Tag: M.W=150-200

Sharma, Apekshya published the artcileDesigning Safer Solvents to Replace Methylene Chloride for Liquid Chromatography Applications Using Thin-Layer Chromatography as a Screening Tool, Quality Control of 627-93-0, the publication is Separations (2021), 8(10), 172, database is CAplus.

Methylene chloride, commonly known as dichloromethane (DCM), is a widely used chem. for chromatog. separation within the polymer, chem., and pharmaceutical industries. With the ability to effectively solvate heterocyclic compounds, and properties including a low b.p., high d., and low cost, DCM has become the solvent of choice for many different applications. However, DCM has high neurotoxicity and is carcinogenic, with exposure linked to damage to the brain and the central nervous system, even at low exposure levels. This research focuses on sustainability and works towards finding safer alternative solvents to replace DCM in pharmaceutical manufacturing The research was conducted with three active pharmaceutical ingredients (API) widely used in the pharmaceutical industry: acetaminophen, aspirin, and ibuprofen. Thin-layer chromatog. (TLC) was used to investigate if an alternative solvent or solvent blend could show comparable separation performance to DCM. The use of the Hansen Solubility Parameter (HSP) theory and solubility testing allowed for the identification of potential alternative solvents or solvent blends to replace DCM. HSP values for the three APIs were exptl. determined and used to identify safer solvents and blends that could potentially replace DCM. Safer solvents or binary solvent blends were down-selected based on their dissolution power, safety, and price. The down-selected solvents (e.g., Et acetate) and solvent blends were further evaluated using three chem. hazard classification approaches to find the best fitting nonhazardous replacement to DCM. Several safer solvent blends (e.g., mixtures composed of Me acetate and Et acetate) with adequate TLC performance were identified. Results from this study are expected to provide guidance for identifying and evaluating safer solvents to sep. APIs using chromatog.

Separations published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C10H12O5, Quality Control of 627-93-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Li published the artcileSynthesis of yolk-shell magnetic porous organic nanospheres supported Pd catalyst for oxidation of alcohols and Heck reactions, Synthetic Route of 103-26-4, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2021), 130237, database is CAplus.

Yolk-shell magnetic porous organic nanospheres (MPONs) supported Pd nanoparticles (Pd@MPONs) were synthesized by encapsulating Fe₃O₄ and Pd nanoparticles in one cavity of hollow porous organic nanospheres (HPONs) using a continuous “ship-in-bottle” strategy. The obtained Pd@MPONs possessed a hierarchically micro/mesoporous structure, high surface area (354 m²/g) and displayed excellent magnetic response (9 emu/g). They showed high catalytic performance in the oxidation of alcs. under mild conditions and the Heck-Mizoroki reaction, and brilliant magnetic recyclability, they can be removed rapidly from a reaction system using external magnetic fields without any catalytic activity decrease. Hence, the Pd@MPONs are easily recoverable nanocatalysts which have practical significance in the future sustainable industry.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C3H5BN2O2, Synthetic Route of 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ren, Jinxuan published the artcileDimethyl itaconate inhibits neuroinflammation to alleviate chronic pain in mice, Product Details of C7H10O4, the publication is Neurochemistry International (2022), 105296, database is CAplus and MEDLINE.

The metabolite itaconate has both anti-inflammatory and immunomodulatory effects. However, its influence on chronic pain is unclear. Here, we demonstrated that i.p. injection of the itaconate derivative di-Me itaconate (DI) alleviated chronic pain symptoms, such as allodynia and hyperalgesia, in spinal nerve ligation (SNL) and inflammatory pain models. Moreover, i.p. DI reduced the secretion of inflammatory cytokines (i.e., interleukin-1β, tumor necrosis factor-alpha) in dorsal root ganglion (DRG), spinal cord and hind paw tissues, suppressed the activation of macrophages in the DRG and glial cells in the spinal dorsal horn and decreased the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) in the DRG and spinal cord. DI boosted nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) levels in the DRG and spinal cord of SNL mice. I.p. administration of the Nrf2 inhibitor ML385 abolished the analgesic effect of DI and decreased the expression of Nrf2 in the DRG and spinal cord. Similarly, administration of DI potently reversed the lipopolysaccharide (LPS)-induced inflammatory effect in microglia. Reduction of endogenous itaconate levels by pretreatment with immune-responsive gene 1 (IRG1) siRNA blocked Nrf2 expression, which impaired the analgesic and anti-inflammatory effects of DI in vitro. Therefore, our findings revealed for the first time that i.p. DI elicited anti-inflammatory effect and sustained chronic pain relief, which may be regarded as a promising therapeutic agent for chronic pain treatment.

Neurochemistry International published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Product Details of C7H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yao, Xiang published the artcilePreparation of cinnamon hydroxamic acid and its flotation characteristics and mechanism to fine-grained wolframite, Name: Methyl 3-phenyl-2-propenoate, the publication is Journal of Molecular Liquids (2022), 119721, database is CAplus.

A new collector-cinnamon hydroxamic acid (CIHA)-was synthesized from Me cinnamate using the hydroxyamine method. The results of single-mineral flotation and artificially mixed-mineral flotation indicated that CIHA had good collection performance and selectivity. Adsorption-capacity test results indicated that the CIHA collector adsorbed wolframite and quartz, and the adsorption intensity of wolframite was higher than that of quartz. The adsorption mechanism was investigated via zeta-potential anal., Fourier transform IR spectroscopy, and XPS. The results indicated that CIHA interacted with Mn on the wolframite surface via Pb²⁺ activation to form a surface Mn-O-Pb²⁺ complex, which formed a new Fe-O bond with Fe. Hydroxamic acid may have formed a five-element chelated hydroxamic group with the metal on the wolframite surface. The hydrophobicity of the wolframite surface was improved, making the wolframite more easily attach to bubbles and be more easily carried to the pulp surface.

Journal of Molecular Liquids published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C5H8N2O, Name: Methyl 3-phenyl-2-propenoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Muliang published the artcileDeoxygenative Deuteration of Carboxylic Acids with D₂O, Product Details of C9H8O4, the publication is Angewandte Chemie, International Edition (2019), 58(1), 312-316, database is CAplus and MEDLINE.

C1-Deuterated aryl and alkyl aldehydes such as 4-PhC₆H₄CDO and PhCH₂CH₂CDO were prepared chemoselectively with 58-96% deuterium incorporation by reduction of aromatic and aliphatic carboxylic acids using iridium photocatalysts, either Ph₃P or Ph₂OEt as an oxygen acceptor, 2,4,6-i-Pr₃C₆H₂SH as a hydrogen atom donor, and using D₂O as an inexpensive deuterium source. The method was used for the preparation of deuterated derivatives of pharmaceuticals and natural products containing aromatic carboxylic acid moieties. The method was also used for chemoselective reduction of aryl and alkyl carboxylic acids to the corresponding aldehydes using H₂O as a hydrogen atom source.

Angewandte Chemie, International Edition published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C11H21BF4N2O2, Product Details of C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Huiqun published the artcileInfluence of hydrolysis rate of carboxylates on dispersion performance of slow-release polycarboxylate superplasticizer, Recommanded Product: Dimethyl itaconate, the publication is Guisuanyan Xuebao (2020), 48(2), 246-252, database is CAplus.

To study the influence of unsaturated carboxylate on the dispersing and flow releasing ability of slow-release polycarboxylate superplasticizer (PCE), the hydrolysis behaviors of carboxylates in sodium hydroxide solution at pH value of 12.0 was investigated, and the constants of hydrolysis rate were derived via a linear fitting. Mini slump was used to examine the variation of flow of cement pastes containing the synthesized slow releasing PCE over time, and the results were compared and analyzed to coordinate the relationship of hydrolysis behaviors of carboxylates and slow-release effectiveness of PCE. The results indicate that PCE with the substitution of acrylic acid with 33.3% Me acrylate and 25.0% di-Me itaconate showed significant slow-release effect, the initial fluidity of cement paste was 149 mm and 104 mm afterwards increased to 223 mm and 212 mm after 2 h resp. PCE with carboxylate monomer of faster hydrolysis rate exhibited quicker flow releasing property, and PCE with carboxylate monomer containing more ester grouped manifested stronger flow releasing ability, but need longer time. The flow releasing property of PCE not only depended on the hydrolysis rate and ester group amount of monomer, but also related to its reactivity of monomer to match the copolymerization system.

Guisuanyan Xuebao published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Recommanded Product: Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nakkala, Jayachandra Reddy published the artcileDimethyl Itaconate-Loaded Nanofibers Rewrite Macrophage Polarization, Reduce Inflammation, and Enhance Repair of Myocardic Infarction, Synthetic Route of 617-52-7, the publication is Small (2021), 17(17), 2006992, database is CAplus and MEDLINE.

Cellular metabolism plays a major role in the regulation of inflammation. The inflammatory macrophages undergo a wide-range of metabolic rewriting due to the production of significant amount of itaconate metabolite from cis-aconitate in the tricarboxylic acid cycle. This itaconate mol. has been recently described as a promising immunoregulator. However, its function and mode of action on macrophages and tissue repair and regeneration are yet unclear. Herein, the itaconate-derivative di-Me itaconate (DMI) suppresses the IL-23/IL-17 inflammatory axis-associated genes and promotes antioxidant nuclear factor erythroid 2-related factor 2 target genes. The poly-ε-caprolactone (PCL)/DMI nanofibers implanted in mice initially maintain inflammation by suppressing anti-inflammatory activity and particular inflammation, while at later stage promotes anti-inflammatory activity for an appropriate tissue repair. Furthermore, the PCL/DMI nanofiber patches show an excellent myocardial protection by reducing infarct area and improving ventricular function via time-dependent regulation of myocardium-associated genes. This study unveils potential DMI macrophage modulatory functions in tissue microenvironment and macrophages rewriting for proper tissue repair.

Small published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Synthetic Route of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tamaru, Yoshinao published the artcilePalladium (0)-catalyzed three-component coupling reaction of allyl benzoate, carbon monoxide, and organozinc carboxylate esters, COA of Formula: C12H14O2, the publication is Angewandte Chemie (1992), 104(5), 662-4 (See also Angew. Chem., Int. Ed. Engl., 1992, 31(5), 645-6), database is CAplus.

The title reaction of an allyl benzoate such as H₂C:CHCMe₂OBz with CO and an organozinc carboxylate such as IZn(CH₂)₃CO₂Et at room temperature in HMPA-PhMe in the presence of (Ph₃P)₄Pd gave allyl ethoxycarbonylalkyl ketones such as 85% Me₂C:CHCH₂CO(CH₂)₃CO₂Et.

Angewandte Chemie published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C4H3Cl2N3, COA of Formula: C12H14O2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chen, Haifeng published the artcileFormation of allylated quaternary carbon centers via C-O/C-O bond fragmentation of oxalates and allyl carbonates, Computed Properties of 5205-11-8, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(3), 454-457, database is CAplus and MEDLINE.

Disclosed herein emphasizes Fe-promoted cross-electrophile allylation of tertiary alkyl oxalates with allyl carbonates that generates all C(sp³)-quaternary centers. The reaction involves fragmentation of tertiary alkyl oxalate C-O bonds to give tertiary alkyl radical intermediates, addition of the radicals to less hindered alkene terminals, and subsequent cleavage of the allyl C-O bonds. Allylation with 2-aryl substituted allyl carbonates was mediated by Zn/MgCl₂, and Fe was used to promote the radical addition efficiency. By introduction of activated alkenes, a three-component radical cascade reaction took place.

Chemical Communications (Cambridge, United Kingdom) published new progress about 5205-11-8. 5205-11-8 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester, name is 3-Methylbut-2-en-1-yl benzoate, and the molecular formula is C12H14O2, Computed Properties of 5205-11-8.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hang, Wei published the artcileCobalt-Catalyzed Reductive Carboxylation of Aryl Bromides with Carbon Dioxide, Recommanded Product: 3-(Methoxycarbonyl)benzoic acid, the publication is Advanced Synthesis & Catalysis (2020), 362(12), 2337-2341, database is CAplus.

Cobalt-catalyzed reductive carboxylation of aryl bromides with carbon dioxide to form the corresponding carboxylic acids ArC(O)OH [Ar = Ph, 4-MeOC₆H₄, 1-naphthyl, etc.] in good to high yields was developed. The reaction proceeded under one atm pressure of CO₂ at 40°C in the presence of cobalt iodide/2,2′-bipyridine catalysts and zinc dust as a reducing reagent. Preliminary mechanistic experiments ruled out intervention of intermediate organozinc species for carboxylation with CO₂, thus suggested direct CO₂ insertion into the corresponding ArCoBr species.

Advanced Synthesis & Catalysis published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Recommanded Product: 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics