Tag: 200-300

Design, synthesis and antimalarial activity of novel, quinoline-Based, zinc metallo-aminopeptidase inhibitors was written by Flipo, Marian;Florent, Isabelle;Grellier, Philippe;Sergheraert, Christian;Deprez-Poulain, Rebecca. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Recommanded Product: Diethyl isobutylmalonate This article mentions the following:

PfA-M1, a neutral zinc aminopeptidase of Plasmodium falciparum, is a new potential target for the discovery of antimalarials. The design and synthesis of a library of 45 quinoline-based inhibitors of PfA-M1 is reported. The best inhibitor displays an IC₅₀ of 854 nM. The antimalarial activity on a CQ-resistant strain and the specificity towards mammalian aminopeptidase N are also discussed. Compounds thus prepared and evaluated included N¹-hydroxy-N²-(2-methylpropyl)-N²-(4-quinolinyl)propanediamide, N¹-hydroxy-N²,2-bis(2-methylpropyl)-N²-(4-quinolinyl)propanediamide and 2-amino-N¹-hydroxy-N²-(2-methylpropyl)-N²-(4-quinolinyl)propanediamide. These compounds were analogs of N-(cyclopropylmethyl)-N-(4-quinolinyl)-β-alaninamide. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Recommanded Product: Diethyl isobutylmalonate).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: Diethyl isobutylmalonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Novel hyperbranched molecules containing pyrrole units from diacetylene compounds was written by Godinez Sanchez, J.;Fomina, L.;Rumsh, L.. And the article was included in Polymer Bulletin (Heidelberg, Germany) in 2010.Category: esters-buliding-blocks This article mentions the following:

Novel hyperbranched mols. containing pyrrole units were obtained from ortho-, meta-, and para-diaminodiphenyldiacetylenes, as AB₂ type monomers by one-step polymerization Diacetylenic fragments reacted with terminal aminogroups in the presence of copper chloride to give pyrrole units. Diaminodiphenyldiacetylene monomers have been synthesized from ethynilanilines in three steps. The novel monomers and hyperbranched mols. were characterized by NMR, IR and thermal anal. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3Category: esters-buliding-blocks).

tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Creation through Immobilization: A New Family of High Performance Heterogeneous Bifunctional Iminophosphorane (BIMP) Superbase Organocatalysts was written by Goldys, Anna M.;Nunez, Marta G.;Dixon, Darren J.. And the article was included in Organic Letters in 2014.SDS of cas: 10203-58-4 This article mentions the following:

An immobilized chiral bifunctional iminophosphorane superbase organocatalyst I has been developed and applied in a range of challenging enantioselective reactions. A unique feature of this novel catalytic system is that the final step creation of the iminophosphorane occurs at the point of immobilization. The utility of the immobilized catalyst system was demonstrated in the nitro-Mannich reaction of ketimines as well as the conjugate addition of high pK_a 1,3-dicarbonyl pro-nucleophiles to nitrostyrene. Catalyst recycling was also demonstrated. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4SDS of cas: 10203-58-4).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.SDS of cas: 10203-58-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Comparative analysis of eastern and western drying-oil binding media used in polychromic artworks by pyrolysis-gas chromatography/mass spectrometry under the influence of pigments was written by Wang, Na;He, Ling;Zhao, Xiang;Simon, Stefan. And the article was included in Microchemical Journal in 2015.Product Details of 106-79-6 This article mentions the following:

The mostly used drying-oils as binding media in historical artworks of eastern tung-oil and western linseed-oil, poppy-oil, walnut-oil are comparatively identified by online methylated pyrolysis-gas chromatog./mass spectrometry (Py-GC/MS). Based on the anal. of un-pigmented and pigmented reference samples after treated by natural aging, hydro-thermal aging and UV aging, resp., the characteristic pyrolysis products of all drying-oils are classed into mono-carboxylic acids (C6-8, 14, 16, 18, 20), di-carboxylic acids (2C6-12), glycerol, erythritol, 2-tridecanone, 8-hydroxy-octanoic acid, 3-octyl-oxiraneoctanoic acid and 2,6,10-trimethyl-9-undecenoic acid. Both benzene derivative and 9,10-dihydroxy-octadecanoic acid are suggested as the marked components for distinguishing eastern and western drying-oil. The investigated pigments of malachite, cinnabar, azurite and ochre do not show obvious influence on the detection of characteristic pyrolysis products of drying-oil, but they are proved to accelerate the aging and hydrolyzing rate of drying-oil, especially the pigment of cinnabar. The established online methylated Py-GC/MS procedure and the summarized data have been successfully applied on the identification of raw tung-oil and boiled tung-oil in historical painting samples collected from Drum Tower (Ming Dynasty), Bell Tower (Ming Dynasty), and Thousand-Buddha Cliff Grotto (Tang Dynasty). It is believed that the established Py-GC/MS procedure is able to provide wide application in archeol. research. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Product Details of 106-79-6).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Product Details of 106-79-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Parahydrophobic Surfaces Made of Intrinsically Hydrophilic PProDOT Nanofibers with Branched Alkyl Chains was written by Mortier, Claudio;Darmanin, Thierry;Guittard, Frederic. And the article was included in Advanced Engineering Materials in 2014.HPLC of Formula: 10203-58-4 This article mentions the following:

We report the synthesis of original 3,4-ethylenedioxythiophene (ProDOT) derivatives containing a branched alkyl chain of various sizes and used as monomers for the formation of parahydrophobic (high apparent contact and high sliding angle) nanofibers by electropolymerization In this work, the size of the branched alkyl chain do not have a significant influence on the surface morphol. because the intrinsic hydrophobicity of the polymers is quite the same. Indeed, assemblies of long polymer nanofibers forming micro- and nanoporous structures are obtained for each polymer. These surfaces display also very high adhesion of water droplets. Indeed, the penetration of water droplets inside the surface roughness was important due to the presence of these nanofibrous structures and the intrinsically hydrophilicity of the polymers. Such materials are excellent candidates for biosensors or anti-bioadhesion. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4HPLC of Formula: 10203-58-4).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 10203-58-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A simple and facile method for the synthesis of 1-octacosanol was written by Kunkuma, Vijaya Lakshmi;Kaki, Shiva Shanker;Rao, Bhamidipati V. S. K.;Prasad, Rachapudi B. N.;Prabhavathi Devi, Bethala L. A.. And the article was included in European Journal of Lipid Science and Technology in 2013.Application of 106-79-6 This article mentions the following:

An efficient synthetic method was developed for the preparation of 1-octacosanol (C₂₈-alc., long-chain aliphatic alc., higher alc.) (I) from com. available lipid-based intermediates namely sebacic acid (decanedioic acid) and stearyl alc. (1-octadecanol). The key step in the synthesis was a Wittig reaction. This product on simultaneous hydrogenation of double bond and deprotection of tert-butyldimethylsilyl protecting group in a single step on treatment with Pd/C and H₂ in methanol at ambient temperature resulted octacosanol in 95% yields. The products were characterized by IR, ¹H NMR, and GC-MS anal. The synthesis of the target compound was achieved by a Wittig reaction of (octadecyl)triphenylphosphonium bromide with 10-[[(1,1-dimethylethyl)dimethylsilyl]oxy]decanal, formation of an alkene and subsequent reduction In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Application of 106-79-6).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 106-79-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Stratigraphic Examination of a Korean Lacquered Wooden Coffin Sample by Pyrolysis/GC/MS was written by Park, Jongseo;Schilling, Michael R.;Khanjian, Herant;Lee, Jiyoung. And the article was included in Chromatographia in 2018.Formula: C12H22O4 This article mentions the following:

A lacquered wooden coffin decorated with gilded Sanskrit letters excavated in the Nongso ancient tomb site was constructed around the fourteenth century in Korea. Pyrolysis/gas chromatog./mass spectrometry was employed to identify the materials of the lacquered surface by analyzing the individual layers. The components of lacquer were detected in all four layers of wood substrate, black, brown, and gilded layers, indicating the coating material was Asian lacquer. The wood seems to be a kind of pine tree from the observation that pine resin-related components were detected in much of the wood substrate and decreasing in the upward direction. Markers of drying oil like azelaic acid and palmitic acid existed in large quantities in the black, brown, and gilded layers, indicating that drying oil was intentionally added to give a luster. In addition, compared with dried Asian lacquer from Korea, the lacquer used in the coffin was determined to be of the same type. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Formula: C12H22O4).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C12H22O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Competition between the β-hydroxylation of a primary and a tertiary carbon atom in rats was written by Moubarik, Soumaya Chraibi-Ben;Menager, Sabine;Lafont, Olivier. And the article was included in European Journal of Medicinal Chemistry in 2000.Name: Diethyl isobutylmalonate This article mentions the following:

In order to study the effect of steric hindrance on competition between two kinds of β-hydroxylation, a compound bearing on a pyrimidinetrione nucleus both a branched side chain with a tertiary carbon atom in position β (iso-Bu group) and a linear side chain (Et group), was selected and administered to rats. Urine and feces were collected and extracted Hydroxymetabolites and their derivatives were isolated and then identified. The β-hydroxylation of the linear chain was more important than the β-hydroxylation of the branched chain. Steric hindrance plays a decisive role in this regioselectivity. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Name: Diethyl isobutylmalonate).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: Diethyl isobutylmalonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and Optoelectronic Properties of Alternating Copolymers Containing Anthracene Unit in The Main Chain by Radical Ring-Opening Polymerization was written by Mori, Hideharu;Tando, Izumi;Tanaka, Hiromi. And the article was included in Macromolecules (Washington, DC, United States) in 2010.Category: esters-buliding-blocks This article mentions the following:

Novel alternating copolymers composed of anthracene moiety and halostyrene unit were synthesized by ring-opening polymerization of cyclic monomers, 10-methylene-9,10-dihydroanthryl-9-spiro-p-chlorophenylcyclopropane and its bromo derivative Reversible addition-fragmentation chain transfer and conventional free radical polymerizations were employed for the purpose. In both cases, the ring-opening polymerization proceeded predominantly to afford alternating copolymer containing anthracene unit in the main chain. Incorporations of optoelectronic groups, involving diphenylamine, carbazole, and phenothiazine, on the halostyrene moieties of the alternating copolymers were conducted by palladium-catalyzed reactions. Novel nonconjugated copolymers having perfect alternating structures were obtained, in which the alternate arrangement of two distinct electronic functionalities is formed owing to the ring-opening polymerization system. Resulting anthracene-based alternating copolymers having two distinct electronic functionalities exhibited characteristic fluorescence resonance energy transfer, as confirmed by UV-vis and fluorescence spectra. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Category: esters-buliding-blocks).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

RAFT Polymerization of Acrylamides Containing Proline and Hydroxyproline Moiety: Controlled Synthesis of Water-Soluble and Thermoresponsive Polymers was written by Mori, Hideharu;Kato, Ikumi;Matsuyama, Motonobu;Endo, Takeshi. And the article was included in Macromolecules (Washington, DC, United States) in 2008.Formula: C14H12S2 This article mentions the following:

Two acrylamides containing proline and hydroxyproline moiety, N-acryloyl-L-proline (A-Pro-OH) and N-acryloyl-4-trans-hydroxy-L-proline (A-Hyp-OH), were polymerized by reversible addition-fragmentation chain transfer (RAFT) process to afford well-defined amino acid based polymers. Two chain transfer agents (CTAs), benzyl dithiobenzoate (CTA 1) and benzyl 1-pyrrolecarbodithioate (CTA 2), were compared for the direct polymerization of these monomers without protecting chem. With 2,2′-azobis(isobutyronitrile) as an initiator, the dithiocarbamate-type RAFT agent (CTA 2) was efficient for the controlled synthesis of poly(A-Pro-OH)s, which can be regarded as a weak polyelectrolyte. Controlled character of the polymerization of A-Hyp-OH, which has a carboxylic acid and a hydroxyl group in the monomer unit, in the presence of CTA 1 was confirmed by the formation of narrow polydispersity products and the linear relationship between the mol. weight and conversion. Water-soluble poly(A-Hyp-OH)s with number-average mol. weights between 8.2 × 10³ and 2.21 × 10⁴ and relatively low polydispersities were obtained, depending on the monomer/CTA ratio. Their methylated samples, poly(A-Pro-OMe) and poly(A-Hyp-OMe), and random copolymers showed characteristic thermal phase transitions in aqueous solutions In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Formula: C14H12S2).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Formula: C14H12S2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics