Tag: 200-300

Design of Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase with Improved Drug Resistance Properties. 2. was written by Freeman, George A.;Andrews, C. Webster III;Hopkins, Andrew L.;Lowell, Gina S.;Schaller, Lee T.;Cowan, Jill R.;Gonzales, Stephen S.;Koszalka, George W.;Hazen, Richard J.;Boone, Lawrence R.;Ferris, Rob G.;Creech, Katrina L.;Roberts, Grace B.;Short, Steven A.;Weaver, Kurt;Reynolds, David J.;Milton, John;Ren, Jingshan;Stuart, David I.;Stammers, David K.;Chan, Joseph H.. And the article was included in Journal of Medicinal Chemistry in 2004.Synthetic Route of C11H20O4 This article mentions the following:

HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) are part of the combination therapy currently used to treat HIV infection. The features of a new NNRTI drug for HIV treatment must include selective potent activity against both wild-type virus as well as against mutant virus that have been selected by use of current antiretroviral treatment regimens. Based on analogy with known HIV-1 NNRTI inhibitors and modeling studies utilizing the x-ray crystal structure of inhibitors bound in the HIV-1 RT, a series of substituted 2-quinolones was synthesized and evaluated as HIV-1 inhibitors. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Synthetic Route of C11H20O4).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C11H20O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Honeycomb-like 2D metal-organic polyhedral framework exhibiting selectively adsorption of CO₂ was written by Du, Liting;Miao, Yinchun;Zheng, Baishu;Ma, Mengtao;Zhang, Jinchi. And the article was included in Journal of Solid State Chemistry in 2021.Recommanded Product: 313648-56-5 This article mentions the following:

A new honeycomb-like 2D Metal-organic polyhedral framework, {Cu_3.75(BrCPEIP)_2.5璺?H₂O)_2.75璺疍MF}_n (NJFU-5, H₃BrCPEIP = 5-((3-bromo-5-carboxyphenyl)ethynyl)isophthalic acid) was solvothermally synthesized and structurally characterized, which shows a BET surface area of 473 m² g^-1. Meanwhile, NJFU exhibits a comparably higher CO₂ adsorption capacity of 37.0 cm³ g^-1 (4.6 wt%) at 1 bar and 298 K in 2D MOF family, and a high CO₂ selective adsorption toward N₂ and CH₄ as well. In the experiment, the researchers used many compounds, for example, Dimethyl 5-ethynylisophthalate (cas: 313648-56-5Recommanded Product: 313648-56-5).

Dimethyl 5-ethynylisophthalate (cas: 313648-56-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.Recommanded Product: 313648-56-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Stability engineering of the Geobacillus stearothermophilus alcohol dehydrogenase and application for the synthesis of a polyamide 12 precursor was written by Kirmair, Ludwig;Seiler, Daniel Leonard;Skerra, Arne. And the article was included in Applied Microbiology and Biotechnology in 2015.Category: esters-buliding-blocks This article mentions the following:

The thermostable NAD⁺-dependent alc. dehydrogenase from Geobacillus stearothermophilus (BsADH) was exploited with regard to the biocatalytic synthesis of 锠?oxo lauric acid Me ester (OLAMe), a key intermediate for biobased polyamide 12 production, from the corresponding long-chain alc. Recombinant BsADH was produced in Escherichia coli as a homogeneous tetrameric enzyme and showed high activity towards the industrially relevant substrate 锠?hydroxy lauric acid Me ester (HLAMe) with K_M = 86娓璏 and 44 U mg^-1. The equilibrium constant for HLAMe oxidation to the aldehyde (OLAMe) with NAD⁺ was determined as 2.16 鑴?10^-3 from the kinetic parameters of the BsADH-catalyzed forward and reverse reactions. Since BsADH displayed limited stability under oxidizing conditions, the predominant oxidation-prone residue Cys257 was mutated to Leu based on sequence homol. with related enzymes and computational simulation. This substitution resulted in an improved BsADH variant exhibiting prolonged stability and an elevated inactivation temperature Semi-preparative biocatalysis at 60鎺矯 using the stabilized enzyme, employing butyraldehyde for in situ cofactor regeneration with only catalytic amounts of NAD⁺, yielded up to 23% conversion of HLAMe to OLAMe after 30 min. In contrast to other oxidoreductases, no overoxidn. to the dodecanoic diacid monomethyl ester was detected. Thus, the mutated BsADH offers a promising biocatalyst for the selective oxidation of fatty alcs. to yield intermediates for industrial polymer production In the experiment, the researchers used many compounds, for example, 12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0Category: esters-buliding-blocks).

12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rhenium-catalyzed regioselective synthesis of phenol derivatives from 1,3-diesters and terminal alkynes was written by Kuninobu, Yoichiro;Iwanaga, Takashi;Nishi, Mitsumi;Takai, Kazuhiko. And the article was included in Chemistry Letters in 2010.Application In Synthesis of malonic acid dibutyl ester This article mentions the following:

Treatment of malonates without a substituent at the active methylene moiety with terminal alkynes gave salicylates, e.g. I, regioselectively. In contrast, when malonates bearing a substituent at the active methylene moiety were used, cyclic 灏?keto esters, e.g. II, were generated regioselectively. Treatment of the formed cyclic 灏?keto esters with In(OTf)₃ gave phenol derivatives, e.g. III, via decarboxylation. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Application In Synthesis of malonic acid dibutyl ester).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application In Synthesis of malonic acid dibutyl ester

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ynamide-Mediated Thionoester and Dithioester Syntheses was written by Yao, Chaochao;Yang, Jinhua;Lu, Xiaobiao;Zhang, Shuyu;Zhao, Junfeng. And the article was included in Organic Letters in 2020.Recommanded Product: Benzyl benzodithioate This article mentions the following:

A novel ynamide-mediated synthesis of thionoesters and dithioesters is described. The selective addition reactions of various monothiocarboxylic acids with ynamide furnish 浼?thioacyloxyenamides, which undergo transesterification with nucleophilic -OH or -SH species to afford thionoesters and dithioesters, resp. The broad substrate scope, mild reaction conditions, and excellent yields make this method an attractive synthetic approach to thionoesters and dithioesters. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Recommanded Product: Benzyl benzodithioate).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: Benzyl benzodithioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Study of phase separation behavior of poly(N,N-diethylacrylamide) in aqueous solution prepared by RAFT polymerization was written by Wu, Mei;Zhang, Haibing;Liu, Hongliang. And the article was included in Polymer Bulletin (Heidelberg, Germany) in 2019.Related Products of 27249-90-7 This article mentions the following:

A series of poly(N,N-diethylacrylamide) samples with low mol. weights (1.9 鑴?10³-5.3 鑴?10⁴) and narrow polydispersities (below 1.5 and usually lower than 1.25) was synthesized by reversible addition-fragmentation chain transfer polymerization The phase separation behavior of poly(N,N-diethylacrylamide) in aqueous solution was investigated by turbidimetry, fluorescent probe technol. and DSC. It is interesting to find that the lower critical solution temperature (LCST) of the samples increases with increasing mol. weight and remains more or less a constant above a critical mol. weight of 1.2 鑴?10⁴. At the same time, an inverse dependence of LCST on the concentration was found and this effect was more pronounced for lower mol. weight To further investigate the novel mol. weight dependence of the LCST, the fluorescent probe study was conducted and the exptl. results demonstrated that there was an increase in hydrophobicity when decreasing the mol. weight and increasing the concentration and flower-like micelles were probably formed which can further be proved by TEM. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Related Products of 27249-90-7).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Related Products of 27249-90-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mediated melt functionalization of polypropylene was written by Drooghaag, X.;Rousseaux, D. D. J.;Henry, G. R. P.;Sclavons, M.;Carlier, V.;Marchand-Brynaert, J.. And the article was included in Polymer Degradation and Stability in 2010.Application of 27249-90-7 This article mentions the following:

This work investigated the ability of several kinds of mols. to mediate the melt functionalization of polypropylene. N-Bromosuccinimide, nitroxides, iniferters, thiols and RAFT chain transfer agents were tested as potential mediators. The grafting of maleic anhydride onto polypropylene was carried out with and without mediator and the grafted polymers are discussed in terms of graft content, graft structure and mol. weights In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Application of 27249-90-7).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application of 27249-90-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Using dilatometry in the reversible addition fragmentation transfer polymerization of N-(S)-(-)-浼?methylbenzyl methacryloylamine was written by Soriano-Moro, J. Guillermo;Percino, M. Judith;Chapela, Victor M.;Guerrero-Santos, Ramiro. And the article was included in Journal of Polymer Research in 2011.Recommanded Product: Benzyl benzodithioate This article mentions the following:

Optically active polymers were prepared using reversible addition-fragmentation chain transfer polymerization (RAFT) of N-(S)-浼?methylbenzylmethacryloylamine (N-(S)-浼?MBMA), a functional optically active monomer. RAFT polymerizations were carried out at 70 鎺矯 in ethanol using AIBN as a thermal initiator and benzyl or (1-phenyl)ethyl dithiobenzoate (BDB and PEDB, resp.) as the RAFT agents. The kinetic study was performed by dilatometry. Plots of conversion vs time indicated that the polymerizations followed first order kinetics. ¹H NMR, IR, and UV-vis spectrophotometric studies confirmed the presence of thiocarbonylthio moieties (-SCS-) in the polymer chains. The mol. weight distributions (MWDs) were moderately narrow with polydispersity indexes between 1.3 and 1.6, which indicated that the control of the reaction was not completely achievement using BDB or PEDB as RAFT agents. The optical activity [浼猐 measurements of synthesized polymers by RAFT did not show a noticeably linear increase dependence with respect to mol. weight, as was previously reported for another controlled free radical polymerization (CRP) system. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Recommanded Product: Benzyl benzodithioate).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: Benzyl benzodithioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Preparation of Orthogonal 锜?Conjugated Aryl Alkynes and Cyclophanes was written by Crisp, G. T.;Turner, P. D.. And the article was included in Tetrahedron in 2000.Application of 313648-56-5 This article mentions the following:

A series of anthracene based orthogonal 锜?conjugated aryl alkynes was prepared using palladium-catalyzed couplings. Thia- and azacyclophanes were prepared from anthracene based orthogonal 锜?conjugated aryl alkynes. In the experiment, the researchers used many compounds, for example, Dimethyl 5-ethynylisophthalate (cas: 313648-56-5Application of 313648-56-5).

Dimethyl 5-ethynylisophthalate (cas: 313648-56-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application of 313648-56-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rapid identification of fatty acids from Leptadenia reticulata areal parts by GC-MS was written by Dhalani, Jayesh;Parmar, Rahul;Rajpara, Raj;Nariya, Pankajkumar. And the article was included in Journal of Scientific & Industrial Research in 2020.Category: esters-buliding-blocks This article mentions the following:

The investigation was carried out to identify the various fatty acids present in the areal parts of Leptadenia reticulata, one of the important medicinal plants of India. Non-polar (Petroleum Ether) extract of areal parts was used for this study. Saponification was carried out using dried extract to obtain fatty acids. Further esterification of saponifiable fraction was performed to obtain fatty acid Me ester. Extracted fatty acid Me esters were analyzed by gas chromatog. and mass spectrometry (GC-MS) technique using NIST library. From GC-MS anal., 14 components were identified in areal parts of Leptadenia reticulata. This study reveals that L. reticulata is a good source of fatty acids with medicinal properties. This methodol. has the advantage of excellent identification of Non polar moiety of medicinal plant. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Category: esters-buliding-blocks).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics