Tag: 200-300

A Systematic Study of the Relationship between Molecular and Crystal Structure among 3,5-Diazabicyclo[2.2.2]octane-2,6-diones was written by Brewer, Jason T.;Parkin, Sean;Grossman, Robert B.. And the article was included in Crystal Growth & Design in 2004.Synthetic Route of C11H20O4 This article mentions the following:

A simple, convergent synthesis of 3,5-diazabicyclo[2.2.2]octane-2,6-diones (bicyclic N,N’-diacylaminals) has been developed, providing access to a large series of compounds differing only in their substituents at the bridgehead positions. These compounds crystallize in several different forms, but always in such a way that each mol. forms four hydrogen bonds. The sheer number of bicyclic amidals that can be synthesized and crystallized provides an opportunity to elucidate crystal-engineering structure-structure relationship (SSR) principles. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Synthetic Route of C11H20O4).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Synthetic Route of C11H20O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Metal-Free Oxidative Double C(sp³)-C(sp³) Coupling of 1,3-Dicarbonyl Compounds and N,N-Dimethylanilines was written by Huang, Ling;Cao, Dongdong;Pan, Jie;Fang, Lingjia;Wang, Qianqian;Chen, Dingben;Yang, Jianguo. And the article was included in Advanced Synthesis & Catalysis in 2020.Recommanded Product: Ethyl 3-oxo-3-(m-tolyl)propanoate This article mentions the following:

A metal-free oxidative tandem cross-dehydrogenative coupling of 1,3-dicarbonyl compounds with N,N-dimethylanilines was developed. The reaction afforded two new C(sp³)-C(sp³) bonds in one pot. A broad range of 灏?dicarbonyl compounds and N,N-dimethylanilines were compatible and the desired products were synthesized in moderate to good yields. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Recommanded Product: Ethyl 3-oxo-3-(m-tolyl)propanoate).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: Ethyl 3-oxo-3-(m-tolyl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Preparation of poly(pentafluorophenyl acrylate) functionalized SiO2 beads for protein purification was written by Kim, Sura;Ku, Jayoung;Park, Jaemin;Kharbash, Raisa;Li, Sheng. And the article was included in Journal of Visualized Experiments in 2018.Application In Synthesis of Benzyl benzodithioate This article mentions the following:

We demonstrate a simple method to prepare poly(pentafluorophenyl acrylate) (poly(PFPA)) grafted silica beads for antibody immobilization and subsequent immunoprecipitation (IP) application. The poly(PFPA) grafted surface is prepared via a simple two-step process. In the first step, 3-aminopropyltriethoxysilane (APTES) is deposited as a linker mol. onto the silica surface. In the second step, poly(PFPA) homopolymer, synthesized via the reversible addition and fragmentation chain transfer (RAFT) polymerization, is grafted to the linker mol. through the exchange reaction between the pentafluorophenyl (PFP) units on the polymer and the amine groups on APTES. The deposition of APTES and poly(PFPA) on the silica particles are confirmed by XPS, as well as monitored by the particle size change measured via dynamic light scattering (DLS). To improve the surface hydrophilicity of the beads, partial substitution of poly(PFPA) with aminefunctionalized poly(ethylene glycol) (amino-PEG) is also performed. The PEG-substituted poly(PFPA) grafted silica beads are then immobilized with antibodies for IP application. For demonstration, an antibody against protein kinase RNA-activated (PKR) is employed, and IP efficiency is determined by Western blotting. The anal. results show that the antibody immobilized beads can indeed be used to enrich PKR while nonspecific protein interactions are minimal. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Application In Synthesis of Benzyl benzodithioate).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application In Synthesis of Benzyl benzodithioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of N-[4-hydroxy(alkoxy, acyloxy)-3-alkoxy-benzylidene]-1-(1-adamantyl)ethanamines from 1-(1-adamantyl)ethanamine hydrochloride (Rimantadine) was written by Dikusar, E. A.;Kozlov, N. G.. And the article was included in Russian Journal of Organic Chemistry in 2007.Application In Synthesis of 4-Formyl-2-methoxyphenyl isobutyrate This article mentions the following:

Reactions of 1-(1-adamantyl)ethanamine hydrochloride with substituted aromatic aldehydes gave previously unknown Schiff bases containing an adamantane fragment. In the experiment, the researchers used many compounds, for example, 4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4Application In Synthesis of 4-Formyl-2-methoxyphenyl isobutyrate).

4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application In Synthesis of 4-Formyl-2-methoxyphenyl isobutyrate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polypropylene membrane surface modification by RAFT grafting polymerization and TiO₂ photocatalysts immobilization for phenol decomposition in a photocatalytic membrane reactor was written by Yang, Song;Gu, Jia-Shan;Yu, Hai-Yin;Zhou, Jin;Li, Shi-Feng;Wu, Xiu-Min;Wang, Liang. And the article was included in Separation and Purification Technology in 2012.Category: esters-buliding-blocks This article mentions the following:

The main tech. barriers that impede photocatalytic membrane reactor (PMR) commercialization remain on the post-recovery of the catalyst particles after water treatment. To overcome this problem, surface modification of the polypropylene macroporous membrane was performed with the technique of photoinduced reversible addition-fragmentation chain transfer grafting polymerization of acrylic acid. Titanium oxide photocatalysts were introduced to the acrylic acid grafted membrane surface. Phenol decomposition was carried out under UV irradiation in a recycle batch photocatalytic membrane reactor. The normalized membrane flux reached 1.7 times that of the unmodified membrane for the PAAc modified membrane. Introducing TiO₂ photocatalysts to the membrane surface reduced the normalized membrane flux slightly. For the PMR with a grafting degree of 12.9% (wt) of PAAc on the membrane surface, the corresponding decomposition percentage was 32.5% after 6 h UV light irradiation In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Category: esters-buliding-blocks).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

An efficient protocol for multicomponent synthesis of 1H-chromeno[4,3-b]pyridin-5(4H)-ones derivatives was written by Chen, Zhiwei;Gu, Jinying;Su, Weike. And the article was included in Journal of Chemical Research in 2013.Recommanded Product: Ethyl 3-oxo-3-(m-tolyl)propanoate This article mentions the following:

A series of 1H-chromeno[4,3-b]pyridin-5(4H)-one derivatives, e.g., I, were synthesized via a three-component condensation of 4-aminocoumarin, aldehydes and Et benzoylacetates, under simple mild reaction conditions. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Recommanded Product: Ethyl 3-oxo-3-(m-tolyl)propanoate).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: Ethyl 3-oxo-3-(m-tolyl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Controlled synthesis of sulfonated block copolymers having thermoresponsive property by RAFT polymerization of vinyl sulfonate esters was written by Mori, Hideharu;Saito, Yosuke;Takahashi, Eri;Nakabayashi, Kazuhiro;Onuma, Atsuhiko;Morishima, Makoto. And the article was included in Polymer in 2012.COA of Formula: C14H12S2 This article mentions the following:

Four vinyl sulfonate ester derivatives, Me ethenesulfonate (MES), Et ethenesulfonate (EES), 2,2,2-trifluoroethyl ethenesulfonate (TFES), and 2,2,2-trichloroethyl ethenesulfonate (TCLES), which are protected forms of vinyl sulfonic acids, were polymerized by reversible addition-fragmentation chain transfer (RAFT) polymerization Polymers having relatively narrow mol. weight distributions and pre-determined mol. weights were obtained by the polymerization of all monomers using a suitable xanthate-type chain transfer agent (CTA). The RAFT polymerizations of EES and TCLES were found to proceed in controlled fashions under suitable conditions, as confirmed by the formation of narrow polydispersity products, mol. weights controlled by the monomer/chain transfer agent ratio, and linear increases in mol. weight with conversion. Deprotection of the Et group of poly(EES) by LiBr in refluxing 2-butanone proceeded smoothly to give water-soluble poly(lithium vinyl sulfonate). Poly(potassium vinyl sulfonate) was also obtained by the deprotection of poly(TCLES) using potassium tert-butoxide. The syntheses of thermoresponsive block copolymers involving poly(lithium vinyl sulfonate) segments were conducted by RAFT polymerization of N-isopropylacrylamide using poly(EES) macro-CTA, followed by deprotection. ^THe thermally-induced phase separation behavior and assembled structures of the block copolymers were also studied in aqueous solution In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7COA of Formula: C14H12S2).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.COA of Formula: C14H12S2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nanoporous well-defined reversible addition-fragmentation chain transfer polymer of N-acrylamido-L-tryptophan: synthesis and characterization was written by Singh, Pooja;Srivastava, Ambika;Kumar, Rajesh. And the article was included in Polymer International in 2014.Electric Literature of C14H12S2 This article mentions the following:

A nanoporous polymer with a chiral pendant chain of N-acrylamido-L-tryptophan was synthesized through a reversible addition-fragmentation chain transfer polymerization process using a dithiobenzoate derivative as chain transfer agent. The polymerization exhibited the usual characteristics of living processes, though slow polymerization rate and low percentage conversion for a chain extension experiment were observed Depending on the monomer/chain transfer agent ratio, poly(N-acrylamido-L-tryptophan) with number-average mol. weights between 640 and 4340 g mol^-1 and molar mass dispersities between 1.10 and 1.24 was obtained, as evidenced from gel permeation chromatog. SEM images indicated that the polymer was porous. Nitrogen adsorption anal. of the polymer evidenced the presence of mesopores (2-19 nm) associated with micropores (0.45-2 nm) according to the Barrett-Joyner-Halenda method with a specific Brunauer-Emmett-Teller surface area of 22.98 m2 g-1. 婕?2013 Society of Chem. Industry. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Electric Literature of C14H12S2).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C14H12S2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hydroxyindole Carboxylic Acid-Based Inhibitors for Receptor-Type Protein Tyrosine Protein Phosphatase Beta was written by Zeng, Li-Fan;Zhang, Ruo-Yu;Bai, Yunpeng;Wu, Li;Gunawan, Andrea M.;Zhang, Zhong-Yin. And the article was included in Antioxidants & Redox Signaling in 2014.Category: esters-buliding-blocks This article mentions the following:

Aims: Protein tyrosine phosphatases (PTPs) play an important role in regulating a wide range of cellular processes. Understanding the role of PTPs within these processes has been hampered by a lack of potent and selective PTP inhibitors. Generating potent and selective probes for PTPs remains a significant challenge because of the highly conserved and pos. charged PTP active site that also harbors a redox-sensitive Cys residue. Results: We describe a facile method that uses an appropriate hydroxyindole carboxylic acid to anchor the inhibitor to the PTP active site and relies on the secondary binding elements introduced through an amide-focused library to enhance binding affinity for the target PTP and to impart selectivity against off-target phosphatases. Here, we disclose a novel series of hydroxyindole carboxylic acid-based inhibitors for receptor-type tyrosine protein phosphatase beta (RPTP灏?, a potential target that is implicated in blood vessel development. The representative RPTP灏?inhibitor 8b-1 (L87B44) has an IC₅₀ of 0.38 娓璏 and at least 14-fold selectivity for RPTP灏?over a large panel of PTPs. Moreover, 8b-1 also exhibits excellent cellular activity and augments growth factor signaling in HEK293, MDA-MB-468, and human umbilical vein endothelial cells. Innovation: The bicyclic salicylic acid pharmacophore-based focused library approach may provide a potential solution to overcome the bioavailability issue that has plagued the PTP drug discovery field for many years. Conclusion: A novel method is described for the development of bioavailable PTP inhibitors that utilizes bicyclic salicylic acid to anchor the inhibitors to the active site and peripheral site interactions to enhance binding affinity and selectivity. Antioxid. Redox Signal. 20, 2130-2140. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3Category: esters-buliding-blocks).

tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of Zinc Tetraphenylporphyrin Rigid Rods with a Built-In Dipole was written by Chitre, Keyur;Batarseh, Alberto;Kopecky, Andrew;Fan, Hao;Tang, Hao;Lalancette, Roger;Bartynski, Robert A.;Galoppini, Elena. And the article was included in Journal of Physical Chemistry B in 2015.SDS of cas: 313648-56-5 This article mentions the following:

Three Zn(II) tetraphenylporphyrins (ZnTPP) were synthesized to study the influence of a mol. dipole on the energy level alignment of a chromophore bound to a metal oxide semiconductor: ZnTPP-PE(DA)-IpaOMe (1), ZnTPP-PE-IpaOMe (2), and ZnTPP-PE(AD)-IpaOMe (3). Each contained a rigid-rod linker made of a p-phenylene ethynylene (PE) moiety terminated with the Me ester of an isophthalic acid unit (Ipa). Porphyrins 1 and 3 contained an intramol. dipole in the central Ph ring, which was built by introducing electron donor (D, NMe₂) and acceptor (A, NO₂) substituents in para position to each other. In 1 and 3, the relative position of the D and A substituents, and therefore the dipole direction, was reversed. Porphyrin 2, without substituents in the linker, was synthesized for a comparison. The structures of precursors to 1 and 3 and the structure of 1 were determined by single crystal x-ray anal. Solution UV-visible and steady-state fluorescence spectra of 1–3 were identical to each other and exhibited the spectral features typical of the ZnTPP chromophore and their electrochem. properties were also very similar. Me esters 1–3 were hydrolyzed to the corresponding carboxylic acids for binding to metal oxide semiconductors. In the experiment, the researchers used many compounds, for example, Dimethyl 5-ethynylisophthalate (cas: 313648-56-5SDS of cas: 313648-56-5).

Dimethyl 5-ethynylisophthalate (cas: 313648-56-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.SDS of cas: 313648-56-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics