Tag: M.W=150-200

Zhu, Jian published the artcileSuperb Ni-foam-structured nano-intermetallic InNi₃C_0.5 catalyst for hydrogenation of dimethyl oxalate to ethylene glycol, Category: esters-buliding-blocks, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2021), 130857, database is CAplus.

A high-performance Ni-foam-structured nano-intermetallic InNi₃C_0.5 catalyst is developed for the gas-phase hydrogenation of di-Me oxalate (DMO) to ethylene glycol (EG). The InNi₃C_0.5/Ni-foam catalyst is obtainable by hydrothermal growth of NiC₂O₄ onto the Ni-foam, impregnation with In₂O₃ precursor, subsequent calcination and carburization in a syngas. Despite DMO cascade hydrogenation to MG, then to EG, and finally to EtOH, such catalyst hydrogenates DMO dexterously until to EG with a high turnover frequency of 636 h^-1, because the 3Ni-In and 3Ni-C sites on InNi₃C_0.5(1 1 1) effectively activate DMO but hinder EG over-hydrogenation to EtOH. Favorable reaction pathway on the InNi₃C_0.5(1 1 1) surface predicted theor. is DMO* → CH₃OCOCO* → CH₃OCOCHO* → CH₃OCOCHOH* → MG* → CH₃OCHOCH₂OH* → CHOCH₂OH* → HOCHCH₂OH* → EG*. Moreover, the neutral Ni-foam diminishes the formation of ethers and diols. The catalyst achieves full DMO conversion with 96-98% EG selectivity and is stable for at least 2500 h under industrial-relevant conditions, and can also hydrogenate a broad scope of carbonyl compounds to corresponding alcs. with high yields.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C2H2N4O2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Liang, Kuan published the artcileBio-based cross-linked polyitaconamides synthesized through a Michael ene-amine addition and bulk polycondensation, Product Details of C7H10O4, the publication is Journal of Polymer Research (2020), 27(3), 56, database is CAplus.

A simple method is established to synthesize bio-based cross-linked polyitaconamides (cPITAs) through a Michael ene-amine addition and bulk polycondensation. A tetraester, i.e. tetra-Me piperazine-N,N’-bis(2-methylene butanedioate) (TMPB), was synthesized through a Michael addition of di-Me itaconate and piperazine at 90°C. Bulk polycondensation of TMPB with butanediamine or hexamethylenediamine was conducted at 130-170°C under atm. pressure, and several cPITAs with tunable properties were prepared The Michael addition and the polycondensation were monitored by FT-IR and ¹H NMR spectra. The cPITA films were characterized by DSC, WAXS, TGA, dynamic mech. anal., and tensile test. cPITAs exhibited Tg ranging from 58 to 72°C, tensile strength up to 85 MPa, and strain at break from 9% to 17%.

Journal of Polymer Research published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Product Details of C7H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Song, Qiuyan published the artcileNondiffusion-Controlled Photoelectron Transfer Induced by Host-Guest Complexes to Initiate Cationic Photopolymerization, Product Details of C11H15NO2, the publication is Macromolecules (Washington, DC, United States) (2021), 54(18), 8314-8320, database is CAplus.

Two novel supramol. photoinitiators (supra-photoinitiators) based on the host-guest complexation of macrocycles (pillar[6]arene, P6; prism[5]arene, NP5) and diphenyl-iodonium salt (Iod) were fabricated. Under light irradiation, macrocycle P6 or NP5 could donate electrons to the guest mol. Iod, which generated highly active free radicals and cationic fragments to achieve efficient polymerization Compared to a com. activator, the electron transfer between macrocycles and Iod were under nondiffusion control, endowing a much higher photopolymerization rate and epoxy resin final conversion. In addition, the host-guest complexation of NP5 extended the initiating wavelength of Iod from ultrashort UV to near-UV, which could better match the environment-friendly LED light source. It is anticipated that a supra-photoinitiator may open a new route for designing novel photoinitiators with high performance.

Macromolecules (Washington, DC, United States) published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C9H7NO4, Product Details of C11H15NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cao, Jiangying published the artcileDevelopment of a bestatin-SAHA hybrid with dual inhibitory activity against APN and HDAC, Product Details of C9H8O4, the publication is Molecules (2020), 25(21), 4991, database is CAplus and MEDLINE.

With five histone deacetylase (HDAC) inhibitors approved for cancer treatment, proteolysis-targeting chimeras (PROTACs) for degradation of HDAC are emerging as an alternative strategy for HDAC-targeted therapeutic intervention. Herein, three bestatin-based hydroxamic acids (P1, P2 and P3) were designed, synthesized and biol. evaluated to see if they could work as HDAC degrader by recruiting cellular inhibitor of apoptosis protein 1 (cIAP1) E3 ubiquitin ligase. Among the three compounds, the bestatin-SAHA hybrid P1 exhibited comparable even more potent inhibitory activity against HDAC1, HDAC6 and HDAC8 relative to the approved HDAC inhibitor SAHA. It is worth noting that although P1 could not lead to intracellular HDAC degradation after 6 h of treatment, it could dramatically decrease the intracellular levels of HDAC1, HDAC6 and HDAC8 after 24 h of treatment. Intriguingly, the similar phenomenon was also observed in the HDAC inhibitor SAHA. Cotreatment with proteasome inhibitor bortezomib could not reverse the HDAC decreasing effects of P1 and SAHA, confirming that their HDAC decreasing effects were not due to protein degradation Moreover, all three bestatin-based hydroxamic acids P1, P2 and P3 exhibited more potent aminopeptidase N (APN, CD13) inhibitory activities than the approved APN inhibitor bestatin, which translated to their superior anti-angiogenic activities. Taken together, a novel bestatin-SAHA hybrid was developed, which worked as a potent APN and HDAC dual inhibitor instead of a PROTAC.

Molecules published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Product Details of C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sun, Guo-Quan published the artcileNickel-catalyzed electrochemical carboxylation of unactivated aryl and alkyl halides with CO₂, Formula: C9H8O4, the publication is Nature Communications (2021), 12(1), 7086, database is CAplus and MEDLINE.

A general and practical electro-reductive Ni-catalytic system, realizing the electrocatalytic carboxylation of unactivated aryl chlorides and alkyl bromides with CO₂ were reported. A variety of unactivated aryl bromides, iodides and sulfonates can also undergo such a reaction smoothly. Notably, realized the catalytic electrochem. carboxylation of aryl (pseudo)halides with CO₂ avoiding the use of sacrificial electrodes. Moreover, this sustainable and economic strategy with electron as the clean reductant features mild conditions, inexpensive catalyst, safe and cheap electrodes, good functional group tolerance and broad substrate scope. Mechanistic investigations indicated that the reaction might proceed via oxidative addition of aryl halides to Ni(0) complex, the reduction of aryl-Ni(II) adduct to the Ni(I) species and following carboxylation with CO₂.

Nature Communications published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C10H20O2, Formula: C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yang, Su published the artcileDimethyl itaconate inhibits LPS-induced microglia inflammation and inflammasome-mediated pyroptosis via inducing autophagy and regulating the Nrf-2/HO-1 signaling pathway, Recommanded Product: Dimethyl itaconate, the publication is Molecular Medicine Reports (2021), 24(3), 672, database is CAplus and MEDLINE.

The endogenous metabolite itaconate and its cell-permeable derivative di-Me itaconate (DI) have been identified as anti-inflammatory regulators of macrophages; however, their contribution to inflammasome-mediated pyroptosis remains unknown. The present study examined the mol. mechanism of DI on NLR family pyrin domain-containing 3 (NLRP3) inflammasome assembly and NLRP3 inflammasome-dependent pyroptosis in microglia. Lipopolysaccharide (LPS) and ATP were used to induce microglia pyroptosis in vitro; this process was confirmed by TUNEL assay, lactate dehydrogenase (LDH) detection and gasdermin D (GSDMD) expression anal. The regulation of microglia polarization and inflammatory cytokine expression was assessed by immunofluorescence assays and ELISA. To investigate the associated mechanism of action, the expression levels of the nuclear factor erythroid 2-related factor 2 (Nrf-2)/heme oxygenase-1 (HO-1) pathway proteins were analyzed by western blotting. Finally, the regulatory effect of DI on autophagy and its association with inflammation was determined by western blotting. The present study demonstrated that DI administration inhibited NLRP3 assembly, LDH release and GSDMD cleavage. Cotreatment of DI with LPS and ATP facilitated the transition from M1 to M2, reduced inflammatory mediator expression and impeded NF-κB phosphorylation. In addition, DI effectively reduced reactive oxygen species production through the Nrf-2/HO-1 pathway. Moreover, DI induced cellular autophagy, whereas inhibition of autophagy with 3-methyladenine markedly reversed its inhibitory effect on NLRP3-dependent pyroptosis. Taken together, the present study suggested that DI participated in the Nrf-2/HO-1 pathway and served a key role in microglia inflammation and NLRP3 inflammasome-mediated pyroptosis via induction of autophagy.

Molecular Medicine Reports published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C23H28N2O4, Recommanded Product: Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Juan published the artcileDetermination of 21 photoinitiators in human plasma by using high-performance liquid chromatography coupled with tandem mass spectrometry: A systemically validation and application in healthy volunteers, Synthetic Route of 10287-53-3, the publication is Journal of Chromatography A (2021), 462079, database is CAplus and MEDLINE.

In the present study, a comprehensive and sensitive method for simultaneous determination of 21 PIs (nine benzophenones, eight amine co-initiators, and four thioxanthones) in human plasma using high-performance liquid chromatog. coupled with tandem mass spectrometry was developed and validated. Two different pre-treatment approaches (liquid-liquid extraction (LLE) and LLE coupled with solid-phase extraction (SPE)) and eight extraction solvents were studied to optimize sample treatment to obtain good recoveries and reduce any matrix effects. The procedure of LLE+SPE was selected as final sample treatment procedure because it obtained higher recoveries as well as lower matrix effects than that performed by LLE alone. The recoveries of 21 target analytes at three spiked concentrations (0.05, 0.5, and 5 ng/mL) ranged from 81% to 109%. The intra- and inter-day relative standard deviations were between 2.5% and 13%. Accuracy and precision data indicated that the detection method was accurate and precise for most of the PIs. The linearities of the labeled dilution calibration curves at 10 concentration levels (iLOQ to 100 ng/mL or iLOQ to 200 ng/mL) were good with correlation coefficients ranged from 0.995 to 0.999. The method quantification limits were in the range of 1.7-16 pg/mL. The anal. method was applied to the anal. of PIs in 14 human plasma samples collected from pregnant women in Guangdong Province, China. Fifteen PIs were detected with total concentrations ranging from 318 to 2772 pg/mL. The ubiquitous contamination of human plasma with PIs suggests that there is widespread exposure to these compounds Consequently, there should be increased awareness of these pollutants in the environment.

Journal of Chromatography A published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Synthetic Route of 10287-53-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Qi, Yujie published the artcileHigh-efficient lignin-based polymerizable macromolecular photoinitiator with UV-blocking property for visible light polymerization, Safety of Ethyl 4-dimethylaminobenzoate, the publication is International Journal of Biological Macromolecules (2022), 234-244, database is CAplus and MEDLINE.

Developing high-efficient visible light macromol. photoinitiator (macro PI) with excellent initiation performance, low migration, high biosafety and multi-function is beneficial to broaden the application of photopolymer. Lignin contains chromophores which could generate free radicals under light irradiation In this study, a lignin-based polymerizable macro PI (DAL-11ene-amine) was designed and synthesized through covalent grafting 10-undecenoyl chloride (11ene) and hydrogen donor 4-(dimethylaminobenzoic acid) Et ester (EDAB) into dealkaline lignin (DAL) skeleton. The structure of DAL-11ene-amine was characterized by UV-vis, FTIR, ¹H NMR, GPC, and ³¹P NMR spectra. Under the irradiation of a 405 nm LED, DAL-11ene-amine can directly produce active species and initiate the polymerization of acrylate monomers or thiol-ene click reaction. The photoinitiation efficiency of DAL-11ene-amine is higher than that of DAL-11ene or the two-component combination of DAL-11ene and EDAB. Using DAL-11ene-amine as PI, the prepared polymer films exhibit excellent UV-blocking property. With only 0.5 weight% addition of DAL-11ene-amine, nearly 100% of UVB + UVC and the most of UVA can be blocked by the films. Moreover, DAL-11ene-amine exhibits higher migration stability and biosafety because it can be covalently linked into polymer crosslinking networks. The results indicate that DAL-11ene-amine has great application potentials in preparing environmentally friendly UV-blocking films and biosafety coatings.

International Journal of Biological Macromolecules published new progress about 10287-53-3. 10287-53-3 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Ester, name is Ethyl 4-dimethylaminobenzoate, and the molecular formula is C11H15NO2, Safety of Ethyl 4-dimethylaminobenzoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dou, Zhansi published the artcileOne-step preparation of lignin-based solid acid by carbonization and sulfonation to catalyze the synthesis of dimethyl adipate, COA of Formula: C8H14O4, the publication is Industrial Crops and Products (2022), 114721, database is CAplus.

Lignin is a high-quality precursor of carbon materials, rich in content and low in price. Sodium lignosulfonate was used as a raw material to prepare a high-efficiency catalyst for the esterification of adipic acid and methanol to synthesize di-Me adipate by a one-step carbonization sulfonation process. The catalyst synthesized by this method has high sulfonic acid groups, and the catalytic process does not need to use sulfuric acid and other advantages. Through characterization anal., study the relationship between the structure of the catalyst and the catalytic performance. A preliminary study on the industrial application of the catalyst has been done. The optimal reaction conditions were reached when the catalyst dosage is 20% of the mass of adipic acid, the alkyd ratio is 8:1, the stirring speed is 600r/min, the reaction temperature is 346 K, and the reaction time is 120 min.

Industrial Crops and Products published new progress about 627-93-0. 627-93-0 belongs to esters-buliding-blocks, auxiliary class Ploymers, name is Dimethyl adipate, and the molecular formula is C8H14O4, COA of Formula: C8H14O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Xu-ling published the artcileRobust and Reactive Neutral Nickel Catalysts for Ethylene Polymerization and Copolymerization with a Challenging 1,1-Disubstituted Difunctional Polar Monomer, Recommanded Product: Dimethyl itaconate, the publication is ACS Catalysis (2021), 11(5), 2902-2911, database is CAplus.

A series of Me nickel complexes with phosphino-naphtholate chelate ligands have been strategically designed, synthesized, and fully characterized. These catalysts showed extremely high activity toward ethylene polymerization and ethylene/unsaturated acid ester copolymerization without any activator under mild conditions. The catalytic activity for ethylene polymerization was up to 3.0 × 10⁷ g_PE mol_Ni^-1 h^-1, which was the topmost among the neutral nickel catalysts previously reported. Besides, the catalytic activity for ethylene/methyl acrylate (MA) copolymerization was also outstanding (up to 3.7 × 10⁵ g mol_Ni^-1 h^-1) among the representative Ni and Pd catalytic systems, which could mediate E/MA copolymerization More remarkably, a very challenging 1,1-disubstituted difunctional ethylene comonomer, di-Me itaconate, was copolymerized with ethylene by these catalysts to give end-difunctional polyethylene with double ester groups and mol. weight up to 10 700 directly.

ACS Catalysis published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C5H5NO3S, Recommanded Product: Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics