Tag: 300-400

Functionalized bicyclic tetramates derived from cysteine as antibacterial agents was written by Panduwawala, Tharindi D.;Iqbal, Sarosh;Thompson, Amber L.;Genov, Miroslav;Pretsch, Alexander;Pretsch, Dagmar;Liu, Shuang;Ebright, Richard H.;Howells, Alison;Maxwell, Anthony;Moloney, Mark G.. And the article was included in Organic & Biomolecular Chemistry in 2019.COA of Formula: C16H22O11 This article mentions the following:

Routes to bicyclic tetramates derived from cysteine permitting ready incorporation of functionality at two different points around the periphery of a heterocyclic skeleton are reported. This has enabled the identification of systems active against Gram-pos. bacteria, some of which show gyrase and RNA polymerase inhibitory activity. In particular, tetramates substituted with glycosyl side chains, chosen to impart polarity and aqueous solubility, show high antibacterial activity coupled with modest gyrase/polymerase activity in two cases. An anal. of physicochem. properties indicates that the antibacterially active tetramates generally occupy physicochem. space with MW of 300-600, clog D_7.4 of -2.5 to 4 and rel. PSA of 11-22%. This work demonstrates that biol. active 3D libraries are readily available by manipulation of a tetramate skeleton. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4COA of Formula: C16H22O11).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C16H22O11

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Ester – Wikipedia,
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Biodegradation of di-(2-ethylhexyl) phthalate by novel Rhodococcus sp. PFS1 strain isolated from paddy field soil was written by Kamaraj, Yoganathan;Jayathandar, Rajesh Singh;Dhayalan, Sangeetha;Subramaniyan, Satheeshkumar;Punamalai, Ganesh. And the article was included in Archives of Microbiology in 2022.Electric Literature of C20H26O4 This article mentions the following:

Di-(2-ethylhexyl)-phthalate (DEHP) is the phthalate ester frequently utilized as a plasticizer, commonly found in cosmetics, packaging materials; moreover, it has carcinogenic and mutagenic effects on humans. In the current study, we isolated the soil bacterium Rhodococcus sp. PFS1 and to assess its DEHP degradation ability in various environmental conditions. The strain PFS1 was isolated from paddy field soil and identified by the 16S rRNA sequencing analyses. The strain PFS1 was examined for its biodegradation ability of DEHP at various pH, temperature, salt concentration, glucose concentration, and high and low concentrations of DEHP. Moreover, the biodegradation of DEHP at a contaminated soil environment by strain PFS1 was assessed. Further, the metabolic pathway of DEHP degradation by PFS1 was analyzed by HPLC-MS anal. The results showed that the strain PFS1 effectively degraded the DEHP at neutral pH and temperature 30°C; moreover, expressed excellent DEHP degradation at the high salt concentration (up to 50 g/L). The strain PFS1 was efficiently degraded the different tested phthalate esters (PAEs) up to 90%, significantly removed the DEHP contamination in soil along with native organisms which are present in soil up to 94.66%; nevertheless, the PFS1 alone degraded the DEHP up to 87.665% in sterilized soil. According to HPLC-MS anal., DEHP was degraded into phthalate (PA) by PFS1 strain via mono(2-ethylehxyl) phthalate (MEHP); then PA was utilized for cell growth. These results suggest that Rhodococcus sp. PFS1 has excellent potential to degrade DEHP at various environmental conditions especially in contaminated paddy field soil. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Electric Literature of C20H26O4).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Electric Literature of C20H26O4

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

N-Acyl derivatives of 2-acylamino-2-deoxyhexoses. Nuclear magnetic resonance spectra and conformations was written by Inch, Thomas D.;Plimmer, Jack R.;Fletcher, Hewitt G. Jr.. And the article was included in Journal of Organic Chemistry in 1966.SDS of cas: 6730-10-5 This article mentions the following:

The N.M.R. spectra of some 1,3,4,6-tetra-O-acetyl-2-(N-acylacylamino)2-deoxyhexoses and of some 2-acetamido-1,3,4,6-tetra-O-acetyl-2-deoxyhexoses of the D-glucose, D-galactose, and D-mannose series have been studied. In contrast to the spectra of the second class of compounds, those of the first class are readily analyzed. The coupling constants for representatives of the D-glucose and D-galactose series clearly show these compounds to exist in the normal chair conformation. In N-acylacylamino derivatives of the D-glucose series, the signal from the axial proton at C-1 occurs at lower field than the signal for the equatorial C-1 proton, a reversal of the normal situation which has not hitherto been observed at C-1. The conformational implications of the N.M.R. spectra are discussed. In the experiment, the researchers used many compounds, for example, (2S,3S,4R,5S,6R)-3-Acetamido-6-(acetoxymethyl)tetrahydro-2H-pyran-2,4,5-triyl triacetate (cas: 6730-10-5SDS of cas: 6730-10-5).

(2S,3S,4R,5S,6R)-3-Acetamido-6-(acetoxymethyl)tetrahydro-2H-pyran-2,4,5-triyl triacetate (cas: 6730-10-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.SDS of cas: 6730-10-5

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Ester – Wikipedia,
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A Synthetic Approach to 3-Hydroxy 4-Substituted Carboxylic Acids based on the Stereoselective Reduction of 1-Trimethylsilyl-1-alkyn-3-ones was written by Alemany, Carme;Bach, Jordi;Garcia, Jordi;Lopez, Marta;Rodriguez, Ana B.. And the article was included in Tetrahedron in 2000.Product Details of 87694-53-9 This article mentions the following:

The oxazaborolidine-mediated reduction of chiral, 4-substituted 1-trimethylsilyl-1-alkyn-3-ones followed by hydroboration affords syn or anti 3-hydroxy 4-substituted carboxylic acids, common substructures of a number of biol. active macrolides, peptides and depsipeptides, with high control on the new C(3) stereocenter. This strategy has been applied to the synthesis of (3S,4S)-3-hydroxy-4-methylheptanoic acid and of N-Boc-statine, constituents of permentin A and pepstatin, resp. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Product Details of 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 87694-53-9

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and conformational analysis of vicinally branched trisaccharide β-D-Galf-(1→2)-[β-D-Galf-(1→3)-]-α-Galp from Cryptococcus neoformans galactoxylomannan was written by Dorokhova, Vera S.;Gerbst, Alexey G.;Komarova, Bozhena S.;Previato, Jose O.;Previato, Lucia Mendonca;Dmitrenok, Andrey S.;Shashkov, Alexander S.;Krylov, Vadim B.;Nifantiev, Nikolay E.. And the article was included in Organic & Biomolecular Chemistry in 2021.HPLC of Formula: 4163-60-4 This article mentions the following:

The synthesis of a vicinally branched trisaccharide composed of two D-galactofuranoside residues attached via β-(1 → 2)- and β-(1 → 3)-linkages to the α-D-galactopyranoside unit has been performed for the first time. The reported trisaccharide represents the galactoxylomannan moiety first described in 2017, which is the capsular polysaccharide of the opportunistic fungal pathogen Cryptococcus neoformans responsible for life-threatening infections in immunocompromised patients. The NMR-data reported here for the synthetic model trisaccharide are in good agreement with the previously assessed structure of galactoxylomannan and are useful for structural anal. of related polysaccharides. The target trisaccharide as well as the constituent disaccharides were analyzed by a combination of computational and NMR methods to demonstrate good convergence of the theor. and exptl. results. The results suggest that the furanoside ring conformation may strongly depend on the aglycon structure. The reported conformational tendencies are important for further anal. of carbohydrate-protein interaction, which is critical for the host response toward C. neoformans infection. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4HPLC of Formula: 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.HPLC of Formula: 4163-60-4

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

CrCl₂ mediated allylation of N-protected α-amino aldehydes. A versatile synthesis of polypeptides containing a hydroxyethylene isostere was written by Ciapetti, Paola;Taddei, Maurizio;Ulivi, Paola. And the article was included in Tetrahedron Letters in 1994.Computed Properties of C16H24N2O4 This article mentions the following:

Substituted allylic bromides react with N-protected amino aldehydes to give intermediate products for the synthesis of hydroxyethylene dipeptide isosteres. The low stereoselectivity of this reaction can be improved using aldehydes protected with hindered groups. This reaction can be efficiently applied to oligopeptide aldehydes. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Computed Properties of C16H24N2O4).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Computed Properties of C16H24N2O4

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

An efficient synthesis of optically active α-(t-butoxycarbonylamino)-aldehydes from α-amino acids was written by Fehrentz, Jean Alain;Castro, Bertrand. And the article was included in Synthesis in 1983.Application of 87694-53-9 This article mentions the following:

BocNHCHRCON(OMe)Me (I; Boc = Me₃CO₂C; R = Me, CH₂CHMe₂, CHMeEt, CHMe₂, CH₂Ph, CHMeOCH₂Ph) were reduced by LiAlH₄ to give BocNHCHRCH(OLi)N(OMe)Me, which were hydrolyzed in situ to give title aldehydes BocNHCHRCHO. I were prepared by condensing BocNHCHRCO₂H with HN(OMe)Me.HCl by BOP in CH₂Cl₂ containing Et₃N. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Application of 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Establishment of Guidelines for the Control of Glycosylation Reactions and Intermediates by Quantitative Assessment of Reactivity was written by Chang, Chun-Wei;Wu, Chia-Hui;Lin, Mei-Huei;Liao, Pin-Hsuan;Chang, Chun-Chi;Chuang, Hsiao-Han;Lin, Su-Ching;Lam, Sarah;Verma, Ved Prakash;Hsu, Chao-Ping;Wang, Cheng-Chung. And the article was included in Angewandte Chemie, International Edition in 2019.Product Details of 4163-60-4 This article mentions the following:

Stereocontrolled chem. glycosylation remains a major challenge despite vast efforts reported over many decades and so far still mainly relies on trial and error. Now it is shown that the relative reactivity value (RRV) of thioglycosides is an indicator for revealing stereoselectivities according to four types of acceptors. Mechanistic studies show that the reaction is dominated by two distinct intermediates: glycosyl triflates and glycosyl halides from N-halosuccinimide (NXS)/TfOH. The formation of glycosyl halide is highly correlated with the production of α-glycoside. These findings enable glycosylation reactions to be foreseen by using RRVs as an α/β-selectivity indicator and guidelines and rules to be developed for stereocontrolled glycosylation. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Product Details of 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A general synthesis of oligopeptides containing an oxirane ring in the place of a peptidic bond was written by Mann, Andre;Quaranta, Laura;Reginato, Gianna;Taddei, Maurizio. And the article was included in Tetrahedron Letters in 1996.Synthetic Route of C16H24N2O4 This article mentions the following:

Mols. structurally analogous to dipeptides, containing an oxirane ring in the place of the peptide bond, can be prepared by oxidative conversion of β-hydroxy selenides obtained by Mukaiyama aldol-type reaction of N-protected β-amino α-selenyl aldehydes derived from naturally occurring amino acids. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Synthetic Route of C16H24N2O4).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Synthetic Route of C16H24N2O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Combining Click Reactions for the One-Pot Synthesis of Modular Biomolecule Mimetics was written by Brinkoe, Anne;Risinger, Christian;Lambert, Annie;Blixt, Ola;Grandjean, Cyrille;Jensen, Henrik H.. And the article was included in Organic Letters in 2019.Computed Properties of C16H22O11 This article mentions the following:

Here, we report on the first combined one-pot use of the two so-called “click reactions”: the thiol-ene coupling and the copper-catalyzed alkyne-azide cycloaddition These reactions were employed in an alternating and one-pot fashion to combine appropriately functionalized monomeric carbohydrate building blocks to create mimics of trisaccharides and tetrasaccharides as single anomers, with only minimal purification necessary. The deprotected oligosaccharide mimics were found to bind both plant lectins and human galectin-3. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Computed Properties of C16H22O11).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics