Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 99769-19-4, formula is C8H9BO4, Name is 3-(Methoxycarbonyl)phenylboronic acid. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. SDS of cas: 99769-19-4.
Kankanala, Jayakanth;Ribeiro, Carlos J. A.;Kiselev, Evgeny;Ravji, Azhar;Williams, Jessica;Xie, Jiashu;Aihara, Hideki;Pommier, Yves;Wang, Zhengqiang research published 《 Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide》, the research content is summarized as follows. Topoisomerase II (TOP2) poisons as anticancer drugs work by trapping TOP2 cleavage complexes (TOP2cc) to generate DNA damage. Repair of such damage by tyrosyl DNA phosphodiesterase 2 (TDP2) could render cancer cells resistant to TOP2 poisons. Inhibiting TDP2, thus, represents an attractive mechanism-based chemosensitization approach. Currently known TDP2 inhibitors lack cellular potency and/or permeability. We report herein two novel subtypes of the deazaflavin TDP2 inhibitor core. By introducing an addnl. Ph ring to the N-10 Ph ring (subtype 11) or to the N-3 site of the deazaflavin scaffold (subtype 12), we have generated novel analogs with considerably improved biochem. potency and/or permeability. Importantly, many analogs of both subtypes, particularly compounds 11a, 11e, 12a, 12b, and 12h, exhibited much stronger cancer cell sensitizing effect than the best previous analog 4a toward the treatment with etoposide, suggesting that these analogs could serve as effective cellular probes.
SDS of cas: 99769-19-4, 3-Methoxycarbonylphenylboronic acid is a useful research compound. Its molecular formula is C8H9BO4 and its molecular weight is 179.97 g/mol. The purity is usually 95%.
3-Methoxycarbonylphenylboronic acid is a reactanct that has been involved in a variety of applications. For instance, it has been used in Suzuki-Miyaura cross-coupling, Iterative cross-coupling of boronate building blocks, cross-coupling with aryl/ alkenyl sulfonates, synthesis of symmetrical biaryls via CuCl catalyzed homocoupling, trifluoromethylation, and cyanation just to name a few of its many uses.
3-Methoxycarbonylphenylboronic acid is a boronate ligand that has been shown to have an interaction with the nitrogen atoms in amines. This compound is used for the Suzuki coupling reaction, which is a chemical reaction between an organoboron compound and an organic electrophile. 3-Methoxycarbonylphenylboronic acid has a helical structure that can be seen by FTIR spectroscopy and it has potent inhibitory activity., 99769-19-4.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics