Tag: 200-300

Khadake, Shivaji Narayan; Karamathulla, Shaik; Jena, Tapan Kumar; Monisha, Mohan; Tuti, Nikhil Kumar; Khan, Faiz Ahmed; Anindya, Roy published an article in 2021. The article was titled 《Synthesis and antibacterial activities of marine natural product ianthelliformisamines and subereamine synthetic analogues》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.COA of Formula: C12H15ClN2O2 The information in the text is summarized as follows:

Marine sponges of the genus Suberea produce a variety of brominated tyrosine alkaloids which display a diverse range of biol. activities including antiproliferative, antimicrobial and antimalarial activities. In continuation of our search for biol. active marine natural products as antibacterial compounds, we report here the synthesis and evaluation of the biol. activity of a panel of ianthelliformisamines and subereamine analogs using the literature-known acid-amine coupling reaction. Several derivatives of ianthelliformisamine were obtained by coupling Boc-protected polyamines with brominated aromatic acrylic acid derivatives followed by Boc-deprotection using TFA. The aromatic acrylic acid derivatives varied in bromine substitution and geometry of the double bond. Similarly, subereamine analogs were synthesized by employing the coupling reaction between various brominated phenylacrylic acids with com. available chiral amino ester derivatives followed by ester hydrolysis. These synthetic analogs were screened for antibacterial activity against both Gram-neg. (Escherichia coli) and Gram-pos. (Staphylococcus aureus) strains. Ianthelliformisamine derivative I showed bactericidal activity against Staphylococcus aureus with an IC50 value of 3.8μM (MIC = 25μM). In the experiment, the researchers used H-Trp-OMe.HCl(cas: 7524-52-9COA of Formula: C12H15ClN2O2)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.COA of Formula: C12H15ClN2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《An endoplasmic reticulum-targeting fluorescent probe for imaging OH in living cells》 was written by Zhao, Yanyan; Li, Hongyu; Chai, Ziyin; Shi, Wen; Li, Xiaohua; Ma, Huimin. Safety of N-Boc-1,6-Diaminohexane And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

The hydroxyl radical (OH) in the endoplasmic reticulum has not been studied thoroughly due to the lack of proper methods. Here, an endoplasmic reticulum-targeting fluorescent probe for detecting OH is reported. With this probe, the action of OH in the endoplasmic reticulum has been imaged in living cells. In the experiment, the researchers used many compounds, for example, N-Boc-1,6-Diaminohexane(cas: 51857-17-1Safety of N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Safety of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adusumalli, Srinivasa Rao; Rawale, Dattatraya Gautam; Thakur, Kalyani; Purushottam, Landa; Reddy, Neelesh C.; Kalra, Neetu; Shukla, Sanjeev; Rai, Vishal published an article in Angewandte Chemie, International Edition. The title of the article was 《Chemoselective and Site-Selective Lysine-Directed Lysine Modification Enables Single-Site Labeling of Native Proteins》.COA of Formula: C13H16O5 The author mentioned the following in the article:

The necessity for precision labeling of proteins emerged during the efforts to understand and regulate their structure and function. It demands selective attachment of tags such as affinity probes, fluorophores, and potent cytotoxins. Here, the authors report a method that enables single-site labeling of a high-frequency Lys residue in the native proteins. At first, the enabling reagent forms stabilized imines with multiple solvent-accessible Lys residues chemoselectively. These linchpins create the opportunity to regulate the position of a second Lys-selective electrophile connected by a spacer. Consequently, it enables the irreversible single-site labeling of a Lys residue independent of its place in the reactivity order. The user-friendly protocol involves a series of steps to deconvolute and address chemoselectivity, site-selectivity, and modularity. Also, it delivers ordered immobilization and anal. pure probe-tagged proteins. Besides, the methodol. provides access to antibody-drug conjugate (ADC), which exhibits highly selective anti-proliferative activity towards HER-2 expressing SKBR-3 breast cancer cells. After reading the article, we found that the author used Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8COA of Formula: C13H16O5)

Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8) belongs to esters.COA of Formula: C13H16O5 They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Product Details of 152942-06-8On November 7, 2018 ,《Single-Site Labeling of Native Proteins Enabled by a Chemoselective and Site-Selective Chemical Technology》 appeared in Journal of the American Chemical Society. The author of the article were Adusumalli, Srinivasa Rao; Rawale, Dattatraya Gautam; Singh, Usha; Tripathi, Prabhanshu; Paul, Rajesh; Kalra, Neetu; Mishra, Ram Kumar; Shukla, Sanjeev; Rai, Vishal. The article conveys some information:

Chem. biol. research often requires precise covalent attachment of labels to the native proteins. Such methods are sought after to probe, design, and regulate the properties of proteins. At present, this demand is largely unmet due to the lack of empowering chem. technol. Here, we report a chem. platform that enables site-selective labeling of native proteins. Initially, a reversible intermol. reaction places the “”chem. linchpins”” globally on all the accessible Lys residues. These linchpins have the capability to drive site-selective covalent labeling of proteins. The linchpin detaches within physiol. conditions and capacitates the late-stage installation of various tags. The chem. platform is modular, and the reagent design regulates the site of modification. The linchpin is a multitasking group and facilitates purification of the labeled protein eliminating the requirement of addnl. chromatog. tag. The methodol. allows the labeling of a single protein in a mixture of proteins. The precise modification of an accessible residue in protein ensures that their structure remains unaltered. The enzymic activity of myoglobin, cytochrome C, aldolase, and lysozyme C remains conserved after labeling. Also, the cellular uptake of modified insulin and its downstream signaling process remain unperturbed. The linchpin directed modification (LDM) provides a convenient route for the conjugation of a fluorophore and drug to a Fab and monoclonal antibody. It delivers trastuzumab-doxorubicin and trastuzumab-emtansine conjugates with selective antiproliferative activity toward Her-2 pos. SKBR-3 breast cancer cells. In the experimental materials used by the author, we found Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8Product Details of 152942-06-8)

Ethyl 4-(4-formyl-3-hydroxyphenoxy)butanoate(cas: 152942-06-8) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Product Details of 152942-06-8 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Post-synthetic functionalization of tryptophan protected peptide sequences through indole (C-2) photocatalytic alkylation》 was written by Lima, Rafaely N.; Delgado, Jose A. C.; Bernardi, Darlon I.; Berlinck, Roberto G. S.; Kaplaneris, Nikolaos; Ackermann, Lutz; Paixao, Marcio W.. HPLC of Formula: 7524-52-9This research focused ontryptophan photocatalytic alkylation bromo amino acid visible light; peptide photocatalytic alkylation bromo carbonyl functional group cyclic voltammetry. The article conveys some information:

We report a selective, mild, and efficient C-H functionalization of tryptophan and tryptophan-containing peptides with activated α-bromo-carbonyl compounds under visible-light irradiation The protocol efficiency is outlined by the wide substrate scope and excellent tolerance of sensitive functional groups present in the amino acid side chains. The method can be successfully extended to access pharmaco-peptide conjugate scaffolds. In the experimental materials used by the author, we found H-Trp-OMe.HCl(cas: 7524-52-9HPLC of Formula: 7524-52-9)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.HPLC of Formula: 7524-52-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Pentafluorobenzoylacetic ester》 was published in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1965. These research results belong to Prudchenko, A. T.; Barkhash, V. A.; Vorozhtsov, N. N. Jr.. Product Details of 4522-93-4 The article mentions the following:

C6F5CO2H heated with EtOH-H2SO4 11 hrs. gave 75.8% Et ester (I), b5 63°, n20D 1.4252. The reaction mixture prepared from 1.02 g. Mg, 4.9 ml. absolute EtOH, 0.1 ml. CCl4, and 6.5 g. CH2(CO2Et)2 in Et2O, was treated with 10 g. C6F5-COCl to yield 65% C6F5COCH(CO2Et),2, b6 137°, n25D 1.4620. The crude ester steam distilled in dilute H2SO4 gave 38% C6F5CO-CH2CO2Et (II) (b4 103.5°, n21D 1.4604), which heated with Ph-NH2 in xylene gave the anilide, m. 148°. The reaction mixture Of 3 g. Mg, 13.8 g. EtBr, and 12.84 g. iso-Pr2NH was treated with 5.31 g. EtOAc and 14.9 g. I 3 hrs. to yield, after quenching in ice-H2SO4, 43% II. AcCH2CO2Et treated with Na-EtOH, then evaporated in vacuo at 100° gave after treatment with I 3 hrs. at 140-5° and finally at 180°, followed by treatment with dilute H2SO4, 55.7% di-Et 2,3,5,6-tetrafluorohomoterephthalate (b5 141-2°, n25D 1.4590), which in 4 hrs. with aqueous KOH saponified to give 77.2% free acid, m. 220-1° (H2O). This heated with Me2NCHO 1 hr. at 130-40° gave 40.4% 2,3,5,6-tetrafluorophenylacetic acid, m. 140.5-1.5° (C6H6). Ir and N.M.R. spectra of the products were reported. In the experiment, the researchers used many compounds, for example, Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4Product Details of 4522-93-4)

Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4) belongs to esters.Product Details of 4522-93-4 They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Category: esters-buliding-blocksOn October 31, 1990 ,《Dimethyl 4-nitrophenylmalonate》 appeared in Organic Preparations and Procedures International. The author of the article were Bowman, M. A. E.; Bowman, R. E.. The article conveys some information:

Title compound 4-O2NC6H4CR2R3CO2R1 (I; R1 = Me, R2 = H, R3 = CO2Me) was prepared in 88% yield from alkylation of 4-ClC6H4NO2 with metalated di-Me malonate. Treatment of I with MeI and K2CO3 in Me2CO gave I (R1 = R2 = Me, R3 = CO2Me). After reading the article, we found that the author used Dimethyl 2-(4-nitrophenyl)malonate(cas: 4033-88-9Category: esters-buliding-blocks)

Dimethyl 2-(4-nitrophenyl)malonate(cas: 4033-88-9) belongs to esters.Category: esters-buliding-blocks They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schneider, Hendrik; Englert, Simon; Palacios, Arturo Macarron; Romero, Jorge Alberto Lerma; Ali, Ataurehman; Avrutina, Olga; Kolmar, Harald published an article in 2021. The article was titled 《Synthetic integrin-targeting dextran-Fc hybrids efficiently inhibit tumor proliferation in vitro》, and you may find the article in Frontiers in Chemistry (Lausanne, Switzerland).Related Products of 51644-96-3 The information in the text is summarized as follows:

Herein, we present the design, synthesis, and biol. evaluation of novel integrin-targeting mol. hybrids combining RGD peptides and a potent cytotoxin presented on dextran polysaccharides. Based on an aglycosylated Fc as a centerpiece, endosomal-cleavable cytotoxic agent monomethyl auristatin E (MMAE) and dextran as multimerization site were covalently connected by two bioorthogonal enzyme-mediated reactions site-specifically. Decoration of dextran with cyclic RGD peptides, introduced by copper “”click”” reaction, resulted in the final constructs with the potential to kill integrin-overexpressing tumor cells. We found that these modifications had little impact on the stability of the Fc scaffold and the RGD-bearing construct showed good binding properties of αvβ3- expressing U87MG cells. Furthermore, the construct showed a remarkable antiproliferative activity. These results demonstrate the general capability of our design to provoke receptor-mediated endocytosis upon binding to the cellular surface, followed by endosomal cleavage of the linkage between Fc-dextran and MMAE and its subsequent release. Our approach opens new avenues to transcribe small mol. binders into tailor-made multimeric mol. hybrids with antitumor potential.tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Related Products of 51644-96-3) was used in this study.

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Related Products of 51644-96-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vinogradov, Andrei S.; Krasnov, Vyacheslav I.; Platonov, Vyacheslav E. published their research in Collection of Czechoslovak Chemical Communications on December 31 ,2008. The article was titled 《Reactions of polyfluoroaromatic organozinc compounds with acyl chlorides and DMF》.Synthetic Route of C9H5F5O2 The article contains the following contents:

N,N-Dimethylbis(polyfluoroaryl)methanamines R2CHNMe2 (R = C6F5, EtO2CC6F4, NCC6F4, etc.) and polyfluoroarenes RH were obtained from polyfluoroarom. organozinc compounds RZnX (X = Cl, R) in DMF in the presence of acyl chlorides. In addition to this study using Ethyl 2,3,4,5,6-pentafluorobenzoate, there are many other studies that have used Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4Synthetic Route of C9H5F5O2) was used in this study.

Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Synthetic Route of C9H5F5O2 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Weber, Edwin; Reutel, Christiane; Foces-Foces, Concepcion; Llamas-Saiz, Antonio L. published an article on January 31 ,1999. The article was titled 《Supramolecular inclusion hosts based on amino acid compound sources: design, synthesis and crystalline inclusion behavior. X-ray crystal structures of two inefficient host compounds》, and you may find the article in Journal of Inclusion Phenomena and Macrocyclic Chemistry.Product Details of 59410-82-1 The information in the text is summarized as follows:

A new design of crystalline hosts derived from amino acids, characterized by an aminoethanol functional unit or its carbonamide structural derivative and appended aromatic residues including secondary substituents, is reported. Fifteen host compounds, including (S)-2-amino-1,1-bis(4-tert-butylphenyl)-1-propanol (3) and (S)-2-(dibenzylamino)-1,1-diphenyl-1-propanol (11), were synthesized. Crystalline inclusion formation is shown and discussed with reference to structural parameters of the host mols. X-Ray crystal structures of compounds 3 and 11 have been determined in order to suggest reasons for their failure to show inclusion ability. In the experiment, the researchers used H-Phg-OEt.HCl(cas: 59410-82-1Product Details of 59410-82-1)

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Product Details of 59410-82-1 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics