Tag: 100-200

Quality Control of 1-Phenylethyl acetateIn 2017, Yu, Wei;Zhou, Minghong;Wang, Tianqi;He, Zidong;Shi, Buyin;Xu, Yang;Huang, Kun published 《”Click Chemistry” Mediated Functional Microporous Organic Nanotube Networks for Heterogeneous Catalysis》. 《Organic Letters》published the findings. The article contains the following contents:

Azide-functionalized microporous organic nanotube networks (MONN) were prepared from graft copolymers of glycidyl methacrylate, DL-lactide, styrene, 4-(chloromethyl)styrene, and an isobutyric acid α-trithiocarbonate by Friedel-Crafts crosslinking with formaldehyde di-Me acetal followed by substitution with NaN₃. 1,3-Dipolar cycloadditions of propargyl-substituted TEMPO and DMAP with the azide-functionalized MONN yielded MONN-bound TEMPO and DMAP. MONN-bound TEMPO and MONN-bound DMAP were recyclable catalysts for the chemoselective oxidation of alcs. to aldehydes and ketones and for the acetylation of alcs. with acetic anhydride to yield acetates, resp.; the TEMPO MONN was recycled ten times with no loss in yield and fourteen times with some (10-15%) decrease in yield.1-Phenylethyl acetate (cas: 93-92-5) were involved in the experimental procedure.

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Quality Control of 1-Phenylethyl acetate It may be prepared by acetylation of methyl phenyl carbinol; from 1-bromoethylbenzene and silver acetate in acetic acid; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application In Synthesis of 1-Phenylethyl acetate《Tropolonate Salts as Acyl-Transfer Catalysts under Thermal and Photochemical Conditions: Reaction Scope and Mechanistic Insights》 was published in 2020. The authors were Lyons, Demelza J. M.;Empel, Claire;Pace, Domenic P.;Dinh, An H.;Mai, Binh Khanh;Koenigs, Rene M.;Nguyen, Thanh Vinh, and the article was included in《ACS Catalysis》. The author mentioned the following in the article:

Acyl-transfer catalysis is a frequently used tool to promote the formation of carboxylic acid derivatives, which are important synthetic precursors and target compounds in organic synthesis. However, there have been only a few structural motifs known to efficiently catalyze the acyl-transfer reaction. Herein, we introduce a different acyl-transfer catalytic paradigm based on the tropolone framework. We show that tropolonate salts, due to their strong nucleophilicity and photochem. activity, can promote the coupling reaction between alcs. and carboxylic acid anhydrides or chlorides to give products under thermal or blue light photochem. conditions. Kinetic studies and d. functional theory calculations suggest interesting mechanistic insights for reactions promoted by this acyl-transfer catalytic system. And 1-Phenylethyl acetate (cas: 93-92-5) was used in the research process.

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Application In Synthesis of 1-Phenylethyl acetate It may be prepared by acetylation of methyl phenyl carbinol; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation; from 1-bromoethylbenzene and silver acetate in acetic acid.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Feng, Yan;Chen, Jian;Zhang, Aijun published 《Commercially Available Natural Benzyl Esters and Their Synthetic Analogs Exhibit Different Toxicities against Insect Pests》 in 2018. The article was appeared in 《Scientific Reports》. They have made some progress in their research.Application In Synthesis of Methyl 3-methylbenzoate The article mentions the following:

Benzyl Me ester, also known as Me benzoate (MB), is a volatile organic compound that exists naturally as a floral fragrance in many plants. Our behavioral bioassays show that MB and some of its naturally occurring and synthetic analogs kill insects at different life stages. Compared to com. pesticides containing pyriproxyfen and acetamiprid, MB and some analogs are 1.3 to 3.4 times more toxic to gypsy moth larvae and brown marmorated stinkbug nymphs. The arthropod repellent DEET is also a benzyl ester, and shares the same chem. skeleton with MB. They differ by the diethylamide ester and a Me group on the benzene ring in DEET. However, unlike MB, DEET does not kill insects; instead, it deters or repels them. Exactly how DEET causes the repellent effect in target organisms is still a mystery. Due to the MB’s structural similarity to DEET, exploring the structure – activity relationship (SAR) of the MB analogs will provide useful information for the discovery of the mode and mechanistic actions of DEET as an insect repellent. In addition, the SAR will allow researchers to modify the chem. structure of the MB mol., leading to the development of more efficient, safe, and environmentally – friendly green pesticides. The experimental procedure involved many compounds, such as Methyl 3-methylbenzoate (cas: 99-36-5) .

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids.Application In Synthesis of Methyl 3-methylbenzoate Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

SDS of cas: 4707-47-5In 2017, Ismed, Friardi;Lohezic-Le Devehat, Francoise;Rouaud, Isabelle;Ferron, Solenn;Bakhtiar, Amri;Boustie, Joel published 《NMR reassignment of stictic acid isolated from a Sumatran lichen Stereocaulon montagneanum (Stereocaulaceae) with superoxide anion scavenging activities》. 《Zeitschrift fuer Naturforschung, C: Journal of Biosciences》published the findings. The article contains the following contents:

The phytochem. study of Stereocaulon montagneanum harvested in Sumatra (Indonesia) led to the isolation of 11 known compounds including two metabolites not previously described in the genus Stereocaulon, peristictic acid (8) and menegazziaic acid (10). The complete ¹H and ¹³C NMR spectral assignments of stictic acid derivatives are reported with some revisions. Five depsidones belonging to the stictic acid chemosyndrome were superoxide anion scavengers as potent as ascorbic acid and with no toxicity on two human cell lines.Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) were involved in the experimental procedure.

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.SDS of cas: 4707-47-5

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

COA of Formula: C9H10O2《Umpolung α-Silylation of Cyclopropyl Acetates via Low-Temperature Catalytic C-C Activation》 was published in 2019. The authors were Avullala, Thirupataiah;Asgari, Parham;Hua, Yuanda;Bokka, Apparao;Ridlen, Shawn G.;Yum, Kyungsuk;Dias, H. V. Rasika;Jeon, Junha, and the article was included in《ACS Catalysis》. The author mentioned the following in the article:

The authors report a redox-neutral, catalytic C-C activation of cyclopropyl acetates to produce Si-containing five-membered heterocycles in a highly regio- and chemoselective fashion. The umpolung α-selective silylation leading to dioxasilolanes is opposed to contemporary β-selective C-C functionalization protocols of cyclopropanols. Lewis base activation of dioxasilolanes as α-silyl carbinol equivalent undergoes the unconventional [1,2]-Brook rearrangement to form tertiary alcs. Notably, mechanistic studies indicate that an electrophilic metal-π interaction harnessing highly fluorinated Tp(CF₃)₂Rh(nbd) catalyst permitted a low temperature C-C activation. To complete the study, the researchers used Methyl 3-methylbenzoate (cas: 99-36-5) .

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester. Esters are widespread in nature and are widely used in industry. Several billion kilograms of polyesters are produced industrially annually, important products being polyethylene terephthalate, acrylate esters, and cellulose acetate.COA of Formula: C9H10O2

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Janta, Pannipa;Pinyo, Duangkamol;Yodta, Yamonporn;Vasasiri, Porames;Weidenbach, Meinolf;Pursch, Matthias;Yang, Xiuhan;Kulsing, Chadin published 《A multi-location peak parking approach for calculation of second dimensional retention indices for improved volatile compound identification with cryogen-free comprehensive heart-cut two-dimensional gas chromatography》 in 2021. The article was appeared in 《Analytical Methods》. They have made some progress in their research.Reference of 1-Phenylethyl acetate The article mentions the following:

Comprehensive heart-cut multidimensional gas chromatog. (CH/C MDGC) without a cryogenic trapping device was developed with an established approach for calculation of first and second dimensional retention indexes (1I and 2I) for improved compound identification. A first dimensional (1D) DB-1MS column (60 m) and a second dimensional (2D) DB-WAX column (60 m) were applied with a Deans switch (DS) using a constant H/C window of 0.2 min and a periodic multiple heartcut strategy comprising 225H/C throughout the CH/C. 1I was calculated based on comparison of the middle of the heartcut time with the alkane retention times on the 1D column. A multi-location peak parking approach using sixteen sets of automated injections of alkane references was also established with the least square curve fitting method for construction of the alkane isovolatility curves which were applied for 2I calculation The untargeted compound anal. of a perfume sample was then performed according to comparison with the libraries of mass spectra, 1I and 2I. The CH/C MDGC system with a 25 h anal. time showed a peak capacity (nc) of 9198 and 128 separated peaks with 71 compounds successfully identified according to MS, 1I and 2I library match under the established error approximation criteria. Furthermore, relationship between the anal. time and number of separated peaks was proposed based on the set of 84 identifiable compounds With the compensation of lower separation performance and greater I errors, the anal. time could be reduced by applying a 2.5 min H/C window with a total anal. time of 2 h and nc of 1134.1-Phenylethyl acetate (cas: 93-92-5) were involved in the experimental procedure.

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Reference of 1-Phenylethyl acetate It may be prepared by acetylation of methyl phenyl carbinol; from 1-bromoethylbenzene and silver acetate in acetic acid; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 99-36-5In 2020, Larson, Nicholas R.;Zhang, Aijun;Feldlaufer, Mark F. published 《Fumigation activities of methyl benzoate and its derivatives against the common bed bug (Hemiptera: Cimicidae)》. 《Journal of Medical Entomology》published the findings. The article contains the following contents:

Common bed bug Cimex lectularius (L.) (Hemiptera: Cimicidae) infestations are on the rise and due to the development of pesticide resistance they are becoming more difficult to control, affordably. We evaluated a naturally occurring compound Me benzoate (MB) and related analogs, previously reported to have insecticidal activity on several agricultural pests, for its fumigant action on the common bed bug, C. lectularius L. A discriminating concentration was used to determine the effectiveness of MB, and several of its analogs as fumigants in a laboratory assay. It was found that MB provided >90% control of adult bed bugs in this laboratory fumigant assay. The LC₅₀ values were calculated for MB against both a pyrethroid-susceptible and a pyrethroidresistant strain of common bed bugs. It was determined that both strains were susceptible in this laboratory assay. However, when MB was tested in a field-like assay and compared to a com. available bed bug control product, it was found to be significantly less effective compared to the com. product. Our study has found that while MB has the potential to be used as a bed bug control agent, refinements in the delivery system will be needed to increase efficacy under field-like conditions.Methyl 3-methylbenzoate (cas: 99-36-5) were involved in the experimental procedure.

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids.Related Products of 99-36-5 Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 93-92-5In 2020, Zarini, Daniele;Sangion, Alessandro;Ferri, Emanuele;Caruso, Enrico;Zucchi, Sara;Orro, Alessandro;Papa, Ester published 《Are In Silico Approaches Applicable As a First Step for the Prediction of e-Liquid Toxicity in e-Cigarettes?》. 《Chemical Research in Toxicology》published the findings. The article contains the following contents:

Recent studies have raised concerns about e-cigarette liquid inhalation toxicity by reporting the presence of chems. with European Union CLP toxicity classification. In this scenario, the regulatory context is still developing and is not yet up to date with vaping current reality. Due to the paucity of toxicol. studies, robust data regarding which components in tent. In this study we applied computational methods for studied chems. as a useful tool for predicting the acute toxicity of chems. contained in e-liquids The purpose of t the potential health concerns associated with e-liquid ingredients, (b) to prioritize e-liquid ingredients by calculating the e-tox index, and (c) to estimate acute toxicity of e-liquid mixtures QSAR models were generated using QSARINS software to fill the acute toxicity data gap of 264 e-liquid ingredients. As a second step, the potential acute toxicity of e-liquids mixtures was evaluated. Our preliminary data suggest that a computational approa serve as a roadmap to enable regulatory bodies to better regulate e-liquid composition and to contribute to consumer health protection. To complete the study, the researchers used 1-Phenylethyl acetate (cas: 93-92-5) .

1-Phenylethyl acetate(cas:93-92-5) is a carboxylic ester. Related Products of 93-92-5 It may be prepared by acetylation of methyl phenyl carbinol; from 1-bromoethylbenzene and silver acetate in acetic acid; from benzaldehyde by reacting with magnesium methyl bromide and subsequent acetylation.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Deng, Yifan;Yang, Chia-Ping H.;Smith, Amos B. III published 《Enantioselective Total Synthesis of (+)-Peniciketals A and B: Two Architecturally Complex Spiroketals》 in 2021. The article was appeared in 《Journal of the American Chemical Society》. They have made some progress in their research.Application In Synthesis of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate The article mentions the following:

The enantioselective total syntheses of (+)-peniciketals A and B (I and II, resp.), two members of a family of architecturally complex spiroketals, have been achieved. Key synthetic transformations comprise Type I Anion Relay Chem. (ARC) to construct the benzannulated [6,6]-spiroketal skeleton, a Negishi cross-coupling/olefin cross-metathesis reaction sequence to generate the trans-enone structure, and a late-stage large fragment union exploiting our recently developed photoisomerization/cyclization tactic. To complete the study, the researchers used Methyl 2,4-dihydroxy-3,6-dimethylbenzoate (cas: 4707-47-5) .

Methyl 2,4-dihydroxy-3,6-dimethylbenzoate(4707-47-5) is used in biological study as role of androgens in inducing distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells.Application In Synthesis of Methyl 2,4-dihydroxy-3,6-dimethylbenzoate

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gu, Yuanyun;Zhang, Zhen;Wang, Yan-En;Dai, Ziteng;Yuan, Yaqi;Xiong, Dan;Li, Jie;Walsh, Patrick J.;Mao, Jianyou published 《Benzylic Aroylation of Toluenes Mediated by a LiN(SiMe₃)₂/Cs⁺ System》 in 2022. The article was appeared in 《Journal of Organic Chemistry》. They have made some progress in their research.Reference of Methyl 3-methylbenzoate The article mentions the following:

Chemoselective deprotonative functionalization of benzylic C-H bonds is challenging, because the arene ring contains multiple aromatic C(sp²)-H bonds, which can be competitively deprotonated and lead to selectivity issues. Recently it was found that bimetallic [MN(SiMe₃)₂ M = Li, Na]/Cs⁺ combinations exhibit excellent benzylic selectivity. Herein, is reported the first deprotonative addition of toluenes to Weinreb amides mediated by LiN(SiMe₃)₂/CsF for the synthesis of a diverse array of 2-arylacetophenones. Surprisingly, simple Me benzoates also react with toluenes under similar conditions to form 2-arylacetophenones without double addition to give tertiary alc. products. This finding greatly increases the practicality and impact of this chem. Some challenging substrates with respect to benzylic deprotonations, such as fluoro and methoxy substituted toluenes, are selectively transformed to 2-aryl acetophenones. The value of benzylic deprotonation of 3-fluorotoluene is demonstrated by the synthesis of a key intermediate in the preparation of Polmacoxib.Methyl 3-methylbenzoate (cas: 99-36-5) were involved in the experimental procedure.

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids.Reference of Methyl 3-methylbenzoate Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics