Tag: M.W=200-250

Kihara, Hideyuki published the artcileIn situ photochemical conversion from cinnamoyl-functionalized liquid-crystalline monomers to liquid-crystalline dimers, Related Products of esters-buliding-blocks, the publication is Liquid Crystals (2007), 34(11), 1337-1347, database is CAplus.

Liquid-crystalline (LC) monomers, which were functionalized with a cinnamoyl group on their extremity, were synthesized and irradiated with UV light in their LC phases. In the presence of a triplet sensitizer, most LC monomers were converted into the corresponding dimers, which were produced by the cycloaddition reaction of the cinnamoyl group. The photodimerization reaction could proceed while the LC phases were maintained, because the dimers showed LC phases whose temperature ranges were wider than those of the corresponding monomers. A ¹H NMR study of the LC dimers indicated that the cyclobutane unit dominantly had an anti-head-to-head configuration, i.e., δ-truxinate. As the LC monomers, which had a Ph biphenyl-4-carboxylate moiety as a mesogen, showed smectic A phases and the corresponding dimers also exhibited smectic A phases, the authors estimated the smectic layer distances by x-ray diffraction anal. and found that the dimers adopted the structure in which the two mesogens aligned laterally and existed in the same smectic layer in the LC phases.

Liquid Crystals published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chen, Lei published the artcileUnusual microporous polycatenane-like metal-organic frameworks for the luminescent sensing of Ln³⁺ cations and rapid adsorption of iodine, Product Details of C15H14O3, the publication is Chemical Communications (Cambridge, United Kingdom) (2012), 48(47), 5919-5921, database is CAplus and MEDLINE.

Two isostructural 2-dimensional 2-dimensional parallel 3-dimensional inclined interpenetrating polycatenane-like metal-organic frameworks, [Zn₂L¹(H₂O)](NO₃)·DMF (IFMC-10) and [Zn₂L²(H₂O)](NO₃)·0.2DMF (IFMC-11) (H₃L¹ = 4′,4”,4”’-(2,4,6-trimethylbenzene-1,3,5-triyl)tris(methyleneoxy)tribiphenyl-4-carboxylic acid, I) and (H₃L² = 4′,4”,4”’-(2,4,6-trimethylbenzene-1,3,5-triyl) II) were successfully constructed based on length-adjusted tricarboxylate ligands. With the merit of being microporous, IFMC-10 can serve as host for encapsulating lanthanide cations (Eu³⁺, Sm³⁺ and/or Tb³⁺) to exhibit luminescent sensing and rapid adsorption of iodine.

Chemical Communications (Cambridge, United Kingdom) published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Product Details of C15H14O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jeong, Hyeon Su published the artcileSpontaneous chirality induction and enantiomer separation in liquid crystals composed of achiral rod-shaped 4-arylbenzoate esters, Recommanded Product: Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, the publication is Journal of the American Chemical Society (2009), 131(41), 15055-15060, database is CAplus and MEDLINE.

The discovery of spontaneously induced chirality and enantiomeric separation in liquid crystal and soft crystal systems composed of achiral rod-shaped 4-arylbenzoate esters is described. Negligibly small CD signals are produced in the smectic A phases of these substances, and the signals were found to increase with increasing smectic order. Since the advent of chirality occurs in freely suspended films, it is not a consequence of surface effects. Both pos. and neg. CD signals are observed with equal probability at different positions in these films. Vibrational CD spectroscopy and theor. calculations are used to analyze the conformational changes that are associated with the induced chirality of the rod-shaped mols. The results show that the phenomenon is caused by the twisting of biphenyl bond associated with the ester moiety in 4-arylbenzoate esters.

Journal of the American Chemical Society published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Recommanded Product: Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gong, Xia published the artcileSynthesis of adenosine-imprinted microspheres for the recognition of ADP-ribosylated proteins, COA of Formula: C12H17NS2, the publication is Biosensors & Bioelectronics (2017), 858-864, database is CAplus and MEDLINE.

Core-shell structural adenosine-imprinted microspheres were prepared via a two-step procedure. Polystyrene core particles (CP) were firstly prepared via a reversible addition-fragmentation chain transfer (RAFT) polymerization leaving the iniferter on the surface of the cores, then a molecularly imprinted polymer (MIP) shell was synthesized on the surface of the cores by using acrylamide (AAm) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the cross-linker. The formation and growth of the MIP layer were seen dependent on the initiator (AIBN), AAm and the polymerization time used within the polymerization SEM/TEM images showed that the dimensions of the cores and shells were 2μM and 44 nm, resp. The MIP microspheres exhibited a fast rebinding rate within 2 h and a maximum adsorption capacity of 177μg per g for adenosine. The adsorption fitted a Langmuir-Freundlich (LF) isotherm model with a K_LF value of 41 mL/μg and a q_m value of 177μg/g for the MIP microspheres. The values were larger than those for a non-molecularly imprinted polymer (NIP) particles (5 mL/μg and 88μg/g) indicating a better adsorption ability towards adenosine. The MIP microspheres showed a good selectivity for adenosine with a higher adsorption (683 nmol/g) for adenosine than that (91 nmol/g, 24 nmol/g and 54 nmol/g) for guanosine, cytidine and uridine resp. Further experiment proved that the adenosine-imprinted polymer microspheres also had a good selectivity for ADP-ribosylated proteins that the MIP could extract the ADP-ribosylated proteins from the cell extract samples.

Biosensors & Bioelectronics published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, COA of Formula: C12H17NS2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Attygalle, Athula B. published the artcileGas-Phase Infrared Spectroscopy for Determination of Double Bond Configuration of Monounsaturated Compounds, Formula: C14H26O2, the publication is Analytical Chemistry (1994), 66(10), 1696-703, database is CAplus and MEDLINE.

Gas-phase Fourier-transform IR spectra allow unambiguous determination of the configuration of the double bonds of long-chain unsaturated compounds bearing RCH:CHR’ type bonds. Although the IR absorption at 970-967 cm^-1 has been used previously for the identification of trans bonds, the absorption at 3028-3011 cm^-1 is conventionally considered to be incapable of distinguishing cis and trans isomers. In this paper, the authors present a large number of gas-phase spectra of monounsaturated long-chain acetates which demonstrate that an absorption, highly characteristic for the cis configuration, occurs at 3013-3011 cm^-1, while trans compounds fail to show any bands in this region. However, if a double bond is present at the C-2 or C-3 carbon atoms, this cis :CH stretch absorption shows a hypsochromic shift to 3029-3028 and 3018-3017 cm^-1, resp. Similarly, if a cis double bond is present at the penultimate carbon atom, this band appears at 3022-3021 cm^-1. All the spectra of trans alkenyl acetates showed the expected C-H wag absorption at 968-964 cm^-1. In addition, the spectra of (E)-2-alkenyl acetates show a unique three-peak “fingerprint” pattern which allows the identification of the position and configuration of this bond. Furthermore, by synthesizing and obtaining spectra of appropriate deuteriated compounds, the authors have proved that the 3013-3011 cm^-1 band is representative of the C-H stretching vibration of cis compounds of RCH:CHR’ type.

Analytical Chemistry published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, Formula: C14H26O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cutts, Suzanne M. published the artcileActivation of clinically used anthracyclines by the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate, Category: esters-buliding-blocks, the publication is Molecular Cancer Therapeutics (2007), 6(4), 1450-1459, database is CAplus and MEDLINE.

The anthracycline group of compounds is extensively used in current cancer chemotherapy regimens and is classified as topoisomerase II inhibitor. However, previous work has shown that doxorubicin can be activated to form DNA adducts in the presence of formaldehyde-releasing prodrugs and that this leads to apoptosis independently of topoisomerase II-mediated damage. To determine which anthracyclines would be useful in combination with formaldehyde-releasing prodrugs, a series of clin. relevant anthracyclines (doxorubicin, daunorubicin, idarubicin, and epirubicin) were examined for their capacity to form DNA adducts in MCF7 and MCF7/Dx (P-glycoprotein overexpressing) cells in the presence of the formaldehyde-releasing drug pivaloyloxymethyl butyrate (AN-9). All anthracyclines, with the exception of epirubicin, efficiently yielded adducts in both sensitive and resistant cell lines, and levels of adducts were similar in mitochondrial and nuclear genomes. Idarubicin was the most active compound in both sensitive and resistant cell lines, whereas adducts formed by doxorubicin and daunorubicin were consistently lower in the resistant compared with sensitive cells. The adducts formed by doxorubicin, daunorubicin, and idarubicin showed the same DNA sequence specificity in sensitive and resistant cells as assessed by λ-exonuclease-based sequencing of α-satellite DNA extracted from drug-treated cells. Growth inhibition assays were used to show that doxorubicin, daunorubicin, and idarubicin were all synergistic in combination with AN-9, whereas the combination of epirubicin with AN-9 was additive. Although apoptosis assays indicated a greater than additive effect for epirubicin/AN-9 combinations, this effect was much more pronounced for doxorubicin/AN-9 combinations. [Mol Cancer Ther 2007;6(4):1450-9].

Molecular Cancer Therapeutics published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cutts, Suzanne M. published the artcileSequence specificity of adriamycin-DNA adducts in human tumor cells, COA of Formula: C10H18O4, the publication is Molecular Cancer Therapeutics (2003), 2(7), 661-670, database is CAplus and MEDLINE.

The anticancer anthracycline compound Adriamycin is a known topoisomerase II inhibitor but is also capable of exerting other cellular consequences. After intercalation, Adriamycin can form covalent adducts with DNA, and the magnitude of these adducts appears to be limited by the cellular availability of formaldehyde. Adducts produced by Adriamycin in the presence of formaldehyde have been well characterized in cell-free systems but not in cells. In this study, we show that when Adriamycin is used in conjunction with the formaldehyde-releasing prodrug AN-9 in IMR-32 tumor cells, this allows the formation of sufficiently high levels of adducts in genomic DNA to enable detection of their DNA sequence specificity for the first time. The 340-bp α-satellite EcoRI repeat sequence was isolated from drug-treated cells and digested with λ-exonuclease to determine adduct sites at which exonuclease digestion was blocked. The Adriamycin adducts were formed predominantly at 5′-GC and GG sequences and unstable with respect to elevated temperatures and extended times at 37°. The use of three anthracycline derivatives lacking a 3’amino group demonstrated that this amino portion is critical for the formation of anthracycline adducts in cells. The structure of these drug-DNA adducts can therefore be considered to be identical to the Adriamycin adducts, which have been characterized rigorously in cell-free systems by x-ray crystallog., two-dimensional NMR, and mass spectrometry.

Molecular Cancer Therapeutics published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, COA of Formula: C10H18O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Forrest, Robert A. published the artcileThe hydroxyl epimer of doxorubicin controls the rate of formation of cytotoxic anthracycline-DNA adducts, Related Products of esters-buliding-blocks, the publication is Cancer Chemotherapy and Pharmacology (2013), 71(3), 809-816, database is CAplus and MEDLINE.

Epirubicin was developed as a semi-synthetic anthracycline derivative to circumvent the cardiotoxic limitations associated with the use of doxorubicin in the clinic. Anthracycline compounds have been demonstrated to form covalent drug-DNA adducts utilizing endogenous and exogenous sources of formaldehyde; however, previous investigations of the formation of epirubicin-DNA adducts provide conflicting evidence for adduct formation. This work provides evidence that epirubicin acts to form drug-DNA adducts at physiol. relevant concentrations and demonstrates that the rate of formation of epirubicin-DNA adducts is slower than that observed for other anthracycline compounds, explaining why they are only detectable under defined exptl. conditions. Formation of covalent epirubicin-DNA adducts improves the apoptotic profile of epirubicin and provides opportunities to overcome drug resistance and cardiotoxic limitations.

Cancer Chemotherapy and Pharmacology published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nakano, Ayako published the artcileβ-Isocupreidine-Catalyzed Baylis-Hillman Reaction of Chiral N-Boc-α-Amino Aldehydes, Product Details of C10H19NO3, the publication is Organic Letters (2006), 8(23), 5357-5360, database is CAplus and MEDLINE.

β-Isocupreidine (β-ICD)-catalyzed Baylis-Hillman reaction of chiral N-Boc-α-amino aldehydes BocNR¹CHR²CHO [Boc = Me₃CO₂C; R¹ = H, R² = Me, Me₂CH, Me₂CHCH₂; R¹R² = (CH₂)₃, CMe₂OCH₂] and 1,1,1,3,3,3-hexafluoroisopropyl acrylate (HFIPA) takes place without racemization and exhibits the match-mismatch relationship between the substrate and the catalyst. In the case of acyclic amino aldehydes, L-substrates show excellent syn selectivity and high reactivity in contrast to D-substrates. On the other hand, in the case of cyclic amino aldehydes, D-substrates rather than L-substrates show excellent anti selectivity and high reactivity. The Baylis-Hillman adducts obtained were transesterified and further converted into carboxyvinyl-substituted oxazolidines and (hydroxy)(methylene)pyrrolidinones.

Organic Letters published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C10H19NO3, Product Details of C10H19NO3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mitchell, Everett R. published the artcileRubber septa as dispensers for the fall armyworm sex attractant, HPLC of Formula: 16974-11-1, the publication is Journal of Environmental Science and Health, Part A: Environmental Science and Engineering (1983), A18(3), 463-70, database is CAplus.

Rubber septa were effective dispensers for the fall armyworm (Spodoptera frugiperda) sex attractant (Z)-9-dodecen-1-ol acetate (Z9-12:AC) [16974-11-1]. Trap captures were related to dose with the highest numbers of males being captured in sticky traps baited with 5 and 10 mg Z9-12:AC/septum; the 10-mg dosage gave catches of males comparable to traps baited with virgin females for up to 2 wk. The addition of 2% (Z)-9-tetradecen-1-ol acetate  [16725-53-4] to septa treated with Z9-12:AC had no significant effect on catches at any of the dosage levels. (Z)-11-hexadecen-1-ol acetate  [34010-21-4] Was also tested as a potential sex attractant.

Journal of Environmental Science and Health, Part A: Environmental Science and Engineering published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, HPLC of Formula: 16974-11-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics