Tag: 200-300

Safety of tert-Butyl (5-aminopentyl)carbamateIn 2020 ,《Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu2/4 heterodimeric receptor results in a compound with mGlu2/2 homodimer selectivity》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Fulton, Mark G.; Loch, Matthew T.; Rodriguez, Alice L.; Lin, Xin; Javitch, Jonathan A.; Conn, P. Jeffrey; Niswender, Colleen M.; Lindsley, Craig W.. The article conveys some information:

This Letter details our ongoing efforts to develop selective pos. allosteric modulators (PAMs) of the mGlu2/4 heterodimeric receptor that exists in the CNS and may represent a novel drug target to modulate the glutamatergic system. As multiple hit-to-lead campaigns from HTS hits failed to produce selective small mol. mGlu2/4 heterodimer PAMs, we were inspired by the work of Portoghese to synthesize and evaluate a set of nine bivalent tethered ligands (possessing an mGlu2 PAM at one terminus and an mGlu4 PAM at the other). Utilizing G protein-Inwardly Rectifying Potassium (GIRK) channel functional assays, we found that the tethered ligands displayed PAM activity in a cell line co-expressing both mGlu2 and mGlu4 but also in cells expressing mGlu2 or mGlu4 alone. In a CODA-RET assay, one of the tethered ligands potentiated mGlu2/4 heterodimers; however, another compound displayed 75-fold preference for the mGlu2/2 homodimer over heterodimeric mGlu2/4 or homomeric mGlu4/4. This work highlights the development of mGlu receptor PAMs with homodimer/heterodimer preference and expands the potential for PAMs as tethered ligands beyond the more classical antagonists and NAMs. In the experimental materials used by the author, we found tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Safety of tert-Butyl (5-aminopentyl)carbamate)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Safety of tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Manickam, Manoj; Boggu, Pulla Reddy; Pillaiyar, Thanigaimalai; Nam, Yeo Jin; Abdullah, Md.; Lee, Seung Jin; Kang, Jong Seong; Jung, Sang-Hun published their research in Bioorganic & Medicinal Chemistry Letters in 2021. The article was titled 《Design, synthesis and anticancer activity of 2-amidomethoxy-1,4-naphthoquinones and its conjugates with Biotin/polyamine》.Synthetic Route of C11H24N2O2 The article contains the following contents:

In continuation with the previous work, a series of 5-hydroxy-2-amidomethoxy-1,4-naphthoquinones were prepared to establish the structure-activity relationship studies toward anticancer activity (IC50 in μM) against three cell lines; colo205 (colon adenocarcinoma), T47D (breast ductal carcinoma) and K562 (chronic myelogenous leukemia). Among the synthesized compounds, naphthoquinone amines, I (0.8; 0.6; 0.8), II (0.8; 0.6; 0.5) and the amine precursor, III (1.3; 0.3; 1.0) displayed potent anticancer activities. A tumor targeting drug delivery system was achieved by synthesizing the conjugate IV (1.4; 0.5; 1.1) of naphthoquinone-amine I and Biotin which also proved its potency. Finally, to introduce polyamine conjugate, spermidine was attached with 2-amidomethoxy-1,4-naphthoquinone. The naphthoquinone-spermidine conjugate V (1.2; 1.7; 1.7) also retained the activity. Thus, potent naphthoquinone amines were explored and Biotin/polyamine conjugate was developed as tumor targeting drug delivery system. In the part of experimental materials, we found many familiar compounds, such as N-Boc-1,6-Diaminohexane(cas: 51857-17-1Synthetic Route of C11H24N2O2)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Synthetic Route of C11H24N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lamotte, Yann; Faucher, Nicolas; Sancon, Julien; Pineau, Olivier; Sautet, Stephane; Fouchet, Marie-Helene; Beneton, Veronique; Tousaint, Jean-Jacques; Saintillan, Yannick; Ancellin, Nicolas; Nicodeme, Edwige; Grillot, Didier; Martres, Paul published an article on February 15 ,2014. The article was titled 《Discovery of novel indazole derivatives as dual angiotensin II antagonists and partial PPARγ agonists》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Name: Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate The information in the text is summarized as follows:

Identification of indazole derivatives acting as dual angiotensin II type 1 (AT1) receptor antagonists and partial peroxisome proliferator-activated receptor-γ (PPARγ) agonists is described. Starting from telmisartan, the authors previously described that indole derivatives were very potent partial PPARγ agonists with loss of AT1 receptor antagonist activity. Design, synthesis and evaluation of new central scaffolds led us to the discovery of pyrrazolopyridine then indazole derivatives provided novel series possessing the desired dual activity. Among the new compounds, I was identified as a potent AT1 receptor antagonist (IC50 = 0.006 μM) and partial PPARγ agonist (EC50 = 0.25 μM, 40% max) with good oral bioavailability in rat. The dual pharmacol. of compound I was demonstrated in two preclin. models of hypertension (SHR) and insulin resistance (Zucker fa/fa rat).Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Name: Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate) was used in this study.

Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Name: Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylateOn October 22, 2020 ,《First Structure-Activity Relationship Study of Potent BLT2 Agonists as Potential Wound-Healing Promoters》 was published in Journal of Medicinal Chemistry. The article was written by Hernandez-Olmos, Victor; Heering, Jan; Planz, Viktoria; Liu, Ting; Kaps, Alexander; Rajkumar, Rinusha; Gramzow, Matthias; Kaiser, Astrid; Schubert-Zsilavecz, Manfred; Parnham, Michael J.; Windbergs, Maike; Steinhilber, Dieter; Proschak, Ewgenij. The article contains the following contents:

The first potent leukotriene B4 (LTB4) receptor type 2 (BLT2) agonists, endogenous 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT), and synthetic CAY10583 (CAY) have been recently described to accelerate wound healing by enhanced keratinocyte migration and indirect stimulation of fibroblast activity in diabetic rats. CAY represents a very valuable starting point for the development of novel wound-healing promoters. In this work, the first structure-activity relationship study for CAY scaffold-based BLT2 agonists is presented. The newly prepared derivatives showed promising in vitro wound-healing activity. In the experimental materials used by the author, we found Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Recommanded Product: Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate)

Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Recommanded Product: Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quality Control of Ethyl 2,3,4,5,6-pentafluorobenzoateOn September 28, 2016 ,《Asymmetric Catalysis with Organic Azides and Diazo Compounds Initiated by Photoinduced Electron Transfer》 was published in Journal of the American Chemical Society. The article was written by Huang, Xiaoqiang; Webster, Richard D.; Harms, Klaus; Meggers, Eric. The article contains the following contents:

Electron-acceptor-substituted aryl azides and α-diazo carboxylic esters are used as substrates for visible-light-activated asym. α-amination and α-alkylation, resp., of 2-acyl imidazoles catalyzed by a chiral-at-metal rhodium-based Lewis acid in combination with a photoredox sensitizer. This novel proton- and redox-neutral method provides yields of up to 99% and excellent enantioselectivities of up to >99% ee with broad functional group compatibility. Mechanistic investigations suggest that an intermediate rhodium enolate complex acts as a reductive quencher to initiate a radical process with the aryl azides and α-diazo carboxylic esters serving as precursors for nitrogen and carbon-centered radicals, resp. This is the first report on using aryl azides and α-diazo carboxylic esters as substrates for asym. catalysis under photoredox conditions. These reagents have the advantage that mol. nitrogen is the leaving group and sole byproduct in this reaction. In the experimental materials used by the author, we found Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4Quality Control of Ethyl 2,3,4,5,6-pentafluorobenzoate)

Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Quality Control of Ethyl 2,3,4,5,6-pentafluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Low molecular weight gelators for organic fluids. Gelation using a family of cyclo(dipeptide)s》 was written by Hanabusa, Kenji; Matsumoto, Mitsuyoshi; Kimura, Mutsumi; Kakehi, Akikazu; Shirai, Hirofusa. Electric Literature of C10H14ClNO2 And the article was included in Journal of Colloid and Interface Science on April 15 ,2000. The article conveys some information:

Simple cyclo(dipeptide)s consisting of diverse amino acids are able to cause phys. gelation in a wide variety of organic fluids, including edible oils, glyceryl esters, alcs., and aromatic mols. Min. gel concentrations (MGC), FTIR spectroscopy, NMR spectroscopy, and electron micrograph were used to characterize gel phenomenon. The intermol. hydrogen bonding between N-H and C=O in cyclo(dipeptide)s plays an important role in gelation. FTIR and x-ray diffraction data suggest that the aggregate responsible for gel is an assembly of hydrogen-bonded mol. ladders, which are initially formed from numerous mols. through intermol. hydrogen bonding. The ladder-like aggregates are intertwined and interlocked, and finally immobilize organic fluids. The gelation ability is discussed in connection with the 3-component solubility parameters of solvents. (c) 2000 Academic Press. In the part of experimental materials, we found many familiar compounds, such as H-Phg-OEt.HCl(cas: 59410-82-1Electric Literature of C10H14ClNO2)

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Electric Literature of C10H14ClNO2 Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《N-Allylnoratropine》 were Nador, K.; Gyorgy, L.; Doda, M. M.. And the article was published in Journal of Medicinal & Pharmaceutical Chemistry in 1961. Related Products of 92652-76-1 The author mentioned the following in the article:

Treatment of N-benzylnortropan-3α-ol HCl salt with O-acetyltropic acid chloride (I) at 85° produced N-benzylnoratropine, m. 115°, hydrogenated in the presence of 10% Pd-C to noratropine (II), m. 114°. II was also prepared by treating nortropan-3α-ol with carbobenzoxy chloride to produce N-carbobenzoxynortropan-3α-ol m. 124°, which treated with I in C5H5N gave N-carbobenzoxynoratropine, m. 113°, and this was subjected to catalytic removal of the carbobenzoxy group. N-allylnoratropine, m. 77°, was prepared by treating excess noratropine with allyl bromide and had a very weak parasympatholytic activity, did not antagonize atropine, had weak adrenolytic and hypotensive activity and had an LD50 500 mg./kg. in mice. The experimental part of the paper was very detailed, including the reaction process of Benzyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate(cas: 92652-76-1Related Products of 92652-76-1)

Benzyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate(cas: 92652-76-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Related Products of 92652-76-1 Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Formula: C12H15ClN2O2In 2022 ,《γ C-H Functionalization of Amines via Triple H-Atom Transfer of a Vinyl Sulfonyl Radical Chaperone》 was published in Journal of the American Chemical Society. The article was written by Herbort, James H.; Bednar, Taylor N.; Chen, Andrew D.; RajanBabu, T. V.; Nagib, David A.. The article contains the following contents:

A selective, remote desaturation has been developed to rapidly access homoallyl amines from their aliphatic precursors. The strategy employs a triple H-atom transfer (HAT) cascade, entailing (i) cobalt-catalyzed metal-HAT (MHAT), (ii) carbon-to-carbon 1,6-HAT, and (iii) Co-H regeneration via MHAT. A new class of sulfonyl radical chaperone (to rapidly access and direct remote, radical reactivity) enables remote desaturation of diverse amines, amino acids, and peptides with excellent site-, chemo-, and regioselectivity. The key, enabling C-to-C HAT step in this cascade was computationally designed to satisfy both thermodn. (bond strength) and kinetic (polarity) requirements, and it has been probed via regioselectivity, isomerization, and competition experiments We have also interrupted this radical transfer dehydrogenation to achieve γ-selective C-Cl, C-CN, and C-N bond formations. The experimental process involved the reaction of H-Trp-OMe.HCl(cas: 7524-52-9Formula: C12H15ClN2O2)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Formula: C12H15ClN2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Gockel, Lukas M.; Pfeifer, Vladlena; Baltes, Fabian; Bachmaier, Rafael D.; Wagner, Karl G.; Bendas, Gerd; Guetschow, Michael; Sosic, Izidor; Steinebach, Christian published an article in Archiv der Pharmazie (Weinheim, Germany). The title of the article was 《Design, synthesis and characterization of PROTACs targeting the androgen receptor in prostate and lung cancer models》.Computed Properties of C11H24N2O2 The author mentioned the following in the article:

Three subgroups of enzalutamide-based PROTACs was presented in which only the exit vector was modified. By recruiting cereblon, the potent degradation of AR in lung cancer cells was demonstrated. Furthermore, the initial evaluation enabled the design of an optimized PROTAC with a rigid linker that degraded AR with a DC50 value in the nanomolar range. These results provide novel AR-directed PROTACs and a clear rationale for further investigating AR involvement in lung cancer models. After reading the article, we found that the author used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Computed Properties of C11H24N2O2)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Computed Properties of C11H24N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness》 was written by Sundaram, Aparna; Chen, Chun; Isik Reed, Nilgun; Liu, Sean; Ki Yeon, Seul; McIntosh, Joel; Tang, You-Zhi; Yang, Hyunjun; Adler, Marc; Beresis, Richard; Seiple, Ian B.; Sheppard, Dean; DeGrado, William F.; Jo, Hyunil. Application In Synthesis of tert-Butyl (5-aminopentyl)carbamate And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020. The article conveys some information:

Inhibition of integrin α5β1 emerges as a novel therapeutic option to block transmission of contractile forces during asthma attack. We designed and synthesized novel inhibitors of integrin α5β1 by backbone replacement of known αvβ1 integrin inhibitors. These integrin α5β1 inhibitors also retain the nanomolar potency against αvβ1 integrin, which shows promise for developing dual integrin α5β1/αvβ1 inhibitor. Introduction of hydrophobic adamantane group significantly boosted the potency as well as selectivity over integrin αvβ3. We also demonstrated one of the inhibitors (11)(I) reduced airway hyperresponsiveness in ex vivo mouse tracheal ring assay. Results from this study will help guide further development of integrin α5β1 inhibitors as potential novel asthma therapeutics.tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Application In Synthesis of tert-Butyl (5-aminopentyl)carbamate) was used in this study.

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Application In Synthesis of tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics