Tag: M.W=250-300

Musser, J. H.; Hudec, T. T.; Bailey, K. published the artcile< A simple one-step synthesis of alkyl benzazol-2-carboxylates>, COA of Formula: C19H34O2, the main research area is benzoxazolecarboxylate ester; cyclocondensation aminophenol trialkoxyacetate; oxalate ortho ester cyclocondensation aminophenol.

Benzoxazoles, benzothiazole derivative, and benzimidazoles I (Z = CH, N; Z1 = O, S, NH, NPh; R = Me, Et; R1 = H and R2 = H, Cl, OMe, or R1R2 = benzo) were prepared from the resp. II and (RO)3CCO2R. Thus, 2-H2NC6H4OH was treated with (MeO)3CCO2Me to give I (R = Me, Z = CH, Z1 = O, R1 = R2 = H).

Synthetic Communications published new progress about Cyclocondensation reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Watanabe, Hitoshi; Ishida, Kyoji; Yamamoto, Masanori; Horiguchi, Masakuni; Isobe, Yoshiaki published the artcile< Synthesis and pharmacological evaluation of 11-(1,6-dimethyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepines with clozapine-like receptor occupancy at dopamine D1/D2 receptor>, Quality Control of 112-63-0, the main research area is dibenzo diazepine preparation dopamine schizophrenia agranulocytosis antipsychotic; Agranulocytosis; Antipsychotics; Clozapine; Dopamine; Reactive metabolites; Treatment resistant schizophrenia.

Clozapine-like compound without agranulocytosis risk is need to cure the treatment resistant schizophrenia (TRS). We discovered I as Clozapine-like dopamine D2/D1 receptor selectivity and improved reactive metabolites formation profile by the modification of piperazine moiety in Clozapine. The optimization of I gave compound II to be best compound (approx. 10-fold stronger affinity for D2/D1 receptor and similar D2/D1 selectivity ratio with Clozapine). Clozapine-like D2/D1 receptor occupancy profile was proved by in vivo evaluation. In addition, the reactive metabolites derived agranulocytosis risk of compound II was considered to be lower than Clozapine. The pharmacol. detail of compound II is being investigated to develop it for TRS treatment.

Bioorganic & Medicinal Chemistry Letters published new progress about Agranulocytosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Odashima, Tsugikatsu; Kikuchi, Takemitsu; Ohtani, Wataru; Ishii, Hajime published the artcile< Synthesis and chromogenic properties of water-soluble substituted 2-pyridyl-3'-sulfophenylmethanone 2-pyridylhydrazones and spectrophotometric and analog derivative spectrophotometric determination of trace amounts of cobalt with 2-pyridyl-3'-sulfophenylmethanone 2-(5-nitro)pyridylhydrazone>, Related Products of 112-63-0, the main research area is cobalt determination spectrophotometry; steel analysis cobalt spectrophotometry; pyridylsulfophenylmethanone nitropyridylhydrazone reagent cobalt determination; ionization pyridylsulfophenylmethanone pyridylhydrazone substituent effect.

Three water-soluble hydrazones, in which the 5-position of the pyridine ring in the hydrazine moiety of 2-pyridyl-3′-sulfophenylmethanone 2-pyridylhydrazone was substituted by a Me, chloro or nitro group, were synthesized and their chromogenic properties and reactivities with metal ions investigated. The acid dissociation constants (Ka) of the synthesized hydrazones were determined spectrophotometrically. These values obeyed Hammett’s law; the inductive effect of the substituents reflect the pKa values. Of the synthesized hydrazones, 2-pyridyl-3′-sulfophenylmethanone 2-(5-nitro)pyridylhydrazone (PSNPH) is the most sensitive for Co(II) determination It reacts with Co(II) complex to form a 1:2 (metal:ligand) complex. This complex is rapidly oxidized above pH 2 to give a stable Co(III) complex with an absorption maximum at 496 nm. Beer’s law is obeyed over the range 0.05-1.0 μg mL-1 of Co and the apparent molar absorptivity of the complex is 5.69 × 104 L mol-1cm-1 at 496 nm. A sensitive and practical spectrophotometric method for the determination of trace amounts of Co with PSNPH is proposed and was successfully applied to the determination of Co in steel samples. The method may be made more sensitive by employing an analog derivative spectrophotometric technique.

Analyst (Cambridge, United Kingdom) published new progress about Ionization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Halat, David M.; Fang, Chao; Hickson, Darby; Mistry, Aashutosh; Reimer, Jeffrey A.; Balsara, Nitash P.; Wang, Rui published the artcile< Electric-field-induced spatially dynamic heterogeneity of solvent motion and cation transference in electrolytes>, Reference of 112-63-0, the main research area is electrolytic solution elec field liquid electrolyte solvent motion.

While elec. fields primarily result in migration of charged species in electrolytic solutions, the solutions are dynamically heterogeneous. Solvent mols. within the solvation shells of the cation will be dragged by the field while free solvent mols. will not. We combine electrophoretic NMR measurements of ion and solvent velocities under applied elec. fields with mol. dynamics simulations to interrogate different solvation motifs in a model liquid electrolyte. Measured values of the cation transference number (t0+) agree quant. with simulation-based predictions over a range of electrolyte concentrations Solvent-cation interactions strongly influence the concentration-dependent behavior of t+0. We identify a critical concentration at whichmost of the solventmols. liewithin solvation shells of the cations. The dynamic heterogeneity of solvent mols. is minimized at this concentration where t+0 is approx. equal to zero.

Physical Review Letters published new progress about Concentration (process). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thangavel, Vigneshwaran; Mastouri, Afef; Guery, Claude; Morcrette, Mathieu; Franco, Alejandro A. published the artcile< Understanding the Reaction Steps Involving Polysulfides in 1 M LiTFSI in TEGDME : DOL Using Cyclic Voltammetry Experiments and Modelling>, SDS of cas: 112-63-0, the main research area is lithium bistrifluoromethanesulfonylimide tetraethylene glycol dimethy ether dioxolane cyclic voltammetry.

The reaction mechanisms of polysulfides in the electrolytes of lithium sulfur (Li-S) batteries are known to be complex. These reaction mechanisms may also change with the electrolyte used. Understanding the reaction steps of the polysulfides in a Li-S battery electrolyte is important to assess the underlying phenomena behind the Li-S cell performance limitations. Here, we investigate the reaction steps of polysulfides in electrolyte solutions containing S8, Li2S8 and Li2S6 in 1 M LiTFSI in TEGDME : DOL (volume/volume 1 : 1) (one of the most interesting electrolytes for use in Li-S batteries), using exptl. cyclic voltammetry and a math. model. The math. model assists in understanding the reaction steps behind the characteristics changes of cyclic voltammograms (CVs) with the scan rate and polysulfides speciation. Our systematic study shows that the reaction steps conventionally used in Li-S battery models are not sufficient to simulate all the CV characteristics of the investigated electrolyte solutions

Batteries & Supercaps published new progress about Cyclic voltammetry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lou, Jiang; He, Yuan; Li, Yunlong; Yu, Zhengkun published the artcile< Transition-Metal-Promoted Direct C-H Cyanoalkylation and Cyanoalkoxylation of Internal Alkenes via Radical C-C Bond Cleavage of Cycloketone Oxime Esters>, SDS of cas: 112-63-0, the main research area is cyanoalkylated alkene preparation cyanoalkoxylation bond cleavage cycloketone oxime ester; cyanoalkoxylation internal alkene bond cleavage cycloketone oxime ester.

Transition-metal-catalyzed alkyl-Heck-type cross-coupling of olefinic C-H bonds has been a challenge in the C-H activation area. Herein, we report FeCl3-promoted efficient direct C-H cyanoalkylation of internal alkenes, i.e., ketene dithioacetals, with cycloketone oxime esters via radical C-C bond cleavage under the redox-neutral conditions. With CuCl2 as the catalyst under a dioxygen atm. direct C-H cyanoalkoxylation of the same internal alkenes was achieved. The cyanoalkylated tetrasubstituted alkene products could be diversely transformed to cyanoalkyl-functionalized N- and S-heterocyclic compounds The mechanistic studies have revealed that these C-H cyanoalkylation and cyanoalkoxylation reactions proceed through a radical pathway.

Advanced Synthesis & Catalysis published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (internal). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wan, Qijuan; Wu, Liqun; Yang, Qiuhua; Lin, Mao; Guo, Songlin published the artcile< First identification and pathogenicity study of Vibrio harveyi isolated from diseased American eel (Anguilla rostrata) cultivated in freshwater>, Electric Literature of 112-63-0, the main research area is Anguilla rostrata disease freshwater Vibrio harveyi isolation pathogenicity.

Diseases caused by Vibrio harveyi in marine organisms have been generally reported in aquaculture, but there has been no reported V. harveyi infection in fish cultivated in freshwater. Herein, we isolated 3 strains of V. harveyi from diseased American eels (Anguilla rostrata) cultivated in freshwater and subsequently confirmed the virulence of V. harveyi and the extracellular product (ECP). The three isolates were identified as V. harveyi based on phenotypic features and homol. of 16S rDNA and 3 house-keeping genes (HKGs). Exptl. infection revealed that V. harveyi and ECP were highly pathogenic to American eels, and the median LDs (LD50) were 1.67 x 103 cfu/g and 7.29μg/g body weight, resp. Moreover, our antibiotic susceptibility test showed that V. harveyi was susceptible to 16 of 20 antibiotics using the VITEK system of Merieux. Furthermore, liver and kidney samples were collected for paraffin sectioning, stained with haematoxylin-eosin (H & E) and Periodic Acid-Schiff (PAS). H & E staining results revealed hepatocyte atrophy and necrosis, hepatic intercellular hemorrhage and intrahepatic venous thrombosis, while the kidney was characterized by renal tubular epithelial cell swelling and renal interstitial haematopoietic cell loss. Interestingly, glycogen deposition was more obvious in the kidney compared with the liver after PAS staining. Cultivated eel infected by V. harveyii was reported for the first time, and the results of this study provide a valuable reference for further prevention and control of fish diseases caused by V. harveyi.

Aquaculture Research published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Williams, Georgia E.; Kociok-Kohn, Gabriele; James, Tony D.; Lewis, Simon E. published the artcile< C4-aldehyde of guaiazulene: synthesis and derivatisation>, Application of C19H34O2, the main research area is guaiazulene aldehyde preparation derivatization halochromism.

Guaiazulene is an alkyl-substituted azulene available from natural sources and is a much lower cost starting material for the synthesis of azulene derivatives than azulene itself. Here we report an approach for the selective functionalization of guaiazulene which takes advantage of the acidity of the protons on the guaiazulene C4 Me group. The aldehyde produced by this approach (I) constitutes a building block for the construction of azulenes substituted on the seven-membered ring. Derivatives of this aldehyde synthesized by alkenylation, reduction and condensation are reported, and the halochromic properties of a subset of these derivatives have been studied.

Organic & Biomolecular Chemistry published new progress about Azulenes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Donghyun; Park, Ji Young; Lee, Dong Hyun; Lim, Jae-Eun; Moon, Hyo-Bang; Kim, Sungkyoon; Lee, Kiyoung published the artcile< Simultaneous assessment of organophosphate flame retardants, plasticizers, trace metals, and house dust mite allergens in settled house dust>, Quality Control of 112-63-0, the main research area is organophosphate flame retardant phenol plasticizer mite allergens house dust; OPFR; alternative; house dust mite allergens; plasticizer; settled house dust.

Settled house dust (SHD) is a reservoir for various contaminants, including endocrine-disrupting chems. (EDCs), trace metals, and house dust mite allergens. This study aimed to characterize various chem. and biol. contaminants in SHD and identify determinants governing the indoor contaminants. In total, 106 SHD samples were collected from 106 houses in Seoul and Gyeonggi Province, Korea, in 2021. Bedding dust samples were collected from 30 of these 106 houses. All participants completed a questionnaire comprised of housing and lifestyle-related factors. The samples were analyzed for 18 organophosphate flame retardants (OPFRs), 16 phthalates, five alternative plasticizers (APs), seven trace metals, and two house dust mite allergens (Dermatophagoides farinae type 1 [Der f1] and Dermatophagoides pteronyssinus type 1 [Der p1]). A multiple regression anal. was conducted to identify the determinants governing the concentrations and profiles of various contaminants. OPFRs, phthalates, APs, and trace metals were detected in all SHD samples, indicating ubiquitous contamination in indoor environments. Among the three EDC groups, APs were detected at the highest concentrations (geometric mean [GM] (geometric standard deviation, [GSD]): 1452 (1.6)μg/g in total), followed by phthalates (GM (GSD): 676 (1.4) μg/g in total) and OPFRs (GM (GSD): 10 (1.4) μg/g in total). Der f1 was detected in all bedding dust samples with significantly higher levels than Der p1 (GM (GSD): 0.1 (1.8) μg/g vs. 1.4 x 10-3 (2.3) μg/g). The concentrations of OPFRs, plasticizers, and trace metals in SHD were significantly associated with the type and number of electronic appliances and combustion activities. Der f1 was significantly associated with the number of occupants and water penetration. Ventilation, vacuum cleaning, and wet cleaning or dry mopping significantly reduced the levels of most contaminants in SHD. As residents are persistently exposed to a wide array of pollutants, comprehensive and adequate measures are required to prevent potential exposures.

Indoor Air published new progress about Allergen Der f Role: ANT (Analyte), ANST (Analytical Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bokharaei-Salim, Farah; Esghaei, Maryam; Khanaliha, Khadijeh; Kalantari, Saeed; Marjani, Arezoo; Fakhim, Atousa; Keyvani, Hossein published the artcile< HIV-1 reverse transcriptase and protease mutations for drug-resistance detection among treatment-experienced and naive HIV-infected individuals>, Formula: C19H34O2, the main research area is HIV infection drug resistance reverse transcriptase protease mutation.

The current study aimed at assessing the prevalence of HIV-1 DRMs among naive and treatment-experienced HIV-1-infected patients in Iran. Methods: From Apr. 2013 to Sept. 2018, the HIV-1 protease and reverse transcriptase genes were amplified and sequenced in plasma specimens of 60 newly diagnosed antiretroviral-naive individuals and 46 participants receiving antiretroviral therapies (ARTs) for at least six months with an HIV viral load of more than 1000 IU/mL to determine the HIV-1 DRMs and subtypes. Results: The SDRMs, D67N and D67E, belonged to the NRTIs class in two patients and K103N and V106A belonged to the NNRTIs class in three patients. Among the 46 ART-experienced participants, 33 (71.7%) carried HIV-1 variants with SDRMs (9.1% against PIs, 78.8% against NRTIs, and 100% against NNRTIs). M46I and I47V were the most common mutations for PIs, M184V was the most common mutation for the NRTIs, and K103N/S was the most common mutation for NNRTIs. Phylogenetic anal. of the polymerase region showed that all of the 46 HIV-1-infected patients who failed on ART carried CRF35_AD. The moderate prevalence of SDRMs (8.3%) in treatment-naive and ART-failed (77.1%) Iranian patients with HIV-1-infection emphasizes the need for systematic viral load monitoring, expanding drug resistance testing, carefully surveilling individuals on ART regimens, and facilitating access to new antiretrovirals by health authorities.

PLoS One published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics