters in biol. systems are key enzymes that deserve special attention due to their significant roles in organic sulfur (OS) mineralization and inorganic sulfur (SO2-4 ) release. In this study, in-vitro experiments were conducted to evaluate S bonded substrate hydrolysis by a com. available arylsulfatase (EC 3.1.6.1) from Aerobacter aerogenes. The enzyme-substrate interactions were assessed to determine: 1-rate of hydrolysis, 2-catalytic efficiency, 3-thermal stability, and 4-optimal pH of this enzyme. Arylsulfatase exhibited substrate hydrolysis with a high affinity for p-nitrophenyl sulfate (potassium 4-nitrophenyl sulfate (pNPS)). The optimum activity for the enzyme was observed to occur at a pH of 7.1. The optimal temperature was 37°C but ranged from 35°C – 45°C. The apparent Km and Kcat of the enzyme for pNPS hydrolysis at the optimal pH, and temperature were determined to be 1.03 mM and 75.73μM/min, resp. This work defines the catalytic and kinetic properties of arylsulfatase (EC 3.1.6.1) and confirms the optimal conditions for sulfatase activity testing. The resulting information is useful in elucidating the contributions that individual enzymes have for specific reactions rather than relying on traditional total enzyme activity measurements.

Advances in Enzyme Research published new progress about 6217-68-1. 6217-68-1 belongs to esters-buliding-blocks, auxiliary class Salt,Nitro Compound,Sulfonate,Benzene, name is Potassium 4-nitrophenyl sulfate, and the molecular formula is C6H4KNO6S, Synthetic Route of 6217-68-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jia, Mengxiao published the artcilePolymer stabilized isotropic phase liquid crystals with large Kerr constant, COA of Formula: C15H20O6, the publication is Liquid Crystals (2022), 49(3), 399-406, database is CAplus.

In this paper, we reported a polymer stabilized isotropic phase liquid crystal (PSILC). The influences of different content of chiral dopant and polymer monomer on PSILC were studied. Adding the proper proportion and total content of polymer monomer TMPTA and C12A into liquid crystal with 1.0 weight% chiral dopant R5011, and UV photo-polymerization at the isotropic phase, we obtain the Kerr constant greater than 10 nm/V2, hysteresis less than 2.0% and fast response in PSILC.

Liquid Crystals published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, COA of Formula: C15H20O6.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Jie published the artcileCu-Catalyzed Decarboxylative Borylation, Application of tert-Butyl N-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]carbamate, the publication is ACS Catalysis (2018), 8(10), 9537-9542, database is CAplus and MEDLINE.

A simple method for the conversion of carboxylic acids to boronic esters via redox-active esters (RAEs) is reported using copper catalysis. The scope of this transformation is broad, and compared with the known protocols available, it represents the most inexpensive, rapid, and operationally simple option. In addition to a full exploration of the scope, a kinetic study was performed to elucidate substrate and reagent concentration dependences.

ACS Catalysis published new progress about 1850305-80-4. 1850305-80-4 belongs to esters-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is tert-Butyl N-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]carbamate, and the molecular formula is C20H19NO4, Application of tert-Butyl N-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)propyl]carbamate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics