Tag: M.W=250-300

Liu, Junnan; Zhao, Min; Zhang, Shuang; Liu, Jiaonan; Zhao, Chunjie; Wang, Miao published the artcile< Rapid characterization of the chemical constituents of Wangbi Capsule by UPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is capsule UPLC ion cyclotron resonance mass spectrometry.

Wangbi Capsule is a compound preparation composed of 17 traditional Chinese medicines, which is widely used in the treatment of rheumatoid arthritis. In our study, a rapid and straightforward anal. method was successfully established by using Ultra performance liquid chromatog. coupled with Fourier transform ion cyclotron resonance mass spectrometry technol. to quickly sep. and identify the chem. constituents of Wangbi Capsule. The chromatog. was performed on a Universal XB-C18 column (2.1 mm x 150 mm, 3μm) by the mobile phase containing acetonitrile (A)-0.1% formic acid and water (B) at the flow rate of 0.2 mL/min. The pos. and neg. ions of the samples were analyzed by extraction ion chromatog. Based on accurate mass spectrometry informations such as excimer ions and fragment ions, combined with the reference materials and the reference literature, 140 compounds in the Wangbi Capsule were identified or preliminarily characterized. The results of the study show that Wangbi Capsules mainly contain 3 types of nucleosides, 31 types of alkaloids, 12 types of organic acids, 29 types of flavonoids, 12 types of monoterpene glycosides, 30 types of coumarins, 10 types of chromones, 3 types of saponins, 6 kinds of phenylethanoid glycosides and other chem. components. The method established in this study can quickly and efficiently identify the chem. constituents in Wangbi Capsules. It is hoped that it will have a certain significance for the characterization of other Chinese medicine components and lay the foundation for pharmacol. research and subsequent in vivo studies of Wangbi Capsules.

Microchemical Journal published new progress about Capsules. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aguilar-Morante, Diana; Gomez-Cabello, Daniel; Quek, Hazel; Liu, Tianqing; Hamerlik, Petra; Lim, Yi Chieh published the artcile< Therapeutic Opportunities of Disrupting Genome Integrity in Adult Diffuse Glioma>, Product Details of C19H34O2, the main research area is review glioma glioblastoma genome central nervous system therapeutics; CNS tumors; DNA damage response; DNA repair; glioma; molecular markers; pharmacotherapeutics; precision medicine; synthetic lethality; targeted therapy.

A review. Adult diffuse glioma, particularly glioblastoma (GBM), is a devastating tumor of the central nervous system. The existential threat of this disease requires on-going treatment to counteract tumor progression. The present outcome is discouraging as most patients will succumb to this disease. The low cure rate is consistent with the failure of first-line therapy, radiation and temozolomide (TMZ). Even with their therapeutic mechanism of action to incur lethal DNA lesions, tumor growth remains undeterred. Delivering addnl. treatments only delays the inescapable development of therapeutic tolerance and disease recurrence. The urgency of establishing lifelong tumor control needs to be re-examined with a greater focus on eliminating resistance. Early genomic and transcriptome studies suggest each tumor subtype possesses a unique mol. network to safeguard genome integrity. Subsequent seminal work on post-therapy tumor progression sheds light on the involvement of DNA repair as the causative contributor for hypermutation and therapeutic failure. In this review, we will provide an overview of known mol. factors that influence the engagement of different DNA repair pathways, including targetable vulnerabilities, which can be exploited for clin. benefit with the use of specific inhibitors.

Biomedicines published new progress about Central nervous system. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Carboni, D.; Jiang, Y.; Malfatti, L.; Innocenzi, P. published the artcile< Selective detection of organophosphate through molecularly imprinted GERS-active hybrid organic-inorganic materials>, Electric Literature of 112-63-0, the main research area is organophosphate graphene mol imprinting hybrid organic inorganic material; graphene enhanced Raman scattering hybrid organic inorganic material.

A selective sensing platform for the organophosphate paraoxon, a highly toxic organic pollutant, has been designed and tested on water samples. A porous hybrid organic-inorganic film, synthesized using tetraethoxysilane, 1,8-bis(triethoxysilyl)octane and cetyltrimethylammonium bromide, has been molecularly imprinted with a structural analog of paraoxon, the diethyl(4-nitrobenzyl)phosphonate, to induce selective recognition. Exfoliated graphene has been incorporated into the porous matrix to provide enhancement of the Raman scattering signal. The Raman sensor has been tested on different concentrations of paraoxon in both ethanol and water/ethanol mixture The mol. selectivity has been assessed by comparing the Raman signal enhancement of paraoxon with a similar organophosphate, the bis-(4-nitrophenyl) phosphate. The molecularly imprinted film has shown a fourfold increase of the paraoxon signal, when compared with the corresponding not-imprinted. The evaluation of the d. of mol. cavities into the molecularly imprinted samples (4.50 * 10-10 μmol μm-3) has allowed assuming that each mol. cavity is capable of providing a remarkable signal enhancement of 1.47 * 1012 count * μmol-1 only when recognising paraoxon. The material design has allowed coupling the sensitivity of the graphene-mediated enhancement of Raman scattering with the selectivity of mol. imprinting into a single and potentially portable, anal. system. Copyright © 2017 John Wiley & Sons, Ltd.

Journal of Raman Spectroscopy published new progress about Density. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Perkin, W. H.; Smith, Alice E. published the artcile< The synthesis of ααγ-trimethylglutaric acid, of the cis- and trans-modifications of β-hydroxy-ααγ-trimethylglutaric acid, and of ααγ-trimethylglutaconic acid>, HPLC of Formula: 112-63-0, the main research area is .

A study on the synthesis of ααγ-trimethylglutaric acid, of the cis- and trans-modifications of β-hydroxy-ααγ-trimethylglutaric acid, and of ααγ-trimethylglutaconic acid was carried out. A mixture of ethyl dimethylmalonate and ethyl acetate was readily acted on by sodium, yielding the sodium compound of ethyl αα-dimethylacetonedicarboxylate. If this was treated with methyl iodide, a methyl group is introduced in the place of the metal and ethyl ααγ-trimethylacetonedicarboxylate is formed. When ethyl ααγ-trimethylacetonedicarboxylate was reduced with sodium amalgam, it yielded a mixture of two isomeric acids that melt at 115° and 155°, and were stereoisomeric modifications of β-hydroxy-ααγ-trimethylglutaric acid.

Journal of the Chemical Society, Transactions published new progress about Charcoal (animal). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alsowayigh, Marwah M.; Timco, Grigore A.; Borilovic, Ivana; Alanazi, Abdulaziz; Vitorica-yrezabal, Inigo J.; Whitehead, George F. S.; McNaughter, Paul D.; Tuna, Floriana; O’Brien, Paul; Winpenny, Richard E. P.; Lewis, David J.; Collison, David published the artcile< Heterometallic 3d-4f Complexes as Air-Stable Molecular Precursors in Low Temperature Syntheses of Stoichiometric Rare-Earth Orthoferrite Powders>, Application In Synthesis of 112-63-0, the main research area is heterometallic lanthanum gadolinium orthoferrite preparation crystal mol structure thermolysis.

Four 3d-4f heteropolymetallic complexes [Fe2Ln2((OCH2)3CR)2(O2CtBu)6(H2O)4] (where Ln = La (1 and 2) and Gd (3 and 4); and R = Me (1 and 3) and Et (2 and 4)) are synthesized and analyzed using elemental anal., Fourier transform IR spectroscopy (FT-IR), thermogravimetric anal. (TGA) and SQUID magnetometry. Crystal structures are obtained for both Me derivatives and show that the complexes are isostructural and adopt a defective dicubane topol. The four heavy metals are connected with two alkoxide bridges. These four precursors are used as single-source precursors to prepare rare-earth orthoferrite pervoskites of the form LnFeO3. Thermal decomposition in a ceramic boat in a tube furnace gives orthorhombic LnFeO3 powders using optimized temperatures and decomposition times: LaFeO3 formed at 650° over 30 min, whereas GdFeO3 formed at 750° over 18 h. These materials are structurally characterized using powder x-ray diffraction, Raman spectroscopy, SEM, energy-dispersive x-ray map spectroscopy, and SQUID magnetometry. EDX spectroscopy mapping reveals a homogeneous spatial distribution of elements for all four materials consistent with LnFeO3. Magnetic measurements on complexes 1-4 confirms the presence of weak antiferromagnetic coupling between the central Fe(III) ions of the clusters and negligible ferromagnetic interaction with peripheral Gd(III) ions in 3 and 4. Zero field cooled (ZFC) and field-cooled (FC) measurements of magnetization of LaFeO3 and GdFeO3 in the solid state suggests that both materials are ferromagnetic, and both materials show open magnetic hysteresis loops at 5 and 300 K, with Msat higher than previously reported for these as nanomaterials. We conclude that this is a new and facile low temperature route to these important magnetic materials that is potentially universal limited only by what metals can be programmed into the precursor complexes. Novel heterometallic 3d-4f complexes are reported, and their use as air stable mol. precursors for the synthesis of solid state rare earth orthoferrites (LnFeO3) is explored.

Inorganic Chemistry published new progress about Antiferromagnetic exchange. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Brunel, Jeremie; Ledoux, Isabelle; Zyss, Joseph; Blanchard-Desce, Mireille published the artcile< Propeller-shaped molecules with giant off-resonance optical nonlinearities>, Category: esters-buliding-blocks, the main research area is nonlinear optical triphenylbenzene crux preparation.

Propeller-shaped mols. based on a triphenylbenzene crux bearing three oligomeric phenylenevinylene branches were designed. Very large first-order hyperpolarizabilities (up to ‖β‖ = 800 10-30 esu) were obtained while maintaining wide transparency in the visible region by taking advantage and boosting of intramol. charge transfer between the center and the periphery.

Chemical Communications (Cambridge, United Kingdom) published new progress about Nonlinear optical materials. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tietze, Ernst; Bayer, Otto published the artcile< Sulfonic acids of pyrene and their derivatives>, Application In Synthesis of 112-63-0, the main research area is .

Pyrene (I) in 6 parts C2Cl4, cooled to 0°, treated with the calculated quantity of ClSO3H in C2Cl4 at 0-5° and stirred 15-20 h. at 10-20°, decomposed with ice-H2O, the C2Cl4 removed by distillation in vacuo, the solution filtered hot and treated with a hot solution of the calculated quantity of Na2SO4, gives 90-2% of Na pyrene-3-sulfonate (II). II (61 g.) in 500 cc. AcOH and 17.5 g. of 80% HNO3, mixed and stirred 12 h. at 15-25°, give a NO2 compound, which is reduced by Fe in AcOH to an NH2 derivative (41 g.), yellow powder, whose aqueous solution shows an intense blue fluorescence; the solution is easily diazotized and couples with R salt to a dull-violet dye. Addition of 202 g. of I to 500 g. H2SO4 (66° Bé) at 0° during 1 h. and allowing the mixture to stand 2 days at 15° give 45 g. I and after addition of NaCl 130 g. III; II (61 g.), added during 30 min. to 400 g. H2SO4 (66°Bé.) at 5-10° and stirred 1 h., gives 42% of di-Na pyrene-3,8-disulfonate (III), yellow powder soluble in H2O with a violet fluorescence. Heating 15 g. III with 38 g. KOH and 115 g. H2O for 6 h. at 260° (internal temperature) and 40 atm. gives 6 g. 3,8-dihydroxypyrene, which is sensitive to the air and was characterized as the di-Ac derivative, m. 222-4°. The mother liquor from III, treated with CaCO3, gives 7 g. of Ca pyrene-3,5-disulfonate (IIIA), the aqueous solution of which shows a pale blue fluorescence; this acid differs from the 3,8-isomer in the much greater solubility of the Na and Ca salts. II (76 g.) in 550 g. H2SO4.H2O at 5-10°, stirred 1 day at 15° poured onto ice, the H2SO4 removed by CaCO3 and neutralized with K2CO3, gives 12-15 g. of di-K mono-Na pyrene-3,5,8-trisulfonate, thick yellow prisms, which shows a strong violet fluorescence in aqueous solution When 924 g. of II are quickly added to 2600 g. H2SO4.H2O at 15-20° and, after cooling, treated with 2400 g. of 65% oleum at 20° and the mixture is stirred for 15 h. at 20°, the H2SO4 removed with CaCO3, the filtrate concentrated to 101., neutralized and treated with 20% NaCl, there results 80% of tetra-Na pyrene-3,5,8,10-tetrasulfonate (IV), a yellow powder; IV can be precipitated directly by addition of NaCl but the yield is lower. IV also results in 70% yield by adding 202 g. I to a mixture of 1300 g. H2SO4.H2O and 300 g. Na2SO4 at 58°, stirring 15 min., cooling to 50-5° and adding 800 g. of 65% oleum during 20 min. NaClO3 and HCl give the known 3,5,8,10-tetrachloropyrene, thus establishing the structure of IV. Refluxing 488 g. IV with 280 g. com. NaOH in 1400 cc. H2O for 18 h., adding 400 cc. com. HCl and neutralizing with HCO2H give on addition of 10% NaCl 340 g. of tri-Na 3-hydroxypyrene-5,8,10-trisulfonate (V), with 1 mol H2O, yellow needles. Heating 61 g. of IV with 610 cc. 22% NH4OH for 18 h. at 200-10° gives 22% of the 3-NH2 analog of V, greenish yellow prisms; the slightly acid solution shows an intense green fluorescence; the NH2 group may be diazotized. 3-Chloropyrene (24 g.) in 130 g. H2SO4.H2O and 30 g. Na2SO4, treated at 50-60° with 80 g. of 65% oleum, gives 41 g. of tri-Na 3-chloropyrene-5,8,10-trisulfonate; the Cl in this salt could not be replaced by NH2 by heating with NH4OH in an autoclave. Addition of 732 g. IV to a melt of 720 g. com. NaOH in 450 cc. H2O at 130° and heating 30 min. at 155°, 20 min. at 165° and 5 min. at 170° give 90% of di-Na 3,5-dihydroxypyrene-8,10-disulfonate (VI), yellow, which shows a green fluorescence in H2O. VI (219 g.) and 2.2 l. 10% H2SO4, heated 12 h. at 140-50°, give 90% (crude) of 3,5-dihydroxypyrene (VII) which, crystallized from AcOH, m. 220° (decomposition) and darkens in the air; di-Ac derivative, m. 154-5°; di-Me ether, m. 177-8°. IV (61 g.) in 450 cc. H2O and 37.5 g. 33% NaOH with 7 g. Zn dust, boiled 7 h., give 29-30 g. of di-Na pyrene-3,5-disulfonate (VIII), which may be purified through IIIA. VIII (40.6 g.) and 110 g. NaOH in 300 cc. H2O, heated 8 h. at 210-20°, give 22 g. of Na 3-hydroxypyrene-5-sulfonate, yellow, the aqueous solution of which shows a strong bluish green fluorescence. Heating VIII with NaOH at 250-60° for 15 h. gives VII. VIII (40.6 g.) and HNO3-H2SO4 at 18° for 20 h. give a 3,5-di-NO2 derivative, which is very soluble in H2O and is reduced to a di-NH2 derivative (27 g.). IV (366 g.) and 360 g. NaOH in 1080 g. H2O, heated 12 h. at 240-50°, give 32% of 3,5,8,10-tetrahydroxypyrene (IX), m. 236-8°; the aqueous solution shows a blue fluorescence; the concentrated H2SO4 solution is yellow with a green fluorescence; IX does not couple with diazo solutions Oxidation of IX with CrO2 gives a black powder. Tetra-Me ether of IX, pale brown, m. 172-3°; it could not be nitrated. Some of these compounds are dyes and the behavior with fabrics is given.

Justus Liebigs Annalen der Chemie published new progress about Dyes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dolenc, Darko; Plesnicar, Bozo published the artcile< Abstraction of Iodine from Aromatic Iodides by Alkyl Radicals: Steric and Electronic Effects>, Application of C19H34O2, the main research area is steric electronic effect abstraction iodine aromatic iodides alkyl radical; crystallog aromatic iodide.

Abstraction of the iodine atom from aryl iodides by alkyl radicals takes place in some cases very efficiently despite the unfavorable difference in bond dissociation energies of C-I bonds in alkyl and aryl iodides. The abstraction is most efficient in iodobenzenes, ortho-substituted with bulky groups. The ease of abstraction can be explained by the release of steric strain during the elimination of the iodine atom. The rate of abstraction correlates fairly well with the strain energy, calculated by d. functional theory (DFT) and Hartree-Fock (HF) methods as a difference in the total energy of ortho and para isomers. However, besides the steric bulk, the presence of some other functional groups in an ortho substituent also influences the rate. The stabilization of the transition state, resembling a 9-I-2 iodanyl radical, by electron-withdrawing groups seems to explain a pos. sign of the Hammett ρ value in the radical abstraction of halogen atoms.

Journal of Organic Chemistry published new progress about Abstraction reaction (iodine). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Trowbridge, P. F.; Diehl, O. C. published the artcile< Halides and perhalides of pyridine>, SDS of cas: 112-63-0, the main research area is .

The range of formation with the periodides is great, C6H5N. HI.I to C5H5N.HI.I6, with the perbromides slight, and zero with the perchlorides. With the normal perhalides, increase in halogen lowers the melting point. With the normal halide, the hydrogen halide melts highest, the methyl halide lower, and the ethyl halide lowest. In the mixed perhalides, the power of displacement and the position of the halogen atoms in the molecule are points of great interest. Iodine in excess displaces bromine and chlorine completely, forming periodides from the normal bromides and chlorides. Bromine seems to displace iodine from the pyridine normal iodides and then combines with it to form a bromoiodide of a normal bromide. Bromine, on the other hand, displaces chlorine completely forming perbromides from the normal chlorides. Chlorine seems to displace both iodine and bromine at first to form normal chlorides, then it combines with the displaced halogen to form mixed perhalides, ICl, ICl3, BrCl, BrCl3, of the normal chlorides from C5H5N.HI and Cl2.

Journal of the American Chemical Society published new progress about Analysis (qual. test). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nack, Tobias; Dinis de Oliveira, Thiago; Weber, Stefan; Schols, Dominique; Balzarini, Jan; Meier, Chris published the artcile< γ-Ketobenzyl-Modified Nucleoside Triphosphate Prodrugs as Potential Antivirals>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is antiviral nucleoside triphosphate prodrugs d4TTP HIV delivery.

The antiviral activity of nucleoside reverse transcriptase inhibitors is often hampered by insufficient phosphorylation. Nucleoside triphosphate analogs are presented, in which the γ-phosphate was covalently modified by a non-bioreversible, lipophilic 4-alkylketobenzyl moiety. Interestingly, primer extension assays using human immunodeficiency virus reverse transcriptase (HIV-RT) and three DNA-polymerases showed a high selectivity of these γ-modified nucleoside triphosphates to act as substrates for HIV-RT, while they proved to be nonsubstrates for DNA-polymerases α, β, and γ. In contrast to d4TTP, the γ-modified d4TTPs showed a high resistance toward dephosphorylation in cell extracts A series of acyloxybenzyl-prodrugs of these γ-ketobenzyl nucleoside triphosphates was prepared The aim was the intracellular delivery of a stable γ-modified nucleoside triphosphate to increase the selectivity of such compounds to act in infected vs. noninfected cells. Delivery of γ-ketobenzyl-d4TTPs was proven in T-lymphocyte cell extracts The prodrugs were potent inhibitors of HIV-1/2 in cultures of infected CEM/0 cells and more importantly in thymidine kinase-deficient CD4+ T-cells.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics