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Wu, Qianlan et al. published their research in Huanjing Kexue Yanjiu in 2021 | CAS: 84-61-7

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.HPLC of Formula: 84-61-7

Pollution characteristics and exposure risks of PAEs in PM_2.5 of indoor environment on university campus was written by Wu, Qianlan;Lei, Jingzheng;Wang, Lijun. And the article was included in Huanjing Kexue Yanjiu in 2021.HPLC of Formula: 84-61-7 This article mentions the following:

In order to determine the pollution characteristics of PM_2.5 and PM_2.5-bound phthalate esters (PAEs) and the risk of teachers and students exposed to PM_2.5-bound PAEs in campus indoor environment, 52 indoor PM_2.5 samples were collected at six sampling sites on the Chang閳ョ瀽n campus of Shaanxi Normal University in autumn and winter. The concentration of 22 PAEs was determined by gas chromatog.-mass spectrometer, the composition and spatial and temporal distribution of PAEs were studied, and the health risks of teachers and students exposed to PM_2.5-bound PAEs were evaluated. The results showed that: (1) The total concentration of the 22 PAEs at different sampling sites ranged from 237 to 413 娓璯/m³, and the sum of 6 priority PAEs ranged from 4.81 to 7.47 娓璯/m³. The predominant PAEs of indoor PM_2.5 were diisobutyl phthalate, dicyclohexyl phthalate, and diisononyl phthalate, which were non-priority PAEs and much higher than those of 6 priority PAEs. (2) The detection rate of 6 priority PAEs was different at different sampling sites. Six priority PAEs were detected in library and classrooms, four priority PAEs were detected in student apartments, and only three priority PAEs were detected in family area. (3) Seasonal changes impacted the concentration of indoor PM_2.5 and PM_2.5-bound PAEs. The average concentration of indoor PM_2.5 in winter (58.3 娓璯/m³) was higher than that in autumn (55.4 娓璯/m³). The concentration of 6 priority PAEs in Dec. was in the range of 0.250-3.86 娓璯/m³, which was significantly higher than that in autumn months. (4) The source anal. results of principal component anal. and cluster anal. showed that PAEs of campus indoor PM_2.5 were mainly related to the emission of indoor decoration materials, the use of ink, cosmetics and personal care products of students, the application of plasticizers, and the release of coatings. (5) The health risk assessment results showed that the non-carcinogenic risk of 6 priority PAEs was low, and the carcinogenic risk of benzyl Bu phthalate and di(2-ethylhexyl) phthalate was below 1鑴?0^-6 and could be ignored. The research showed that the pollution of PM_2.5 and the concentration and composition of PM_2.5-bound PAEs varied in different indoor environments on campus. The non-carcinogenic risk of teachers and students exposed to six priority PAEs of indoor PM_2.5 was relatively low, and the carcinogenic risk was negligible. However, much attention should be paid to the pollution and risk of non-priority PAEs in the environment. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7HPLC of Formula: 84-61-7).

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhou, Bin et al. published their research in Chemosphere in 2022 | CAS: 84-61-7

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.Reference of 84-61-7

Effects of phthalate esters on soil microbial community under different planting patterns in Northern China: Case study of Hebei Province was written by Zhou, Bin;Zhao, Lixia;Sun, Yang;Li, Xiaojing;Weng, Liping;Xue, Yong;Li, Yongtao. And the article was included in Chemosphere in 2022.Reference of 84-61-7 This article mentions the following:

Soil microorganisms are biol. factors involved in the farmland environment. The factors that shape soil microbial communities and how these are influenced by geog. location, planting pattern (open-field or greenhouse), and soil organic pollutants (phthalate esters, PAEs) remain poorly understood at large scales. Using 16 S rRNA gene and ITS sequencing, we characterized the soil microbiota in open-field and greenhouse soils in Hebei Province, China, and correlated their structure and composition to geog. location, planting pattern and PAEs. Compared with geog. location, planting pattern is more decisive for shaping soil microbes and has more significant effects on bacteria, and the effects are shaped by the number and types of core OTUs. PAEs participated in the shaping of soil microbial communities by altering the relative abundances of dominant microorganisms in the two planting patterns, and the effects of PAEs with high Kow were more significant. PAEs have a greater impact on bacteria than fungi in both planting patterns. Bacteria in the greenhouse soil were sensitive to the 9 kinds of PAEs detected, however in the open-field samples, mainly responded to PAEs with high Kow and rarely respond to PAEs with low Kow. DEHP and DBP, as two monomers with the highest concentration, have significant effects on dominant genera of microorganisms under both planting patterns, with inhibiting effect on bacteria and significantly promotion on fungi. Our study clarified the factors that have a substantial impact on soil microorganisms at the provincial scale and the mechanisms involved in shaping soil microbial community structure, as well as the significant impact of PAEs on soil microbial dominant microorganisms. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Reference of 84-61-7).

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Yu et al. published their research in Environmental Science & Technology in 2021 | CAS: 84-61-7

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. COA of Formula: C20H26O4

Risk assessment of agricultural plastic films based on release kinetics of phthalate acid esters was written by Wang, Yu;Wang, Fang;Xiang, Leilei;Gu, Chenggang;Redmile-Gordon, Marc;Sheng, Hongjie;Wang, Ziquan;Fu, Yuhao;Bian, Yongrong;Jiang, Xin. And the article was included in Environmental Science & Technology in 2021.COA of Formula: C20H26O4 This article mentions the following:

Plastic films have become an integral part of fruit and vegetable production systems, but their release of phthalate acid esters (PAEs) is a threat to human health. The release kinetics of PAEs and measures of risk are still not well understood. We investigated 50 agricultural films, with concentrations ranging from 2.59 to 282,000 mg kg^-1. The seven com. available film types included were polyvinylchloride (PVC), metallocene polyethylene (mPE), ethylene vinyl acetate (EVA), polyolefin (PO), and three mulch films. Bis(2-ethylhexyl) phthalate (DEHP) was detected in most of films, and its release fitted well into the first-order kinetic model. The release rate of DEHP was neg. related to the film thickness. The potential carcinogenic risks of DEHP in the air of six kinds of plastic greenhouses to human health were estimated We found that the carcinogenic risks associated with PVC and mPE greenhouse films warrant greater attention. Though EVA, PO greenhouse, and mulch films were lower risk, we advise keeping plastic greenhouses well ventilated during the first month of use to reduce direct human exposure to volatile PAEs. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7COA of Formula: C20H26O4).

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tie, Jiancheng et al. published their research in Fenxi Shiyanshi in 2021 | CAS: 84-61-7

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application In Synthesis of Dicyclohexyl phthalate

Determination of 18 phthalate plasticizers in waste cotton by solid phase extraction gas chromatography tandem mass spectrometry was written by Tie, Jiancheng;Liu, Rui;Long, Zhixin;Liu, Jun;Zhu, Peng. And the article was included in Fenxi Shiyanshi in 2021.Application In Synthesis of Dicyclohexyl phthalate This article mentions the following:

A solid phase extraction-gas chromatog. tandem mass spectrometry (SPE-GC/MS) method was established for the anal. of 18 phthalate plasticizers in waste cotton. The research results showed that when the sample was extracted with Et acetate-n-hexane (1: 3, V/V), enriched and purified with the HC-C₁₈ solid phase extraction column, separated with the HP-5 MS capillary column, analyzed with the selected ion scanning (SIM) mode and external standard method for quantification, good linear relationships were found for 18 plasticizers in the range of 0.1-10 娓璯/mL (DIHP, DINP, DIDP were 0.5-50 娓璯/mL). The correlation coefficient was 0.9959-1.0000, the detection limit was 0.051-1.73 娓璯/g, and the quantification limit was 0.24-6.94 娓璯/g, resp. At the spiked levels of 0.2, 1, and 5 娓璯/mL, the recoveries of the 18 plasticizers were 82.2-104.7%, and the intra-day and inter-day relative standard deviations were 1.1-7.9% and 0.8-8.3%, resp. This method is suitable for the anal. of phthalate plasticizers in waste cotton. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Application In Synthesis of Dicyclohexyl phthalate).

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zimuwandeyi, Memory et al. published their research in Tetrahedron in 2018 | CAS: 87694-53-9

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Computed Properties of C16H24N2O4

PADAM reactions of 浼?aminoaldehydes: Identity of major and minor diastereomers from the Passerini reaction was written by Zimuwandeyi, Memory;Kola, Fatima;Lemmerer, Andreas;Brady, Dean;Rousseau, Amanda L.;Bode, Moira L.. And the article was included in Tetrahedron in 2018.Computed Properties of C16H24N2O4 This article mentions the following:

The Passerini reaction was conducted using N-Boc-L-phenylalaninal and a variety of achiral or chiral acids and isocyanides to prepare a library of 27 Passerini products. Reaction diastereoselectivity varied between 1.7:1 and 2.5:1 and in most cases isolation of the individual diastereomers was possible. Passerini products were subjected to a deprotection and acyl migration sequence to give a library of peptidomimetic 浼?hydroxy-灏?acylaminoamides in generally excellent yield. Single crystal X-ray anal. of two of the final products enabled identification of the major diastereomer as having an (R) configuration at the newly-formed stereogenic center, which corresponds to anti-Felkin-Anh addition of the isocyanide to the aldehyde. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Computed Properties of C16H24N2O4).

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Yu et al. published their research in Environmental Science & Technology in 2021 | CAS: 84-61-7

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120掳 C鈥揅鈥揙 and O鈥揅鈥揙 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C鈥揙鈥揅 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. COA of Formula: C20H26O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tie, Jiancheng et al. published their research in Fenxi Shiyanshi in 2021 | CAS: 84-61-7

A solid phase extraction-gas chromatog. tandem mass spectrometry (SPE-GC/MS) method was established for the anal. of 18 phthalate plasticizers in waste cotton. The research results showed that when the sample was extracted with Et acetate-n-hexane (1: 3, V/V), enriched and purified with the HC-C₁₈ solid phase extraction column, separated with the HP-5 MS capillary column, analyzed with the selected ion scanning (SIM) mode and external standard method for quantification, good linear relationships were found for 18 plasticizers in the range of 0.1-10 渭g/mL (DIHP, DINP, DIDP were 0.5-50 渭g/mL). The correlation coefficient was 0.9959-1.0000, the detection limit was 0.051-1.73 渭g/g, and the quantification limit was 0.24-6.94 渭g/g, resp. At the spiked levels of 0.2, 1, and 5 渭g/mL, the recoveries of the 18 plasticizers were 82.2-104.7%, and the intra-day and inter-day relative standard deviations were 1.1-7.9% and 0.8-8.3%, resp. This method is suitable for the anal. of phthalate plasticizers in waste cotton. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Application In Synthesis of Dicyclohexyl phthalate).

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zimuwandeyi, Memory et al. published their research in Tetrahedron in 2018 | CAS: 87694-53-9

PADAM reactions of 伪-aminoaldehydes: Identity of major and minor diastereomers from the Passerini reaction was written by Zimuwandeyi, Memory;Kola, Fatima;Lemmerer, Andreas;Brady, Dean;Rousseau, Amanda L.;Bode, Moira L.. And the article was included in Tetrahedron in 2018.Computed Properties of C16H24N2O4 This article mentions the following:

The Passerini reaction was conducted using N-Boc-L-phenylalaninal and a variety of achiral or chiral acids and isocyanides to prepare a library of 27 Passerini products. Reaction diastereoselectivity varied between 1.7:1 and 2.5:1 and in most cases isolation of the individual diastereomers was possible. Passerini products were subjected to a deprotection and acyl migration sequence to give a library of peptidomimetic 伪-hydroxy-尾-acylaminoamides in generally excellent yield. Single crystal X-ray anal. of two of the final products enabled identification of the major diastereomer as having an (R) configuration at the newly-formed stereogenic center, which corresponds to anti-Felkin-Anh addition of the isocyanide to the aldehyde. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Computed Properties of C16H24N2O4).

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Maiti, Sudip et al. published their research in Nature Communications in 2022 | CAS: 4163-60-4

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate

Expanding chemical space by para-C-H arylation of arenes was written by Maiti, Sudip;Li, Yingzi;Sasmal, Sheuli;Guin, Srimanta;Bhattacharya, Trisha;Lahiri, Goutam Kumar;Paton, Robert S.;Maiti, Debabrata. And the article was included in Nature Communications in 2022.Quality Control of (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate This article mentions the following:

A robust catalytic system that displayed unique efficacy toward para-arylation of highly functionalized substrates such as drug entities, giving access to structurally diversified biaryl scaffolds, e.g., I was developed. This diversification process provided access to an expanded chem. space for further exploration in drug discovery. Further, the applicability of the transformation was realized through the synthesis of drug mols. bearing a biphenyl fragment. Computational and exptl. mechanistic studies further provided insight into the catalytic cycle operative in this versatile C-H arylation protocol. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Quality Control of (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate).

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Xiuling et al. published their research in Inorganic Chemistry in 2018 | CAS: 4163-60-4

Click Chemistry-Assisted Synthesis of a β-D-Galactose-Targeted SiO₂@RC Shell-Core Structure as a Nanoplatform for Metal-Based Complex Delivery was written by Xu, Xiuling;Hu, Fan;Shuai, Qi. And the article was included in Inorganic Chemistry in 2018.Formula: C16H22O11 This article mentions the following:

A facile reversed-phase microemulsion method was used to synthesize shell-core nanospheres of SiO₂@RCs (SiO₂-encapsuled rare-earth metal complexes). β-D-Galactose was then grafted onto the surfaces of the nanospheres through the copper(I)-catalyzed azide-alkyne cycloaddition click reaction for targeted delivery. The chem. characteristics and surface profiles of the nanocarriers were investigated by Fourier transform IR spectroscopy, dynamic light scattering, transmission electron microscopy, and SEM. A high-efficiency microwave synthesis method was applied to prepare five complex cores by the reaction of different rare-earth metal salts with two isomeric ligands, o-CPA (2-chlorophenoxyacetic acid) and m-CPA (3-chlorophenoxyacetic acid). The crystal structures of the five synthesized RC cores were confirmed through X-ray diffraction, which revealed the formulas of five RCs, [Dy(o-CPA)₃(H₂O)]·H₂O RC₁, [Ho(o-CPA)₃(H₂O)]·H₂O RC₂, 2[Er(m-CPA)₃(H₂O)]·3H₂O RC₃, 2[Gd(m-CPA)₃(H₂O)]·3H₂O RC₄, and [Ce₂(m-CPA)₆(H₂O)₃]·2H₂O RC₅. An in vitro cell study revealed that all RCs exhibited certain anticancer activities. RC₂, in particular, showed the strongest cytotoxicity against HepG2 cells. The enhanced cell permeability and drug retention considerably improved the cytotoxicity of all SiO₂@RC₂-gal relative to that of RC₂. The selective uptake of the β-D-galactose-conjugated nanospheres by HepG2 cells through mechanisms mediated by cell surface receptors resulted in fewer side effects on extrahepatic tissues. Our contribution provides a novel design concept of a target SiO₂@RCs-gal nanocarrier for delivering affordable antitumor complexes in cancer therapy. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Formula: C16H22O11).

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics