Tag: 200-300

In 2013,Applied Organometallic Chemistry included an article by Lei, Xiangyang; Obregon, Karla A.; Alla, Jhansi. Quality Control of Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate. The article was titled 《Suzuki-Miyaura coupling reactions of aryl chlorides catalyzed by a new nickel(II) σ-aryl complex》. The information in the text is summarized as follows:

A new nickel(II) σ-aryl complex, trans-chloro(9-phenanthrenyl)bis(triphenylphosphine)nickel(II), was used as a precatalyst for the Suzuki-Miyaura coupling reactions of aryl chlorides. The catalytic conditions were optimized by investigating the cross-coupling of p-chloroanisole with phenylboronic acid. The results show that this complex is efficient for both electron-rich and electron-deficient aryl chlorides, though it gives better yields for activated arylboronic acids than deactivated ones. All isolated cross-coupled biaryl products have been characterized by 1H and 13C NMR, and their spectral data are consistent with those reported. Side products from the coupling of arylboronic acid with the precatalyst complex have also been isolated and characterized, which is helpful for understanding the coupling mechanism. Copyright 2013 John Wiley & Sons, Ltd. In the experimental materials used by the author, we found Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4Quality Control of Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate)

Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate(cas: 144291-47-4) belongs to esters.Quality Control of Methyl 4′-formyl-[1,1′-biphenyl]-2-carboxylate They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Matam, Sivakumar; Kaliyan, Prabakaran; Selvaraj, Loganathan; Muthu, Seenivasa Perumal; Lohanathan, Bharathi Priya; Viswanadhan, Vijaya Padma; Makala, Himesh; Venkatasubramanian, Ulaganathan published their research in Journal of Heterocyclic Chemistry in 2021. The article was titled 《Convenient method for the synthesis of some novel chiral methyl 2-(2-oxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)propanoate derivatives and biological evaluation of their antioxidant, cytotoxic, and molecular docking properties》.Reference of H-Trp-OMe.HCl The article contains the following contents:

Ten chiral Me 2-(2-oxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)propanoate derivatives, e.g. I, have been synthesized from optically pure amino Me phenols and 4-nitrophenyl chloroformate. Synthesized ester derivatives were screened for their in vitro antioxidant activity. Title compounds have exhibited comparable antioxidant activity with ascorbic acid as a standard Further, the in vitro cytotoxicity of these compounds were studied through MTT cell proliferation assay in addition the effect on LDH leakage and NO release. Among the derivatives, I showed extremely best activity and the IC50 value (12.54 ± 0.71μM) is very close to doxorubicin (7.2 ± 0.58μM) as a standard Also, mol. docking studies have been carried out with STAT-3 (PDB ID: 1BG1) and BCL-2 (PDB ID: 4AQ3) proteins against the four active compounds, e.g. I. The binding energies of the tested compounds were in the range of -7.76 to -8.41 kcal/mol, which is very close to doxorubicin (-8.53 kcal/mol) as a standard These mol. docking results are in good agreement with the in vitro studies. The experimental part of the paper was very detailed, including the reaction process of H-Trp-OMe.HCl(cas: 7524-52-9Reference of H-Trp-OMe.HCl)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Reference of H-Trp-OMe.HCl

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Probing the B- & C-rings of the antimalarial tetrahydro-β-carboline MMV008138 for steric and conformational constraints》 was written by Ding, Sha; Ghavami, Maryam; Butler, Joshua H.; Merino, Emilio F.; Slebodnick, Carla; Cassera, Maria B.; Carlier, Paul R.. SDS of cas: 7524-52-9 And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020. The article conveys some information:

The antimalarial candidate MMV008138 (1a, I, (1R,3S) active isomer shown) is of particular interest because its target enzyme (IspD) is absent in human. To achieve higher potency, and to probe for steric demand, a series of analogs of 1a were prepared that featured methyl-substitution of the B- and C-rings, as well as ring-chain transformations. X-ray crystallog., NMR spectroscopy and calculation were used to study the effects of these modifications on the conformation of the C-ring and orientation of the D-ring. Unfortunately, all the B- and C-ring analogs explored lost in vitro antimalarial activity. The possible role of steric effects and conformational changes on target engagement are discussed. The experimental part of the paper was very detailed, including the reaction process of H-Trp-OMe.HCl(cas: 7524-52-9SDS of cas: 7524-52-9)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.SDS of cas: 7524-52-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer》 were Wang, Xin; Yu, Chenhua; Wang, Cheng; Ma, Yakun; Wang, Tianqi; Li, Yao; Huang, Zhi; Zhou, Manqian; Sun, Peiqing; Zheng, Jianyu; Yang, Shengyong; Fan, Yan; Xiang, Rong. And the article was published in European Journal of Medicinal Chemistry in 2019. Safety of tert-Butyl (5-aminopentyl)carbamate The author mentioned the following in the article:

A series of novel, highly potent, selective CDK9 inhibitors with cancer stem cells (CSCs) inhibition activity were designed and synthesized for non-small-cell lung cancer (NSCLC) therapy. Structure-activity relationship anal. based on enzymic and cellular activities led to the discovery of a promising inhibitor 21e(I). I potently inhibited CDK9 with IC50 value of 11 nM and suppressed the stemness properties of NSCLC effectively. It could decrease the stemness phenotypes of NSCLC cells, including tumor sphere formation, side-population and stemness markers abundance. I displayed good selectivity over the CDK family kinases and kinase profiling assay against 381 kinases. In addition, I inhibited cell proliferation, colony-formation, and cell cycle progression and induced apoptosis in NSCLC. In H1299 xenograft mouse model, a once-daily dose of I at 20 mg/kg significantly suppressed the tumor growth without obvious toxicity. Studies of mechanisms of action indicated that I efficiently inhibited CDK9 signaling pathway and stemness both in vitro and in vivo. Collectively, I as a novel CDK9 inhibitor with CSCs inhibition properties could be a promising agent for the treatment of NSCLC. In the experiment, the researchers used tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Safety of tert-Butyl (5-aminopentyl)carbamate)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Safety of tert-Butyl (5-aminopentyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase α/β-Hydrolase Domain-Containing 12 (ABHD12)》 were Ogasawara, Daisuke; Ichu, Taka-Aki; Jing, Hui; Hulce, Jonathan J.; Reed, Alex; Ulanovskaya, Olesya A.; Cravatt, Benjamin F.. And the article was published in Journal of Medicinal Chemistry in 2019. Formula: C10H22N2O2 The author mentioned the following in the article:

ABHD12 is a membrane-bound hydrolytic enzyme that acts on the lysophosphatidylserine (lyso-PS) and lysophosphatidylinositol (lyso-PI) classes of immunomodulatory lipids. Human and mouse genetic studies point to a key role for the ABHD12-(lyso)-PS/PI pathway in regulating (neuro)immunol. functions in both the central nervous system and periphery. Selective inhibitors of ABHD12 would offer valuable pharmacol. probes to complement genetic models of ABHD12-regulated (lyso)-PS/PI metabolism and signaling. Here, we provide a detailed description of the discovery and activity-based protein profiling (ABPP) guided optimization of reversible thiourea inhibitors of ABHD12 that culminated in the identification of DO264 as a potent, selective, and in vivo active ABHD12 inhibitor. We also show that DO264, but not a structurally related inactive control probe (S)-DO271, augments inflammatory cytokine production from human THP-1 macrophage cells. The in vitro and in vivo properties of DO264 designate this compound as a suitable chem. probe for studying the biol. functions of ABHD12-(lyso)-PS/PI pathways. The results came from multiple reactions, including the reaction of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Formula: C10H22N2O2)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Formula: C10H22N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin》 were Gao, Feng; Liang, Yuru; Zhou, Pengfei; Cheng, Jiayi; Ding, Kuiling; Wang, Yang. And the article was published in European Journal of Medicinal Chemistry in 2019. HPLC of Formula: 51644-96-3 The author mentioned the following in the article:

Microtubule is one of the important targets for cancer treatment. A novel class of diaryl substituted imidazo[4,5-c]pyridin-2-ones and imidazo[4,5-c]pyridines were designed based on combination principles by merging the structures of β-lactams and purine-type compounds known as tubulin polymerization inhibitor and katanin activity up-regulator, resp. Their antitumor activities were evaluated in vitro and the mechanism was elucidated, leading to the identification of 1,6-diaryl-1H-imidazo[4,5-c]pyridin-2(3H)-one I as the first bifunctional agent that can target both tubulin and katanin simultaneously. The in vivo assays verified that compound I significantly inhibited xenograft tumor growth with good pharmacokinetic characteristics, demonstrating a promising potential for further development into anti-tumor drug candidates with a unique mechanism of dual-targeting microtubule. After reading the article, we found that the author used tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3HPLC of Formula: 51644-96-3)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).HPLC of Formula: 51644-96-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: N-Boc-1,6-DiaminohexaneIn 2021 ,《Discovery of sertraline and its derivatives able to combat drug-resistant gastric cancer cell via inducing apoptosis》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Mu, Chao; Peng, Rui-Kun; Guo, Chun-Ling; Li, Ao; Yang, Xiu-Ming; Zeng, Rong; Li, Yu-Long; Gu, Jing; Ouyang, Qin. The article contains the following contents:

Resistance phenomena during chemotherapy of tumor has been severely hampering the applications of chemotherapeutics. Due to advantage of drug repurposing, discovery of new chemosensitizers based on approved drugs is an effect strategy to find new candidates. Herein, we found antidepressant drug – sertraline, could sensitize drug-resistant gastric cancer cell (SGC-7901/DDP) with the IC50 value of 18.73μM. To understand the structure-activity relationship and improve the activity, 30 derivatives were synthesized and evaluated. The IC50 value of the best compound was improved to 5.2μM. Moreover, we found apoptosis induction and cell cycle arrest was the reason for the cell death of the drug-resistant cells after treatment of sertraline and derivatives, and PI3K/Akt/mTOR pathway was involved. The experimental process involved the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Recommanded Product: N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Recommanded Product: N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: N-Boc-1,6-DiaminohexaneIn 2021 ,《Mechanical bonding activation in rotaxane-based organocatalysts》 was published in Organic Chemistry Frontiers. The article was written by Perez, Jesus de Maria; Puigcerver, Julio; Orlando, Tainara; Pastor, Aurelia; Martins, Marcos A. P.; Alajarin, Mateo; Martinez-Cuezva, Alberto; Berna, Jose. The article contains the following contents:

Herein the enhanced efficiency as organocatalysts of a series of succinamide-based hydrogen-bonded [2]rotaxanes functionalized with an acyclic secondary amine as the catalytically active site was reported. Their catalytic activity was also evaluated by, comparing with that of their non-interlocked threads, in an iminium-type process between crotonaldehyde and acetylacetone. The presence of an interlocked polyamide macrocycle notably increased the catalytic activity of the entwined organocatalysts. The mechanized catalysts rapidly form a reactive iminium intermediate with the aldehyde, increasing its population. The hydrogen-bonding interaction established between the macrocycle and the electrophile was proposed as one of the reasons for the rapid formation and stabilization of this key intermediate. The experimental part of the paper was very detailed, including the reaction process of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Recommanded Product: N-Boc-1,6-Diaminohexane)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Recommanded Product: N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Product Details of 51857-17-1In 2020 ,《Development of selective mono or dual PROTAC degrader probe of CDK isoforms》 appeared in European Journal of Medicinal Chemistry. The author of the article were Zhou, Fei; Chen, Luyu; Cao, Chaoguo; Yu, Jiang; Luo, Xiaojiao; Zhou, Peiting; Zhao, Lifeng; Du, Wu; Cheng, Jijun; Xie, Yongmei; Chen, Yuanwei. The article conveys some information:

Cyclin-dependent kinase (CDK) family members are promising mol. targets in discovering potent inhibitors in disease settings, they function differentially. CDK2, CDK4 and CDK6, directly regulate the cell cycle, while CDK9 primarily modulates the transcription regulation. In discovering inhibitors of these CDKs, toxicity associated with off-target effect on other CDK homologs often posts as a clin. issue and hinders their further therapeutic development. To improve efficacy and reduce toxicity, here, using the Proteolysis Targeted Chimeras (PROTACs) approach, we design and further optimize small mol. degraders targeting multiple CDKs. We showed that heterobifunctional compound A9 selectively degraded CDK2. We also identified a dual-degrader, compound F3, which potently induced degradation of both CDK2 (DC50: 62 nM) and CDK9 (DC50: 33 nM). In human prostate cancer PC-3 cells, compound F3 potently inhibits cell proliferation by effectively blocking the cell cycle in S and G2/M phases. Our preliminary data suggests that PROTAC-oriented CDK2/9 degradation is potentially an effective therapeutic approach. In the experimental materials used by the author, we found N-Boc-1,6-Diaminohexane(cas: 51857-17-1Product Details of 51857-17-1)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Product Details of 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Singh, Manpreet; Jamra., Rahul; Paul, Avijit K.; Malakar, Chandi C.; Singh, Virender published an article in Asian Journal of Organic Chemistry. The title of the article was 《KI-assisted Sulfur Activation/Insertion/Denitration Strategy towards Dual C-S Bond Formation for One-pot Synthesis of β-Carboline-tethered 2-Acylbenzothiophenes》.Synthetic Route of C12H15ClN2O2 The author mentioned the following in the article:

A simple and efficient KI promoted sulfur activation-insertion/de-nitration strategy has been developed for the synthesis of β-carboline C1 tethered 2-acylbenzothiophenes via one-pot assembly of 1-acetyl β-carbolines (an alkaloid based scaffold), 2-nitrobenzaldehydes and elemental sulfur. This expeditious reaction proceeds through the formation of β-carboline linked nitro-chalcones followed by embodiment of elemental sulfur to generate the multifunctional β-carboline linked benzothiophene derivatives The highlighted features of this efficient methodol. are transition metal-free conditions, use of inexpensive and non-toxic catalyst, easy procedure, short reaction time, and broad substrate scope with good yields. The scope of this protocol has been extended for the synthesis of a range of novel compounds with significant diversity. The results came from multiple reactions, including the reaction of H-Trp-OMe.HCl(cas: 7524-52-9Synthetic Route of C12H15ClN2O2)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Synthetic Route of C12H15ClN2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics