Tag: 300-400

Determination of phthalate esters in bottled beverages by direct immersion solid-phase microextraction with a porous boron nitride coated fiber followed by gas chromatography-mass spectrometry was written by Zang, Xiaohuan;Wang, Mengting;Chang, Qingyun;Wang, Chun;Wang, Zhi;Xu, Jianzhong. And the article was included in Journal of Separation Science in 2022.Application In Synthesis of Dicyclohexyl phthalate This article mentions the following:

A porous boron nitride with a large surface area was synthesized by a one-step grinding method with melamine, urea, and boric acid as the precursors. The prepared porous boron nitride was used as the fiber coating material for the solid-phase microextraction of seven phthalate esters (di-Et phthalate, diallyl phthalate, diisobutyl phthalate, di-Bu phthalate, butylbenzyl phthalate, dicyclohexyl phthalate, and di-2-ethylhexyl phthalate) prior to their gas chromatog.-mass spectrometric detection. The important exptl. parameters including the extraction time, extraction temperature, salt concentration, and stirring rate were optimized by both single factor and central composite design methods. Under the optimized exptl. conditions, the linear response range for the analytes was from 0.030 to 30.0娓璯/L, and the limits of detection were from 0.010 to 0.040娓璯/L, resp. The relative recoveries of the analytes for spiked samples at two concentration levels were 83.0%-109% with the relative standard deviations less than 12%. The established method was successfully applied for the determination of the phthalate esters in bottled juice beverage samples. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Application In Synthesis of Dicyclohexyl phthalate).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of Dicyclohexyl phthalate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lectin and E. coli binding to carbohydrate-functionalized oligo(ethylene glycol)-based microgels: effect of elastic modulus, crosslinker and carbohydrate density was written by Schroeer, Fabian;Paul, Tanja J.;Wilms, Dimitri;Saatkamp, Torben H.;Jaeck, Nicholas;Mueller, Janita;Strzelczyk, Alexander K.;Schmidt, Stephan. And the article was included in Molecules in 2021.SDS of cas: 4163-60-4 This article mentions the following:

The synthesis of carbohydrate-functionalized biocompatible poly oligo(ethylene glycol) methacrylate microgels and the anal. of the specific binding to Con A (ConA) and Escherichia coli (E. coli) is shown. By using different crosslinkers, the microgels閳?size, d. and elastic modulus were varied. Given similar mannose (Man) functionalization degrees, the softer microgels show increased ConA uptake, possibly due to increased ConA diffusion in the less dense microgel network. Furthermore, although the microgels did not form clusters with E. coli in solution, surfaces coated with mannose-functionalized microgels are shown to bind the bacteria whereas galactose (Gal) and unfunctionalized microgels show no binding. While ConA binding depends on the overall microgels閳?d. and Man functionalization degree, E. coli binding to microgels閳?surfaces appears to be largely unresponsive to changes of these parameters, indicating a rather promiscuous surface recognition and sufficiently strong anchoring to few surface-exposed Man units. Overall, these results indicate that carbohydrate-functionalized biocompatible oligo(ethylene glycol)-based microgels are able to immobilize carbohydrate binding pathogens specifically and that the binding of free lectins can be controlled by the network d. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4SDS of cas: 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.SDS of cas: 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Novel carbohydrate modified berberine derivatives: synthesis and in vitro anti-diabetic investigation was written by Han, Liwen;Sheng, Wenlong;Li, Xiaobin;Sik, Attila;Lin, Houwen;Liu, Kechun;Wang, Lizhen. And the article was included in MedChemComm in 2019.Related Products of 4163-60-4 This article mentions the following:

Berberine is a bioactive alkaloid used in Chinese medicine and has numerous pos. effects on biol. systems. This paper describes the facile and highly efficient synthesis of some carbohydrate modified berberine derivatives, and conjugation of the carbohydrate moiety with berberine was finished by “click” chem. The cytotoxicity and anti-diabetic measurements of all berberine derivatives were accomplished on HepG2 cell lines, and the results indicated that most of the derivatives exhibit higher anti-diabetic activity than berberine. The mannose modified berberine derivative has significantly lower cytotoxicity than berberine, and the induced IC50 value of this derivative is nearly 1.5 times that of berberine. Furthermore, this mannose modified berberine derivative exhibits high anti-diabetic activity at both high and low drug concentrations, thereby indicating its potential application for the development of novel anti-diabetic drugs. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Related Products of 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Related Products of 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Binding Peptide-Guided Immobilization of Lipases with Significantly Improved Catalytic Performance Using Escherichia coli BL21(DE3) Biofilms as a Platform was written by Dong, Hao;Zhang, Wenxue;Xuan, Qize;Zhou, Yao;Zhou, Shengmin;Huang, Jiaofang;Wang, Ping. And the article was included in ACS Applied Materials & Interfaces in 2021.HPLC of Formula: 84-61-7 This article mentions the following:

Developing novel immobilization methods to maximize the catalytic performance of enzymes has been a permanent pursuit of scientific researchers. Engineered Escherichia coli biofilms have attracted great concern as surface display platforms for enzyme immobilization. However, current biol. conjugation methods, such as the SpyTag/SpyCatcher tagging pair, that immobilize enzymes onto E. coli biofilms seriously hamper enzymic performance. Through phage display screening of lipase-binding peptides (LBPs) and co-expression of CsgB (nucleation protein of curli nanofibers) and LBP2-modified CsgA (CsgALBP2, major structural subunit of curli nanofibers) proteins, we developed E. coli BL21::铻朇sgA-CsgB-CsgALBP2 (LBP2-functionalized) biofilms as surface display platforms to maximize the catalytic performance of lipase (Lip181). After immobilization onto LBP2-functionalized biofilm materials, Lip181 showed increased thermostability, pH, and storage stability. Surprisingly, the relative activity of immobilized Lip181 increased from 8.43 to 11.33 U/mg through this immobilization strategy. Furthermore, the highest loading of lipase on LBP2-functionalized biofilm materials reached up to 27.90 mg/g of wet biofilm materials, equivalent to 210.49 mg/g of dry biofilm materials, revealing their potential as a surface with high enzyme loading capacity. Addnl., immobilized Lip181 was used to hydrolyze phthalic acid esters, and the hydrolysis rate against di-Bu phthalate was up to 100%. Thus, LBP2-mediated immobilization of lipases was demonstrated to be far more advantageous than the traditional SpyTag/SpyCatcher strategy in maximizing enzymic performance, thereby providing a better alternative for enzyme immobilization onto E. coli biofilms. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7HPLC of Formula: 84-61-7).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.HPLC of Formula: 84-61-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Stereospecific Synthesis of Peptidyl 浼?Keto Amides as Inhibitors of Calpain was written by Harbeson, Scott L.;Abelleira, Susan M.;Akiyama, Alan;Barrett, Robert III;Carroll, Renee M.;Straub, Julie Ann;Tkacz, Jaroslaw N.;Wu, Chichih;Musso, Gary F.. And the article was included in Journal of Medicinal Chemistry in 1994.Product Details of 87694-53-9 This article mentions the following:

Peptidyl 浼?keto amides have been synthesized and tested as inhibitors of the cysteine protease calpain. A stereospecific synthesis was devised in which protected dipeptidyl 浼?hydroxy amides were oxidized with TEMPO/hypochlorite to the corresponding 浼?keto amides. This oxidation was accomplished in good yields and without epimerization of the chiral center adjacent to the ketone. The potent inhibition of porcine calpain I by the L,L diastereomers, combined with the poor inhibition by the L,D diastereomers, established the requirement for the all-L stereochem. of the active inhibitor. The early lead inhibitors were very hydrophobic and, therefore, poorly soluble in aqueous solutions Using the stereospecific route, new compounds were prepared with polar groups at the C- and N-termini. These modifications resulted in more soluble inhibitors that were still potent inhibitors of calpain. Studies of the stability of these 浼?keto amides showed that absolute stereochem. can be maintained in acidic and unbuffered environments but general base-catalyzed epimerization of the chiral center adjacent to the ketone occurred rapidly. The 浼?hydroxy precursors were inactive as inhibitors of calpain, which supports the hypothesis that the 浼?keto compounds reversibly form an enzyme-bound tetrahedral species that results from the nucleophilic addition of the catalytic thiol of calpain to the electrophilic ketone of the inhibitor. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Product Details of 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Preparation of sulfonated galactose-based glycopolymers and interactions with lectins was written by Ye, Bao-tong;Cai, Zhi;Wu, Jing;Lin, Xin;Chen, Jing-xiao;Chen, Jing-hua. And the article was included in Gaofenzi Xuebao in 2018.Reference of 4163-60-4 This article mentions the following:

A series of sulfonated galactose-based glycopolymers with different chem. structures were synthesized through reversible addition-fragmentation chain transfer (RAFT) polymerization Galactose modified hydroxyethyl methacrylate and sodium p-styrene sulfonate were used as monomers to construct homo-, block-, and random-glycopolymers. The chem. structures and mol. weights of the synthesized polymers were characterized through ¹H-NMR spectroscopy and GPC-MALLS analyses. Results showed that each glycopolymer possessed an average mol. weight of 1.5 鑴?10⁴ with narrow mol. weight distribution (PDI 閳?1.1). The turbidimetry assay indicated that the interactions between the glycopolymers and peanut agglutinin (PNA), which were used as model lectin, were influenced by the structure of the glycopolymers. The introduction of the sulfonic group significantly improved the PNA-binding ability of the glycopolymers through the synergistic effect of specific recognition and electrostatic interactions. Importantly, this effect was adjustable by varying the amount and distribution of the sulfonic groups. Both block- and random-glycopolymers exhibited significantly enhanced PNA-binding behavior with increasing amount of sulfonic groups. Moreover, the binding ability peaked when the molar ratio of the sulfonic groups was 66.7%. By contrast, the random-type glycopolymer, namely, P(Gal₂₁-r-SS₄₁), exhibited the strongest PNA-binding ability, which increased by 2.7-fold compared with that of the homo-type glycopolymer PGal. The ELISA assay further revealed that the polymerization and random distribution of the sulfonic groups in the glycopolymer substantially enhanced the recognition between PNA and the galactose moiety. The inhibition rate of galactose (30 mmol/L) against the PNA binding of PGal, P(Gal₂₁-r-SS₄₃), and P(Gal₂₁-r-SS₄₁) were 80%, 57.3%, and 34.2%, resp. However, the contents of the galactose moiety in these samples were 3.8, 2.1 and 2.0 mmol/L, resp. Overall, the order of PNA-binding ability was: P(Gal-r-SS) > P(Gal-b-SS) > PGal > PSS. In addition, the viability of B16 cancer cells and COS7 normal cells was higher than 80% when the concentration of the glycopolymers was 256 mg/L, indicating a good biocompatibility of these polymers. Based on the anal. of glycopolymer-lectin interactions, P(>) effectively inhibited the migration of B16 tumor cells and thus can be applied in clin. therapy for tumor metastasis. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Reference of 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Reference of 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Amino sugar synthesis. XVII. Synthesis of D-rhamnosamine and of 2,6-diamino-2,6-dideoxy-D-mannose from N-acetyl-D-mannosamine was written by Gross, Paul H.;Brendel, Klaus;Zimmerman, Howard K. Jr.. And the article was included in Justus Liebigs Annalen der Chemie in 1966.Synthetic Route of C16H23NO10 This article mentions the following:

2-acetamido-2-deoxy-D-mannose-H₂O (I) by 2 distillations under reduced pressure with 500 ml. 1:2 C₆H₆-EtOH azeotrope, then addition of 40 g. Dowex 50WX2 (H⁺ form) resin (similarly dehydrated), distillation with 2.5 l. azeotrope slowly at 760 mm., and working up the EtOH solution and washings gave 15.5 g. sirupy Et 2-acetamido-2-deoxy-D-mannoside (II), giving a neg. Fehling test and consuming 0.9 mole NaIO₄ in 6 hrs. (0.15-0.2 mole HCHO formed). Extracting the resin with 150 ml. 2N HCl 6 times gave 6 g. 2-amino-2-deoxy-D-mannose-HCl (III), [浼猐²³_D -4鎺?(c 0.33, H₂O). 2-Acetamidotetra-O-acetyl-2-deoxy-灏?D-mannose, obtained from I or III with Ac₂O and C₅H₅N, m. 160-1鎺? [浼猐²⁵_D – 19鎺? II (3 g.) and Ph₃CCl in C₅H₅N 2 hrs. at 90鎺?gave 4.6 g. 6-O-trityl ether, m. 160-1鎺? [浼猐²³_D -9鎺?(c 2, C₅H₅N); hydrolysis of the Ph₃C group with aqueous HOAc and NaIO₄ oxidation showed 19% furanoside. II triacetate (from Ac₂O and C₅H₅N 10 hrs. at room temperature) was a sirup, [浼猐²³_D 60鎺?(c 3.6, CHCl₃). Reaction of 10 g. II and 8 g. p-MeC₆H₄SO₂Cl in C₅H₅N 8 days at 0鎺?then addition of 12 ml. Ac₂O and reaction 36 hrs. at 0鎺?gave 34% 6-(O-p-tolylsulfonyl) derivative (IV), m. 135-6鎺? [浼猐²³_D 54鎺?(c 2, C₅H₅N). Heating IV with KOAc, Ac₂O, and AcOH 15 hrs. at 130鎺?gave, not the expected II triacetate, but a half-crystalline substance, which was deacetylated and showed, by NaIO₄ oxidation, a 5% furanoside content. Heating IV and NaI in EtAc 15 hrs. at 110鎺?gave 88% 6-deoxy-6-iodo derivative, m. 56-8鎺? [浼猐²³_D 44鎺?(c 2, C₅H₅N), hydrogenated over Raney Ni 10 hrs., and the product hydrolyzed in 2N HCl 1 hr. at 60鎺? then 2 hrs. at 100鎺? to give 71% 2-amino-2,6-dideoxy-D-mannose-HCl, m. 175鎺?(decomposition), [浼猐²⁵_D -28鎺?(5 min.) to -23鎺?(4 hrs.) (c 0.33, H₂O), [浼猐²⁵₅₄₆ -26鎺?(12 hrs., c 0.33, H₂O). The 6-azido-6-deoxy derivative, prepared from 4.87 g. IV and 5 g. NaN₃ in 25 ml. Me₂SO 3 hrs. at 110鎺? 98% yield, was an oil, which was hydrogenated 5 hrs. over Pd black in MeOH and Ac₂O to give 74% Et 2,6-diacetamido-3,4-di-O-acetyl-2,6-dideoxy-浼?D-mannopyranoside, m. 225-6鎺? [浼猐)²⁴_D 71鎺?(c 2, C₅H₅N), and then hydrolyzed 1 hr. at 60鎺?and 2 hrs. at 100鎺?in 3N HCl to give 72% 2,6-diamino-2,6-dideoxy-浼?D-mannose-2 HCl, m. 135-6鎺?[浼猐²⁴_D 9鎺?(10 min.) to -1鎺?(25 hrs.). Reaction of 50 mg. 2,6-diamino-2,6-dideoxy-浼?D-glucose-2HCl in 1 ml. H₂O, and 5 ml. MeOH with 7 ml. 1% AgOAc and 0.5 ml. Ac₂O 48 hrs. in the dark, treatment with cation-exchange resin, and crystallization from MeCH(OMe)₂ gave 35 mg. 2,6-diacetamido-2,6-dideoxy-浼?D-glucose, m. 208-9鎺?(decomposition), [浼猐²⁰_D 36鎺?(2 hrs.) to 32鎺?(15 hrs., c 0.5, H₂O). In the experiment, the researchers used many compounds, for example, (2S,3S,4R,5S,6R)-3-Acetamido-6-(acetoxymethyl)tetrahydro-2H-pyran-2,4,5-triyl triacetate (cas: 6730-10-5Synthetic Route of C16H23NO10).

(2S,3S,4R,5S,6R)-3-Acetamido-6-(acetoxymethyl)tetrahydro-2H-pyran-2,4,5-triyl triacetate (cas: 6730-10-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C16H23NO10

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of 浼? 灏?unsaturated 绾?amino esters with unprecedented high (E)-stereoselectivity and their conformational analysis in peptides was written by Mali, Sachitanand M.;Bandyopadhyay, Anupam;Jadhav, Sandip V.;Kumar, Mothukuri Ganesh;Gopi, Hosahudya N.. And the article was included in Organic & Biomolecular Chemistry in 2011.HPLC of Formula: 87694-53-9 This article mentions the following:

Mild, efficient and racemization-free synthesis of N-protected 浼? 灏?unsaturated 绾?amino esters with unprecedented high E- stereoselectivity is described. This method is found to be compatible with Boc- (Boc = tert-butoxycarbonyl), Fmoc- (Fmoc = 9-fluorenylmethoxycarbonyl) and other side chain protecting groups. The crystal conformations of the vinylogous 绾?amino esters in monomers and in homo- and mixed dipeptides are studied. Further, the vinylogous homo-dipeptide showed a 灏?sheet conformation, while mixed 浼? and 浼?灏?unsaturated 绾?hybrid dipeptide adapted an irregular structure in single crystals. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9HPLC of Formula: 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.HPLC of Formula: 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery of novel tripeptide propylene oxide proteasome inhibitors for the treatment of multiple myeloma was written by Zhang, Wen;Wang, Xueyuan;Zhang, Haoyang;Wen, Tiantian;Yang, Lin;Miao, Hang;Wang, Jia;Liu, Hailong;Yang, Xu;Lei, Meng;Zhu, Yongqiang. And the article was included in Bioorganic & Medicinal Chemistry in 2021.Related Products of 87694-53-9 This article mentions the following:

The ubiquitin proteasome pathway (UPP) plays a critical role in the maintenance of cell homeostasis and the development of diseases, such as cancer and neurodegenerative disease. A series of novel tripeptide propylene oxide compounds as proteasome inhibitors were designed, synthesized and biol. investigated in this manuscript. The enzymic activities of final compounds against 20S human proteasome were investigated and structure-activity relationship (SAR) was summarized. Some potent compounds were further evaluated to inhibit the proliferation of multiple myeloma (MM) cancer cell lines RPMI8226 and U266B. The results showed that some compounds were active against MM cancer cell lines with IC₅₀ values of less than 50 nM. The microsomal metabolic stabilities in human, rat and mice species were carried out and the results showed that compounds (I) (R¹ = iso-Bu, Bn) were stable enough to be in vivo investigated. The in vivo pharmacokinetic results showed that compounds I (R¹ = iso-Bu, Bn) had acceptable biol. parameters for both ig and iv administrations. In vivo antitumor activities of compounds I (R¹ = iso-Bu, Bn) with the doses of 100 mg/kg and 50 mg/kg BIW were performed by using RPMI8226 xenograft nude mouse model. Toxicities of compounds I (R¹ = iso-Bu, Bn) were not observed during the experiment and dose dependent effect was obvious and the tumor volume was greatly inhibited. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Related Products of 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Identification of bioactive components in the hydroalcoholic extract of Syringodium Isoetifolium and assessment of its biological activity by gas chromatography – masspectrometry was written by Kalaivani, P.;Amudha, P.. And the article was included in International Journal of Research in Pharmaceutical Sciences (Madurai, India) in 2021.HPLC of Formula: 84-61-7 This article mentions the following:

Herbal plants show a growing interest in natural antioxidant, also play an important role in the treatment of muscle pain, stomach problems, wounds etc. About 75 to 80% of the world population uses herbal medicine. One such herb (Marine Plants) used in the treatment of cancer is Syringodium isoetifolium. In a previous study, Syringodium isoetifolium with three different extracts (Aqueous, ethanol and 70% hydroalc.) proves the presence of phytocompound such as Tannin, Saponin, Flavonoids, Stroids, Terpenoids, coumarin etc and also has high antioxidant activity. The current study aims to identify the bioactive compounds from the hydroalcoholic extract of Syringodium isoetifolium. The photo components present in the hydroalcoholic extract was determined by GC-MS Anal. and the mass spectra of compounds present in the extract were matched with the National Institute of Standards and Technol. library. 20 different phytocompounds were found to be present in the hydroalcoholic extract of Syringodium isoetifolium using GC-MS anal. Some of the important phytocompounds are Hexanoic acid, Me ester, Octadecanoic acid, 1,2-Benzenedicarboxylic acid, bis(2-methylpropyl) ester, 1-Isopropylidene-3-methyl-3-vinylcyclobutane. The study reveals that the identified phytocompounds from the hydroalcoholic extract of Syringodium isoetifolium has essential biol. activities such as Antibacterial, Antifungal, Antimicrobial, Antifouling and Anticancer properties. Further depth of the study will deal with the exact mode of action of the phytocompounds. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7HPLC of Formula: 84-61-7).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 84-61-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics