Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 99769-19-4, formula is C8H9BO4, Name is 3-(Methoxycarbonyl)phenylboronic acid. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Recommanded Product: 3-(Methoxycarbonyl)phenylboronic acid.
Gavai, Ashvinikumar V.;Norris, Derek;Delucca, George;Tortolani, David;Tokarski, John S.;Dodd, Dharmpal;O’Malley, Daniel;Zhao, Yufen;Quesnelle, Claude;Gill, Patrice;Vaccaro, Wayne;Huynh, Tram;Ahuja, Vijay;Han, Wen-Ching;Mussari, Christopher;Harikrishnan, Lalgudi;Kamau, Muthoni;Poss, Michael;Sheriff, Steven;Yan, Chunhong;Marsilio, Frank;Menard, Krista;Wen, Mei-Li;Rampulla, Richard;Wu, Dauh-Rurng;Li, Jianqing;Zhang, Huiping;Li, Peng;Sun, Dawn;Yip, Henry;Traeger, Sarah C.;Zhang, Yingru;Mathur, Arvind;Zhang, Haiying;Huang, Christine;Yang, Zheng;Ranasinghe, Asoka;Everlof, Gerry;Raghavan, Nirmala;Tye, Ching Kim;Wee, Susan;Hunt, John T.;Vite, Gregory;Westhouse, Richard;Lee, Francis Y. research published 《 Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design》, the research content is summarized as follows. Inhibition of the bromodomain and extra-terminal (BET) family of adaptor proteins is an attractive strategy for targeting transcriptional regulation of key oncogenes, such as c-MYC. Starting with the screening hit 1, a combination of structure-activity relationship and protein structure-guided drug design led to the discovery of a differently oriented carbazole 9 with favorable binding to the tryptophan, proline, and phenylalanine (WPF) shelf conserved in the BET family. Identification of an addnl. lipophilic pocket and functional group optimization to optimize pharmacokinetic (PK) properties culminated in the discovery of 18 (BMS-986158) (I) with excellent potency in binding and functional assays. On the basis of its favorable PK profile and robust in vivo activity in a panel of hematol. and solid tumor models, BMS-986158 was selected as a candidate for clin. evaluation.
Recommanded Product: 3-(Methoxycarbonyl)phenylboronic acid, 3-Methoxycarbonylphenylboronic acid is a useful research compound. Its molecular formula is C8H9BO4 and its molecular weight is 179.97 g/mol. The purity is usually 95%.
3-Methoxycarbonylphenylboronic acid is a reactanct that has been involved in a variety of applications. For instance, it has been used in Suzuki-Miyaura cross-coupling, Iterative cross-coupling of boronate building blocks, cross-coupling with aryl/ alkenyl sulfonates, synthesis of symmetrical biaryls via CuCl catalyzed homocoupling, trifluoromethylation, and cyanation just to name a few of its many uses.
3-Methoxycarbonylphenylboronic acid is a boronate ligand that has been shown to have an interaction with the nitrogen atoms in amines. This compound is used for the Suzuki coupling reaction, which is a chemical reaction between an organoboron compound and an organic electrophile. 3-Methoxycarbonylphenylboronic acid has a helical structure that can be seen by FTIR spectroscopy and it has potent inhibitory activity., 99769-19-4.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics