Tag: 300-400

A convenient method for the synthesis of chiral N-protected 1,2-amino alcohols via the reduction of the aminoketones was written by Zhou, Zheng Hong;Tang, Yi Long;Li, Kang Ying;Liu, Bing;Tang, Chu Chi. And the article was included in Chinese Chemical Letters in 2003.Product Details of 87694-53-9 This article mentions the following:

A series of optically active N-protected 1,2-amino alcs. were synthesized via the reduction of the corresponding 浼?aminoketones starting from the readily available L-amino acids. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Product Details of 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sustainable polypyrrole-based magnetic-microextraction of phthalates from jellies and apple-based beverages prior to tandem mass spectrometry analysis was written by Rodriguez-Ramos, Ruth;Socas-Rodriguez, Barbara;Santana-Mayor, Alvaro;Salazar-Carballo, Pedro Angel;Rodriguez-Delgado, Miguel Angel. And the article was included in Journal of Chromatography A in 2021.Application of 84-61-7 This article mentions the following:

Synthesized polypyrrole-coated Fe3O4 magnetic nanoparticles have been successfully characterised and applied as sorbent for the magnetic-micro-dispersive solid-phase extraction of eleven phthalic acid esters from jelly and apple-based beverage matrixes widely consumed by the population and, especially, by children. Sorbent was synthesized through chem. coprecipitation and subsequently characterised by different techniques. The influence of several parameters on the extraction efficiency was exhaustively evaluated using a step-by-step strategy. The separation and quantification of the selected phthalates were performed by ultra-high performance liquid chromatog. coupled to tandem mass spectrometry. The validation of the methodol. was carried out for jellies and apple-based beverages, employing dihexyl phthalate-3,4,5,6-d4 as the surrogate standard Relative recovery values were in the range 70-114% for both matrixes and relative standard deviations below 20% were obtained. The limits of quantification of the method were found in the range 0.147-0.416 娓璯/L. Feasibility of the developed methodol. was proved by the anal. of commercialised jelly and apple-based beverage products. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Application of 84-61-7).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application of 84-61-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of a complete series of C-4 fluorinated Phe-Gly mimetics was written by Berts, Wei;Luthman, Kristina. And the article was included in Tetrahedron in 1999.HPLC of Formula: 87694-53-9 This article mentions the following:

The complete series of allylic monofluorinated derivatives I (R¹ = H, R² = F; R¹ = F, R² = H) and difluorinated derivatives II of Boc-Phe-Gly-OMe has been synthesized using facile methods. The saturated derivatives of I and II were also synthesized. Diastereomeric allylic alc. derivatives were used as key intermediates. Cis- and trans-aziridine derivatives were synthesized in high yields from the diastereomeric alcs. using Mitsunobu conditions. The aziridines were treated with diethylaminosulfur trifluoride (DAST) at room temperature, which resulted in stereoselective ring openings yielding the monofluorinated derivatives The difluorinated isostere was synthesized from the 绾?keto ester derivative using DAST. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9HPLC of Formula: 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Significance of Hydrogen Bonding at the S₁‘ Subsite of Calpain I was written by Donkor, I. O.;Zheng, X.;Han, J.;Lacy, C.;Miller, D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2001.Name: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate This article mentions the following:

浼?Ketohydroxamates were synthesized as bioisosteres of 浼?ketoamides. The 浼?ketohydroxamates were generally more potent than the corresponding 浼?ketoamides. The potency of the compounds suggests that hydrogen bonding and steric bulk of substituents on the nitrogen atom of the ketoamide moiety influence calpain inhibition. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Name: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Asymmetric synthesis of D– and L-mannosamine was written by O’Neill, A. N.. And the article was included in Canadian Journal of Chemistry in 1959.Related Products of 6730-10-5 This article mentions the following:

D-Mannosamine-HCl (I) was prepared in four steps from D-arabino-tetraacetoxy-1-nitro-1-hexene (D-II). The critical step involved the stereo-specific addition of NH₃ to D-II. The steric course of the addition was discussed in terms of the Cram rule. Powd. D-II was added slowly to a saturated solution of NH₃ in absolute MeOH and left at 5鎺?for 18 h. Concentration in vacuo gave 82% N-acetyl-1-deoxy-1-nitro-D-mannosaminol (D-III), m. 172-3鎺?(MeOH), [浼猐²⁴_D -13.2鎺?(c 1.1, H₂O), main IR bands given. Similarly, L-II gave L-III, m. 172.0-2.5鎺? [浼猐²⁴_D 14.9鎺?(c 1.5, H₂O). A cold solution of 10 g. D-III in 25 mL. 2N NaOH was added dropwise to a cold solution of 12 mL. H₂SO₄ in 15 mL. H₂O while the temperature was maintained at 10-5鎺? The solution was neutralized with warm aqueous Ba(OH)₂ and the filtrate was concentrated in vacuo. The residue was dried in vacuo over P₂O₅ and then treated with 125 mL. Ac₂O and 100 mL. pyridine at 0鎺?for 3 days. The mixture was poured onto 500 mL. ice and H₂O and extracted with CHCl₃. The CHCl₃ extract was washed, dried, and concentrated in vacuo to afford 13 g. 2-acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-灏?D-mannose (D-IV), m. 162-3鎺?(EtOH-Et₂O), [浼猐²⁴_D -17.0 (c 1.8, CHCl₃). Similarly, L-III afforded L-IV, m. 162-3鎺? [浼猐²⁵_D 18.0鎺?(c 1.1, CHCl₃). Treating 0.200 g. D-IV with hot dilute HCl yielded 0.107 g. I, [浼猐²⁵_D -4 (c 1.0, 3% HCl). A cold solution of 10 g. D-IV in 150 mL. absolute MeOH was treated with 0.4N Ba(OH)₂ 24 h. at 0鎺? An equal volume H₂O was added and the solution was shaken with IR-120 and IR-45 Amberlite resins. The filtrate was concentrated in vacuo to afford 5.0 g. sirup (V) and 0.75 g. 2-acetamido-2-deoxy-D-glucose (VI), m. 193-6鎺?(EtOH-Et₂O) with decomposition starting at 185鎺? [浼猐²⁶_D 75.0鎺?(c 1.2, H₂O), with mutarotation. A solution of 0.100 g. VI in 1 mL. 2N HCl was heated at 100鎺?for 2 h. to give 0.093 g, D-glucosamine-HCl (VII), [浼猐²⁵_D 82.4鎺?(c 0.91, H₂O) with mutarotation. Treating V with aqueous HCl afforded VII, [浼猐²⁵_D 98鎺?(c 1.1, H₂O) with mutarotation, and a small amount of I, [浼猐²⁶_D -4鎺?(c 1.0, 2.5% aqueous HCl). An aqueous solution of 80 g. VII was oxidized with 200 g. yellow H₂O to provide 50% D-glucosaminic acid (VIII), [浼猐²⁵_D -14鎺?(c 1.3, 2.5% aqueous HCl). A solution of 40 g. VIII in 400 mL. H₂O and 40 mL. pyridine was heated at 100鎺?for 24 h. to yield D-mannosaminic acid (IX), [浼猐²⁴_D 10鎺?(c 1.5, 2.5% aqueous HCl). Treating IX with alc. HCl afforded 75% IX lactone, [浼猐²⁴_D 45鎺?(c 1.4, H₂O). The IX lactone was reduced with 2.5% Na-Hg to give 60% I, [浼猐²⁴_D -4.0鎺?(c 2.0, 2.5% aqueous HCl); pentaacetate m. 161-2鎺? [浼猐²⁴_D -18鎺?(c 1.5, CHCl₃). In the experiment, the researchers used many compounds, for example, (2S,3S,4R,5S,6R)-3-Acetamido-6-(acetoxymethyl)tetrahydro-2H-pyran-2,4,5-triyl triacetate (cas: 6730-10-5Related Products of 6730-10-5).

(2S,3S,4R,5S,6R)-3-Acetamido-6-(acetoxymethyl)tetrahydro-2H-pyran-2,4,5-triyl triacetate (cas: 6730-10-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Related Products of 6730-10-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A facile approach to trans-4,5-pyrrolidine lactam and application in the synthesis of nemonapride and streptopyrrolidine was written by Huang, Wei;Ma, Jing-Yi;Yuan, Mu;Xu, Long-Fei;Wei, Bang-Guo. And the article was included in Tetrahedron in 2011.Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate This article mentions the following:

An efficient approach to trans-4-hydroxylpyrrolidine lactams, e.g. I [R¹ = t-Bu, PhCH₂; R² = H, Me; Me₂CH, etc.; R³ = H, TBSO], starting from an amino acid is described. The utility of this method has been demonstrated in the synthesis of antipsychotic nemonapride and antiangiogenic streptopyrrolidine. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Janus glycosides of next generation: Synthesis of 4-(3-chloropropoxy)phenyl and 4-(3-azidopropoxy)phenyl glycosides was written by Stepanova, Elena V.;Abronina, Polina I.;Zinin, Alexander I.;Chizhov, Alexander O.;Kononov, Leonid O.. And the article was included in Carbohydrate Research in 2019.Product Details of 4163-60-4 This article mentions the following:

Efficient procedures for the preparative synthesis of per-O-acyl derivatives of 4-(3-chloropropoxy)phenyl (CPP) glycosides of a series of common mono- and disaccharides (D-glucose, D-galactose, D-mannose, L-rhamnose, D-arabinofuranose, D-glucosamine, lactose) are described. The CPP glycosides obtained were transformed in almost quant. yields to the corresponding unprotected 4-(3-azidopropoxy)phenyl (APP) glycosides, which could become next-generation Janus glycosides with cleavable spacer aglycon, ready for conjugation or further transformation. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Product Details of 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Study of the N⁷ Regioselective Glycosylation of 6-Chloropurine and 2,6-Dichloropurine with Tin and Titanium Tetrachloride was written by Tranova, Lenka;Styskala, Jakub. And the article was included in Journal of Organic Chemistry in 2021.Reference of 4163-60-4 This article mentions the following:

6-Chloropurine and 2,6-dichloropurine were regioselectively glycosylated at position 7 to give the corresponding peracetylated N⁷-nucleosides, which can be suitable for other purine transformations. In this work, we study the distribution of N⁷/N⁹-isomers produced via the Vorbruggen method under different conditions, using an N-trimethylsilylated purine derivative and SnCl₄ or TiCl₄ as a catalyst. The main effort is devoted to reversing the disadvantageous predominant selectivity of most glycosylation reactions at the N⁹ position and thus to determining conditions that maximize the regioselectivity of glycosylation toward the desired N⁷-isomer. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Reference of 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Reference of 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Regio- and Stereoselective Modification of Chiral 浼?Amino Ketones by Pd-Catalyzed Allylic Alkylation was written by Huwig, Kai;Schultz, Katharina;Kazmaier, Uli. And the article was included in Angewandte Chemie, International Edition in 2015.Electric Literature of C16H24N2O4 This article mentions the following:

Chiral 浼?amino ketones are excellent nucleophiles for stereoselective palladium-catalyzed allylic alkylations. Both chiral as well as achiral allylic substrates can be applied, while the stereochem. outcome of the reaction is controlled by the chiral ketone enolate. The substituted amino ketones formed can be reduced stereoselectively, and up to five consecutive stereogenic centers can be obtained. This approach can be used for the synthesis of highly substituted piperidine derivatives In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Electric Literature of C16H24N2O4).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Electric Literature of C16H24N2O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Glycomimetic-Conjugated Photosensitizer for Specific Pseudomonas aeruginosa Recognition and Targeted Photodynamic Therapy was written by Zhao, Yu;Lu, Zhentan;Dai, Xiaomei;Wei, Xiaosong;Yu, Yunjian;Chen, Xuelei;Zhang, Xinge;Li, Chaoxing. And the article was included in Bioconjugate Chemistry in 2018.Electric Literature of C16H22O11 This article mentions the following:

Due to the rapid development of bacterial resistance, there is an urgent need to explore new antibacterial agents to substitute for traditional antibiotic therapy. Photodynamic therapy has been identified as a promising bactericidal method to conquer antibiotic-resistant pathogens. To solve the problem of photosensitizer damage to normal tissues in vivo, we developed a boron-dipyrrolemethene (BODIPY)-based glycosylated photosensitizer for ablating Pseudomonas aeruginosa (P. aeruginosa). This glycosylated photosensitizer exhibited good water solubility and generated ¹O₂ rapidly in an aqueous solution under light exposure. The photosensitizer did not cause detectable toxicity to human cells in the dark. Importantly, the photosensitizer was able to selectively attach to P. aeruginosa over normal cells, thus resulting in effective pathogen ablation by reactive oxygen species. Moreover, the photosensitizer inhibited over 90% of the biofilm formation produced by P. aeruginosa. The results indicate that the design of the macromol. photosensitizer-induced bacterial death and inhibited biofilm formation provide a novel strategy for overcoming bacterial infection. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Electric Literature of C16H22O11).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Electric Literature of C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics