Tag: 200-300

Thin thermo-responsive polymer films onto the pore system of chromatographic beads via reversible addition-fragmentation chain transfer polymerization was written by Roohi, Farnoosh;Titirici, Maria-Magdalena. And the article was included in New Journal of Chemistry in 2008.Electric Literature of C14H12S2 This article mentions the following:

Mesoporous silica beads modified with an azo initiator were used for grafting of a thermo-responsive polymer (poly-N-isopropylacrylamide, PNIPAAM) through reversible addition-fragmentation chain transfer (RAFT) mediated polymerization The RAFT mediation allowed an efficient control of the grafting process and led to suppression of the solution propagation preventing any visible gel formation. The resulting composites were characterized by FTIR spectroscopy, nitrogen adsorption anal., elemental anal., transmission and SEM and as thermo-responsive stationary phases in chromatog. The resulting material proved to be efficient for the separation of a mixture of five hydrophobic steroids and the retention time and efficiency of separation improved with increasing the column temperature above the lowest critical solution temperature of PNIPAAM. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Electric Literature of C14H12S2).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C14H12S2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A series of novel HDAC inhibitors with anthraquinone as a cap group was written by Zou, Yefang;Cao, Zhuoxian;Wang, Jie;Chen, Xiaoxue;Chen, Yan-qin;Li, Yan;Liu, Jingzi;Zhao, Yonglong;Wang, Aimin;He, Bin. And the article was included in Chemical & Pharmaceutical Bulletin in 2020.Recommanded Product: 3903-40-0 This article mentions the following:

Although anthraquinone derivatives possess significant antitumor activity, most of them also displayed those side effects like cardiotoxicity, mainly owing to their inhibition of topoisomerase II of DNA repair mechanisms. Our raised design strategy by switching therapeutic target from topoisomerase II to histone deacetylase (HDAC) has been applied to the design of anthraquinone derivatives in current study. Consequently, a series of novel HDAC inhibitors with a tricylic diketone of anthraquinone as a cap group have been synthesized. After screening and evaluation, compounds 4b, 4d, 7b and 7d have displayed the comparable inhibition in enzymic activity and cell proliferation than that of Vorinostat (SAHA). Notably, compound 4b showed certain selectivity of antiproliferative effects on cancer cell lines over non-cancer cell lines. In the experiment, the researchers used many compounds, for example, 12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0Recommanded Product: 3903-40-0).

12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 3903-40-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Catalytic synthesis of 2,2′-arylmethylenebis(3-hydroxy-5,5-dimethylcyclohex-2-en-1-ones) and 3,3,6,6-tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-diones was written by Dikusar, E. A.;Potkin, V. I.;Kozlov, N. G.;Pavlyuchenkova, A. S.;Murashova, M. Yu.;Petkevich, S. K.;Kletskov, A. V.;Polikarpov, A. P.;Ogorodnikova, M. M.;Zolotar’, R. M.;Chepik, O. P.. And the article was included in Russian Journal of Organic Chemistry in 2013.Name: 4-Formyl-2-methoxyphenyl isobutyrate This article mentions the following:

Hexahydroxanthenediones I [R = Ph, 4-HOC₆H₄, 4-MeOC₆H₄, 4-HO₂CC₆H₄, 2,4-(HO)₂C₆H₃, 2-HO-3-MeOC₆H₃, 3-HO-4-MeOC₆H₃, 1,3-benzodioxol-5-yl, 3-MeO-4-HOC₆H₃, 2-Br-4,5-(MeO)₂C₆H₂, 3-MeO-4-R¹COOC₆H₃, 3-EtO-4-HOC₆H₃, 3-EtO-4-R¹COOC₆H₃, 3-MeO-4-R²COOC₆H₃, 3-EtO-4-R²COOC₆H₃, 3-MeO-4-R³COOC₆H₃, 3-EtO-4-R³COOC₆H₃, 3-MeO-4-R⁴COOC₆H₃, 3-EtO-4-R⁴COOC₆H₃; R¹ = Me(CH₂)_n, Me₂CH, Me₂CHCH₂, Me₃CH, Me₂CHCH₂CH₂, Ph; R² = 5-phenyl-3-isoxazolyl; R³ = 5-(4-methylphenyl)-3-isoxazolyl; R⁴ = 4,5-dichloro-3-isothiazolyl; n = 0-4, 8, 11, 16] were prepared in two steps from aryl aldehydes RCHO and dimedone (5,5-dimethyl-1,3-cyclohexanedione) or from acid chlorides R³COCl or R⁴COCl and I [R = 3-MeO-4-HOC₆H₄, 3-EtO-4-HOC₆H₄]. Condensation of benzaldehydes RCHO [R = Ph, 4-HOC₆H₄, 4-MeOC₆H₄, 4-HO₂CC₆H₄, 2,4-(HO)₂C₆H₃, 2-HO-3-MeOC₆H₃, 3-HO-4-MeOC₆H₃, 1,3-benzodioxol-5-yl, 3-MeO-4-HOC₆H₃, 2-Br-4,5-(MeO)₂C₆H₂, 3-MeO-4-R¹COOC₆H₃, 3-EtO-4-HOC₆H₃, 3-EtO-4-R¹COOC₆H₃, 3-MeO-4-R²COOC₆H₃, 3-EtO-4-R²COOC₆H₃, 3-MeO-4-R³COOC₆H₃, 3-EtO-4-R³COOC₆H₃, 3-MeO-4-R⁴COOC₆H₃, 3-EtO-4-R⁴COOC₆H₃; R¹ = Me(CH₂)_n, Me₂CH, Me₂CHCH₂, Me₃CH, Me₂CHCH₂CH₂, Ph; R² = 5-phenyl-3-isoxazolyl; n = 0-4, 8, 11, 16] with dimedone gave arylmethylenebis(dimethylhydroxycyclohexenones) (or in some cases provided I directly). Cyclocondensation of the intermediate arylmethylenebis(dimethylhydroxycyclohexenones) in the presence of the sulfo cation exchanger FIBAN K-1 gave hexahydroxanthenediones. In some cases, the arylisoxazolylcarboxylic and dichloroisothiazolylcarboxylic esters underwent partial or full hydrolysis during the (attempted) preparation of the corresponding hexahydroxanthenediones. In the experiment, the researchers used many compounds, for example, 4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4Name: 4-Formyl-2-methoxyphenyl isobutyrate).

4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Name: 4-Formyl-2-methoxyphenyl isobutyrate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Regioselective functionalization of nonactivated CH bonds. 2. Photochemical functionalization of the myristoyl group in 1,2-alkanediyl and o-phenylene 4-benzoylbenzoate myristates was written by Dors, Bernhard;Luftmann, Heinrich;Schaefer, Hans J.. And the article was included in Chemische Berichte in 1983.Recommanded Product: 3903-40-0 This article mentions the following:

Me(CH₂)₁₂CO₂QO₂CC₆H₄COPh-4 (Q = CH₂CH₂, trans-1,2-cyclohexanediyl, o-phenylene) were prepared and cyclized photochem. to I, which were converted to Me 7- to 13-oxomyristates. This ketofunctionalization of the remote CH₂ groups in myristic acid was more selective than in 4-PhCOC₆H₄CO₂(CH₂)_nMe (n = 11, 15, 16, 17), and the maximum functionalization occurred more toward the middle, rather than the end, of the chain. The solvent polarity had only a small effect on the selectivity. In the experiment, the researchers used many compounds, for example, 12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0Recommanded Product: 3903-40-0).

12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 3903-40-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A Highly Stereoselective Organocatalytic Tandem Aminoxylation/Aza-Michael Reaction for the Synthesis of Tetrahydro-1,2-Oxazines was written by Zhu, Di;Lu, Min;Chua, Pei Juan;Tan, Bin;Wang, Fei;Yang, Xinhao;Zhong, Guofu. And the article was included in Organic Letters in 2008.Formula: C11H20O4 This article mentions the following:

A facile stereoselective synthesis of multifunctionalized tetrahydro-1,2-oxazines (THOs) has been achieved by the organocatalyzed asym. tandem 浼?aminoxylation/aza-Michael reaction for the C-O/C-N bond formations in moderate to good yields with excellent diastereo- (>99:1 dr) and enantioselectivities (92% to >99% ee). E.g., reaction of di-Me 2-(5-oxopentylidene)malonate (I) with nitrosobenzene, catalyzed by L-proline, gave 84% tetrahydro-1,2-oxazine II (98% ee). In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Formula: C11H20O4).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C11H20O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Identification of Inhibitors of Checkpoint Kinase 1 through Template Screening was written by Matthews, Thomas P.;Klair, Suki;Burns, Samantha;Boxall, Kathy;Cherry, Michael;Fisher, Martin;Westwood, Isaac M.;Walton, Michael I.;McHardy, Tatiana;Cheung, Kwai-Ming J.;Van Montfort, Rob;Williams, David;Aherne, G. Wynne;Garrett, Michelle D.;Reader, John;Collins, Ian. And the article was included in Journal of Medicinal Chemistry in 2009.SDS of cas: 173341-02-1 This article mentions the following:

Checkpoint kinase I (CHKI) is an oncol. target of significant current interest. Inhibition of CHK1 abrogates DNA damage-induced cell cycle checkpoints and sensitizes p53 deficient cancer cells to genotoxic therapies. Using template screening, a fragment-based approach to small mol. hit generation, we have identified multiple CHK1 inhibitor scaffolds suitable for further optimization. The sequential combination of in silico low mol. weight template selection, a high concentration biochem. assay and hit validation through protein-ligand X-ray crystallog. provided 13 template hits from an initial in silico screening library of ca. 15000 compounds The use of appropriate counter-screening to rule out nonspecific aggregation by test compounds was essential for optimum performance of the high concentration bioassay. One low mol. weight, weakly active purine template hit was progressed by iterative structure-based design to give submicromolar pyrazolopyridines with good ligand efficiency and appropriate CHK1-mediated cellular activity in HT29 colon cancer cells. In the experiment, the researchers used many compounds, for example, tert-Butyl (morpholin-2-ylmethyl)carbamate (cas: 173341-02-1SDS of cas: 173341-02-1).

tert-Butyl (morpholin-2-ylmethyl)carbamate (cas: 173341-02-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 173341-02-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

An L-glutaminase enzyme reactor based on porous bamboo sticks and its application in enzyme inhibitors screening was written by Qiao, Juan;Zhao, Liping;Liu, Lili;Qi, Li. And the article was included in Talanta in 2019.HPLC of Formula: 27249-90-7 This article mentions the following:

Inspired by the porous and fibrous structure of com. available bamboo, herein we created an L-glutaminase enzyme reactor based on bamboo sticks. The enzyme was immobilized onto the bamboo sticks through a glutaraldehyde modification to achieve covalent bonding. The enzymic hydrolysis efficiency of the prepared L-glutaminase@bamboo sticks based porous enzyme reactor was evaluated by chiral ligand exchange capillary electrochromatog. using L-glutamine as the substrate. L-Glutaminase@bamboo exhibited improved enzymic hydrolysis performances, including high hydrolysis efficiency (maximum rate V_max: two fold higher than the free enzyme), prolonged stability (14 days) and good reusability. L-Glutaminase@bamboo sticks also expanded application capability in pharmaceutical industry in enzyme inhibitor screening. These excellent properties could be attributed to the micropores of bamboo sticks, which led to the fast enzymic kinetics. The results suggest that the pores of bamboo sticks played an important role in the proposed enzyme reactor during the hydrolysis of L-glutamine and L-glutaminase inhibitor screening. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7HPLC of Formula: 27249-90-7).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 27249-90-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Selective monomethyl esterification of linear dicarboxylic acids with bifunctional alumina catalysts was written by Santacroce, Veronica;Bigi, Franca;Casnati, Alessandra;Maggi, Raimondo;Storaro, Loretta;Moretti, Elisa;Vaccaro, Luigi;Maestri, Giovanni. And the article was included in Green Chemistry in 2016.Electric Literature of C13H24O4 This article mentions the following:

An environmentally friendly protocol for the selective protection of dicarboxylic acids OHC(O)(CH₂)_nC(O)OH (n = 2, 4, 6, 7, 10) was reported using methanol as a cheap esterifying agent and alumina as a heterogeneous catalyst; the selectivity of the process has been ascribed to a balanced acidity/basicity of the bifunctional alumina catalyst. In the experiment, the researchers used many compounds, for example, 12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0Electric Literature of C13H24O4).

12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Electric Literature of C13H24O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Optically transparent bio-based polyamides with microcellular foaming properties derived from renewable difunctional aminoamides was written by Ranganathan, Palraj;Chen, Yu-Hao;Rwei, Syang-Peng;Lee, Yi-Huan. And the article was included in Journal of Applied Polymer Science in 2022.Application of 106-79-6 This article mentions the following:

A green approach for the synthesis of bio-based polyamides (PAs) with a new macromol. structure was developed. These bio-based PAs were synthesized by solvent and catalyst-free polycondensation combining fatty dimer acid Pripol 1009 with new difunctional aminoamides (DAAs). The later DAAs building blocks were synthesized by aminolysis of renewable di-Me sebacate (DMS) and di-Me adipate (DMA) with 3 different aliphatic diamines having diverse chain lengths, 2, 4, and 6 carbons. Bio-based PAs showed M_w up to 30,581 g/mol, initial thermal degradation over 380掳, T_m from 168.3-202.4掳C, T_g from 28.3-37.5掳C, strain from 36.4 卤4.0-313.5 卤2.0%, and tensile strength up to 27.4 卤0.1 MPa. All the PAs films had excellent optical transparency with cut-off wavelengths of 276.0-283.0 nm, transmittance from 82.7%-90.7% at 600 nm. As a proof-of-concept of their usage, 1 of the PA can form microcellular foam by the green scCO₂ method. The foams possessed uniform (cell size; 40渭m, foam d.; 0.265 g/cm³, expansion rate; 7.2) and bimodal (cell size; 24/38渭m, foam d.; 0.302 g/cm³, expansion rate; 6.5) cell textures depending on their foaming temperatures This is the first report of bio-based PA foams and transparent films manufacturing without toxic solvents. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Application of 106-79-6).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application of 106-79-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aggregation behaviour of poly(fluoro(meth)acrylate)-block-poly(acrylic acid) copolymers at the air /water interface was written by Grigoreva, Alexandra;Tarankova, Kseniia;Zamyshlyayeva, Olga;Zaitsev, Sergey. And the article was included in Journal of Polymer Research in 2021.Safety of Benzyl benzodithioate This article mentions the following:

The formation of monolayers of poly(fluoro(meth)acrylate)-b-poly(acrylic acid) (PFA-b-PAA) amphiphilic diblock copolymers at the air/water interface was characterized with the Langmuir film balance technique and at. force microscopy. Both internal and external effects on the aggregation behavior of the amphiphilic copolymers were considered. The structure of fluorinated hydrophobic part, as an internal factor, affects the surface behavior of the amphiphilic copolymers through changes in the packing d. of the hydrophobic core. The morphol. of the LB films of all the three copolymers exhibit circular micelles with the hydrophobic core and hydrophilic coronas. The variation in pH and ionic strength leads to changes in charge distribution of PAA coronas. The surface area occupied by the PFA-b-PAA copolymers decrease with the rise of pH of subphase. The increase in salt concentration provides for the reduction of electrostatic repulsion between the hydrophilic blocks. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Safety of Benzyl benzodithioate).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Safety of Benzyl benzodithioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics