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Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold was written by Manera, Clementina;Saccomanni, Giuseppe;Malfitano, Anna Maria;Bertini, Simone;Castelli, Francesca;Laezza, Chiara;Ligresti, Alessia;Lucchesi, Valentina;Tuccinardi, Tiziano;Rizzolio, Flavio;Bifulco, Maurizio;Di Marzo, Vincenzo;Giordano, Antonio;Macchia, Marco;Martinelli, Adriano. And the article was included in European Journal of Medicinal Chemistry in 2012.SDS of cas: 14667-47-1 This article mentions the following:

CB2 receptor ligands are becoming increasingly attractive drugs due to the potential role of this receptor in several physiopathol. processes. Using the previously described series of 1,8-naphthyridin-2(1H)-on-3-carboxamides as a lead class, several nitrogen heterocyclic derivatives, characterized by different central cores, were synthesized and tested for their affinity toward the human CB1 and CB2 cannabinoid receptors. The obtained results suggest that the new series of quinolin-2(1H)-on-3-carboxamides, 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamides and 1,2-dihydro-2-oxopyridine-3-carboxamides represent novel scaffolds very suitable for the development of promising CB2 ligands. Furthermore, the newly synthesized CB2 ligands inhibit proliferation of several cancer cell lines. In particular, it was demonstrated that in DU-145 cell line these ligands exert a CB2-mediated anti-proliferative action and decrease the CB2 receptor expression levels. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1SDS of cas: 14667-47-1).

Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.SDS of cas: 14667-47-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Enolate anions. III. Substituent effects of sodium diethyl alkylmalonates in DMSO was written by Kiyooka, Shunichi;Kodani, Tsukasa;Suzuki, Kojiro. And the article was included in Bulletin of the Chemical Society of Japan in 1980.Application In Synthesis of Diethyl isobutylmalonate This article mentions the following:

The conformations of Na enolate anions derived from RCH(CO₂Et)₂ (I; R = H, Me, Et, Pr, Me₂CH, Bu, Me₂CHCH₂, EtCHMe) were of the Z,Z type, according to their ¹H NMR spectra in Me₂SO. In the case of Me₃CCH(CO₂Et)₂ (II), such a Z,Z conformation contributes to a lesser extent to the conformations of the Na enolate anion because of repulsion between the tert-Bu substituent and the 2 EtO groups, which exist in 3 types of conformations (Z,Z, Z,E and E,E). All I (R = alkyl) except for II have 2 characteristic IR bands in the 1500-1700 cm^-1 region, the bands on the high-frequency side of which have nearly equal wavenos., while those on the low-frequency side correlate well with the substituent constant σ^*. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Application In Synthesis of Diethyl isobutylmalonate).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application In Synthesis of Diethyl isobutylmalonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gamma-decanolactone: Preliminary evaluation as potential antiparkinsonian drug was written by Pfluger, Pricila;Pereira, Patricia;Loza, Maria I.;Brea, Jose;Vina, Dolores;Kumar, Amit;Fontenla, Jose A.. And the article was included in European Journal of Pharmacology in 2021.Quality Control of 5-Hexyldihydrofuran-2(3H)-one This article mentions the following:

Treatment of Parkinson’s disease (PD) includes the use of monoamine oxidase-B (MAO-B) inhibitor drugs. In this work we have evaluated the possible gamma-decanolactone (GD) effect in vitro to inhibit the A and B isoforms of human monoamine oxidase (hMAO) enzyme and their citotoxicity in human hepatoma cell line (HepG2). Also, binding studies to A₁, A_2A A_2B and A₃ adenosine receptors were performed. A docking study of gamma-decanolactone has been carried out with the mol. targets of MAO-A and MAO-B isoforms. The physicochem. properties and ability to cross physiol. barriers, as the blood brain barrier (BBB), was elucidated by computational studies. The in vivo assays, the rota-rod test, body temperature assessment and open field test were performed in reserpinized mice (1.5 mg/kg, i.p.; 18:00 before) to evaluate the effect of gamma-decanolactone (300 mg/kg), alone or associated with Levodopa plus Benserazide (LD + BZ, 100:25 mg/kg, i.p.). Gamma-decanolactone inhibited preferentially the MAO-B in a reversible manner, with an inhibitory concentration of 50% (IC₅₀) 55.95 ± 9.06μM. It was shown to be a safe drug since only at the highest concentration decreased the viability of HepG2 cells. It also does not bind to adenosine receptors investigated in this study. The mol. docking study show that the gamma-decanolactone ligand adopts a relatively compact conformation in the active site of hMAO-B, while we note an extended conformation of gamma-decanolactone ligand in the hMAO-A isoform. The physicochem. properties obtained, and the theor. models utilized for the evaluation of ability to cross the BBB, predict a good gamma-decanolactone bioavailability and access to the central nervous system (CNS). In the in vivo studies, gamma-decanolactone partially reversed the ataxia of the reserpinized mice at 01:00 h and 01:30 h post-administration. Concomitant treatment of gamma-decanolactone with LD + BZ, at 01:30 h showed a potentiation of the reversibility of ataxia and facilitated the reversal of hypothermia caused by reserpine for all measured times (P <0.01 vs vehicle), except at 24:00 h, but not reversed the hypokinesia in the open field test. In summary, the results herein obtained and in conjunction with previous studies, suggest that gamma-decanolactone could be a drug with potential utility as antiparkinsonian drug. In the experiment, the researchers used many compounds, for example, 5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9Quality Control of 5-Hexyldihydrofuran-2(3H)-one).

5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Quality Control of 5-Hexyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wan, Yiqian published the artcileChemical studies on soft coral Lobophytum catelai. II., Quality Control of 110-34-9, the publication is Redai Haiyang (1997), 16(3), 78-82, database is CAplus.

The chem. constituents of the soft coral Lobophytum catelai collected from Xisha Islands were studied by spectroscopies and GC/MS. Eight compounds were isolated and identified, which were palmitic acid, iso-Bu palmicate, Bu alc., Pr palmitate, 2,3-dihydroxypropyloctadecaicate, 2β,3β-epoxy-5α-androsta-17-ol, 14-methyl-5α-cholesta-8-ene-3-one, and 2α,3α-epoxy-5α-androsta- 17-β-ol.

Redai Haiyang published new progress about 110-34-9. 110-34-9 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester, name is Isobutyl palmitate, and the molecular formula is C7H11N, Quality Control of 110-34-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mei, W. T. published the artcilePreparation and UV curing properties of oxazolidinone-based acrylate derivatives, SDS of cas: 15625-89-5, the publication is Reactive & Functional Polymers (2022), 105250, database is CAplus.

The oxazolidinone-based acrylate derivatives were prepared by the oxa-Michael addition reaction of neopentyl glycol diacrylate (NPGDA), trimethylolpropane triacrylate (TMPTA) and ethylene glycol dimethacrylate (EGDMA) with 3-(2-hydroxyethyl)-2-oxazolidinone (Z1), which was prepared by the reaction of di-Me carbonate (DMC) with diethanolamine (DEA). The mol. structures of the products were characterized by FT-IR, ¹H NMR and electrospray ionization high resolution mass spectrometry (ESI-HRMS). Under initiated by 1 weight% 2-isopropyl-9H-thioxanthen-9-one (ITX) and 1 weight% 2-hydroxy-2-methyl-1-phenylpropan-1-one (Da-1173), the oxazolidinone- based acrylates were cured in 30 s with double bond conversion of 92% and 98%, resp. The photopolymerization activity is in the order of oxazolidinone-based acrylate > conventional acrylate with 3 weight% EDB > conventional acrylate. The first-order kinetics for oxazolidinone part indicates that the oxazolidinone group is a hydrogen donor, which can terminate the polymeric radicals, forming an active radical to re-initiate the polymerization HRMS anal. of oligomers extracted from the UV-cured film of Bu acrylate confirms further the role of oxazolidinone part, and the plausible UV polymerization mechanism was proposed. The composition of addition product of TMPTA with Z1 (named as TMPTA-Z1) with epoxy acrylate can be 3D printed forming various models with the hardness of 5H.

Reactive & Functional Polymers published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, SDS of cas: 15625-89-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jeong, Soon Yeon published the artcileAntidiabetic Effect of Noodles Containing Fermented Lettuce Extracts, Recommanded Product: Ethyl nonanoate, the main research area is antidiabetic noodle fermented lettuce extract; GC–TOF-MS; antidiabetic effect; fermented lettuce extract; metabolomics; noodles.

The aim of the current study was to examine the antidiabetic effect of noodle containing fermented lettuce extract (FLE) on diabetic mice as a pre-clin. study. The γ-aminobutyric acid (GABA) content, antioxidant capacity, and total polyphenol content of the FLE noodles were analyzed and compared with those of standard noodles. In addition, oral glucose and sucrose tolerance, and fasting blood glucose tests were performed using a high-fat diet/streptozotocin-mediated diabetic mouse model. Serum metabolite profiling of mice feed standard or FLE noodles was performed using gas chromatog.-time-of-flight mass spectrometry (GC-TOF-MS) to understand the mechanism changes induced by the FLE noodles. The GABA content, total polyphenols, and antioxidant activity were high in FLE noodles compared with those in the standard noodles. In vivo experiments also showed that mice fed FLE noodles had lower blood glucose levels and insulin resistance than those fed standard noodles. Moreover, glycolysis, purine metabolism, and amino acid metabolism were altered by FLE as determined by GC-TOF-MS-based metabolomics. These results demonstrate that FLE noodles possess significant antidiabetic activity, suggesting the applicability of fermented lettuce extract as a potential food additive for diabetic food products.

Metabolites published new progress about Antidiabetic agents. 123-29-5 belongs to class esters-buliding-blocks, name is Ethyl nonanoate, and the molecular formula is C11H22O2, Recommanded Product: Ethyl nonanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

PiPo: random copolymers of C- with N-substituted glycines was written by Wang, Siqi;Chen, Wanli;Ling, Jun. And the article was included in Polymer Chemistry in 2022.Safety of Diphenyl carbonate The following contents are mentioned in the article:

Random copolymers of C- with N-substituted glycines (PiPo) were synthesized by carrying out a statistical copolymerization of N-phenyloxycarbonyl-C-substituted glycine (NPC) monomers with N-phenyloxycarbonyl-N-substituted glycine (NNPC) monomers. The copolymerization kinetics were analyzed in detail. The solubility of PiPo was found to highly depend on the compositions of the peptide and peptoid repeat units. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Safety of Diphenyl carbonate).

Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Safety of Diphenyl carbonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 2020, Sun, Xuefei; Dang, Guofang; Ding, Xiaobin; Shen, Chunxiang; Liu, Gongping; Zuo, Chengye; Chen, Xinjun; Xing, Weihong; Jin, Wanqin published an article.Product Details of 123-25-1 The title of the article was Production of alcohol-free wine and grape spirit by pervaporation membrane technology. And the article contained the following:

This study reports on production of alc.-free wine and grape spirit from red wine using pilot-scale pervaporation membrane equipment. The ethanol and aroma substances were concentrated from the wine via an organophilic pervaporation membrane, which were further processed by the membrane to obtain an ethanol content above 50 volume%. The separation performance for ethanol/water and red wine was compared to show that fouling existed when processing the red wine, and the 1st-stage permeate was found to be an excellent cleaning agent that can recover 99.15% of the initial flux. The results of aroma anal. showed that 65-70 wt% of the aroma substances existed in the permeate of pervaporation, which exhibited better smell and taste than traditional distilled liquor. The membrane performance was stable for the separation of red wine during 180 days of continuous operation. Though the investment and operating cost of pilot-scale equipment are relatively high, remuneration can be greatly improved by the utilization of alc.-free wine and grape spirit. The experimental process involved the reaction of Diethyl succinate(cas: 123-25-1).Product Details of 123-25-1

The Article related to alc free wine grape spirit pervaporation membrane technol, Food and Feed Chemistry: Beverages and other aspects.Product Details of 123-25-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gilmour, Sandra; Marder, Seth R.; Tiemann, Bruce G.; Cheng, Lap Tak published the artcile< Synthesis and first hyperpolarizabilities of acceptor-substituted β-apo-8'-carotenal derived compounds>, Related Products of 112-63-0, the main research area is hyperpolarizability apocarotenal derivative; optical property apocarotenal derivative; harmonic generation apocarotenal derivative.

The synthesis and second-order nonlinear optical properties of acceptor-substituted biol. derived β-apo-8′-carotenal compounds I [Z = C(CN)2, (E)-CHC6H4NO2-4] are reported. Elec. field-induced second harmonic generation (EFISH) measurements give values of β(0) which are 2-6 times greater than for 4-N,N-dimethylamino-4′-nitrostilbene (DANS).

Journal of the Chemical Society, Chemical Communications published new progress about Carotenes Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Khan, M. K. A.; Morgan, K. J.; Morrey, D. P. published the artcile< Carbonyl derivatives of heterocyclic compounds. III. The preparation of 3-acylpyrroles>, SDS of cas: 7126-50-3, the main research area is .

Synthetic routes to 3-acylpyrroles by methods involving ring closure, transformation of substituents, and further substitution of monosubstituted pyrroles were investigated. The condensation of H2NCHCHO with acylpyruvates appears to provide a general route to the 3-ketones. The related condensation of N-carbethoxyglycine ester and nitrile gave poor yields of 3-cyanopyrrole but attempts to obtain the 3-Ac derivative by the use of MeCOCH:CH2 showed the occurrence of an alternative reaction path and gave no useful product. Attempts to convert 3-cyano- and 3-carboxypyrroles into acyl derivatives by the action of nucleophilic reagents were not successful. Pyrrole-3-carboxaldehyde was obtained by decarboxylation of the minor formylation product of Et pyrrole-2-carboxylate. 24 references.

Tetrahedron published new progress about Carbonyl compounds (organic). 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, SDS of cas: 7126-50-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics