Tag: M.W=150-200

Yang, Lishou published the artcileSynthesis of novel 1-phenyl-benzopyrrolizidin-3-one derivatives and evaluation of their cytoneuroprotective effects against NMDA-induced injury in PC12 cells, HPLC of Formula: 103-26-4, the publication is Bioorganic & Medicinal Chemistry (2022), 116675, database is CAplus and MEDLINE.

A range of novel 1-phenyl-benzopyrrolizidin-3-one derivatives I (R¹ = Ph, 2-MeOC₆H₄, 3-BnOC₆H₄, etc.; R² = H, 8-F, 7-OBn) were synthesized and evaluated for neuroprotective effects against N-methyl-D-aspartate (NMDA)-induced injury in PC12 cells. Interestingly, derivatives that 1-Ph moiety bearing electron-donating group, especially benzyloxy, and the trans-forms exhibited better protective activity against NMDA-induced neurotoxicity. Compound I (R¹ = 3-BnOC₆H₄; R² = 8-F) demonstrated the best neuroprotective potency and shown a dose-dependent prevention. The increased intracellular calcium (Ca²⁺) influx caused by NMDA in PC12 cells was reversed in the case of compound I (R¹ = 3-BnOC₆H₄; R² = 8-F) pretreatment at 15μM. These results suggested that the synthesized 1-phenyl-benzopyrrolizidin-3-one derivatives exerted neuroprotective effect on NMDA-induced excitotoxicity in PC12 cells associated with inhibition of Ca²⁺ overload and can be further optimized for the development of neuroprotective agents.

Bioorganic & Medicinal Chemistry published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C4H6O3, HPLC of Formula: 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ren, Shi-Chao published the artcileCarbene and photocatalyst-catalyzed decarboxylative radical coupling of carboxylic acids and acyl imidazoles to form ketones, Safety of 3-(Methoxycarbonyl)benzoic acid, the publication is Nature Communications (2022), 13(1), 2846, database is CAplus and MEDLINE.

The carbene and photocatalyst co-catalyzed radical coupling of acyl electrophile and a radical precursor is emerging as attractive method for ketone synthesis. However, previous reports mainly limited to prefunctionalized radical precursors and two-component coupling. Herein, an N-heterocyclic carbene and photocatalyst catalyzed decarboxylative radical coupling of carboxylic acids and acyl imidazoles is disclosed, in which the carboxylic acids are directly used as radical precursors. The acyl imidazoles could also be generated in situ by reaction of a carboxylic acid with CDI thus furnishing a formally decarboxylative coupling of two carboxylic acids. In addition, the reaction is successfully extended to three-component coupling by using alkene as a third coupling partner via a radical relay process. The mild conditions, operational simplicity, and use of carboxylic acids as the reacting partners make our method a powerful strategy for construction of complex ketones from readily available starting materials, and late-stage modification of natural products and medicines.

Nature Communications published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Safety of 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Peng, X. published the artcileNewly Synthesized Chromophore-linked Iodonium Salts as Photoinitiators of Free Radical Photopolymerization, SDS of cas: 10287-53-3, the publication is Macromolecular Chemistry and Physics (2021), 222(9), 2100035, database is CAplus.

Iodonium salts are the topic of interest in the field of photopolymerization as they act as effective photoinitiators and generators of photoacid. Yet, the current com. available iodonium salts have low absorption above 300 nm whereby limiting the use of the long-wavelength of light irradiations to trigger polymerization Iodonium salts are thus generally used in couples with photosensitizers (e.g., dyes) to extend the usage under irradiation of red-shifted light wavelength. In this research, the synthesis of chromophore-linked (anthraquinone-based and flavone-based chromophores) iodonium salts is present. They can initiate free radical polymerization with 320-480 nm irradiation and show much better photoinitiation ability as compared to com. iodonium salts, especially when they act as mono-component photoinitiators. Steady-state photolysis and ESR spin trapping experiments are also carried out to evaluate the relevant photochem. mechanism.

Macromolecular Chemistry and Physics published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, SDS of cas: 10287-53-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Takai, Toshihiro published the artcileAerobic oxygenation of olefinic compounds to the corresponding α-hydroxy ketones using an osmium tetroxide-nickel(II) complex catalyst system, Related Products of esters-buliding-blocks, the publication is Chemistry Letters (1991), 1499-502, database is CAplus.

In the presence of the catalyst system OsO₄-bis(3-methyl-2,4-pentanedionato)nickel(II), various olefinic compounds are directly converted to α-hydroxy ketones in good yields with O₂ and an aldehyde.

Chemistry Letters published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C8H15NO, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Deng, Weiping published the artcileEfficient Catalysts for the Green Synthesis of Adipic Acid from Biomass, Quality Control of 627-93-0, the publication is Angewandte Chemie, International Edition (2021), 60(9), 4712-4719, database is CAplus and MEDLINE.

Green synthesis of adipic acid from renewable biomass is a very attractive goal of sustainable chem. Herein, we report efficient catalysts for a two-step transformation of cellulose-derived glucose into adipic acid via glucaric acid. Carbon nanotube-supported platinum nanoparticles are found to work efficiently for the oxidation of glucose to glucaric acid. An activated carbon-supported bifunctional catalyst composed of rhenium oxide and palladium is discovered to be powerful for the removal of four hydroxyl groups in glucaric acid, affording adipic acid with a 99% yield. Rhenium oxide functions for the deoxygenation but is less efficient for four hydroxyl group removal. The co-presence of palladium not only catalyzes the hydrogenation of olefin intermediates but also synergistically facilitates the deoxygenation. This work presents a green route for adipic acid synthesis and offers a bifunctional-catalysis strategy for efficient deoxygenation.

Angewandte Chemie, International Edition published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, Quality Control of 627-93-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jiang, Min published the artcileVisible-Light-Induced Decarboxylative Iodination of Aromatic Carboxylic Acids, Quality Control of 1877-71-0, the publication is Synlett (2018), 29(12), 1572-1577, database is CAplus.

A convenient, efficient and practical visible-light-induced decarboxylative iodination of aromatic carboxylic acids was developed, and the corresponding aryl iodides were obtained in good yields. The method showed some advantages including the use of readily available aromatic carboxylic acids as the starting materials, simple and mild conditions, high efficiency, wide substrate scope and tolerance of various functional groups.

Synlett published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Quality Control of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Nan published the artcileAltered fecal metabolomics and potential biomarkers of psoriatic arthritis differing from rheumatoid arthritis, Recommanded Product: Methyl 3-phenyl-2-propenoate, the publication is Frontiers in Immunology (2022), 812996, database is CAplus and MEDLINE.

Psoriatic arthritis (PsA) is a chronic inflammatory joint disease, and the diagnosis is quite difficult due to the unavailability of reliable clin. markers. This study aimed to investigate the fecal metabolites in PsA by comparison with rheumatoid arthritis (RA), and to identify potential diagnostic biomarkers for PsA. The metabolic profiles of the fecal samples from 27 PsA and 29 RA patients and also 36 healthy controls (HCs) were performed on ultrahigh- performance liquid chromatog. coupled with hybrid triple quadrupole time-offlight mass spectrometry (UHPLC-Q-TOF-MS). And differentially altered metabolites were screened and assessed using multivariate anal. for exploring the potential biomarkers of PsA. The results showed that 154 fecal metabolites were significantly altered in PsA patients when compared with HCs, and 45 metabolites were different when compared with RA patients. A total of 14 common differential metabolites could be defined as candidate biomarkers. Furthermore, a support vector machines (SVM) model was performed to distinguish PsA from RA patients and HCs, and 5 fecal metabolites, namely, α/β-turmerone, glycerol 1-hexadecanoate, dihydrosphingosine, pantothenic acid and glutamine, were determined as biomarkers for PsA. Through the metabolic pathways anal., we found that the abnormality of amino acid metabolism, bile acid metabolism and lipid metabolism might contribute to the occurrence and development of PsA. In summary, our research provided ideas for the early diagnosis and treatment of PsA by identifying fecal biomarkers and analyzing metabolic pathways.

Frontiers in Immunology published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C9H10O4, Recommanded Product: Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Luo, Yani published the artcileCopper-Catalyzed Three-Component Germyl Peroxidation of Alkenes, Category: esters-buliding-blocks, the publication is Organic Letters (2022), 24(12), 2425-2430, database is CAplus and MEDLINE.

The concurrent incorporation of a germyl fragment and another functional group (beyond the hydrogen atom) across the C=C double bond is a highly appealing yet challenging task. Herein, the efficient germyl peroxidation of alkenes with germanium hydrides and tert-Bu hydroperoxide via a copper-catalyzed three-component radical relay strategy is demonstrated. This protocol exhibits excellent functional group tolerance and exquisite chemo- and regioselectivity under mild conditions and represents a rare example of constructing synthetically challenging metal-embedded organic peroxides.

Organic Letters published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yang, Rulin published the artcileSelective, Sequential, and “One-Pot” Depolymerization Strategies for Chemical Recycling of Commercial Plastics and Mixed Plastics, Computed Properties of 627-93-0, the publication is ACS Sustainable Chemistry & Engineering (2022), 10(30), 9860-9871, database is CAplus.

The com. plastics that are currently used in large-scale are primarily concerned with performance and durability, rather than degradability and recyclability. As a result, the chem. recycling of plastics becomes a significant challenge. Selective depolymerization of the mixed plastic waste is a promising solution to the challenges caused by plastic accumulation. Here we present sequential and “one-pot” depolymerization strategies for chem. recycling of com. plastics (PLA, BPA-PC, PBS, PBAT, PCL, and PET) and mixed plastics (BPA-PC/PET, PLA/PBS, and PLA/PBAT) to their initial monomers or value-added chems. Taking advantage of the differences in depolymerization reactivity of com. plastics and versatile catalytic degradation ability of zinc bis[bis(trimethylsilyl)amide] [Zn(HMDS)₂], the selective depolymerization process was smoothly achieved under mild conditions. These strategies provide ideas for promoting the sustainable development of plastics that are currently being used in large-scale.

ACS Sustainable Chemistry & Engineering published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C5H9IO2, Computed Properties of 627-93-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Jing-Wen published the artcileDegradation of dimethyl phthalate esters by a filamentous fungus Aspergillus versicolor isolated from deep-sea sediments, Synthetic Route of 1877-71-0, the publication is Botanica Marina (2017), 60(3), 351-359, database is CAplus.

Di-Me phthalate esters (DMPEs), which belong to phthalate esters (PAEs), are widely distributed environmental pollutants with endocrine-disrupting toxicity. The present study focused on a filamentous fungus capable of degrading DMPEs isolated from deep-sea sediments of the Indian Ocean at a water depth of 3300 m using an enrichment culture technique. The filamentous fungus was identified as Aspergillus versicolor IR-M4 based on internal transcribed spacer gene sequence anal. The degradation pathways of three isomers of DMPEs [dimethyl phthalate (DMP), di-Me isophthalate (DMI) and di-Me terephthalate (DMT)] were investigated with this marine fungus. The results showed that A. versicolor IR-M4 was able to degrade DMI to monomethyl isophthalate (MMI) from an initial concentration of 21.52 mg l^-1 to undetectable in 2 days of incubation, but without the ability for further degradation of MMI. The marine fungus also conducted sequential cleavage of the ester bonds of DMT to terephthalic acid (TA) via monomethyl terephthalate, and TA was the final end product and was resistant to further metabolism However, this marine fungus was not able to degrade DMP. The different metabolic pathways of the three DMPE isomers by the fungus suggest that the phthalate esterases produced by A. versicolor IR-M4 have a very high substrate specificity for DMPEs and monomethyl phthalate esters (MMPEs).

Botanica Marina published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C12H10FeO4, Synthetic Route of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics