Tag: 200-300

Recommanded Product: 34260-72-5On May 14, 2020 ,《Pyridobenzothiazolones Exert Potent Anti-Dengue Activity by Hampering Multiple Functions of NS5 Polymerase》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Cannalire, Rolando; Chan, Kitti Wing Ki; Burali, Maria Sole; Gwee, Chin Piaw; Wang, Sai; Astolfi, Andrea; Massari, Serena; Sabatini, Stefano; Tabarrini, Oriana; Mastrangelo, Eloise; Barreca, Maria Letizia; Cecchetti, Violetta; Vasudevan, Subhash G.; Manfroni, Giuseppe. The article conveys some information:

Treatment of dengue virus (DENV) and other flavivirus infections is an unmet medical need. The highly conserved flaviviral NS5 RNA-dependent RNA polymerase (RdRp) is an attractive antiviral target that interacts with NS3 and viral RNA within the replication complex assembly. Biochem. and cell-based evidence indicate that targeting cavity B may lead to dual RdRp and NS5-NS3 interaction inhibitors. By ligand-based design around 1H-pyrido[2,1-b][1,3]benzothiazol-1-one (PBTZ) 1, we identified new potent and selective DENV inhibitors that exert dual inhibition of NS5 RdRp and NS3-NS5 interaction, likely through binding cavity B. Resistance studies with compound 4 generated sequence variants in the 3′-untranslated region of RNA while further biochem. experiments demonstrated its ability to block also RNA-NS5 interaction, required for correct RNA synthesis in cells. These findings shed light on the potential mechanism of action for this class of compounds, underlying how PBTZs are very promising lead candidates for further evaluation. In the experimental materials used by the author, we found (S)-Methyl 2-amino-3-(3-hydroxyphenyl)propanoate hydrochloride(cas: 34260-72-5Recommanded Product: 34260-72-5)

(S)-Methyl 2-amino-3-(3-hydroxyphenyl)propanoate hydrochloride(cas: 34260-72-5) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Recommanded Product: 34260-72-5 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Min, Jaeki; Mayasundari, Anand; Keramatnia, Fatemeh; Jonchere, Barbara; Yang, Seung Wook; Jarusiewicz, Jamie; Actis, Marisa; Das, Sourav; Young, Brandon; Slavish, Jake; Yang, Lei; Li, Yong; Fu, Xiang; Garrett, Shalandus H.; Yun, Mi-Kyung; Li, Zhenmei; Nithianantham, Stanley; Chai, Sergio; Chen, Taosheng; Shelat, Anang; Lee, Richard E.; Nishiguchi, Gisele; White, Stephen W.; Roussel, Martine F.; Potts, Patrick Ryan; Fischer, Marcus; Rankovic, Zoran published an article in 2021. The article was titled 《Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs》, and you may find the article in Angewandte Chemie, International Edition.Related Products of 51644-96-3 The information in the text is summarized as follows:

Targeting cereblon (CRBN) is currently one of the most frequently reported proteolysis-targeting chimera (PROTAC) approaches, owing to favorable drug-like properties of CRBN ligands, immunomodulatory imide drugs (IMiDs). However, IMiDs are known to be inherently unstable, readily undergoing hydrolysis in body fluids. Here we show that IMiDs and IMiD-based PROTACs rapidly hydrolyze in commonly utilized cell media, which significantly affects their cell efficacy. We designed novel CRBN binders, Ph glutarimide (PG) analogs, and showed that they retained affinity for CRBN with high ligand efficiency (LE >0.48) and displayed improved chem. stability. Our efforts led to the discovery of PG PROTAC 4 c (SJ995973), a uniquely potent degrader of bromodomain and extra-terminal (BET) proteins that inhibited the viability of human acute myeloid leukemia MV4-11 cells at low picomolar concentrations (IC50=3 pM; BRD4 DC50=0.87 nM). These findings strongly support the utility of PG derivatives in the design of CRBN-directed PROTACs. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Related Products of 51644-96-3)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Related Products of 51644-96-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Duan, Zhenyu; Luo, Qiang; Dai, Xinghang; Li, Xiaoling; Gu, Lei; Zhu, Hongyan; Tian, Xiaohe; Zhang, Hu; Gong, Qiyong; Gu, Zhongwei; Luo, Kui published an article in 2021. The article was titled 《Synergistic Therapy of a Naturally Inspired Glycopolymer-Based Biomimetic Nanomedicine Harnessing Tumor Genomic Instability》, and you may find the article in Advanced Materials (Weinheim, Germany).Safety of N-Boc-1,6-Diaminohexane The information in the text is summarized as follows:

Inspired by natural saccharide-protein complexes, a stimuli-responsive biodegradable and branched glycopolymer-pyropheophorbide-a (Ppa) conjugate (BSP) with saccharide units for cancer therapy is constructed. A linear glycopolymeric conjugate (LSP), a branched glycopolymeric conjugate (BShP) from Ppa with long carbon chains, and a branched conjugate (BHSP) based on poly[N-(2-hydroxypropyl) methacrylamide] (polyHPMA) without saccharide units are prepared as controls. Through structure-activity relationship studies, BSP with a 3D network structure forms stable nanostructures via weak intermol. interactions, regulating the stacking state of Ppa to improve the singlet oxygen quantum yield and the corresponding photodynamic therapy (PDT) effect. BSP shows high loading of olaparib, and are further coated with tumor cell membranes, resulting in a biomimetic nanomedicine (CM-BSPO). CM-BSPO shows highly efficient tumor targeting and cellular internalization properties. The engulfment of CM-BSPO accompanied with laser irradiation results in a prominent antitumor effect, evidenced by disruption of cell cycles in tumor cells, increased apoptosis and DNA damage, and subsequent inhibition of repair for damaged DNA. The mechanism for the synergistic effect from PDT and olaparib is unveiled at the genetic and protein level through transcriptome anal. Overall, this biodegradable and branched glycopolymer-drug conjugate could be effectively optimized as a biomimetic nanomedicine for cancer therapy. In the part of experimental materials, we found many familiar compounds, such as N-Boc-1,6-Diaminohexane(cas: 51857-17-1Safety of N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Safety of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2013,Angewandte Chemie, International Edition included an article by Lv, Hongbin; Cai, Yuan-Bo; Zhang, Jun-Long. Category: esters-buliding-blocks. The article was titled 《Copper-Catalyzed Hydrodefluorination of Fluoroarenes by Copper Hydride Intermediates》. The information in the text is summarized as follows:

We have reported the first example of copper-catalyzed hydrodefluorination of fluoroarenes using silanes as a hydrogen source. Copper exhibited high reactivity and regioselectivity toward a broad scope of fluoroarenes. Moreover, copper hydrides were observed during catalytic process and the unprecedented reactivity toward C-F bonds has been demonstrated. Furthermore, DFT calculations suggest a mechanism for nucleophilic attack on the C-F bonds by the copper hydride. This work presents valuable insights for further studies using copper catalysts for C-F bond functionalization. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4Category: esters-buliding-blocks)

Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

HPLC of Formula: 69134-53-8On October 31, 2019 ,《Compositional characterization of commercial sparkling wines from cv. Ribolla Gialla produced in Friuli Venezia Giulia》 appeared in European Food Research and Technology. The author of the article were Voce, Sabrina; Skrab, Domen; Vrhovsek, Urska; Battistutta, Franco; Comuzzo, Piergiorgio; Sivilotti, Paolo. The article conveys some information:

Ribolla Gialla (RG) is a white grape variety used in the production of high-quality sparkling wines. It is cultivated in a limited area between Friuli Venezia Giulia (FVG-Northeast Italy) and Slovenia; for this reason, there is little information about the composition and chem. characteristics of the sparkling wines produced. This work used different anal. approaches (FTIR spectroscopy, UHPLC-MS/MS, liquid-liquid extraction, SPE and SPME-GC-MS) to characterize thirty-three com. sparkling RG wines from different areas of FVG. The characteristics included the overall volatile profile and content of terpenes, C13-norisoprenoids, lipids, and metabolites of aromatic amino acids. The aroma profile of RG wines was mainly characterized by fermentative esters and β-damascenone, whereas other norisoprenoids and varietal aromas were below the odor threshold. Appreciable amounts of certain fatty acids were found (e.g., palmitic acid), which could be potentially correlated with greater foam stability. However, high concentrations of aromatic amino acids metabolites highlighted a higher risk of developing atypical aging defects. In the experiment, the researchers used Diethyl 2-hydroxypentanedioate(cas: 69134-53-8HPLC of Formula: 69134-53-8)

Diethyl 2-hydroxypentanedioate(cas: 69134-53-8) belongs to esters.HPLC of Formula: 69134-53-8 They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Computed Properties of C10H13ClN2O4On May 31, 1989, Tokutake, S.; Imanishi, Y.; Sisido, M. published an article in Molecular Crystals and Liquid Crystals. The article was 《Efficiency of second harmonic generation from amino acids, peptides, and polypeptides carrying polarizable aromatic groups》. The article mentions the following:

The SHG (2nd harmonic generation) efficiencies of optically active amino acids, their monomeric derivatives, linear and cyclic dipeptides, tripeptides, and polypeptides carrying polarizable groups were tested. Among the 91 samples, L-valine-p-nitroanilide (Val-NA) showed the largest SHG [9.2 × I2ω(urea)]. Val-NA was phase-matchable and transparent at ≥420 nm. Monopeptide and dipeptide derivatives of p-nitrophenylalanine showed large SHG and were transparent at ≥420 nm. In the experiment, the researchers used many compounds, for example, H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6Computed Properties of C10H13ClN2O4)

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Computed Properties of C10H13ClN2O4 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: Ethyl 2,3,4,5,6-pentafluorobenzoateOn October 3, 2012 ,《π-π Interaction Assisted Hydrodefluorination of Perfluoroarenes by Gold Hydride: A Case of Synergistic Effect on C-F Bond Activation》 was published in Journal of the American Chemical Society. The article was written by Lv, Hongbin; Zhan, Jin-Hui; Cai, Yuan-Bo; Yu, Yi; Wang, Bingwu; Zhang, Jun-Long. The article contains the following contents:

“”Synergistic effect”” is prevalent in natural metalloenzymes in activating small mols., and the success has inspired the development of artificial catalysts capable of unprecedented organic transformations. In this work, we found that the attractive π-π interaction between organic additives (as electron-donors) and the perfluorinated arenes (as electron acceptors) is effective in gold hydride catalyzed activation of C-F bonds, specifically hydrodefluorination (HDF) of perfluoroarenes catalyzed by the Sadighi’s gold hydrides [(NHC)AuH] (NHC = N-heterocyclic carbene). Although a weak interaction between [(NHC)AuH] and perfluoroarenes was observed from 1H NMR and UV-vis spectroscopies, low reactivity of [(NHC)AuH] toward HDF was found. In contrast, in the presence of p-N,N-dimethylaminopyridine (DMAP), the HDF of perfluoroarenes with silanes can be efficiently catalyzed by [(NHC)AuH], resulting in mainly the para-hydrodefluorinated products with up to 90% yield and 9 turnovers. The yield of the reaction increases with the more electron-withdrawing groups and degree of fluorination on the arenes, and the HDF reaction also tolerates different function groups (such as formyl, alkynyl, ketone, ester, and carboxylate groups), without reduction or hydrogenation of these function groups. To reveal the role of DMAP in the reactions, the possible π-π interaction between DMAP and perfluoroarenes was suggested by UV-vis spectral titrations, 1H NMR spectroscopic studies, and DFT calculations Moreover, 1H and 19F-NMR studies show that this π-π interaction promotes hydrogen transfer from [(NHC)AuH] to pyridyl N atom, resulting in C-F bond cleavage. The interpretation of π-π interaction assisted C-F activation is supported by the reduced activation barriers in the presence of DMAP (31.6 kcal/mol) than that in the absence of DMAP (40.8 kcal/mol) for this reaction. An anal. of the charge distribution and transition state geometries indicate that this HDF process is controlled by the π-π interaction between DMAP and perfluoroarenes, accompanied with the changes of partial at. charges. In the experimental materials used by the author, we found Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4Recommanded Product: Ethyl 2,3,4,5,6-pentafluorobenzoate)

Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Recommanded Product: Ethyl 2,3,4,5,6-pentafluorobenzoate They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: 144291-47-4On October 13, 2016 ,《Discovery of ONO-7300243 from a Novel Class of Lysophosphatidic Acid Receptor 1 Antagonists: From Hit to Lead》 was published in ACS Medicinal Chemistry Letters. The article was written by Terakado, Masahiko; Suzuki, Hidehiro; Hashimura, Kazuya; Tanaka, Motoyuki; Ueda, Hideyuki; Kohno, Hiroshi; Fujimoto, Taku; Saga, Hiroshi; Nakade, Shinji; Habashita, Hiromu; Takaoka, Yoshikazu; Seko, Takuya. The article contains the following contents:

Lysophosphatidic acid (LPA) evokes various physiol. responses through a series of G protein-coupled receptors known as LPA1-6. A high throughput screen against LPA1 gave compound 4′-{[(4-methoxybenzoyl)(3-phenylpropyl)amino]methyl}-2-biphenylcarboxylic acid (7a) as a hit. The subsequent optimization of 7a led to ONO-7300243 (17a) as a novel, potent LPA1 antagonist, which showed good efficacy in vivo. The oral dosing of 17a at 30 mg/kg led to reduced intraurethral pressure in rats. Notably, this compound was equal in potency to the α1 adrenoceptor antagonist tamsulosin, which is used in clin. practice to treat dysuria with benign prostatic hyperplasia (BPH). In contrast to tamsulosin, compound 17a had no impact on the mean blood pressure at this dose. These results suggest that LPA1 antagonists could be used to treat BPH without affecting the blood pressure. Herein, the authors report the hit-to-lead optimization of a unique series of LPA1 antagonists and their in vivo efficacy. In the part of experimental materials, we found many familiar compounds, such as Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Recommanded Product: 144291-47-4)

Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Recommanded Product: 144291-47-4 Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application In Synthesis of Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylateOn May 13, 2015 ,《Simple Amine-Directed Meta-Selective C-H Arylation via Pd/Norbornene Catalysis》 appeared in Journal of the American Chemical Society. The author of the article were Dong, Zhe; Wang, Jianchun; Dong, Guangbin. The article conveys some information:

Herein we report a highly meta-selective C-H arylation using simple tertiary amines as the directing group. This method takes advantage of Pd/norbornene catalysis, offering a distinct strategy to control the site selectivity. The reaction was promoted by com. available AsPh3 as the ligand and a unique “”acetate cocktail””. Aryl iodides with an ortho electron-withdrawing group were employed as the coupling partner. A wide range of functional groups, including some heteroarenes, are tolerated under the reaction conditions. In addition, the amine directing group can be easily installed and transformed to other common versatile functional groups. We expect this C-H functionalization mode to have broad implications for developing other meta-selective transformations beyond this work. In the experiment, the researchers used many compounds, for example, Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Application In Synthesis of Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate)

Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters.Application In Synthesis of Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Heterocycles from nitrile oxides. II. 1,2,4-Oxadiazin-6-ones》 was written by Hussein, Ahmad Q.; El-Abadelah, Mustafa M.; Sabri, Wail S.. Product Details of 59410-82-1 And the article was included in Journal of Heterocyclic Chemistry on April 30 ,1984. The article conveys some information:

Condensation of RC6H4CCl:NOH (I, R = H, Br, Cl, Me, NO2), precursors of nitrile oxides, with α-amino acid esters, except those of glycine and alanine, gives oxadiazinones II (R1 = H, Me; R2 = CHMe2, CHMeEt, CH2CHMe2, CH2Ph, Ph; R1R2 = CH2CH2CH2). α-Amino alcs., treated with I, give RC6H4C(:NOH)NHCHR2CH2OH, which are also obtained by borohydride reduction of II. In contrast, the products formed from I and α-amino acids decompose readily into the aldehyde, derived from the amino acid, together with the aldoxime. Both products are also formed by mild hydrolysis of II.H-Phg-OEt.HCl(cas: 59410-82-1Product Details of 59410-82-1) was used in this study.

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Product Details of 59410-82-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics