Tag: M.W=150-200

Wang, Xinchao published the artcileNative carboxyl group-assisted C-H acetoxylation of hydrocinnamic and phenylacetic acids, Recommanded Product: Methyl 3-phenyl-2-propenoate, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(32), 4993-4996, database is CAplus and MEDLINE.

A method of native carboxyl-assisted, Pd(II)-catalyzed ortho-C-H acetoxylation of both hydrocinnamic and phenylacetic acids 2-R-3-R¹-4-R²C₆H₂CH(R³)CH₂C(O)OH (R = H, Me, Cl, OCF₃, etc.; R¹ = Me, Br, CF₃, etc.; R² = Me, F, COOMe, etc.; R³ = H, Me, Et)/2-R⁴-3-R⁵-4-R⁶-5-R⁷C₆HC(R⁸)(R⁹)C(O)OH (R⁴ = H, Me, I, etc.; R⁵ = H, OMe, CF₃, etc.; R⁶ = F, OMe, COOMe, etc.; R⁷ = R⁸ = R⁸ = H, Me) that can be found in many biol. active mols. as the key moieties was reported. Based on the broad scope and the application potential showcased with drug mols., such as (ibuprofen, ketoprofen, and flurbiprofen) it is anticipated that this C-H acetoxylation reaction will find attractive applicability in future synthetic endeavors.

Chemical Communications (Cambridge, United Kingdom) published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C20H40O2, Recommanded Product: Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Weichao published the artcileDetermining Roles of Cu⁰ in the Chemosynthesis of Diols via Condensed Diester Hydrogenation on Cu/SiO₂ Catalyst, Category: esters-buliding-blocks, the publication is ChemCatChem (2020), 12(15), 3849-3852, database is CAplus.

Copper-based catalyst was applied in the condensed diester hydrogenation with unexpected high selectivity (∼100%) to 1,6-hexanediol. On basis of the mass transfer anal. and kinetics results, the reaction rate of the condensed diester hydrogenation was deduced to be controlled by the activation of hydrogen on Cu⁰ sites, which was further demonstrated by the correlations between the catalytic activity and different copper species. Importantly, this catalysis mechanism is different with that of gas-phase diester hydrogenation, which is generally determined by the adsorption of ester on Cu⁺ species.

ChemCatChem published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H7ClO3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chen, Huan published the artcileBurn Intensity Drives the Alteration of Phenolic Lignin to (Poly) Aromatic Hydrocarbons as Revealed by Pyrolysis Gas Chromatography-Mass Spectrometry (Py-GC/MS), Quality Control of 103-26-4, the publication is Environmental Science & Technology, database is CAplus and MEDLINE.

High-intensity wildfires alter the chem. composition of organic matter, which is expected to be distinctly different from low-intensity prescribed fires. Herein, we used pyrolysis gas chromatog./mass spectrometry (Py-GC/MS), in conjunction with solid-state ¹³C NMR and Fourier transform IR (FT-IR) spectroscopy, to assess chem. alterations from three wildfires and a long-term frequent prescribed fire site. Our results showed that black ash formed under moderate intensity burns contained less aromatic (ArH), polyaromatic hydrocarbon (PAH), and nitrogen-containing compounds (Ntg) but more lignin (LgC) and phenol compounds (PhC), compared to white ash formed under high intensity burns. Both ¹³C NMR and FT-IR confirmed a higher relative percentage of carboxyl carbon in white ash, indicating the potential for higher water solubility and more mobile carbon, relative to black ash. Compared to wildfires, ash from low-intensity prescribed fire contained less ArH, PAH, and Ntg and more LgC and PhC. Controlled laboratory burning trials indicated that organic matter alteration was sensitive to the burn temperature, but not related to the fuel type (pine vs. fir) nor oxygen absence/presence at high burn temperatures This study concludes that higher burn temperatures resulted in higher (poly)aromatic carbon/nitrogen and lower lignin/phenol compounds

Environmental Science & Technology published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Quality Control of 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Guowen published the artcileDesign and Control for the Dimethyl Adipate Process with a Side-Reactor Column Configuration, Synthetic Route of 627-93-0, the publication is Chemical Engineering & Technology (2021), 44(9), 1716-1725, database is CAplus.

A side-reactor column (SRC) configuration, which integrates vacuum distillation with atm. reaction, was developed for di-Me adipate (DMA) production The sequential optimization method was applied to optimize the design parameters including side stream drawn stage, reactor numbers, and catalyst loading with total annual cost (TAC) as objective function in order to realize the economical design. The best economic performance was achieved as the result of the specific SRC configuration featuring one column with 20 stages where DMA was drawn from the 5th stage and one side-reactor was equipped in the bottom. Moreover, a proportion-temperature cascade control structure was successfully developed which avoids the disturbance of inlet flow rate and composition

Chemical Engineering & Technology published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C16H24BF4Ir, Synthetic Route of 627-93-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ning, Lei published the artcileA Reductive Deuteration Approach to the Efficient Synthesis of Deuterated Polymers, Synthetic Route of 627-93-0, the publication is Synlett (2022), 33(8), 771-776, database is CAplus.

Deuterated polymers have wide applications but limited synthetic methods. In this study, we report an efficient two-step approach for the synthesis of deuterated polyesters and polyurethanes. Firstly, two practical single-electron transfer (SET) reductive-deuteration methods have been developed for site-selective introduction of C(sp³)-D into diol monomers. Nine deuterated diol monomers with high deuterium incorporations were synthesized under SmI₂-D₂O and/or Na-EtOD- d₁SET reductive-deuteration conditions. Then, six typical deuterated polyesters and polyurethanes were synthesized using those deuterated monomers under typical polymerization conditions. In all the synthesized polymers, high deuterium incorporation was fully maintained, which showcased the potential application of this approach for the synthesis of polymers with site-specific deuterium labeling.

Synlett published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Synthetic Route of 627-93-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Yinwen published the artcileCatalytic Transformation of PET and CO₂ into High-Value Chemicals, Application In Synthesis of 627-93-0, the publication is Angewandte Chemie, International Edition (2022), 61(10), e202117205, database is CAplus and MEDLINE.

Polyethylene terephthalate (PET) and CO₂, two chem. wastes that urgently need to be transformed in the environment, are converted simultaneously in a one-pot catalytic process through the synergistic coupling of three reactions: CO₂ hydrogenation, PET methanolysis and di-Me terephthalate (DMT) hydrogenation. More interestingly, the chem. equilibrium of both reactions were shifted forward due to a revealed dual-promotion effect, leading to significantly enhanced PET depolymerization The overall methanol yield from CO₂ hydrogenation exceeded the original thermodn. equilibrium limit since the methanol was in situ consumed in the PET methanolysis. The degradation of PET by a stoichiometric ratio of methanol was significantly enhanced because the primary product, DMT was hydrogenated to di-Me cyclohexanedicarboxylate (DMCD) or p-xylene (PX). This synergistic catalytic process provides an effective way to simultaneously recycle two wastes, polyesters and CO₂, for producing high-value chems.

Angewandte Chemie, International Edition published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Application In Synthesis of 627-93-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gao, Mingzhang published the artcileSynthesis of carbon-11-labeled CK1 inhibitors as new potential PET radiotracers for imaging of Alzheimer’s disease, Safety of 3-(Methoxycarbonyl)benzoic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(13), 2234-2238, database is CAplus and MEDLINE.

The reference standards Me 3-((2,2-difluoro-5H-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-d]imidazol-6-yl)carbamoyl)benzoate and N-(2,2-difluoro-5H-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-d]imidazol-6-yl)-3-methoxybenzamide, and their corresponding desmethylated precursors 3-((2,2-difluoro-5H-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-d]imidazol-6-yl)carbamoyl)benzoic acid and N-(2,2-difluoro-5H-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-d]imidazol-6-yl)-3-hydroxybenzamide, were synthesized from 5-amino-2,2-difluoro-1,3-benzodioxole and 3-substituted benzoic acids in 5 and 6 steps with 33% and 11%, 30% and 7% overall chem. yield, resp. Carbon-11-labeled casein kinase 1 (CK1) inhibitors, [¹¹C]methyl 3-((2,2-difluoro-5H-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-d]imidazol-6-yl)carbamoyl)benzoate and N-(2,2-difluoro-5H-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-d]imidazol-6-yl)-3-[¹¹C]methoxybenzamide, were prepared from their O-desmethylated precursors with [¹¹C]CH₃OTf through O-[¹¹C]methylation and isolated by HPLC combined with SPE in 40-45% radiochem. yield, based on [¹¹C]CO₂ and decay corrected to end of bombardment (EOB). The radiochem. purity was >99%, and the molar activity (MA) at EOB was 370-740GBq/μmol with a total synthesis time of ∼40-min from EOB.

Bioorganic & Medicinal Chemistry Letters published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Safety of 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sun, Huahua published the artcileMutagenesis of the orco odorant receptor co-receptor impairs olfactory function in the malaria vector Anopheles coluzzii, Name: Benzyl acetate, the main research area is Anopheles coluzzii orco odorant receptor mutagenesis olfactory function; Anopheles coluzzii; CRISPR/Cas9; Host seeking; Odorant receptor co-receptor; Olfaction; Oviposition.

Mosquitoes rely heavily on their olfactory systems for host seeking, selection of oviposition sites, and avoiding predators and other environmental dangers. Of these behaviors, the preferential selection of a human blood-meal host drives the vectorial capacity of anthropophilic female Anopheles coluzzii mosquitoes. Olfactory receptor neurons (ORNs) are dispersed across several appendages on the head and express an obligate odorant receptor co-receptor (Orco) coupled with a ”tuning” odorant receptor (OR) to form heteromeric, odor-gated ion channels in the membrane of these neurons. To examine the mechanistic and functional contributions of Orco/OR complexes to the chemosensory processes of An. coluzzii, we utilized CRISPR/Cas9 gene editing to create a line of homozygous, Orco-knockout, mutant mosquitoes. As expected, orco-/- ORNs across both adult and larval stages of An. coluzzii display significantly lower background activity and lack nearly all odor-evoked responses. In addition, blood-meal-seeking, adult female, orco-/- mutant mosquitoes exhibit severely reduced attraction to human- and non-human-derived odors while gravid females are significantly less responsive to established oviposition attractants. These results reinforce observations in other insects that Orco is crucial in maintaining the activity of ORNs. In that light, it significantly influences a range of olfactory-driven behaviors central to the anthropophilic host preference that is critical to the vectorial capacity of An. coluzzii as a primary vector for human malaria.

Insect Biochemistry and Molecular Biology published new progress about Adult, nonmammalian. 140-11-4 belongs to class esters-buliding-blocks, name is Benzyl acetate, and the molecular formula is C9H10O2, Name: Benzyl acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

He, Guiqiang published the artcileAlteration of microbial community for improving flavor character of Daqu by inoculation with Bacillus velezensis and Bacillus subtilis, Application of Ethyl octanoate, the main research area is Bacillus bioaugmentation Daqu flavor volatile compound.

Daqu, an important saccharification and fermentation starter, provides microbes, hydrolytic enzymes, and flavor compounds, and plays a crucial role for production of Chinese Baijiu. To evaluate the feasibility of bioaugmentation inoculated with Bacillus velezensis and Bacillus subtilis for improving the flavor character of Daqu, microbial community, enzyme activity, and volatile compound were analyzed and compared between traditional Daqu (T Daqu) and fortified Daqu (F Daqu). Bioaugmentation inoculation increased the abundance of Bacillus, Lactobacillus, and Candida. Addnl., anal. of enzyme activity showed that liquefying power, saccharifying power, and esterifying power were significantly higher (P < 0.05) in F Daqu than T Daqu. Meanwhile, the contents of volatile compounds including esters, pyrazines, and alcs. significantly increased (P < 0.05) after bioaugmentation inoculation. In particular, the contents of tetramethylpyrazine and phenethyl alc. in F Daqu significantly increased (P < 0.05) by 90.8% and 69.5% compared to T Daqu, resp. Moreover, many enzymes involved in saccharification, ethanol fermentation, and aroma generation were predicted, and the abundance of their encoding genes obviously increased in F Daqu. Taken as whole, bioaugmentation inoculation with B. velezensis and B. subtilis altered the microbial community for regulating their metabolic activities, and subsequently, improved the flavor character of Daqu. LWT--Food Science and Technology published new progress about Alcoholic beverages. 106-32-1 belongs to class esters-buliding-blocks, name is Ethyl octanoate, and the molecular formula is C10H20O2, Application of Ethyl octanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mu, Xiaoqing published the artcileOptimization and Validation of a Headspace Solid-Phase Microextraction with Comprehensive Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometric Detection for Quantification of Trace Aroma Compounds in Chinese Liquor (Baijiu), Name: Ethyl nonanoate, the main research area is Chinese liquortracein aroma compound solid phase microextraction; Chinese liquor (Baijiu); GC×GC-TOFMS; quantitative analysis; trace aroma compounds.

The detection of trace aroma compounds in samples with complex matrixes such as Chinese liquor (Baijiu) requires a combination of several methods, which makes the anal. process very complicated. Therefore, a headspace solid-phase microextraction (HS-SPME) method coupled with two-dimensional gas chromatog. time-of-flight mass spectrometry (GCxGC-TOFMS) was developed for the quantitation of a large number of trace compounds in Baijiu. Optimization of extraction conditions via a series of experiments revealed that dilution of the alc. content of 8 mL of Baijiu to 5%, followed by the addition of 3.0 g of NaCl and subsequent SPME extraction with DVB/CAR/PDMS fiber coating over 45 min at 45°C was the most suitable. To check the matrix effects, various model Baijiu matrixes were investigated in detail. The quant. method was established through an optimized model synthetic solution, which can identify 119 aroma compounds (esters, alcs., fatty acids, aldehydes and ketones, furans, pyrazines, sulfur compounds, phenols, terpenes, and lactones) in the Baijiu sample. The developed procedure provided high recovery (86.79-117.94%), good repeatability (relative standard deviation < 9.93%), high linearity (R2 > 0.99), and lower detection limits than reported methods. The method was successfully applied to study the composition of volatile compounds in different types of Baijiu. This research indicated that the optimized HS-SPME-GCxGC-TOFMS method was a valid and accurate procedure for the simultaneous determination of different types of trace compounds in Baijiu. This developed method will allow an improved anal. of other samples with complex matrixes.

Molecules published new progress about Alcoholic beverages. 123-29-5 belongs to class esters-buliding-blocks, name is Ethyl nonanoate, and the molecular formula is C11H22O2, Name: Ethyl nonanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics