Tag: M.W=100-150

Wang, Xiao-Mei published the artcileEnantioselective Synthesis of Nitrogen-Nitrogen Biaryl Atropisomers via Copper-Catalyzed Friedel-Crafts Alkylation Reaction, Name: Methyl 3-oxovalerate, the publication is Journal of the American Chemical Society (2021), 143(37), 15005-15010, database is CAplus and MEDLINE.

Nitrogen-nitrogen bonds containing motifs are ubiquitous in natural products and bioactive compounds However, the atropisomerism arising from a restricted rotation around an N-N bond is largely overlooked. Here, a method to access the first enantioselective synthesis of N-N biaryl atropisomers via a Cu-bisoxazoline-catalyzed Friedel-Crafts alkylation reaction is described. A wide range of axially chiral N-N bisazaheterocycle compounds were efficiently prepared in high yields with excellent enantioselectivities via desymmetrization and kinetic resolution Heating experiments showed that the axially chiral bisazaheterocycle products have high rotational barriers.

Journal of the American Chemical Society published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C13H9FO, Name: Methyl 3-oxovalerate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhao, Guoqing published the artcileSynthesis of Cyclopentenes, Pyrroles, and Thiophenes via a Sequence of Propargyl-Allenyl Isomerizations, Michael Additions, and Intramolecular Wittig Reactions, Recommanded Product: Ethyl 2-mercaptopropanoate, the publication is Journal of Organic Chemistry (2014), 79(22), 10867-10872, database is CAplus and MEDLINE.

Allenylphosphonium species, reactive Michael acceptors, could be generated from simple, readily available propargylphosphonium salts through propargyl-allenyl isomerization. We developed an efficient synthesis for cyclopentenes, pyrroles, and thiophenes via a sequence of propargyl-allenyl isomerizations, Michael additions, and intramol. Wittig reactions.

Journal of Organic Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C8H7N3, Recommanded Product: Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Mei published the artcileHigh-performance recyclable cross-linked polyurethane with orthogonal dynamic bonds: The molecular design, microstructures, and macroscopic properties, SDS of cas: 517-23-7, the publication is Polymer (2018), 127-137, database is CAplus.

Polyurethane materials (PUs) have been widely used in industry and daily life due to the versatile chem. However, despite the rapid advance in synthetic chem., it still remains a significant challenge for the facile fabrication of PUs with a single crosslinked network embedded with excellent mech. properties and recyclability. Herein, in this study, we proposed a simple strategy to fabricate a high-performance recyclable crosslinked PU and revealed the relationship between microscopic structure and macroscopic properties. The UPy (2-ureido-4-[1H]-pyrimidione) motifs were incorporated into the backbone chains of PUs, where the quadruple hydrogen bonding interactions between UPy dimers can significantly enhance the mech. strength and toughness. Furthermore, a single small mol. Diels-Alder adduct was utilized as the chem. crosslinker, rendering the final crosslinked PUs healable and recyclable. The thermal reversibility of the Diels-Alder reaction was well verified by DSC and solid-state NMR spectroscopy. Notably, it was found that the incorporation of UPy motifs could enhance the strain-induced crystallization (SIC), leading to a large stress at break. The structural and dynamic changes induced by SIC were quant. addressed by proton multiple-quantum NMR spectroscopy and SAXS experiments, where SIC further imposed restrictions on the mobility of surrounding polymer chains in the soft domain and led to the change of microphase separated nanostructures. Overall, a simple strategy is proposed here for the facile fabrication of high performance recyclable PUs, and the detailed investigation here on the structure-property relationship may further provide insights into developing high performance polymeric materials.

Polymer published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, SDS of cas: 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Wenxing published the artcileElectrochemical synthesis of 1,2,4,5-tetrasubstituted imidazoles from enamines and benzylamines, Quality Control of 30414-53-0, the publication is Organic & Biomolecular Chemistry (2021), 19(30), 6682-6686, database is CAplus and MEDLINE.

An electrochem. method for synthesizing 1,2,4,5-tetrasubstituted imidazoles I (R = Me, Et, Ph, i-Pr; R¹ = n-Bu, Bn, cyclohexyl, 4-chlorophenyl, naphthalen-1-yl, etc.; R² = Me, OMe, OEt, Ot-Bu; R³ = Ph, 2,3-dichlorophenyl, thiophen-2-yl, etc.) was developed under undivided electrolytic conditions. This synthesis was specifically realized based on electrochem. C(sp³)-H amination via enamines (Z)-RC(NHR¹)=C(O)R² and amines R³NH₂. Readily available starting materials were used, avoiding the use of both transition metals and oxidants. The practicability of the method lies in its broad substrate adaptability and in its ability to provide a simple green pathway for synthesizing GABAA receptor analogs I (R = Me; R¹ = 2,4-dichlorophenyl; R² = OEt; R³ = 4-bromophenyl).

Organic & Biomolecular Chemistry published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C4H10O2, Quality Control of 30414-53-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chen, Kai published the artcileAlternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions, Quality Control of 517-23-7, the publication is Journal of the American Chemical Society (2018), 140(48), 16402-16407, database is CAplus and MEDLINE.

We report a biocatalytic platform of engineered cytochrome P 450 enzymes to carry out carbene-transfer reactions using a lactone-based carbene precursor. By simply altering the heme-ligating residue, we obtained two enzymes that catalyze olefin cyclopropanation (Ser) or S-H bond insertion (Cys). Both enzymes exhibit high catalytic efficiency and stereoselectivity, thus enabling facile access to structurally diverse spiro[2.4]lactones and α-thio-γ-lactones. Computational studies revealed the mechanism of carbene S-H insertion and explain how the axial ligand controls reactivity and selectivity. This work expands the catalytic repertoire of hemeproteins and offers insights into how these enzymes can be tuned for new chem.

Journal of the American Chemical Society published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Quality Control of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Zhanguo published the artcileParallel solution-phase synthesis of 4H-benzo[1,4]thiazin-3-one and 1,1-dioxo-1,4-dihydro-2H-1λ⁶-benzo[1,4]thiazin-3-one derivatives from 1,5-difluoro-2,4-dinitrobenzene, SDS of cas: 19788-49-9, the publication is Journal of Combinatorial Chemistry (2007), 9(4), 652-660, database is CAplus and MEDLINE.

This paper discusses the synthesis of privileged structures 4H-benzo[1,4]thiazin-3-one and 1,1-dioxo-1,4-dihydro-2H-1λ⁶-benzo[1,4]thiazin-3-one derivatives in a parallel solution-phase manner using 1,5-difluoro-2,4-dinitrobenzene. Each scaffold possesses four diversity points. A cheap and efficient oxidant, urea-hydrogen peroxide (UHP), was applied for the introduction of the sulfone group. The intramol. cyclization to 1,1-dioxo-1,4-dihydro-2H-1λ⁶-benzo[1,4]thiazin-3-one was achieved by microwave assistance or the use of an inorganic base.

Journal of Combinatorial Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C6H4ClNO2, SDS of cas: 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nazir, Nausheen published the artcileChemical composition, in vitro antioxidant, anticholinesterase, and antidiabetic potential of essential oil of Elaeagnus umbellata Thunb, Computed Properties of 5340-78-3, the publication is BMC Complementary Medicine and Therapies (2021), 21(1), 73, database is CAplus and MEDLINE.

Elaeagnus umbellata Thunb. (autumn olive) is a high valued medicinal plant. It belongs to Elaeagnaceae family and is widely distributed in Himalayan regions of Pakistan. In the present study essential oil were extracted from the fruit of this plant and their antioxidant, anticholinesterase and antidiabetic potentials were also evaluated. Essential oils were extracted from the fruit of E. umbellata using hydro-distillation method and were characterized by GC-MS. The extracted oil were tested for its antioxidant, anticholinesterase, and antidiabetic potentials using standard protocols. About 68 compounds were identified by GC-MS. The extracted oil exhibited a fairly high free radical scavenging activities against DPPH and ABTS radicals with IC50 values of 70 and 105 μg/mL resp. (for ascorbic acid, used as standard, the IC50 values were 32 and 29 μg/mL, resp. against the mentioned radicals). The essential oil also exhibited anticholinesterase activities with IC50 values of 48 and 90 μg/mL resp. against AChE and BChE (for galantamine used as standard, the IC50 values were 25 and 30 μg/mL resp.). The essential oil also exhibited antidiabetic potential with IC50 values of 120 and 110 μg/mL resp. against α-glucosidase and α-amylase (IC50 values for standard acarbose = 28 and 30 μg/mL resp.). Conclusion: Essential oil extracted from the fruits of E. umbellata exhibited reasonable antioxidant, anticholinesterase, and antidiabetic potentials that could be used as alternative medicine in treating diabetes and neurodegenerative disorders. However, further studies are needed to isolate responsible compounds and evaluate the observed potential in animal models.

BMC Complementary Medicine and Therapies published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Computed Properties of 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Al-Qawasmeh, Raed A. published the artcileSynthesis and antibacterial activity of 9-cyclopropyl-4-fluoro-6-oxo-6,9-dihydro-[1,2,5]thiadiazolo[3,4-h]quinoline-7-carboxylic acid and its ethyl ester, Safety of Ethyl 3-(dimethylamino)acrylate, the publication is ARKIVOC (Gainesville, FL, United States) (2009), 322-336, database is CAplus.

Synthesis and the antimicrobial activity of 9-cyclopropyl-4-fluoro-6-oxo[1,2,5]thiadiazolo[3,4-h]quinoline-5-carboxylic acid (I) and Et ester are reported. Compound I was prepared in good yield via thermal cyclocondensation of Et 7,8-diamino-9-cyclopropyl-4-fluoro-6-oxoquinoxaline-7-carboxylate with thionyl chloride, followed by acid-catalyzed hydrolysis. The structures of all synthesized compounds were characterized by IR, MS, ¹H- and ¹³C NMR spectra; the structure of compound I was confirmed by X-ray crystal structure anal. The antibacterial and antifungal evaluation against a broad panel of wild and resistant Gram-pos. and Gram-neg. bacteria and fungal species demonstrated the high antibacterial activity of compound I, even at the concentration of 0.015 μg mL^-1.

ARKIVOC (Gainesville, FL, United States) published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Safety of Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gonnella, Roberta published the artcileMechanisms of Sensitivity and Resistance of Primary Effusion Lymphoma to Dimethyl Fumarate (DMF), Computed Properties of 624-49-7, the publication is International Journal of Molecular Sciences (2022), 23(12), 6773, database is CAplus and MEDLINE.

PEL is a rare B cell lymphoma associated with KSHV that mainly arises in immune-deficient individuals. The search for new drugs to treat this cancer is still ongoing given its aggressiveness and the poor response to chemotherapies. In this study, we found that DMF, a drug known for its anti-inflammatory properties which is registered for the treatment of psoriasis and relapsing-remitting MS, could be a promising therapeutic strategy against PEL. Indeed, although some mechanisms of resistance were induced, DMF activated NRF2, reduced ROS and inhibited the phosphorylation of STAT3 and the release of the pro-inflammatory and immune suppressive cytokines IL-6 and IL-10, which are known to sustain PEL survival. Interestingly, we observed that DMF displayed a stronger cytotoxic effect against fresh PEL cells in comparison to PEL cell lines, due to the activation of ERK1/2 and autophagy in the latter cells. This finding further encourages the possibility of using DMF for the treatment of PEL.

International Journal of Molecular Sciences published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Computed Properties of 624-49-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kodama, Susumu published the artcileAssociation between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats, SDS of cas: 517-23-7, the publication is Journal of Toxicological Sciences (2021), 46(12), 569-587, database is CAplus.

The liver plays critical roles to maintain homeostasis of living organisms and is also a major target organ of chem. toxicity. Meanwhile, nuclear receptors (NRs) are known to regulate major liver functions and also as a critical target for hepatotoxic compounds In this study, we established mammalian one-hybrid assay systems for five rat-derived NRs, namely PXR, PPARα, LXRα, FXR and RXRα, and evaluated a total of 326 compounds for their NR-activating profiles. Then, we assessed the association between their NR-activating profile and hepatotoxic endpoints in repeated-dose toxicity data of male rats from Hazard Evaluation Support System. In the in vitro cell-based assays, 68, 38, 20, 17 and 17 compounds were identified as positives for PXR, PPARα, LXRα, FXR and RXRα, resp. The association analyses demonstrated that the PXR-pos. compounds showed high frequency of endpoints related to liver hypertrophy, such as centrilobular hepatocellular hypertrophy, suggesting that PXR activation is involved in chem.-induced liver hypertrophy in rats. It is intriguing to note that the PXR-pos. compounds also showed statistically significant associations with both prolonged activated partial thromboplastin time and prolonged prothrombin time, suggesting a possible involvement of PXR in the regulation of blood clotting factors. Collectively, our approach may be useful for discovering new functions of NRs as well as understanding the complex mechanism for hepatotoxicity caused by chem. compounds

Journal of Toxicological Sciences published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, SDS of cas: 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics