Tag: M.W=250-300

Wu, Jingjing; Zhang, Dongmei; Hu, Linlin; Zheng, Xiaowei; Chen, Caihong published the artcile< Paeoniflorin alleviates NG-nitro-L-arginine methyl ester (L-NAME)-induced gestational hypertension and upregulates silent information regulator 2 related enzyme 1 (SIRT1) to reduce H2O2-induced endothelial cell damage>, HPLC of Formula: 112-63-0, the main research area is gestational hypertension SIRT1 paeoniflorin endothelium cell injury; Paeoniflorin; SIRT1; pregnancy hypertension; vascular endothelial cell dysfunction.

Pregnancy-induced hypertension (PIH) is a leading cause of maternal mortality. Paeoniflorin has been reported to alleviate hypertension, thus relieving the injury of target organ. This study aimed to investigate the role of paeoniflorin in PIH development by regulating SIRT1 in rats. The mean arterial pressure (MAP), urine protein and histopathol. damage of placenta in gestational hypertension rats were, resp., detected by noninvasive tail-artery pressure measuring instrument, BCA method and H&E staining. The viability of human umbilical vein endothelial cells (HUVECs) treated with paeoniflorin or/and H2O2 was observed by CCK-8 assay. SIRT1 protein expression in HUVECs treated with paeoniflorin or/and H2O2 was analyzed by Western blot. Tunel assay, wound healing assay and tube formation assay were used to detect the apoptosis, migration and tube formation of HUVECs administrated with paeoniflorin or/and H2O2 or/and EX527 (SIRT1 inhibitor). As a result, MAP, urine protein and histopathol. damage of placenta were enhanced in PIH rats, which were then alleviated by paeoniflorin. Paeoniflorin decreased the levels of sFlt-1, PlGF and VEGF in serum and placental tissues of gestational hypertension rats as well as the inflammatory response and oxidative stress. In addition, paeoniflorin promoted the expressions of SIRT1 and NO/eNOS and inhibited the production of iNOS in gestational hypertension rats to improve vascular endothelial cell injury. However, SIRT1 inhibition could suppress the protective effects of paeoniflorin on endothelial dysfunction of H2O2-induced HUVECs. In conclusion, paeoniflorin could improve gestational hypertension development by upregulating SIRT1.

Bioengineered published new progress about Cell injury. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jovanovic, Predrag; Petkovic, Milos; Simic, Milena; Jovanovic, Milos; Tasic, Gordana; Crnogorac, Marija Djordjic; Zizak, Zeljko; Savic, Vladimir published the artcile< Stereocontrolled Synthesis of Highly Substituted trans α,β-Unsaturated Ketones with Potent Anticancer Properties from Glycals>, Quality Control of 4098-06-0, the main research area is stereocontrolled synthesis unsaturated ketone Heck ring opening glycal; anticancer unsaturated ketone.

A novel synthetic route for highly substituted conjugated ketones has been developed utilizing glycals as starting materials. The two-step process combined the Heck reaction/Lewis acid promoted ring opening to afford the products in 33-80 % overall yields and with a high level of trans stereoselectivity [e.g., I + 4-iodoanisole → II → III]. Since the products are essentially the aldols, this methodol. may be employed in some cases as an alternative synthetic route to the typical aldol condensation. Densely substituted, selectively protected conjugated ketones are synthetically attractive structures which, in our case, proved to be biol. equally appealing. Namely, they showed activity against several cancer cell lines, such as HeLa, K562, MDA-MB-453, in some instances overperforming cisplatin used as a standard

European Journal of Organic Chemistry published new progress about Antitumor agents. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Quality Control of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ge, Yang; Yang, Haijun; Wang, Changyuan; Meng, Qiang; Li, Lei; Sun, Huijun; Zhen, Yuhong; Liu, Kexin; Li, Yanxia; Ma, Xiaodong published the artcile< Design and synthesis of phosphoryl-substituted diphenylpyrimidines (Pho-DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors: Targeted treatment of B lymphoblastic leukemia cell lines>, Quality Control of 112-63-0, the main research area is preparation phosphoryl derivative diphenylpyrimidine Bruton’s kinase inhibitor leukemia; BTK; DPPY; Inhibitor; Leukemia; Phosphoryl.

A family of phosphoryl-substituted diphenylpyrimidine derivatives (Pho-DPPYs) were synthesized and biol. evaluated as potent BTK inhibitors in this study. Compound 7b was found to markedly inhibit BTK activity at concentrations of 0.82 nmol/L, as well as to suppress the proliferations of B-cell leukemia cell lines (Ramos and Raji) expressing high levels of BTK at concentrations of 3.17 μM and 6.69 μM. Moreover, flow cytometry anal. results further indicated that 7b promoted cell apoptosis to a substantial degree. In a word, compound 7b is a promising BTK inhibitor for the treatment of B-cell lymphoblastic leukemia.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huertas, Raul; William Allwood, J.; Hancock, Robert D.; Stewart, Derek published the artcile< Iron and zinc bioavailability in common bean (Phaseolus vulgaris) is dependent on chemical composition and cooking method>, Application of C19H34O2, the main research area is Phaseolus genotyoe iron zinc bioavailability cooking biofortification; Bioavailability; Common bean; Domestic processing; In vitro digestion; Iron; Phaseolus vulgaris; Zinc.

The influence of genotype and domestic processing on iron and zinc bioavailability in common bean germplasm was investigated using an in vitro digestion model. Raw beans exhibited diversity in iron content (50 to >90 mg kg-1) although zinc content was similar (30-40 mg kg-1). Following preparation by different household cooking methods < 5% of the iron in raw beans was recovered in the bioavailable fraction following in vitro digestion. However, up to 20% of zinc present in dry seeds was bioavailable. A high proportion of iron and zinc in raw beans (up to 40%) was lost by leaching into cooking water when beans were prepared by boiling. Although untargeted LC/MS revealed genotype-dependent differences in grain chem., correlations between mineral bioavailability and antinutritional phytates and polyphenols were mostly insignificant. Our data highlight the need to consider losses during domestic processing and the related physicochem. traits in biofortification programs. Food Chemistry published new progress about Aldaric acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nurhayati; Saputra, L.; Awaluddin, A.; Kurniawan, E. published the artcile< Converting waste cooking oil to biodiesel catalyzed by NaOH-impregnated CaO derived from cockle shell (Anadara granosa)>, Quality Control of 112-63-0, the main research area is sodium hydroxide calcium oxide biodeisel waste cooking oil transesterification.

Herein, we developed an efficient and easily separable Na/CaO catalyst derived from cockle shell (Anadara granosa) for biodiesel production from waste cooking oil. Impregnation with 3 wt % of NaOH could enhance the sp. surface area and catalytic performance (>89% biodiesel yield). The effects of calcination temperature, reaction time, and stirring speed were also carefully studied. The quality of biodiesel obtained using this method mainly fulfills the requirements for biodiesel standard (ASTM D 6751).

Kinetics and Catalysis published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Enders, Dieter; Henseler, Alexander published the artcile< A Direct Intermolecular Cross-Benzoin Type Reaction: N-Heterocyclic Carbene-Catalyzed Coupling of Aromatic Aldehydes with Trifluoromethyl Ketones>, Reference of 112-63-0, the main research area is aldehyde aromatic coupling ketone trifluoromethyl benzoin heterocyclic carbene coupling.

A direct intermol. cross-benzoin-type condensation catalyzed by an N-heterocyclic carbene has been developed. The cross-coupling of com. available aromatic aldehydes R1CHO (R1 = Ph, 4-ClC6H4, 4-MeC6H4, etc.) and trifluoromethyl ketones R2COCF3 (R2 = Ph, 4-ClC6H4, 4-FC6H4) gave α-hydroxy-α-trifluoromethyl ketones R1C(O)C(OH)(CF3)R2 bearing a quaternary stereocenter with excellent chemoselectivity and good to excellent yields.

Advanced Synthesis & Catalysis published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pastore, Carlo; D’Ambrosio, Valeria published the artcile< Intensification of processes for the production of ethyl levulinate using AlCl3·6H2O>, Category: esters-buliding-blocks, the main research area is aluminum chloride catalyst ethyl levulinate esterification thermodn property.

A process for obtaining Et levulinate through the direct esterification of levulinic acid and ethanol using AlCl3·6H2O as a catalyst was investigated. AlCl3·6H2O was very active in promoting the reaction and, the correspondent kinetic and thermodn. data were determined The reaction followed a homogeneous second-order reversible reaction model: in the temperature range of 318-348 K, Ea was 56.3 kJ·K-1·mol-1, whereas Keq was in the field 2.37-3.31. The activity of AlCl3·6H2O was comparable to that of conventional mineral acids. Besides, AlCl3·6H2O also induced a separation of phases in which Et levulinate resulted mainly (>98 wt%) dissolved into the organic upper layer, well separated by most of the co-formed water, which decanted in the bottom. The catalyst resulted wholly dissolved into the aqueous phase (>95 wt%), allowing at the end of a reaction cycle, complete recovery, and possible reuse for several runs. With the increase of the AlCl3·6H2O content (from 1 to 5 mol%), the reaction proceeded fast, and the phases’ separation improved. Such a behavior eventually results in an intensification of processes of reaction and separation of products and catalyst in a single step. The use of AlCl3·6H2O leads to a significant reduction of energy consumed for the final achievement of Et levulinate, and a simplification of line-processes can be achieved.

Energies (Basel, Switzerland) published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Caltagirone, Claudia; Gale, Philip A.; Hiscock, Jennifer R.; Hursthouse, Michael B.; Light, Mark E.; Tizzard, Graham J. published the artcile< 2-Amidoindole-based anion receptors>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is indolecarboxamide dimer preparation anion receptor stability constant; dihydrogen phosphate ligand indolecarboxamide.

The title compounds were obtained by a reaction of diamines [i.e., 1,5-pentanediamine, 1,3-benzenedimethanamine] with 1H-indole-2-carboxylic acid derivatives The above-mentioned product structures were confirmed by NMR, elemental anal., and IR. X-ray crystal structure elucidation reveals that N,N’-1,5-pentanediylbis[1H-indole-2-carboxamide] complexes dihydrogen phosphate ion pairs in the solid state, which are part of a continuous chain. While this receptor binds dihydrogen phosphate in a 1:1 stoichiometry in solution, N,N’-[1,3-phenylenebis(methylene)]bis[7-nitro-1H-indole-2-carboxamide] (i.e., a 7-nitroindole derivative), forms 1:2 receptor:dihydrogen phosphate complexes in DMSO-d6/0.5% water.

Supramolecular Chemistry published new progress about Amidation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Easmon, Johnny; Heinisch, Gottfried; Puerstinger, Gerhard; Langer, Thierry; Oesterreicher, Juergen K.; Grunicke, Hans H.; Hofmann, Johann published the artcile< Azinyl and Diazinyl Hydrazones Derived from Aryl N-Heteroaryl Ketones: Synthesis and Antiproliferative Activity>, Quality Control of 112-63-0, the main research area is azinyl hydrazone preparation antiproliferative activity; hydrazone diazinyl preparation antiproliferative activity; antiproliferative structure activity azinyl hydrazone preparation.

A series of N-heteroaryl hydrazones derived from aryl N-heteroaryl or bis-N-heteroaryl methanones was prepared in search for potential novel antitumor agents. The stereochem. of these compounds was established by NMR. Antiproliferative activity was determined in a panel of human tumor cell lines (CCRF-CEM, Burkitt’s lymphoma, HeLa, ZR-75-1, HT-29, and MEXF 276L) in vitro. Generally, the new compounds were more potent (IC50 = 0.011-0.436 μM) than the ribonucleotide reductase inhibitor hydroxyurea (IC50 = 140 μM). Most of the compounds exhibited the highest activity against Burkitt’s lymphoma with IC50 = 0.011-0.035 μM. [14C]Cytidine incorporation into DNA was quantitated for selected hydrazones as a measure of the inhibition of ribonucleotide reductase in Burkitt’s lymphoma cells. (E)-Hydrazones inhibit [14C]cytidine incorporation to a greater extent (IC50 = 0.67-5.05 μM) than the (Z)-isomers (IC50 = 7.20 to >10 μM). Principal component anal. of the IC50 values obtained for inhibition of cell proliferation revealed that the cell lines tested can be grouped into three main families showing different sensitivities toward the compounds in our series (i, CCRF-CEM, Burkitt’s lymphoma, and HeLa; ii, HT-29; and iii, MEXF 276 L).

Journal of Medicinal Chemistry published new progress about Cytotoxic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gardiner, John M.; Bruce, Sarah E. published the artcile< Unexpected diastereoselectivity in AD of an L-proline-derived 1,1-disubstituted alkene>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is asym dihydroxylation diastereoselectivity.

Asym. dihydroxylation of the L-proline-derived 1,1-disubstituted alkene I catalyzed by either (DHQ)2PHAL or (DHQD)2PHAL unexpectedly leads to preference for the same diastereomer, both reactions proceeding with apparently matching double diastereoselectivity. In contrast, AD using the analogous (DHQ)2PYR or (DHQD)2PYR ligands leads to preferences for diastereomeric diols.

Tetrahedron Letters published new progress about Dihydroxylation catalysts, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics