Tag: M.W=100-150

Nguyen, Duc H. published the artcileSolid-Supported MADIX Polymerization of Vinyl Acetate, Category: esters-buliding-blocks, the publication is Macromolecules (Washington, DC, United States) (2008), 41(19), 7071-7078, database is CAplus.

A simple, one-pot synthesis of a surface-tethered MADIX agent was established via the reaction of 1,1′-thiocarbonyl diimidazole (TCDI) with a thiol, followed by reaction with the hydroxyl groups of a Wang resin. The supported RAFT agent was used to control the polymerization of vinyl acetate in toluene. The amount of surface-bound polymer was found to greatly increase with increasing content of solid MADIX agent, reaching values of almost 80%. The grafted PVAc chains were cleaved from the Wang resin support via radical reaction with tert-amyl peroxy acetate (TAPA), and the mol. weight distributions exhibited the typical shape of polymers formed via a well-controlled living radical polymerization (LRP), with the free polymers showing a slightly higher mol. weight than the living fraction. The M_n values of both living polymer fraction (surface-bound polymer) and dead polymer (free polymer) increased steadily with monomer conversion-as expected for a well controlled MADIX polymerization-and were in good agreement with the theor. mol. weights PDI values of both polymer fractions scatter around 1.5, with a slight tendency of narrower mol. weight distributions of the living polymer, which shows a min. value of 1.43. Addition of free MADIX agent to the solution phase led to a decrease in PDI values of both free and bound polymer, and the exptl. molar masses were in good agreement with theor. predictions.

Macromolecules (Washington, DC, United States) published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Song, Runzhe published the artcileDesign and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity, Quality Control of 924-99-2, the publication is Bioorganic Chemistry (2020), 104176, database is CAplus and MEDLINE.

The desfluoroquinolone-based hybrids with involvement of C-7 aminopyrimidine functional group were designed and synthesized. The biol. results showed majority of these hybrids still demonstrated potent anti-MRSA activity with MIC values between 0.38 and 1.5μg/mL, despite the lack of the typical C-6 fluorine atom. Particularly, the most active 1-cyclopropyl-7-((4-(3,4-dimethylphenoxy)pyrimidin-2-yl) amino)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid exhibited activities at submicromolar concentrations against a panel of MRSA strains including vancomycin-intermediate strains, levofloxacin-resistant isolates, and linezolid-resistant isolates, etc. As expected, it also displayed highly selective toxicity toward bacterial cells and low hERG inhibition. Further resistance development study indicated MRSA is unlikely acquired resistance against 1-cyclopropyl-7-((4-(3,4-dimethylphenoxy)pyrimidin-2-yl)amino)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. The docking study revealed that two hydrogen bonds were formed between the C-7 substituent and the surrounding DNA bases, which contributed to resistance by reducing the dependence on the magnesium-water bridge interactions with topoisomerase IV. These indicated a promising strategy for developing new antibiotic quinolones to combat multidrug resistance and cardiotoxicity was resulted.

Bioorganic Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C9H7NO3, Quality Control of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xu, Yan-Li published the artcileOrganocatalytic enantioselective electrophilic amination of benzoyl butyrolactones, HPLC of Formula: 517-23-7, the publication is Tetrahedron Letters (2022), 153745, database is CAplus.

Organocatalytic electrophilic amination of benzoyl butyrolactones with azodicarboxylates was demonstrated to highly efficiently prepare quaternary carbon stereocenter-bearing α-amino-γ-butyrolactones I [R = Me, Ph, OBn, etc.], key framework in numerous bioactive compounds The squaramide catalyst II realized the highest yield (99%) and enantioselectivity (93%).

Tetrahedron Letters published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C24H29N5O3, HPLC of Formula: 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Qin, Qixue published the artcileA metal-free desulfurizing radical reductive C-C coupling of thiols and alkenes, Quality Control of 19788-49-9, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(71), 10583-10586, database is CAplus and MEDLINE.

An intermol. reductive C-C coupling of electrophilic alkyl radicals and alkenes was developed. Thiols were used as both hydrogen-donating reagents and alkyl radical precursors in the presence of tri-Et phosphite and radical initiator. A wide range of alkenes, including styrenes and aliphatic olefins were well tolerated in this transformation. Mechanistic studies indicated that a phosphite promoted radical desulfurization of thiols to accessed electrophilic alkyl radicals and a radical chain propagation process may be involved in this transformation.

Chemical Communications (Cambridge, United Kingdom) published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Quality Control of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Huang, Hanchu published the artcileRadical Ring-Closing/Ring-Opening Cascade Polymerization, Application In Synthesis of 19788-49-9, the publication is Journal of the American Chemical Society (2019), 141(32), 12493-12497, database is CAplus and MEDLINE.

A novel strategy for the synthesis of main-chain polymers through radical ring-closing/ring-opening cascade polymerization is reported. Efficient radical cyclopolymn. was achieved through systematic optimization of the electronic properties of 1,6-diene structures. Fusing 1,6-diene with allylic sulfide or allylic sulfone motifs enabled a ring-closing/ring-opening cascade reaction that provides a strong driving force for the ring-opening polymerization of large macrocyclic monomers. The ability of 1,6-diene-fused allylic sulfone to undergo efficient SO₂ extrusion generated a propagating alkyl radical capable of reversible deactivation. This strategy provides a general platform for the synthesis of polymers incorporating complex main-chain structures and degradable functionalities.

Journal of the American Chemical Society published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Application In Synthesis of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xiao, Hua-Ming published the artcileSensitive analysis of multiple low-molecular-weight thiols in a single human cervical cancer cell by chemical derivatization-liquid chromatography-mass spectrometry, Related Products of esters-buliding-blocks, the publication is Analyst (Cambridge, United Kingdom) (2019), 144(22), 6578-6585, database is CAplus and MEDLINE.

Low-mol.-weight (LMW) thiols are important small mols. that regulate or maintain redox homeostasis in physiol. and pathol. processes. Assessing the concentrations of LMW thiols in biol. systems may provide valuable information regarding physiol. processes and the early diagnosis of some diseases. Here, we developed a method to simultaneously determine the concentrations of multiple LWM thiols in single cells by chem. derivatization assisted liquid chromatog.-mass spectrometry (LC-MS). In this method, we synthesized a pair of stable isotope reagents, N-(acridin-9-yl)-2-bromoacetamide (AYBA) and N-(1,2,3,4-[²H₄]-acridin-9-yl)-2-bromoacetamide ([²H₄]AYBA). AYBA was used to derivatize LWM thiols in human cervical cancer (HeLa) cells, while [²H₄]AYBA was used to derivatize standard LWM thiols to prepare internal standards for the LC-MS method development. The proposed AYBA derivatization greatly enhanced the detection sensitivity of LWM thiols by LC-MS, and thereby achieved the simultaneous detection of multiple LWM thiols by LC-MS in ∼1000 HeLa cells. Finally, the developed method was successfully utilized for the quant. anal. of multiple LWM thiols in a single HeLa cell and the content changes of LWM thiols in a single HeLa cell before and after oxidative stress treatment. Accordingly, six LMW thiols were detected, including cysteamine, cysteine, glutathione, homocysteine, hydrogen sulfide, and pantetheine.

Analyst (Cambridge, United Kingdom) published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C18H12FN, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhou, Yao published the artcileCu-Catalyzed Denitrogenative Transannulation of 3-Aminoindazoles To Assemble 1-Aminoisoquinolines and 3-Aminobenzothiophenes, Computed Properties of 30414-53-0, the publication is Organic Letters (2019), 21(22), 8869-8873, database is CAplus and MEDLINE.

Discloses is a Cu-catalyzed denitrogenative transannulation of 3-aminoindazoles to afford diverse functionalized 3-aminobenzothiophenes and 1-aminoisoquinolines. This transformation proceeds via an “extrude-and-sew” strategy with an unprecedented radical reactivity of 3-aminoindazoles.

Organic Letters published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C12H17NS2, Computed Properties of 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Pan, Haiyan published the artcileDimethyl fumarate improves cognitive impairment by enhancing hippocampal brain-derived neurotrophic factor levels in hypothyroid rats., Application of Dimethyl fumarate, the publication is BMC endocrine disorders (2022), 22(1), 188, database is MEDLINE.

BACKGROUND: Dimethyl fumarate (DMF) is an effective drug for multiple sclerosis and can improve the cognitive dysfunction caused by streptozotocin, but the effect on cognitive dysfunction caused by hypothyroidism is unclear. METHODS: After the hypothyroidism rat model induced by propylthiouracil, we gave rats 25 mg/kg DMF by gavage. The body weight during model building and administration was recorded. The levels of T4 and T3 in serum were detected by an automatic biochemical analyzer. Morris water maze test was used to detect the effect of DMF on cognitive learning ability. The effect of DMF on Nissl bodies in the brain tissue was evaluated by Nissl staining. The mRNA and protein levels of BDNF in brain tissue were detected by quantitative reverse transcription-polymerase chain reaction and Western blot. The degrees of p-AKT/AKT and p-CREB/CREB in brain tissue were detected by Western blot. RESULTS: After DMF treatment, the body weight of hypothyroid rats recovered, and the levels of T3 and T4 in the serum were ameliorated. DMF also reduced the escape latency and distance traveled, and increased the swim speed. The number of Nissl bodies and expression of BDNF, p-AKT/AKT, and p-CREB/CREB in the brain tissue were increased after DMF treatment. CONCLUSION: DMF improved the cognitive dysfunction of hypothyroid rats by increasing the level of BDNF in the brain tissue of hypothyroid rats.

BMC endocrine disorders published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Application of Dimethyl fumarate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Liu, Cheng published the artcileDimethyl fumarate ameliorates stress urinary incontinence by reversing ECM remodeling via the Nrf2-TGF-β1/Smad3 pathway in mice., Quality Control of 624-49-7, the publication is International urogynecology journal (2022), 33(5), 1231-1242, database is MEDLINE.

INTRODUCTION AND HYPOTHESIS: Mechanical trauma and oxidative injury are involved in the pathogenesis of stress urinary incontinence (SUI), and oxidative stress (OS) is considered a potential therapeutic target. The antioxidant properties of dimethyl fumarate (DMF), a potent activator of Nrf2, have been highlighted recently. We therefore predicted that DMF might have therapeutic effects on mechanical trauma-induced SUI. METHODS: The SUI mice model was established by vaginal distension (VD). Leak point pressure (LPP), serum OS biomarkers, cell proliferation and apoptosis, collagen, elastin, matrix metalloproteinases (MMP), Nrf2, the TGF-β1/Smad3 signaling pathway, and the associated tissue growth factors in the anterior vaginal wall were measured in either wild-type or Nrf2-knockout (Nrf2^–/^–) female C57BL/6 mice. RESULTS: The results showed that DMF improved the VD-induced LPP reduction, alleviated oxidative injury, stimulated cell proliferation and inhibited apoptosis in the anterior vaginal wall tissue of mice. Moreover, DMF treatment reduced the hydrolysis of ECM proteins by MMP2 and MMP9. The above effects may be mediated by a series of tissue growth factors, including α-SMA, PAI-1, and TIMP-2, with the TGF-β1/Smad3 signaling pathway as the core regulatory mechanism. In further study, Nrf2^–/^– mice were used to replicate the SUI model. And the difference is that DMF failed to reactivate the TGF-β1/Smad3 pathway, nor did it improve LPP. CONCLUSIONS: Dimethyl fumarate can ameliorate urethra closure dysfunction in the VD-induced SUI mice model, and the therapeutic effect of DMF is mediated by the Nrf2-dominated antioxidant system and its downstream TGF-β1/Smad3 signaling pathway.

International urogynecology journal published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Quality Control of 624-49-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yang, Zhijun published the artcileBio-inspired self-healing polyurethanes with multiple stimulus responsiveness, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one, the publication is Polymer Chemistry (2019), 10(24), 3362-3370, database is CAplus.

High-performance stimuli-responsive polymers that exhibit spontaneous, sophisticated and reversible responses to a wide range of external stimuli are highly desirable for applications in diverse fields and have attracted dramatic attention in recent decades. However, it still remains a great challenge to precisely design mol. architectures which can integrate multi-stimuli responsive functions into one structure in polymeric materials. In this study, we reported the synthesis and preparation of a novel multi-responsive self-healing polyurethane with superior mech. properties by adapting a stimuli-responsive dynamic covalent chem. crosslinker and a biomimetic modular polymer design. This unique crosslinker was synthesized through the Michael addition reaction between thiols and bismaleimides, making the chem. crosslinked polyurethanes healable and recyclable at an elevated temperature as well as stimuli-responsive to heat, pH and ammonia gas. A visible color change can be clearly observed when the polymer is in the base or ammonia gas environment, giving the sample great potential for being a gas or pH sensor. Furthermore, the incorporation of self-complementary quadruple hydrogen bonding interactions between 2-ureido-4-[1H]-pyrimidione (UPy) motifs in the polyurethane backbone chains enables the formation of modular hydrogen bonding domains, endowing the material with enhanced mech. properties.

Polymer Chemistry published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H13I, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics