Tag: 200-300

N-[(E)-3-alkoxy-4-hydroxy(alkoxy, alkanoyloxy, aroyloxy)-benzylidene]-4-phenoxyanilines was written by Dikusar, E. A.;Potkin, V. I.;Kozlov, N. G.;Ogorodnikova, M. M.. And the article was included in Russian Journal of Organic Chemistry in 2009.SDS of cas: 20665-85-4 This article mentions the following:

Condensation of 4-phenoxyaniline with benzaldehydes of the vanillin series in methanol gave the corresponding Schiff bases, N-[(E)-3-alkoxy-4-hydroxy(alkoxy, alkanoyloxy, aroyloxy)benzylidene]-4-phenoxyanilines I. In the experiment, the researchers used many compounds, for example, 4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4SDS of cas: 20665-85-4).

4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.SDS of cas: 20665-85-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and Biological Evaluation of C-5 Methyl Substituted 4-Arylthio and 4-Aryloxy-3-Iodopyridin-2(1H)-one Type Anti-HIV Agents was written by Guillemont, Jerome;Benjahad, Abdellah;Oumouch, Said;Decrane, Laurence;Palandjian, Patrice;Vernier, Daniel;Queguiner, Laurence;Andries, Koen;de Bethune, Marie-Pierre;Hertogs, Kurt;Grierson, David S.;Nguyen, Chi Hung. And the article was included in Journal of Medicinal Chemistry in 2009.Related Products of 173341-02-1 This article mentions the following:

A series of C-5 Me substituted 4-arylthio- and 4-aryloxy-3-iodopyridin-2(1H)-ones, e.g. I (X = O, S; R = SCH₂CONHMe, 2-tetrazolyl, 1-imidazolyl, etc.), has been synthesized as new pyridinone analogs for their evaluation as anti-HIV inhibitors. The optimization at the 5-position was developed through an efficient use of the key intermediates 5-ethoxycarbonyl- and 5-cyano-pyridin-2(1H)-ones. Biol. studies revealed that several compounds show potent HIV-1 reverse transcriptase inhibitory properties, for example, I [X = S; R = 1-tetrazolyl, 2-tetrazolyl] are active at 0.6-50 nM against wild type HIV-1 and a panel of major simple/double HIV mutant strains. In the experiment, the researchers used many compounds, for example, tert-Butyl (morpholin-2-ylmethyl)carbamate (cas: 173341-02-1Related Products of 173341-02-1).

tert-Butyl (morpholin-2-ylmethyl)carbamate (cas: 173341-02-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Related Products of 173341-02-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Photochemical hydrogen abstraction as a radiationless transition in the photoketonization of β-dicarbonyl compounds was written by Nikolov, G.;Markov, P.. And the article was included in Journal of Photochemistry in 1981.COA of Formula: C12H14O3 This article mentions the following:

The photoketonization of 2 series of β-dicarbonyl compounds, namely, RC₆H₄COCH₂CO₂Et (R = H, p-Me, m-NO₂, p-Cl, etc.) and R¹COCHR²CO₂R³ (R¹ = Et, hexyl, Me; R² = H, Me, Et, CH₂Ph; R³ = Et, C₅H₁₁, cyclopentylmethyl, etc.), was treated in terms of the tunnel effect theory as a radiationless transition. These series showed a strong dependence of the overall photoketonization reaction rate constants on the reaction coordinate, which is constant for a given series. The rate constants of the 2nd series were reproduced using a single value of the enol OH bond energy D_OH, whereas the rate constants k_r of the 1st series show a marked dependence of D_OH and a correlation between log k_r and D_OH was found. The successful application of the tunnel effect theory to the photoketonization processes of the compounds studied was interpreted to imply that these processes may in fact involve through-space photochem. H migration which is governed by the tunnel effect. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9COA of Formula: C12H14O3).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.COA of Formula: C12H14O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Controlled radical (co)polymerization of (meth)acrylic esters via the reversible addition-fragmentation chain-transfer mechanism was written by Zaitsev, S. D.;Semchikov, Yu. D.;Vasil’eva, E. V.;Kurushina, L. V.. And the article was included in Polymer Science, Series B in 2012.Application of 27249-90-7 This article mentions the following:

The homopolymerization of acrylic and fluoroacrylic esters mediated by benzyl dithiobenzoate and dibenzyl trithiocarbonate proceeds in the controlled mode via the reversible addition-fragmentation chain-transfer mechanism, while the controlled radical polymerization of methacrylic esters is not effected under these conditions. The mol.-mass characteristics of the copolymers of acrylic and methacrylic esters may be satisfactorily controlled by benzyl dithiobenzoate-mediated copolymerization when the content of acrylic esters is no less than 50 mol %. If a reversible addition-fragmentation chain-transfer agent active with respect to only one of the monomers is used, compositionally homogeneous narrowly dispersed copolymers are formed via the azeotropic copolymerization of the monomers up to high conversions. The controlled copolymerization of N-vinylpyrrolidone and fluoroacrylates allows the synthesis of alternating narrowly dispersed amphiphilic copolymers with properties different from those of alternating copolymers with a broad mol.-mass distribution. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Application of 27249-90-7).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application of 27249-90-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lewis acid-catalyzed one-pot sequential reaction for the synthesis of α-halogenated β-keto esters was written by Cui, Han-Feng;Dong, Ke-Yan;Nie, Jing;Zheng, Yan;Ma, Jun-An. And the article was included in Tetrahedron Letters in 2010.Category: esters-buliding-blocks This article mentions the following:

A Lewis acid-catalyzed one-pot sequential transformation of β-keto esters, aromatic aldehydes, and NCS/NBS was reported. The reaction proceeds by way of Knoevenagel condensation/Nazarov cyclization/halogenation to give α-chloro- and α-bromo-β-keto esters in moderate yields with high diastereoselectivities. However, several aromatic aldehydes with electron-withdrawing substituents afforded unexpected α,β’-dichloro-β-keto esters in good to high yields. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Category: esters-buliding-blocks).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chemical composition and antimicrobial activity of the essential oil and lipid content of Carduus pycnocephalus L. growing in Saudi Arabia was written by Al-Shammari, Latifa A.;Hassan, Wafaa H. B.;Al-Youssef, Hanan M.. And the article was included in Journal of Chemical and Pharmaceutical Research in 2012.COA of Formula: C12H22O4 This article mentions the following:

The essential oil of the air dried aerial parts of Carduus pycnocephalus L. F. Asteraceae was prepared by hydrodistillation GC/MS anal. revealed the presence of nineteen components representing 100% of the total oil. Hexadecanoic acid (39.62%) was the prominent component of the oil. GC/MS anal. of the unsaponifiable matter of the petroleum ether extract of the aerial parts of the plant revealed the presence of nineteen compounds; sixteen compounds were identified constituting 72.80% of total unsaponifiable matter. Olean-12-en-3-α-ol (20.39%), ursa-9(11), 12-dien-3-ol (17.74%) and hexadecanoic acid (17.62%) were the major components. GC/MS anal. of fatty acid Me ester showed the presence of twenty fatty acids Me esters (91.38%). The main known components were 1,2benzendicarboxylic acid dimethylester (31.08), palmitic acid Me ester (20.08%) and azelaic acid di-Me ester (7.60%). The antimicrobial, antispasmodic and anti-inflammatory effects were studied. The volatile oil and petroleum ether extract showed no antimicrobial activity, while the petroleum ether extract showed antispasmodic, anti-inflammatory effects. This is the first study on chem. composition and biol. activities of the volatile oil and lipid contents of Carduus pycnocephalus L. endemic for Saudi Arabia. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6COA of Formula: C12H22O4).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C12H22O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

RAFT synthesis of triply responsive poly[N-[2-(dialkylamino)ethyl]acrylamide]s and their N-substitute determined response was written by Wang, Ke;Song, Zefeng;Liu, Chonggao;Zhang, Wangqing. And the article was included in Polymer Chemistry in 2016.Name: Benzyl benzodithioate This article mentions the following:

The thermo- and pH/CO₂-responsive poly[N-[2-(dialkylamino)ethyl]acrylamide]s containing a polyacrylamide backbone but different N-substitutes of dialkylamine were synthesized and their solution properties were comparatively checked. A controllable RAFT synthesis of poly[N-[2-(dialkylamino)ethyl]acrylamide]s was achieved when a typical trithiocarbonate containing an easily cleavable R group was employed. The RAFT polymerization rate decreases with the increasing C-number in the N-substitutes. The thermo- and pH/CO₂-responsive property of poly[N-[2-(dialkylamino)ethyl]acrylamide]s is firmly correlative to the N-substitutes. With the C-number in the R-substitute increasing, the solution properties of poly(N-[2-(dialkylamino)ethyl]acrylamide)s undergo a soluble-to-thermoresponsive-to-insoluble evolution, and the critical pH of poly[N-[2-(dialkylamino)ethyl]acrylamide]s gradually decreases. The dialkylamine moieties in the poly[N-[2-(dialkylamino)ethyl]acrylamide]s lead to a characteristic CO₂-response during CO₂/N₂ bubbling. The present study reveals the structure-dependent solution properties of the thermo- and pH/CO₂-responsive poly[N-[2-(dialkylamino)ethyl]acrylamide]s, and these multistimuli-responsive polymers are believed to be useful due to the controllable RAFT synthesis and tunable solution properties. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Name: Benzyl benzodithioate).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Name: Benzyl benzodithioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

2-Oxo-1,8-naphthyridine-3-carboxylic acid derivatives with potent gastric antisecretory properties was written by Santilli, Arthur A.;Scotese, Anthony C.;Bauer, Raymond F.;Bell, Stanley C.. And the article was included in Journal of Medicinal Chemistry in 1987.Category: esters-buliding-blocks This article mentions the following:

The syntheses of 2-oxo-1,8-naphthyridine-3-carboxylic acid derivatives, e.g., I (R = H, Me, Et, Pr, allyl, etc.; R¹ = NH₂, 4-methylpiperazinyl, etc.; R² = H, Me), having potent gastric antisecretory properties in the Shay rat model are described. Two of the more potent compounds tested that were selected for more detailed dose-response evaluation were I (R = Et, R¹ = NH₂, R² = H; II) and I (R = Et, R¹ = 4-methylpiperazinyl, R² = Me; III). II and III lowered total acid output in a dose-related fashion, were more potent than cimetidine, and showed inhibitory activity in food-stimulated acid secretion in the Pavlov dog. The mechanism of action for this series is not known. Details of structure-activity relationships are described. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Category: esters-buliding-blocks).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 3: Exploration of effective compounds in arthritis models was written by Shimizu, Hiroki;Yamasaki, Tomonori;Yoneda, Yoshiyuki;Muro, Fumihito;Hamada, Tomoaki;Yasukochi, Takanori;Tanaka, Shinji;Toki, Tadashi;Yokoyama, Mika;Morishita, Kaoru;Iimura, Shin. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.HPLC of Formula: 525362-07-6 This article mentions the following:

We have discovered imidazo[1,2-b]pyridazine derivatives that show suppressive activity of inflammation in arthritis models. We optimized the substructures of imidazo[1,2-b]pyridazine derivatives to combine potent IKKβ inhibitory activity, TNFα inhibitory activity in vivo and excellent pharmacokinetics. The compound we have acquired, which had both potent activities and good pharmacokinetic profiles based on improved physicochem. properties, demonstrated efficacy on collagen-induced arthritis models in mice and rats. In the experiment, the researchers used many compounds, for example, Methyl 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas: 525362-07-6HPLC of Formula: 525362-07-6).

Methyl 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas: 525362-07-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.HPLC of Formula: 525362-07-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sol-gel-sol-cloudy transitions of aqueous solutions of multi-responsive hydrophilic diblock copolymer poly(methoxytri (ethylene glycol) acrylate-co-acrylic acid)-b-poly(ethoxydi(ethylene glycol) acrylate) was written by Jin, Naixiong;Woodcock, Jeremiah W.;Xue, Chenming;O’Lenick, Thomas G.;Jiang, Xueguang;Jin, Shi;Dadmun, Mark D.;Zhao, Bin. And the article was included in PMSE Preprints in 2012.Reference of 27249-90-7 This article mentions the following:

Herein, we present a strategy to tune the upper boundary of the sol-gel phase diagram of a thermosensitive hydrophilic diblock copolymer. The polymer, poly(c-co-acrylic acid)-b-poly(ethoxydi(ethylene glycol) acrylate) (P(TEGMA-co-AA)-b-PDEGEA), was prepared by reversible addition-fragmentation chain transfer polymerization The higher LCST block of the diblock copolymer contained a small amount of carboxylic acid groups, and thus its LCST can be tuned by changing the pH of the solution, which allowed us to shift the upper boundary of the sol-gel phase diagram. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Reference of 27249-90-7).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Reference of 27249-90-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics