Tag: 200-300

An Improved Preparation of Arylboronates: Application in One-Pot Suzuki Biaryl Synthesis was written by Zhu, Lei;Duquette, Jason;Zhang, Mingbao. And the article was included in Journal of Organic Chemistry in 2003.HPLC of Formula: 525362-07-6 This article mentions the following:

The Miyaura arylboronate synthesis was modified by substituting a ligandless palladium catalyst for PdCl₂(dppf). Palladium acetate, free of ligand, was highly effective for these coupling reactions. This modified procedure is advantageous over the original Miyaura synthesis in ease of workup, catalyst removal, and low catalyst cost. Furthermore, the boronates formed in this manner can be used directly for Suzuki coupling reactions in a one-pot fashion. The biaryl products have improved impurity profiles and reduced heavy metal contamination. Thus, 4-BrC₆H₄COMe and bis(pinacolato)diboron reacted in DMF containing Pd(OAc)₂ and KOAc for 2-3 h at 80° and the cooled reaction mixture treated with 4-BrC₆H₄NO₂ in the presence of cesium carbonate and Pd(PPh₃)₄ at 80° overnight to give 1-(4′-nitrobiphenyl-4-yl)ethanone in >99% yield and >95% purity. In the experiment, the researchers used many compounds, for example, Methyl 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas: 525362-07-6HPLC of Formula: 525362-07-6).

Methyl 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas: 525362-07-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.HPLC of Formula: 525362-07-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Controlled radical copolymerization of N-(4-hydroxyphenyl) maleimide and styrene based on RAFT process was written by Lu, Yan-bing;Sun, Rong-xin;Sun, Li-li;Xia, Xin-nian;Xu, Wei-jian. And the article was included in Gaofenzi Cailiao Kexue Yu Gongcheng in 2009.Quality Control of Benzyl benzodithioate This article mentions the following:

Copolymerization of N-(4-carboxyphenyl) maleimide with styrene was introduced in THF by taking S-benzyl dithiobenzoate as a RAFT reagent. Results show that the number average mol. weight of the obtained copolymers increases linearly with the increase of the monomer conversion and the distributions of the copolymers are less than 1.5, showing that the RAFT regent S-benzyl dithiobenzoate possesses a good ability to control the copolymerization of N-(4-carboxyphenyl) maleimide, with styrene. Investigations of the copolymerization at different temperatures gave the apparent activation energy about 1.39 kJ/mol. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Quality Control of Benzyl benzodithioate).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Quality Control of Benzyl benzodithioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Photoredox-Induced Radical Relay toward Functionalized β-Amino Alcohol Derivatives was written by An, Xiao-De;Jiao, Yan-Yan;Zhang, Hao;Gao, Yuxiang;Yu, Shouyun. And the article was included in Organic Letters in 2018.Recommanded Product: tert-Butyl (3-ethynylphenyl)carbamate This article mentions the following:

A radical relay strategy is described to synthesize functionalized β-amino alcs. This strategy is enabled by photoredox-catalyzed and nitrogen-centered radical-triggered cascade reactions of styrenes (or phenylacetylenes), enol derivatives, and O-acyl hydroxylamines in DMSO. The broad synthetic application of this method is demonstrated by the reaction of structurally diverse reaction components, including complex mol. scaffolds. Multiple functional groups of the resultant highly functionalized β-amino alc. derivatives facilitate their further transformations. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3Recommanded Product: tert-Butyl (3-ethynylphenyl)carbamate).

tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: tert-Butyl (3-ethynylphenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Highly selective formation of unsaturated esters or cascade reactions to α,ω-diesters by the methoxycarbonylation of alkynes catalyzed by palladium complexes of 1,2-bis(ditertbutylphosphinomethyl)benzene was written by Magro, A. Alberto Nunez;Robb, Lynzi-Marie;Pogorzelec, Peter J.;Slawin, Alexandra M. Z.;Eastham, Graham R.;Cole-Hamilton, David J.. And the article was included in Chemical Science in 2010.Application of 106-79-6 This article mentions the following:

The methoxycarbonylation of phenylethyne catalyzed by Pd/1,2-bis-(ditertiarybutylphosphinomethyl)benzene gives the unusual linear product, Me cinnamate with high activity (initial turnover frequency, TOF_o > 1700 mol product·(mol catalyst·h)^-1) and regioselectivity (>90%). Terminal aliphatic alkynes give α,β-unsaturated esters after short reaction times or α,ω-diesters, including di-Me 1,6-hexanedioate (di-Me adipate), from 1-butyne after longer times. The diesters are formed by a cascade methoxycarbonylation-isomerization-methoxycarbonylation sequence. Methoxycarbonylation of internal alkynes (e.g. 4-octyne) gives the mono-carbonylated product as a result of the low propensity of the tri-substituted double bond of the product towards isomerization. Hydroxycarbonylation of phenylethyne gives predominantly E-3-phenylpropanoic acid with smaller amounts of branched and disubstituted products as well as 3-phenylpropanoic acid. Evidence is presented that the reactions occur via a hydride mechanism. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Application of 106-79-6).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 106-79-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and some pharmacological properties of alkyl esters of various ω-phenyl DL-amino acids was written by Schulz, Elisabeth;Sprung, W. D.;Kroening, G.. And the article was included in Pharmazie in 1983.HPLC of Formula: 10203-58-4 This article mentions the following:

DL-Ph(CH₂)_mCH(NH₂)(CH₂)_nCO₂R.HCl (I; m = 0, n = 0, 1, 2; m = 2, n = 0; R = straight- or branched-chain alkyl) (28 compounds) were prepared by esterification of the corresponding acids. Spasmolytic activities were determined in vitro and found to correlate with the length of the carbon chain in the mol. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4HPLC of Formula: 10203-58-4).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. HPLC of Formula: 10203-58-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Controlled synthesis of copolymers of styrene and methyl methacrylate in the presence of reversible chain transfer agents was written by Chernikova, E. V.;Tarasenko, A. V.;Yulusov, V. V.;Garina, E. S.;Golubev, V. B.. And the article was included in Vysokomolekulyarnye Soedineniya, Seriya A i Seriya B in 2009.Category: esters-buliding-blocks This article mentions the following:

Mol. weight characteristics of styrene-Me methacrylate copolymer obtained via reversible chain transfer mechanism in the presence of dithiobenzoate agents were studied. In order to obtain copolymers with narrow mol. weight distributions, low mol. weight chain transfer agents (CTA) were be used. CTA were active in homopolymerization of both monomers. Conditions for the preparation of block copolymers with narrow mol. weight distribution with and a given structure and mol. weight of the blocks were determined Polymeric reversible CTA was responsible for the composition and mol. weight of the 1st block, while the structure of the second block depended on the compositions of the monomer mixture Mol. weight characteristics depended on the concentration of CTA and monomer conversion. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Category: esters-buliding-blocks).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Water-soluble anionic fluorophores from truxene was written by Earmrattana, Nopporn;Sukwattanasinitt, Mongkol;Rashatasakhon, Paitoon. And the article was included in Dyes and Pigments in 2012.Recommanded Product: 313648-56-5 This article mentions the following:

Two new water-soluble fluorophores are synthesized from truxene and ester-substituted aryl acetylenes. The truxene core is decorated by 2-(2′-methoxy)ethoxyethyl groups to enhance the hydrophilicity of these fluorophores and to prevent the aggregation by π-stacking in aqueous media. The conjugated structures are assembled by iodination of the truxene core and subsequent Sonogashira coupling with aryl acetylenes. Upon the hydrolysis of the ester groups, water-soluble fluorophores are obtained in good to excellent yield (30-71% for 3 steps). A photophys. study reveals that these compounds exhibit strong fluorescence signals (quantum yield 46-63%) with maximum emission wavelength around 390-400 nm in aqueous phosphate buffer. Preliminary screening on sensing application shows that their fluorescent signals can be selectively quenched by porphyrin-containing metalloproteins. In the experiment, the researchers used many compounds, for example, Dimethyl 5-ethynylisophthalate (cas: 313648-56-5Recommanded Product: 313648-56-5).

Dimethyl 5-ethynylisophthalate (cas: 313648-56-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: 313648-56-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and Investigation of Therapeutic Potential of Isoform-Specific HDAC8 Inhibitors for the Treatment of Cutaneous T Cell Lymphoma was written by Umamaheswari, Appavoo;Puratchikody, Ayarivan;Hari, Natarajan. And the article was included in Anti-Cancer Agents in Medicinal Chemistry in 2019.Recommanded Product: 106-79-6 This article mentions the following:

The aim of this paper was to synthesis and evaluates HDAC8 isoform specific inhibitors. Based on the preliminary report on the design and in-silico studies of 52 hydroxamic acid derivatives bearing multi-substituent heteroaromatic rings with chiral amine linker, five compounds were shortlisted and synthesized by microwave assisted approach and high yielding synthetic protocol. A series of in-vitro assays in addition to HDAC8 inhibitory activity was used to evaluate the synthesized compounds Serine derivatives I [R = H, MeO, OH; R¹ = H, Br; R² = Me, NH₂, MeO] and II exerted the anti-proliferative activities against CTCL cell lines at 20- 100 μM concentrations Both the compounds I and II exhibited μM inhibitory activity against HDAC8. The compound I [R = OH, R¹ = Br, R² = Me] displayed remarkable HDAC8 selectivity superior to that of the standard drug, SAHA with an IC50 at 0.1μM. Simple modifications at different portions of pharmacophore in the hydroxamic acid analogs were effective for improving both HDAC8 inhibitory activity and isoform selectivity. Potent and highly isoform-selective HDAC8 inhibitors were identified. These findings were expedient for further development of HDAC8-selective inhibitors. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Recommanded Product: 106-79-6).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 106-79-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vanillin esters in reactions with indan-1,3-dione was written by Kozlov, N. G.;Basalaeva, L. I.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2006.Recommanded Product: 4-Formyl-2-methoxyphenyl isobutyrate This article mentions the following:

2-Methoxy-4-(12-oxo-12H-benzo[f]indeno[1,2-b]quinolin-13-yl)phenyl esters of carboxylic acids were synthesized by the three-component condensation of indan-1,3-dione, 2-naphthylamine, and O-acylvanillin. 2-Arylideneindan-1,3-diones formed during the reaction were isolated. In the experiment, the researchers used many compounds, for example, 4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4Recommanded Product: 4-Formyl-2-methoxyphenyl isobutyrate).

4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: 4-Formyl-2-methoxyphenyl isobutyrate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of new donor-acceptor copolymer and its application in organic bulk hetero-junction solar cells was written by Zou, Wenwu;Liu, Ying;Jia, Qingming;Ge, Ziyi. And the article was included in Youji Huaxue in 2013.Category: esters-buliding-blocks This article mentions the following:

Alternative copolymer (PBDTDT) was synthesized from acceptor unit with strong electro-withdrawing structure of di-Bu malonate in branch chain and donor unit based on benzo[1,2-b:4,5-b’]dithiophene. And its thermal, optical, electrochem. properties and photovoltaic properties blending with [6,6]-phenyl-C₇₁ butyric acid Me ester as the active layer in the bulk hetero-junction devices of organic solar cells were investigated. The influence of different ratio of polymer PBDTDT and PC₇₁BM on the photovoltaic properties was also studied. And the open voltage reached 0.82 V, when the weight ratio of PBDTDT and PC₇₁BM is 1 3, and its power conversion efficiency (PCE) was 0.90%, with V_oc of 0.82 V, J_sc of 3.25 mA/cm² and FF of 33.8%. Comparing with the poly(3-hexylthiophene) (P3HT) in the same method, the solar cells with P3HT blending with PC₇₁BM as the active layer can only get 0.55 V, which can be lower about 0.29 V than that of the PBDTDT. And the possible factors resulting in low PCE and the higher open voltage than that of P3HT were analyzed. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Category: esters-buliding-blocks).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics