Tag: 200-300

《Chromones bearing amino acid residues: Easily accessible and potent inhibitors of the breast cancer resistance protein ABCG2》 was published in European Journal of Medicinal Chemistry in 2020. These research results belong to Roussel, Emile; Moreno, Alexis; Altounian, Nicolas; Philouze, Christian; Peres, Basile; Thomas, Aline; Renaudet, Olivier; Falson, Pierre; Boumendjel, Ahcene. Application of 7524-52-9 The article mentions the following:

The Breast Cancer Resistance Protein (BCRP/ABCG2) belongs to the G class of ABC (ATP-Binding Cassette) proteins, which is known as one of the main transporters involved in the multidrug resistance (MDR) phenotype that confer resistance to anticancer drugs. The aim of this study was to design, synthesize and develop new potent and selective inhibitors of BCRP that can be used to abolish MDR and potentialize clin. used anticancer agents. In previous reports, we showed the importance of chromone scaffold and hydrophobicity for the inhibition of ABC transporters. In the present study we report the design and development of chromones linked to one or two amino acids residues that are either hydrophobic or found in the structure of FTC, one of most potent (but highly toxic) inhibitors of BCRP. Herewith, we report the synthesis and evaluation of 13 compounds The studied mols. were found to be not toxic and showed strong inhibition activity as well as high selectivity toward BCRP. The highest activity was obtained with the chromone bearing a valine residue (I) which showed an inhibition activity against BCRP of 50 nM. The rationalization of the inhibition potential of the most active derivatives was performed through docking studies. Taken together, the ease of synthesis and the biol. profile of these compounds render them as promising candidates for further development in the field of anticancer therapy. In addition to this study using H-Trp-OMe.HCl, there are many other studies that have used H-Trp-OMe.HCl(cas: 7524-52-9Application of 7524-52-9) was used in this study.

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Application of 7524-52-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Fluorescent Probes for Ecto-5′-nucleotidase (CD73)》 was published in ACS Medicinal Chemistry Letters in 2020. These research results belong to Schmies, Constanze C.; Rolshoven, Georg; Idris, Riham M.; Losenkova, Karolina; Renn, Christian; Schaekel, Laura; Al-Hroub, Haneen; Wang, Yulu; Garofano, Francesca; Schmidt-Wolf, Ingo G. H.; Zimmermann, Herbert; Yegutkin, Gennady G.; Mueller, Christa E.. Safety of N-Boc-1,6-Diaminohexane The article mentions the following:

Ecto-5′-nucleotidase (CD73) catalyzes the hydrolysis of AMP to anti-inflammatory, immunosuppressive adenosine. It is expressed on vascular endothelial, epithelial, and also numerous cancer cells where it strongly contributes to an immunosuppressive microenvironment. In the present study we designed and synthesized fluorescent-labeled CD73 inhibitors with low nanomolar affinity and high selectivity based on N6-benzyl-α,β-methylene-ADP (PSB-12379) as a lead structure. Fluorescein was attached to the benzyl residue via different linkers resulting in PSB-19416 (14b, Ki 12.6 nM) and PSB-18332 (14a, Ki 2.98 nM) as fluorescent high-affinity probes for CD73. These compounds are anticipated to become useful tools for biol. studies, drug screening, and diagnostic applications. In the experimental materials used by the author, we found N-Boc-1,6-Diaminohexane(cas: 51857-17-1Safety of N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Safety of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Baek, Du-Jong; Kang, Tae-Beom; Kim, Hyun Ju published their research in Bulletin of the Korean Chemical Society on December 20 ,2004. The article was titled 《Synthesis of nonclassical quinazolinone antifolates as thymidylate synthase inhibitors and their antitumor activity in vitro》.Formula: C10H14ClNO2 The article contains the following contents:

Nonclassical quinazolinone analogs, e.g., I (R = H, Me; R1 = H, OH, CO2H, CO2Me), in which the glutamic acid moiety of the classical antifolates is substituted by phenylglycine, phenylalanine or aminobenzoic acid and their Me esters, were synthesized and evaluated as lipophilic inhibitors of thymidylate synthase (TS). The target compounds were generally potent inhibitors of L. casei and human TS with IC50 values within the narrow range of 0.2-10 μM and 0.003-0.03 μM, resp. Further, most of the target compounds showed cytotoxicity against tumor cell lines of murine and human origin with IC50 values of as low as 0.050 μM. Substitution of another hydroxyl or carboxylic acid/ester group at the Ph ring further increased the potency of TS inhibition and cell growth inhibition. Most effective were compounds I (R = H, R1 = CO2H; R = Me, R1 = CO2Me) in which extra carboxylic acid/ester was present at the Ph ring with nanomolar IC50 values of 0.0044 and 0.0093 μM against human TS and submicro-molar cytotoxic growth inhibition against all four tumor cell lines. In addition to this study using H-Phg-OEt.HCl, there are many other studies that have used H-Phg-OEt.HCl(cas: 59410-82-1Formula: C10H14ClNO2) was used in this study.

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Formula: C10H14ClNO2 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: tert-Butyl (5-aminopentyl)carbamateIn 2021 ,《First orally bioavailable prodrug of proteolysis targeting chimera (PROTAC) degrades cyclin-dependent kinases 2/4/6 in vivo》 was published in European Journal of Medicinal Chemistry. The article was written by Wei, Mingming; Zhao, Rui; Cao, Yuting; Wei, Yujiao; Li, Ming; Dong, Zhiqiang; Liu, Yulin; Ruan, Hao; Li, Ying; Cao, Sheng; Tang, Zhiwen; Zhou, Yuanyuan; Song, Wei; Wang, Yubo; Wang, Jiefu; Yang, Guang; Yang, Cheng. The article contains the following contents:

A growing number of reports suggested that the inhibitor targeting cyclin-dependent kinases (CDK) 2/4/6 can act as a more feasible chemotherapy strategy. In the present paper, a novel PROTAC mol. was developed based on the structure of Ribociclib′s derivative In malignant melanoma cells, the degrader can not only degrade CDK 2/4/6 simultaneously and effectively, but also remarkably induce cell cycle arrest and apoptosis of melanoma cells. Moreover, PROTAC mols. with CRBN ligands always have poor oral bioavailability. We developed the orally bioavailable prodrug for the first time. It would provide general solution for oral administration of the PROTAC mols., derived from CRBN ligands, for animal test conveniently. In the experiment, the researchers used many compounds, for example, tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Recommanded Product: tert-Butyl (5-aminopentyl)carbamate)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Recommanded Product: tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Name: tert-Butyl (5-aminopentyl)carbamateIn 2020 ,《Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1》 appeared in European Journal of Medicinal Chemistry. The author of the article were Cheng, Binbin; Ren, Yichang; Cao, Hao; Chen, Jianjun. The article conveys some information:

Novel resorcinol di-Ph ether-based PROTACs (PROteolysis TArgeting Chimeras) were designed and evaluated for their inhibitory activity against the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) pathway and their ability to degrade PD-L1 protein. Most of the compounds displayed excellent inhibitory activities against PD-1/PD-L1, as assessed by the homogeneous time-resolved fluorescence (HTRF) binding assay, with IC50 values ranging from 25 nM to 200 nM. Among them, compound P22 (I) is one of the best with an IC50 value of 39.2 nM. In addition to inhibiting PD-1/PD-L1 interaction, P22 also significantly restored the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. Furthermore, flow cytometry (FCM) and western-blot data demonstrated that P22 could moderately reduce the protein levels of PD-L1 in a lysosome-dependent manner, which may contribute to its immune effects. Preliminary FCM and western-blot data suggest that it is possible to build PD-L1-targeting PROTAC-like mols. based on PD-1/PD-L1 small mol. inhibitors, though these compounds showed only modest degradation efficiencies. Collectively, this work suggests that P22 may serve as a starting point for exploring the degradation of PD-L1 by PROTAC-like strategy. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Name: tert-Butyl (5-aminopentyl)carbamate)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Name: tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Characterization of the promiscuous N-acyl CoA transferase, LgoC, in legonoxamine biosynthesis》 was written by Maglangit, Fleurdeliz; Alrashdi, Saad; Renault, Justine; Trembleau, Laurent; Victoria, Catherine; Tong, Ming Him; Wang, Shan; Kyeremeh, Kwaku; Deng, Hai. Product Details of 51644-96-3 And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:

More than 500 siderophores are known to date, but only three were identified to be aryl-containing hydroxamate siderophores, legonoxamines A and B from Streptomyces sp. MA37, and aryl ferrioxamine 2 from Micrococcus luteus KLE1011. Siderophores are produced by microorganisms to scavenge iron from the environment, thereby making this essential metal nutrient available to the microbe. We demonstrate here that LgoC from MA37 is responsible for the key aryl-hydroxamate forming step in legonoxamine biosynthesis. Biochem. characterization established that LgoC displays considerable promiscuity for the acylation between N-hydroxy-cadaverine and SNAC (N-acetylcysteamines) thioester derivatives The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Product Details of 51644-96-3)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Product Details of 51644-96-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Synthesis, antimicrobial activity, structure-activity relationship, and molecular docking studies of indole diketopiperazine alkaloids》 were Jia, Bin; Ma, Yang-min; Liu, Bin; Chen, Pu; Hu, Yan; Zhang, Rui. And the article was published in Frontiers in Chemistry (Lausanne, Switzerland) in 2019. SDS of cas: 7524-52-9 The author mentioned the following in the article:

Strategies for the synthesis of indole diketopiperazine alkaloids (indole DKPs) have been described and involve three analogs of indole DKPs – tryprostatin open-ring indole DKPs I [R1 = H, R2 = PhCH2, 4-MeOC6H4CH2, 4-HOC6H4CH2, 4-O2NC6H4CH2; R1 = COR, R = Ph, 4-MeOC6H4, CH:CHPh, 2-furyl, 4-(Me2N)2C6H3, R2 = H], fused pentacyclic indole DKPs II [R3 = Ph, (R)-4-MeOC6H4, (S)-4-HO6H4, etc.], and spiro-pentacyclic indole DKPs III [R4 = Et, n-Pr, n-Bu, CH2CHMe2] and IV [R5 = Ph, 4-MeOC6H4, 3-ClC6H4, 4-ClC6H4, 2-Br-5-ClC6H3]. . The antimicrobial activity and structure-activity relationship (SAR) of 24 indole DKPs were explored. Compounds I (R1 = COR, R = 4-MeOC6H4, 4-HOC6H4) were found to be the most active, with min. inhibitory concentrations (MIC) values in the range of 0.94-3.87μM (0.39-1.56μg/mL) against the four tested bacteria (Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli). Furthermore, compounds III (R4 = Et, n-Pr) displayed broad-spectrum antimicrobial activity with MIC values of 1.10-36.9μM (0.39-12.5μg/mL) against all tested bacteria and plant pathogenic fungi (Colletotrichum gloeosporioides, Valsa mali, Alternaria alternata and Alternaria brassicae). According to the in silico study, compound I (R1 = COR, R = 4-HOC6H4, R2 = H) showed significant binding affinity to the FabH protein from Escherichia coli, which has been identified as the key target enzyme of fatty acid synthesis (FAS) in bacteria. Therefore, these compounds are not only promising new antibacterial agents but also potential FabH inhibitors. In the experiment, the researchers used H-Trp-OMe.HCl(cas: 7524-52-9SDS of cas: 7524-52-9)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.SDS of cas: 7524-52-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vinogradov, A. S.; Krasnov, V. I.; Platonov, V. E. published an article on January 31 ,2008. The article was titled 《Organozinc reagents from polyfluoroarenes: preparation and reactions with allyl halides. Synthesis of allylpolyfluoroarenes》, and you may find the article in Russian Journal of Organic Chemistry.Quality Control of Ethyl 2,3,4,5,6-pentafluorobenzoate The information in the text is summarized as follows:

Organozinc compounds of the general formula ArFZnX (X = Cl, ArF) were synthesized by reactions of Zn with chloropolyfluoroarenes and of Zn/SnCl2 with polyfluoroarenes. Polyfluorinated organozinc compounds reacted with allyl chloride and allyl bromide to give the corresponding allyl-substituted polyfluoroarenes. The reactions with allyl chloride were carried out in the presence of copper(I) salts (CuCl or CuI). In the experiment, the researchers used Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4Quality Control of Ethyl 2,3,4,5,6-pentafluorobenzoate)

Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Quality Control of Ethyl 2,3,4,5,6-pentafluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

HPLC of Formula: 51857-17-1In 2022 ,《Adjusted degradation of BRD4 S and BRD4 L based on fine structural modifications of the pyrrolopyridone scaffold》 appeared in European Journal of Medicinal Chemistry. The author of the article were Chen, Jingjing; He, Huixin; Wei, Aihuan; Li, Yalei; Cheng, Gang; Qin, Hui; Zhong, Hanyue; Liu, Hongchun; Geng, Meiyu; Shen, Aijun; Hu, Youhong. The article conveys some information:

Novel pyrrolopyridone BET degraders were designed and synthesized based on the binding mode between the pyrrolopyridone BET inhibitor with the BRD4 protein. The potent degraders on MV-4-11 cells were discovered through structure-activity relationship study. Modification of warhead on pyrrolopyridone BET degraded significantly regulates BRD4 isoform (long and short) protein degradation, which induced differential cell cycle arrest and apoptosis on MV-4-11 cells. Docking study revealed that the fine structural modification of BET degraders might bind with the BD domain of BRD4 protein to engaged various surface areas that bind with CRBN. In the part of experimental materials, we found many familiar compounds, such as N-Boc-1,6-Diaminohexane(cas: 51857-17-1HPLC of Formula: 51857-17-1)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.HPLC of Formula: 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jiang, Xueyang; Zhou, Junting; Wang, Yang; Liu, Xin; Xu, Kaiying; Xu, Jian; Feng, Feng; Sun, Haopeng published an article in 2021. The article was titled 《PROTACs suppression of GSK-3β, a crucial kinase in neurodegenerative diseases》, and you may find the article in European Journal of Medicinal Chemistry.HPLC of Formula: 51857-17-1 The information in the text is summarized as follows:

Glycogen synthase kinase 3β (GSK-3β) is involved in a variety of diseases such as neurodegenerative diseases, bipolar disorder, and diabetes. In this study, a series of heterobifunctional small mol. proteolysis targeting chimera (PROTAC) were designed and synthesized based on E3 ubiquitin ligase cereblon (CRBN). Most of PROTACs displayed good inhibitory activity, with the IC50 values at the double-digits nanomolar levels and moderate protein degradation ability against GSK-3β. Western-blot data showed compound PG21(I) can effectively degrade GSK-3β in a dose-dependent manner, which can induce 44.2% protein degradation at 2.8μM. Further pharmacol. experiments revealed that the ability of PG21 to degrade GSK-3β is mediated by the ubiquitin-proteasome system (UPS). In addition, PG21 protects against glutamate-induced cell death in HT-22 cells. As the first PROTAC example to degrade GSK-3β protein, the present study has provided potential candidates for further investigation in the biol. function of GSK-3β protein and its association with diseases. In the part of experimental materials, we found many familiar compounds, such as N-Boc-1,6-Diaminohexane(cas: 51857-17-1HPLC of Formula: 51857-17-1)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsHPLC of Formula: 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics