Xiao, Zhi-qiang published the artcileStudy on synthesis process of p-hydroxyphenyl acetic acid-N,N-dimethylformamide, dimethyl carbamyl, HPLC of Formula: 59721-16-3, the publication is Yingyong Huagong (2014), 43(12), 2237-2238, database is CAplus.
Using N,N-dimethyl-2-chloro-acetamide, 4-hydroxyphenyl acetic acid, triethylamine, etc. as raw materials, the reaction in acetonitrile, HPLC was used to detect hydroxyphenyl acetic acid for synthesis of N,N-dimethylformamide, carbamoyl ester (compound B). The result showed that the optimal synthesis parameters were: reaction time 12 h, the reaction temperature 60 degree C, the amount of solvent 2200 m L, and material ratio of n(4-hydroxyphenyl acetic acid):n(N, N-dimethyl-2-chloroacetamide) = 1:1.10. Under the optimal conditions the yield was 86%, with a purity of over 98%.
Yingyong Huagong published new progress about 59721-16-3. 59721-16-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Phenol,Ester,Amide, name is 2-(Dimethylamino)-2-oxoethyl 2-(4-hydroxyphenyl)acetate, and the molecular formula is C16H11Cl2N3O2, HPLC of Formula: 59721-16-3.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics