Synthetic Route of 99548-56-8, A common heterocyclic compound, 99548-56-8, name is Methyl 2-bromo-6-methylbenzoate, molecular formula is C9H9BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
7-Bromoisoindolin-l-one was prepared by bromination of methyl 2-bromo-6-methyl benzoate (using N-bromosuccinimide and benzoyl peroxide in refluxing CC14) and treatment of the resulting benzyl bromide with ammonia gas in refluxing ethanol. Further elaboration via the procedure of Example 135 gave the title compound. delta (500 MHz, d6 DMSO): 8.62 (1 H, s), 8.24 (1 H, d, J = 7.3 Hz), 7.96 (2 H, d, J = 8.4 Hz), 7.91-7.85 (2 H, m), 7.71-7.64 (4 H, m), 7.40 (1 H, d, J = 16.5 Hz), 7.25 (2 H, d, J = 16.2 Hz), 7.21 (1 H, d, J = 8.8 Hz), 4.36 (2 H, s).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2006/21805; (2006); A1;,
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