Tag: M.W=150-200

Zhang, Muliang published the artcileA general deoxygenation approach for synthesis of ketones from aromatic carboxylic acids and alkenes, Application In Synthesis of 1877-71-0, the publication is Nature Communications (2018), 9(1), 1-10, database is CAplus and MEDLINE.

The construction of an aryl ketone structural unit by means of catalytic carbon-carbon coupling reactions represents the state-of-the-art in organic chem. Herein we achieved the direct deoxygenative ketone synthesis in aqueous solution from readily available aromatic carboxylic acids and alkenes, affording structurally diverse ketones I (FG = 4-Me, 4-Ph, 4-BnO, etc.) in moderate to good yields. Visible-light photoredox catalysis enables the direct deoxygenation of acids as acyl sources with triphenylphosphine and represents a distinct perspective on activation. The synthetic robustness is supported by the late-stage modification of several pharmaceutical compounds and complex mols. This ketone synthetic strategy is further applied to the synthesis of the drug zolpidem in three steps with 50% total yield and a concise construction of cyclophane-braced 18-20 membered macrocycloketones. It represents not only the advancement for the streamlined synthesis of aromatic ketones from feedstock chems., but also a photoredox radical activation mode beyond the redox potential of carboxylic acids.

Nature Communications published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H13BO3, Application In Synthesis of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wei, Rongbiao published the artcileIron-Catalyzed Alkylazidation of 1,1-Disubstituted Alkenes with Diacylperoxides and TMSN₃, Category: esters-buliding-blocks, the publication is Organic Letters (2020), 22(8), 3195-3199, database is CAplus and MEDLINE.

An iron-catalyzed radical alkylazidation of electron-deficient alkenes was reported. Alkyl diacyl peroxides worked as the alkyl source, and trimethylsilyl azide acted as the azido reservoir. This method featured mild reaction conditions, wide substrate scope, and good functional group tolerance, providing a range of α-azido compounds I [R = H, Me, Ph, etc.; R¹ = Me, Et, Bn; R² = Me, C₅H₁₁, C₁₁H₂₃, etc.] in high yields. These azides could be easily transferred into many kinds of amino acid derivatives

Organic Letters published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C3H8N2S, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Jun-xing published the artcileDetection and comparison of volatiles in fruit from three different kinds of loofah, Recommanded Product: Dimethyl adipate, the publication is Xiandai Shipin Keji (2021), 37(7), 228-237, database is CAplus.

To fully identify the volatile compounds of loofah fruit aroma, and understand the variation features in different types of loofah, head space solid-phase micro-extraction (HS-SPME) combined with gas chromatog. (GC)-mass spectrometry (MS) was used to analyze the volatile profiles of three kinds of loofah (SG, DR and YL). A total of 55 volatiles were identified in three kinds of materials, in which 15 kinds of hydrocarbon compounds were identified and showed the most species. The 43, 52 and 47 volatiles were detected in the YL, DR and SG, resp., in which benzaldehyde, nonanal and linalool with the highest relative content, resp. The principal component anal. and hierarchical cluster anal. based on the 55 compounds were used. It indicated that SG was clearly distinguished from DR and YL, and the volatiles in DR and YL were similar. These results were consistent with the biol. classification of three types of resources. The 30 distinct volatiles (p<0.05) were detected in two groups of three types of loofah through one-factor ANOVA. The 20 variant volatiles were displayed the higher contents compared to these of DR and YL. Hexanal and (E)-2-Hexenal were mainly related to the green aroma characteristics, while benzeneacetaldehyde might result in the sweet aroma in DR. The results of this work will provide the reference for the research of flavor traits and quality breeding of loofah.

Xiandai Shipin Keji published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Recommanded Product: Dimethyl adipate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Guo, Daoyi published the artcileDe Novo Biosynthesis of Methyl Cinnamate in Engineered Escherichia coli, Application of Methyl 3-phenyl-2-propenoate, the publication is Journal of Agricultural and Food Chemistry (2022), 70(25), 7736-7741, database is CAplus and MEDLINE.

Me cinnamate with a fruity balsamic odor is an important fragrance ingredient in perfumes and cosmetics. Chem. processes are currently the only means of producing Me cinnamate. But consumers prefer natural flavors. Therefore, it is necessary to design and develop microbial cell factories for the production of Me cinnamate. In this study, we established for the first time a biosynthetic pathway in engineered Escherichia coli for production of Me cinnamate from glucose. We further increased the Me cinnamate production to 302 mg/L by increasing the availability of the metabolic precursors. Finally, the titer was increased to 458 mg/L in a two-phase culture system.

Journal of Agricultural and Food Chemistry published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Application of Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rajabi, Fatemeh published the artcileA Bronsted acidic, ionic liquid containing, heteropolyacid functionalized polysiloxane network as a highly selective catalyst for the esterification of dicarboxylic acids, SDS of cas: 1877-71-0, the publication is Green Chemistry (2020), 22(14), 4438-4444, database is CAplus.

A Bronsted acidic, ionic liquid containing, heteropolyanion functionalized polysiloxane network I [R = OEt/H] was formed by self-condensation of dodecatungstophosphoric acid and a zwitterionic organosilane precursor II containing both imidazolinium and sulfonate groups. The resulting hybrid material POS-HPA-IL I was investigated as a catalyst for the selective esterification of dicarboxylic acids such as benzene-1,4-dicarboxylic acid, citric acid, citraconic acid, etc..

Green Chemistry published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, SDS of cas: 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nastasi, Claudia published the artcileInhibition of succinate dehydrogenase activity impairs human T cell activation and function, Quality Control of 617-52-7, the publication is Scientific Reports (2021), 11(1), 1458, database is CAplus and MEDLINE.

Abstract: T cell activation is intimately linked to metabolism, as distinct metabolic requirements support the functional and phenotypical differences between quiescent and activated T cells. Metabolic transition from mitochondrial oxidative phosphorylation to aerobic glycolysis is crucial for a proper T cell activation. However, the role of tricarboxylic acid cycle (TCA), and in particular succinate dehydrogenase (SDH) in activated T cells needs further elucidation. Here we show that inhibition of SDH during activation of T cells results in strong impairment of proliferation, expression of activation markers, and production of key inflammatory cytokines, despite a concomitant increase in glycolytic metabolic activity. Similar effect of SDH inhibition were demonstrated in pre-activated T cell. Interestingly, itaconic acid, an endogenous SDH inhibitor released from activated macrophages and dendritic cells, had no immunomodulator effect. Taken together, our findings demonstrate that SDH enzyme fitness is critical for mounting and maintaining appropriate activation and function of human T cells.

Scientific Reports published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Quality Control of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kong, Xianqiang published the artcileCyanation and cyanomethylation of trimethylammonium salts via electrochemical cleavage of C-N bonds, SDS of cas: 10287-53-3, the publication is Organic Chemistry Frontiers (2022), 9(5), 1288-1294, database is CAplus.

A practical and mild electrochem. protocol for cyanation and cyanomethylation of trimethylammonium salts through a pathway involving C-N bond cleavage without the need for an external stoichiometric reducing agent or a sacrificial anode was developed. The reaction employed tosyl cyanide (TsCN) or azido allyl alc. as the cyanation or cyanomethylation reagent, resp. It showed high functional group compatibility and can be applied for the cyanation of natural product derivatives Preliminary mechanistic studies indicated the involvement of a radical addition pathway.

Organic Chemistry Frontiers published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, SDS of cas: 10287-53-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Ziyang published the artcileTi³⁺ Tuning the Ratio of Cu⁺/Cu⁰ in the Ultrafine Cu Nanoparticles for Boosting the Hydrogenation Reaction, SDS of cas: 627-93-0, the publication is Small (2021), 17(23), 2008052, database is CAplus and MEDLINE.

Hydrogenation of diesters to diols is a vital process for chem. industry. The inexpensive Cu⁺/Cu⁰-based catalysts are highly active for the hydrogenation of esters, however, how to efficiently tune the ratio of Cu⁺/Cu⁰ and stabilize the Cu⁺ is a great challenge. In this work, it is demonstrated that doped Ti ions can tune the ratio of Cu⁺/Cu⁰ and stabilize the Cu⁺ by the Ti-O-Cu bonds in Ti-doped SiO₂ supported Cu nanoparticle (Cu/Ti-SiO₂) catalysts for the high conversion of di-Me adipate to 1,6-hexanediol. In the synthesis of the catalysts, the Ti⁴⁺-O-Cu²⁺ bonds promote the reduction of Cu²⁺ to Cu⁺ by forming Ti³⁺-O_V-Cu⁺ (O_V: oxygen vacancy) bonds and the amount of Ti doping can tune the ratio of Cu⁺/Cu⁰. In the catalytic reaction, the O vacancy activates C-O in the ester by forming new Ti^3+δ-O_R-Cu^1+δ bonds (O_R: reactant oxygen), and Cu⁰ activates hydrogen. After the products are desorbed, the Ti^3+δ-O_R-Cu^1+δ bonds return to the initial state of Ti³⁺$-O_V-Cu⁺ bonds. The reversible Ti-O-Cu bonds greatly improve the activity and stability of the Cu/Ti-SiO₂ catalysts. When the content of Ti is controlled at 0.4 wt%, the conversion and selectivity can reach 100% and 98.8%, resp., and remain stable for 260 h without performance degradation

Small published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C9H9ClN2, SDS of cas: 627-93-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Liang, Yutong published the artcileAging of Volatile Organic Compounds in October 2017 Northern California Wildfire Plumes, Recommanded Product: Methyl 3-phenyl-2-propenoate, the publication is Environmental Science & Technology, database is CAplus and MEDLINE.

In the western United States, the number and severity of large wildfires have been growing for decades. Biomass burning (BB) is a major source of volatile organic compounds (VOCs) to the atm. both globally and regionally. Following emission, BB VOCs are oxidized while being transported downwind, producing ozone, secondary organic aerosols, and secondary hazardous VOCs. In this research, we measured VOCs using proton transfer reaction time-of-flight mass spectrometry (PTR-ToF-MS) in an urban area 55-65 km downwind of the Oct. 2017 Northern California wildfires. Nonaromatic oxygenated compounds were the dominant component of BB VOCs measured. In the smoke plumes, the VOCs account for 70-75% of the total observed organic carbon, with the remainder being particulate matter (with a diameter of <2.5 μm, PM_2.5). We show that the correlation of VOCs with furan (primary BB VOC) and maleic anhydride (secondary BB VOC) can indicate the origin of the VOCs. This was further confirmed by the diurnal variations of the VOCs and their concentration-weighted trajectories. Oxidation during transport consumed highly reactive compounds including benzenoids, furanoids, and terpenoids and produced more oxygenated VOCs. Furthermore, wildfire VOCs altered the ozone formation regime and raised the O₃ levels in the San Francisco Bay Area.

Environmental Science & Technology published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, Recommanded Product: Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Rader, Chris published the artcileBiobased Polyester-Amide/Cellulose Nanocrystal Nanocomposites for Food Packaging, Product Details of C8H14O4, the publication is Macromolecular Materials and Engineering (2021), 306(3), 2000668, database is CAplus.

The worldwide plastic waste production is steadily increasing, since the use of polymeric materials continues to rise. One area of particular high plastic consumption is food packaging. Flexible and rigid packaging films are typically made from petrochem.-sourced polymers, which are utilized because of their low cost, ductility, melt-processability, and gas barrier properties, but a major downside is their inability to biodegrade in a reasonable time. Packaging-relevant properties of nanocomposites based on polyester-amides (PEAs) are reported, which are chosen on account of their tunable crystallinity, biobased starting materials, and biodegradability. These polymers are synthesized via melt polycondensation of a building block made from caprolactone and 1,4-diaminobutane, with the addition of 1,4-butanediol and di-Me adipate. The fraction of the amide segment is varied between 25 and 75 mol%. The oxygen transmission rate (O₂TR) drops upon increasing the amide content from 1.6 × 105 to 2.9 × 10^-4 cm³ m^-2 d^-1 on account of increasing crystallinity. In order to improve the gas barrier properties further, nanocomposites of the PEAs and 1-10 weight% cellulose nanocrystals (CNCs) are prepared These nanocomposites have indeed lower O₂TR values than the neat PEAs, with reductions of as much as 50% for a CNC content of 10 weight%.

Macromolecular Materials and Engineering published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Product Details of C8H14O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics