Tag: 100-200

Wei, Lijuan;Zhang, Ming;Zhang, Xiaoming;Xin, Hongchuan;Yang, Hengquan published 《Pickering Emulsion as an Efficient Platform for Enzymatic Reactions without Stirring》. The research results were published in《ACS Sustainable Chemistry & Engineering》 in 2016.COA of Formula: C10H12O2 The article conveys some information:

To address the current limitations of enzymic reactions, we develop a novel strategy to conduct stirring-free biphasic enzymic reactions. This strategy involves translation of a conventional biphasic enzymic reaction to a water-in-oil (W/O) Pickering emulsion system by adding a small amount of solid particle emulsifier. In such a system, enzymes, for example, a Candida Antarctica lipase B (CALB), are compartmentalized within millions of micron-sized water droplets, while organic substrates are dissolved in the oil phase (outside the droplets). It was demonstrated that CALB-catalyzed hydrolysis kinetic resolution of racemic esters in the stirring-free Pickering emulsion system gave favorable reaction efficiency and enantioselectivity as compared to those for the conventional biphasic system under stirring conditions, which was due to the large reaction interfacial area and the short mol. distances created by the Pickering emulsion droplets. The specific activity was found to depend on the water droplet size, highlighting the importance of the presence of droplets in the reaction system. Moreover, the convenient and effective recycling of CALB could be achieved through simple demulsification by centrifugation. After 27 reaction cycles, the ee values of ester and alc. were still as high as 87.5% and 99%, resp., which significantly exceed those of the conventional biphasic reaction. The high recyclability may be attributed to avoiding stirring that often causes damage to the three-dimensional structure of enzymes. This study compellingly demonstrates that a Pickering emulsion is an innovative platform to efficiently process enzymic reactions without need for stirring and immobilization. To complete the study, the researchers used 1-Phenylethyl acetate (cas: 93-92-5) .

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. COA of Formula: C10H12O2 It may be prepared by acetylation of methyl phenyl carbinol; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation; from 1-bromoethylbenzene and silver acetate in acetic acid.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peixoto, Philippe A.;Boulange, Agathe;Ball, Malcolm;Naudin, Bertrand;Alle, Thibault;Cosette, Pascal;Karuso, Peter;Franck, Xavier published 《Design and Synthesis of Epicocconone Analogues with Improved Fluorescence Properties》. The research results were published in《Journal of the American Chemical Society》 in 2014.Recommanded Product: 4707-47-5 The article conveys some information:

Epicocconone is a natural latent fluorophore that is widely used in biotechnol. because of its large Stokes shift and lack of fluorescence in its unconjugated state. However, the low photostability and quantum yields of epicocconone have limited its wider use, and in the absence of a total synthesis, this limitation was a long-standing problem. Here the authors report a general strategy for the synthesis of epicocconone analogs that relies on a 2-iodoxybenzoic acid-mediated dearomatization and on the replacement of the triene tail of the natural product by an aromatic ring. This design element is general and the synthesis is straightforward, providing ready access to libraries of polyfunctional fluorophores with long Stokes shifts based on the epicocconone core. The structural modifications resulted in analogs with increased photostability and quantum yields compared with the natural product. Staining proteomic gels with these new analogs showed significant lowering of the detection limit and a 30% increase in the number of low-abundance proteins detected. These epiccoconone analogs will substantially improve the discovery rate of biomarker needles in the proteomic haystack. And Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) was used in the research process.

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Recommanded Product: 4707-47-5

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quality Control of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate《Chemical constituents from stem bark of Pterostyrax psilophyllus》 was published in 2015. The authors were Zhang, Ya-mei;Zhang, Pu-zhao, and the article was included in《Zhongguo Shiyan Fangjixue Zazhi》. The author mentioned the following in the article:

Objective: To study the chem. constituents in the stem bark of Pterostyrax psilophyllus. Method: The chem. constituents were separated and purified by chromatog. methods combined with spectroscopic analyses. Result: Twelve compounds were isolated from the stem bark of P. psilophyllus and identified as following: methyl-2,4-dihydroxy-3,6-dimethylbenzoate (1), lupeol (2), prunetin (3), genistein (4), 2-hydroxy-4-methoxy-3,6-dimethyl benzoic acid (5), genistein-4′-O-β-glucoside (6), amyrin (7), catechin (8), epicatechin (9), vanillic acid (10), β-sitosterol (11), daucosterol (12). Conclusion: All twelve compounds were isolated from the plants of P. psilophyllus for the first time. The experimental procedure involved many compounds, such as Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) .

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Quality Control of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiang, Ming;Zhou, Chao;Yang, Xiu-Long;Chen, Bin;Tung, Chen-Ho;Wu, Li-Zhu published 《Visible Light-Catalyzed Benzylic C-H Bond Chlorination by a Combination of Organic Dye (Acr⁺-Mes) and N-Chlorosuccinimide》 in 2020. The article was appeared in 《Journal of Organic Chemistry》. They have made some progress in their research.Formula: C9H10O2 The article mentions the following:

By combining “N-chlorosuccinimide (NCS)” as the safe chlorine source with “Acr⁺-Mes” as the photocatalyst, we successfully achieved benzylic C-H bond chlorination under visible light irradiation Furthermore, benzylic chlorides could be converted to benzylic ethers smoothly in a one-pot manner by adding sodium methoxide. This mild and scalable chlorination method worked effectively for diverse toluene derivatives, especially for electron-deficient substrates. Careful mechanistic studies supported that NCS provided a hydrogen abstractor “N-centered succinimidyl radical,” which was responsible for the cleavage of the benzylic C-H bond, relying on the reducing ability of Acr^•-Mes.Methyl 3-methylbenzoate (cas: 99-36-5) were involved in the experimental procedure.

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids.Formula: C9H10O2 Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dave, Alpa Y.;Parmar, Kokila A.;Begari, Eeshwaraiah;Joshi, Deepkumar S. published 《Synthesis and biological evaluation of oxadiazole clubbed thiadiazole derivatives as antimicrobial agents》. The research results were published in《Indian Journal of Heterocyclic Chemistry》 in 2021.Application of 99-36-5 The article conveys some information:

A series of 1,3,4-oxadiazole clubbed 1,3,4-thiadiazole derivatives I [R¹ = H, 3-Me, 2-Cl, etc; R² = H, 3-Me, 4-HO, 2-Cl, 4-Cl] were synthesized and assessed in-vitro for their activity as antimicrobial agents. The target compounds I were synthesized using a basic condensation reaction between 5-(substituted phenyl)-1,3,4-oxadiazole-2-thiols and 2-chloro-N-(5-(substituted phenyl)-1,3,4-thiadiazol-2-yl)acetamides in presence of K₂CO₃ as a scavenging agent and acetone as reaction solvent. The compounds I synthesized here, exhibited excellent to moderate antimicrobial activity against a broad panel of antibacterial strains of Gram-pos. and Gram-neg. bacteria and fungi.Methyl 3-methylbenzoate (cas: 99-36-5) were involved in the experimental procedure.

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids.Application of 99-36-5 Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kekuda, T. R. Prashith;Lavanya, D.;Rao, Pooja published 《Lichens as promising resources of enzyme inhibitors: a review》 in 2019. The article was appeared in 《Journal of Drug Delivery and Therapeutics》. They have made some progress in their research.Reference of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate The article mentions the following:

A review. Inhibition of some enzymes seems to be one of the therapeutic strategies for the management of certain diseases or conditions such as diabetes, Alzheimer’s disease, cancer and obesity. In this review, an updated information on the enzyme inhibitory activity of lichen extracts and lichen compounds by an intensive literature survey is presented. Crude solvent extracts and isolated compounds from lichens were shown to be effective in causing inhibition of several enzymes such as amylase, lipase, lipoxygenase, aromatase, cyclooxygenase, trypsin, β-glucoronidase, prolyl endopeptidase, monoamine oxidase, urease, tyrosinase, xanthine oxidase, Thioredoxin reductase, glucosidase, topoisomerase, pancreatic elastase, phosphodiesterase, telomerase and acetylcholinesterase. Lichen metabolites such as usnic acid and its derivatives, lobaric acid, physodic acid, ramalin, protolichestrinic acid, salazinic acid, atranorin, evernic acid, zeorin, diffractic acid, psoromic acid, Me β-orcinolcarboxylate, methylorsellinate, and anziaic acid were shown to be inhibitors of some enzymes. In conclusion, lichens can be employed as promising therapeutic agents in terms of their potential to inhibit the activity of certain enzymes that are involved in some diseases or disorders. In vitro culturing of lichen symbionts in optimized media can be carried out to isolate enzyme inhibitors in larger scale and to develop effective therapeutic agents. To complete the study, the researchers used Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) .

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Reference of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schulze, Julia S.;Brand, Raoul D.;Hering, Joachim G. C.;Riegger, Luise M.;Schreiner, Peter R.;Smarsly, Bernd M. published 《DMAP Immobilized on Porous Silica Particles and Monoliths for the Esterification of Phenylethanol in Continuous Flow》. The research results were published in《ChemCatChem》 in 2022.Recommanded Product: 1-Phenylethyl acetate The article conveys some information:

We report the immobilization of 4-dimethylaminopyridine (DMAP), a versatile organocatalyst for sterically demanding esterifications, on mesoporous silica particles and macro-mesoporous silica monoliths, both possessing optimized properties for continuous flow synthesis. An alkyne-functionalized DMAP derivative was immobilized via click chem.; the materials were characterized by physisorption anal., diffuse reflectance IR Fourier transform spectroscopy (DRIFT) and elemental anal. While silica particles were functionalized in batch and packed into a packed-bed reactor, monoliths were cladded with a polyether ether ketone (PEEK) tube after sol-gel synthesis and functionalized in a circulating flow process. Samples with three different catalyst loadings were prepared, in order to study the impact of the catalyst amount on the mesopore space as well as the catalytic performance. In continuous flow experiments, complete conversion of 1-phenylethanol to phenylethylacetate was achieved with both materials and short contact times. Monoliths exhibited far lower pressures than packed bed reactors (7 bar at a flow rate of 1 mL min^-1) and reached turnover rates up to 9.3 × 10^-2 s^-1, which is almost twice as high as a comparable batch experiment The absence of diffusion limitations in monoliths made investigations on reaction kinetics with microkinetics-dominated experiments possible. This study demonstrates that all properties needed for a successful transfer of immobilized organocatalysts to sophisticated flow syntheses with complex organocatalysts can be met with functionalized meso-macroporous monoliths. The experimental procedure involved many compounds, such as 1-Phenylethyl acetate (cas: 93-92-5) .

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Recommanded Product: 1-Phenylethyl acetate It may be prepared by acetylation of methyl phenyl carbinol; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation; from 1-bromoethylbenzene and silver acetate in acetic acid.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

HPLC of Formula: 4707-47-5In 2018, Seklic, Dragana S.;Obradovic, Ana D.;Stankovic, Milan S.;Zivanovic, Marko N.;Mitrovic, Tatjana Lj.;Stamenkovic, Slavisa M.;Markovic, Snezana D. published 《Proapoptotic and antimigratory effects of Pseudevernia furfuracea and Platismatia glauca on colon cancer cell lines original scientific paper》. 《Food Technology and Biotechnology》published the findings. The article contains the following contents:

The aim of this study is to investigate cytotoxic, proapoptotic, antimigratory and pro-antioxidant effects of methanol, acetone and Et acetate extracts of lichens Pseudevernia furfuracea and Platismatia glauca on colorectal cancer (HCT-116 and SW-480) cell lines. We compared the cytotoxic effects on colorectal cancer cells with the effects obtained from normal human fibroblast (MRC-5) cell line. Tetrazolium (MTT) test evaluated the cytotoxic effects, Transwell assay evaluated cell migration, acridine orange/ethidium bromide (AO/EB) fluorescent method followed the apoptosis, while prooxidant/antioxidant effects were determined spectrophotometrically through concentration of redox parameters. The tested extracts showed considerable cytotoxic effect on cancer cells with no observable cytotoxic effect on normal cells. Et acetate and acetone extract of P. furfuracea induced the highest cytotoxicity (IC50 = (21.2 ± 1.3) μg/mL on HCT-116, and IC50 = (51.3 ± 0.8) μg/mL on SW-480 cells, resp., after 72 h), with noteworthy apoptotic and prooxidant effects, and antimigratory potential of methanol extract P. glauca extracts induced cytotoxic effects on HCT-116 cells after 72 h (IC50<40μg/mL), while only methanol and acetone extracts had cytotoxic effects on SW-480 cells after 24 h, with proapoptotic/necrotic activity, as a consequence of induced oxidative stress. In conclusion, lichen extracts changed to a great extent cell viability and migratory potential of colorectal cancer cell lines. HCT-116 cells were more sensitive to treatments, P. furfuracea had better proapoptotic and antimigratory effects, and both investigated lichen species might be a source of substances with anticancer activity.Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) were involved in the experimental procedure.

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.HPLC of Formula: 4707-47-5

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Carvalho da Silva, Romezio Alves;Marques de Mesquita, Bruna;Frota de Farias, Iolanda;Garcia do Nascimento, Patricia Georgiana;Gomes de Lemos, Telma Leda;Monte, Francisco Jose Queiroz published 《Enzymatic chemical transformations of aldehydes, ketones, esters and alcohols using plant fragments as the only biocatalyst: Ximenia americana grains》 in 2018. The article was appeared in 《Molecular Catalysis》. They have made some progress in their research.Electric Literature of C10H12O2 The article mentions the following:

The present study demonstrated the ability of Ximenia american as a biocatalyst in reduction, hydrolysis and esterification reactions. The reduction reactions of aldehydes and ketones, ester hydrolysis and esterification of alcs. were carried out with interesting results. Reduction of ketones afforded yields of 6-60% with ee in the range of 35->99% and that of aldehydes in yields of 51-99%. On the other hand, ester hydrolysis afforded yields of 58-98% with ee in the range 34-87%, while esterification of alcs. in 18-99% yields. Exptl. conditions for all reactions have been defined using standard substrates as indicated in results and discussion. Some of the products are the potential building blocks for the synthesis of mols. which are of pharmaceutical and agrochem. importance. To complete the study, the researchers used 1-Phenylethyl acetate (cas: 93-92-5) .

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Electric Literature of C10H12O2 It may be prepared by acetylation of methyl phenyl carbinol; from 1-bromoethylbenzene and silver acetate in acetic acid; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of C9H10O2《Reactions of benzyltriphenylphosphonium salts under photoredox catalysis》 was published in 2021. The authors were Boldt, Andrew M.;Dickinson, Sidney I.;Ramirez, Jonathan R.;Benz-Weeden, Anna M.;Wilson, David S.;Stevenson, Susan M., and the article was included in《Organic & Biomolecular Chemistry》. The author mentioned the following in the article:

The development of benzyltriphenylphosphonium salts RCH₂P⁺(C₆H₅)₃X^– (R = 3-methylphenyl, 4-bromophenyl, 3,5-dimethylphenyl, etc.; X = Cl, Br) as alkyl radical precursors using photoredox catalysis is described. Depending on substituents, the benzylic radicals may couple to form C-C bonds or abstract a hydrogen atom to form C-H bonds. A natural product, brittonin A, was also synthesized using this method. The experimental procedure involved many compounds, such as Methyl 3-methylbenzoate (cas: 99-36-5) .

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids.Synthetic Route of C9H10O2 Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics