Tag: M.W=100-150

Peng, Panpan published the artcileFabrication of N-halamine polyurethane fi lms with excellent antibacterial properties, Product Details of C6H8O3, the publication is e-Polymers (2021), 21(1), 47-56, database is CAplus.

An N-halamine precursor, namely, 2-amino-5-(2-hydroxyethyl)-6-methylpyrimidin-4-one (AHM), was used as a chain extender in the preparation of a series of N-halamine polyurethane (PU) films, in order to also instill antibacterial properties. The mech. properties, thermodn. performance, and antimicrobial performance of the functionalized PU films were systematically studied. The results showed that the addition of AHM could improve the thermodn. and mech. properties of the developed PU films. Conducting tests in the presence of Escherichia coli and Staphylococcus aureus as the model microorganisms revealed that prior to chlorination the antibacterial properties of the chlorinated PU-AHM-Cl films improved significantly relative to the analogus films. The excellent antibacterial properties and the overall superior performance of the PU-AHMCl films allow their potential application in microbiol. protection materials and related fields.

e-Polymers published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Product Details of C6H8O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Luo, Yani published the artcileCopper-Catalyzed Three-Component Germyl Peroxidation of Alkenes, HPLC of Formula: 624-49-7, the publication is Organic Letters (2022), 24(12), 2425-2430, database is CAplus and MEDLINE.

The concurrent incorporation of a germyl fragment and another functional group (beyond the hydrogen atom) across the C=C double bond is a highly appealing yet challenging task. Herein, the efficient germyl peroxidation of alkenes with germanium hydrides and tert-Bu hydroperoxide via a copper-catalyzed three-component radical relay strategy is demonstrated. This protocol exhibits excellent functional group tolerance and exquisite chemo- and regioselectivity under mild conditions and represents a rare example of constructing synthetically challenging metal-embedded organic peroxides.

Organic Letters published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, HPLC of Formula: 624-49-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Jia published the artcileCatalytic Conversion of Bamboo Sawdust over ZrO₂-CeO₂/γ-Al₂O₃ to Produce Ketonic Hydrocarbon Precursors and Furans, Formula: C6H8O3, the publication is ACS Sustainable Chemistry & Engineering (2018), 6(11), 13797-13806, database is CAplus.

A series of metal oxides including ZrO₂/γ-Al₂O₃, CeO₂/γ-Al₂O₃, and ZrO₂-CeO₂/γ-Al₂O₃ were synthesized and employed to conduct catalytic fast pyrolysis of bamboo sawdust via an anal. pyrolyzer/gas chromatograph/mass spectrometer (Py-GC/MS) to produce hydrocarbon precursors such as ketones and furans. Exptl. results illustrated that the use of metal oxides enhanced the formation of ketones and monoarom. hydrocarbons compared to catalyst-free trial. Among the metal oxides, ZrO₂-CeO₂/γ-Al₂O₃ exhibited the most significant ketonization and aldol condensation activities yielding the highest concentration of linear and cyclic ketones. In addition, nonacidic oxygenates such as furfural, acetol, butanedial, 2,3-dihydrobenzofuran, and Me acetate, were efficiently converted into hydrocarbon precursors over metal oxides. A dual catalytic bed system integrating ZrO₂-CeO₂/γ-Al₂O₃ and HZSM-5 significantly facilitated the production of aromatic hydrocarbons compared to pure HZSM-5 catalytic run. The use of ZrO₂-CeO₂/γ-Al₂O₃ mixed with HZSM-5 mode maximized the formation of xylenes, while ZrO₂-CeO₂/γ-Al₂O₃ mixed with bamboo sawdust catalytic trial increased the concentration of benzene, toluene, and alkylbenzenes.

ACS Sustainable Chemistry & Engineering published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C10H18O, Formula: C6H8O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Li-feng published the artcileSynthesis of 3-difluoromethyl-1-methyl-1H-pyrazol-4-carboxylic acid, HPLC of Formula: 924-99-2, the publication is Jingxi Huagong Zhongjianti (2013), 43(6), 17-19, 47, database is CAplus.

3-Difluoromethyl-1-methyl-1H-pyrazol-4-carboxylic acid was prepared in overall yield of 52% with purity of 98% (HPLC) starting from propargyl alc. through several reaction steps including oxidation, esterification, addition, methylation and hydrolysis.

Jingxi Huagong Zhongjianti published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, HPLC of Formula: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yang, Han-Lin published the artcileBase-iodine-promoted metal-catalyst-free reactions of [60]fullerene with β-keto esters for the selective formation of [60]fullerene derivatives, COA of Formula: C6H10O3, the publication is RSC Advances (2020), 10(41), 24549-24554, database is CAplus and MEDLINE.

Methanofullerenes and 2′,3′-dihydrofuran C₆₀derivatives were selectively synthesized in high yields via the reactions of C₆₀with β-keto esters under mild conditions by controlling the addition sequence and molar ratio of iodine and base. The structures of the products were determined by spectroscopic characterization. Moreover, a possible reaction mechanism for the selective formation of fullerene derivatives was proposed.

RSC Advances published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C20H28B2O4S2, COA of Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Geng, Xiao published the artcileVisible-Light-Driven Multicomponent Cyclization by Trapping a 1,3-Vinylimine Ion Intermediate: A Direct Approach to Pyrimido[1,2-b]indazole Derivatives, Category: esters-buliding-blocks, the publication is Organic Letters (2021), 23(21), 8343-8347, database is CAplus and MEDLINE.

Here a novel visible-light-driven three-component cyclization by trapping an 1,3-vinylimine ion intermediate for the direct synthesis of pyrimido[1,2-b]indazole derivatives from bromodifluoroacetic acid derivatives, enaminones, and 3-aminoindazoles under mild conditions was developed. Notably, the robust methodol. provided a valuable opportunity for the introduction of aliphatic substituents and enables good compatibility of complex bioactive mols. Furthermore, this was the first example of photoinduced multicomponent reaction by employing bromodifluoroacetic acid derivatives as a C1-synthon.

Organic Letters published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Liu, Junzhao published the artcileROS-responsive liposomes as an inhaled drug delivery nanoplatform for idiopathic pulmonary fibrosis treatment via Nrf2 signaling, Formula: C6H8O4, the publication is Journal of Nanobiotechnology (2022), 20(1), 213, database is CAplus and MEDLINE.

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease with pathophysiol. characteristics of transforming growth factor-β (TGF-β), and reactive oxygen species (ROS)-induced excessive fibroblast-to-myofibroblast transition and extracellular matrix deposition. Macrophages are closely involved in the development of fibrosis. Nuclear factor erythroid 2 related factor 2 (Nrf2) is a key mol. regulating ROS and TGF-β expression. Therefore, Nrf2 signaling modulation might be a promising therapy for fibrosis. The inhalation-based drug delivery can reduce systemic side effects and improve therapeutic effects, and is currently receiving increasing attention, but direct inhaled drugs are easily cleared and difficult to exert their efficacy. Therefore, we aimed to design a ROS-responsive liposome for the Nrf2 agonist di-Me fumarate (DMF) delivery in the fibrotic lung. Moreover, we explored its therapeutic effect on pulmonary fibrosis and macrophage activation. We synthesized DMF-loaded ROS-responsive DSPE-TK-PEG@DMF liposomes (DTP@DMF NPs). DTP@DMF NPs had suitable size and neg. zeta potential and excellent capability to rapidly release DMF in a high-ROS environment. We found that macrophage accumulation and polarization were closely related to fibrosis development, while DTP@DMF NPs could attenuate macrophage activity and fibrosis in mice. RAW264.7 and NIH-3T3 cells coculture revealed that DTP@DMF NPs could promote Nrf2 and downstream heme oxygenase-1 (HO-1) expression and suppress TGF-β and ROS production in macrophages, thereby reducing fibroblast-to-myofibroblast transition and collagen production by NIH-3T3 cells. In vivo experiments confirmed the above findings. Compared with direct DMF instillation, DTP@DMF NPs treatment presented enhanced antifibrotic effect. DTP@DMF NPs also had a prolonged residence time in the lung as well as excellent biocompatibility. DTP@DMF NPs can reduce macrophage-mediated fibroblast-to-myofibroblast transition and extracellular matrix deposition to attenuate lung fibrosis by upregulating Nrf2 signaling. This ROS-responsive liposome is clin. promising as an ideal delivery system for inhaled drug delivery.

Journal of Nanobiotechnology published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Formula: C6H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Langer, Peter published the artcileNew and efficient synthesis of pyrrolo[3,2-b]pyrrole-2,5-diones by double-anion-capture reactions of ester carbanions with bis(imidoyl)chlorides of oxalic acid, Application of Ethyltert-butylacetate, the publication is Journal of Organic Chemistry (2000), 65(3), 729-734, database is CAplus.

A variety of pyrrolo[3,2-b]pyrrole-2,5-diones were efficiently prepared by a new domino-reaction of ester carbanions with oxalic acid bis(imidoyl)chlorides. This reaction proceeded by condensation of 2 equiv of the ester with the bis(imidoyl)chloride and subsequent intramol. attack of the nitrogen atoms of the bis-enamine intermediate onto the ester groups. The products, which can be regarded as dilactams of pentalene, represent useful synthetic pigments due to their optical features, their stability, and low solubility The UV-visible properties of the pyrrolo[3,2-b]pyrrole-2,5-diones could be efficiently controlled by the substituents attached to the heterocyclic core. The scope and the limitations of the new cyclization reaction were investigated.

Journal of Organic Chemistry published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Application of Ethyltert-butylacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kong, Jiahui published the artcilePreparation of the key dolutegravir intermediate via MgBr2-promoted cyclization, Related Products of esters-buliding-blocks, the publication is Molecules (2021), 26(10), 2850, database is CAplus and MEDLINE.

A novel approach for synthesizing the key dolutegravir intermediate is described via MgBr₂-promoted intramol. cyclization. Condensation of com. available Me oxalyl chloride and Et 3-(N,N-dimethylamino)acrylate afforded the vinylogous amide in an excellent yield. Subsequent substitution by aminoacetaldehyde di-Me acetal and Me bromoacetate gave rise to the expected precursor for cyclization, which was promoted by MgBr₂ to highly selectively convert into pyridinone diester. The key dolutegravir intermediate was finally prepared by the selective hydrolysis of the corresponding diester via LiOH.

Molecules published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Beck, James R. published the artcileSynthesis of 1-aryl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acids and esters, Recommanded Product: Ethyl 3-(dimethylamino)acrylate, the publication is Journal of Heterocyclic Chemistry (1987), 24(3), 739-40, database is CAplus.

Et 1-aryl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylates I (R¹ = H, Cl, CF₃, OMe) were prepared by the condensation of arylhydrazines with Et 3-ethoxy-2-(trifluoroacetyl)-2-propenoate at low temperature The corresponding acids were also synthesized.

Journal of Heterocyclic Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Recommanded Product: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics