Category: 99-36-5

Dave, Alpa Y.;Parmar, Kokila A.;Begari, Eeshwaraiah;Joshi, Deepkumar S. published 《Synthesis and biological evaluation of oxadiazole clubbed thiadiazole derivatives as antimicrobial agents》. The research results were published in《Indian Journal of Heterocyclic Chemistry》 in 2021.Application of 99-36-5 The article conveys some information:

A series of 1,3,4-oxadiazole clubbed 1,3,4-thiadiazole derivatives I [R¹ = H, 3-Me, 2-Cl, etc; R² = H, 3-Me, 4-HO, 2-Cl, 4-Cl] were synthesized and assessed in-vitro for their activity as antimicrobial agents. The target compounds I were synthesized using a basic condensation reaction between 5-(substituted phenyl)-1,3,4-oxadiazole-2-thiols and 2-chloro-N-(5-(substituted phenyl)-1,3,4-thiadiazol-2-yl)acetamides in presence of K₂CO₃ as a scavenging agent and acetone as reaction solvent. The compounds I synthesized here, exhibited excellent to moderate antimicrobial activity against a broad panel of antibacterial strains of Gram-pos. and Gram-neg. bacteria and fungi.Methyl 3-methylbenzoate (cas: 99-36-5) were involved in the experimental procedure.

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids.Application of 99-36-5 Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiang, Ming;Zhou, Chao;Yang, Xiu-Long;Chen, Bin;Tung, Chen-Ho;Wu, Li-Zhu published 《Visible Light-Catalyzed Benzylic C-H Bond Chlorination by a Combination of Organic Dye (Acr⁺-Mes) and N-Chlorosuccinimide》 in 2020. The article was appeared in 《Journal of Organic Chemistry》. They have made some progress in their research.Formula: C9H10O2 The article mentions the following:

By combining “N-chlorosuccinimide (NCS)” as the safe chlorine source with “Acr⁺-Mes” as the photocatalyst, we successfully achieved benzylic C-H bond chlorination under visible light irradiation Furthermore, benzylic chlorides could be converted to benzylic ethers smoothly in a one-pot manner by adding sodium methoxide. This mild and scalable chlorination method worked effectively for diverse toluene derivatives, especially for electron-deficient substrates. Careful mechanistic studies supported that NCS provided a hydrogen abstractor “N-centered succinimidyl radical,” which was responsible for the cleavage of the benzylic C-H bond, relying on the reducing ability of Acr^•-Mes.Methyl 3-methylbenzoate (cas: 99-36-5) were involved in the experimental procedure.

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids.Formula: C9H10O2 Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Jidan;Xu, Erjie;Jiang, Jinyuan;Huang, Zeng;Zheng, Liyao;Liu, Zhao-Qing published 《Copper-mediated tandem ring-opening/cyclization reactions of cyclopropanols with aryldiazonium salts: synthesis of N-arylpyrazoles》 in 2020. The article was appeared in 《Chemical Communications (Cambridge, United Kingdom)》. They have made some progress in their research.Category: esters-buliding-blocks The article mentions the following:

A general method for the synthesis of structurally diverse N-arylpyrazoles I [R = H, 3-Me, 4-Cl, etc.; R¹ = c-Pr, Ph, 3-thienyl, etc.; R² = H, Me, Et, etc.] from readily available cyclopropanols and aryldiazonium salts was disclosed. The reaction was conducted at room temperature within minutes with a broad substrate scope and excellent regioselectivity. And Methyl 3-methylbenzoate (cas: 99-36-5) was used in the research process.

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are common in organic chemistry and biological materials, and often have a pleasant characteristic, fruity odor. This leads to their extensive use in the fragrance and flavor industry. Ester bonds are also found in many polymers.Category: esters-buliding-blocks

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Long, Jiao;Gao, Wenchao;Guan, Yuqing;Lv, Hui;Zhang, Xumu published 《Nickel-Catalyzed Highly Enantioselective Hydrogenation of β-Acetylamino Vinylsulfones: Access to Chiral β-Amido Sulfones》 in 2018. The article was appeared in 《Organic Letters》. They have made some progress in their research.Electric Literature of C9H10O2 The article mentions the following:

In the presence of Ni(OAc)₂ and (S)-Binapine in 1:9 MeOH/F₃CCH₂OH (TFE), β-(acetylamino)-α,β-unsaturated sulfones (Z)-RC(NHCOMe):CHSO₂R¹ (R = Ph, 4-MeC₆H₄, 3-MeC₆H₄, 4-t-BuC₆H₄, 4-MeOC₆H₄, 4-ClC₆H₄, 3-ClC₆H₄, 4-BrC₆H₄, 4-FC₆H₄, 3-FC₆H₄, 4-F₃CC₆H₄, 2-thienyl, cyclohexyl, Et; R¹ = Me, Ph) underwent enantioselective hydrogenation to give β-(acetylamino) sulfones (S)-RCH(NHCOMe)CH₂SO₂R¹ (R = Ph, 4-MeC₆H₄, 3-MeC₆H₄, 4-t-BuC₆H₄, 4-MeOC₆H₄, 4-ClC₆H₄, 3-ClC₆H₄, 4-BrC₆H₄, 4-FC₆H₄, 3-FC₆H₄, 4-F₃CC₆H₄, 2-thienyl, cyclohexyl, Et; R¹ = Me, Ph) in 75-95% yields and in 90->99% ee. The 1:1 (E):(Z) mixture of PhC(NHCOMe):CHSO₂Ph underwent enantioselective hydrogenation to give (S)-PhCH(NHCOMe)CH₂SO₂Ph in 85% yield and 97% ee; in a sep. hydrogenation reaction performed on gram scale, 0.2 mol% of the nickel catalyst was used.Methyl 3-methylbenzoate (cas: 99-36-5) were involved in the experimental procedure.

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids.Electric Literature of C9H10O2 Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhou, Quan-Cheng;Wang, Tian-Rui;Li, Hui;Chen, Lei;Xin, Jia-Jin;Guo, Shen;Sheng, Gui-Hua;You, Zhong-Lu published 《Synthesis, crystal structures and insulin-like activity of three new oxidovanadium(V) complexes with aroylhydrazone ligand》 in 2019. The article was appeared in 《Journal of Inorganic Biochemistry》. They have made some progress in their research.Quality Control of Methyl 3-methylbenzoate The article mentions the following:

Three new oxidovanadium(V) complexes were designed, synthesized and characterized by C, H, N elemental anal., single crystal x-ray diffraction,UV/visible and IR spectra. Complex 1: [VOL¹X] (H₂L¹ = (E)-N’-(2-hydroxybenzylidene)-3-methbenzohydrazide, HX = ethylmaltol = 2-ethyl-3-hydroxy-4-pyrone), Complex 2: [VOL²(CH₃O)(CH₃OH)], (H₂L² = C₁₆H₁₆N₂O₄ = (E)-N’-(2-hydroxybenzylidene)-3,5-dimethoxybenzohydrazide, CH₃OH = methanol), Complex 3: [VOL³X] (H₂L³ = (E)-N’-(3-ethoxy-2-hydroxybenzylidene)-3,5-dimethoxybenzohydrazide). The insulin-like activity of the three complexes was tested. Both normal and streptozotocin (STZ)-diabetic mice were administered intragastrically for two weeks. The complexes at doses of 10.0 and 5.0 mg V·kg^-1 can significantly decrease the blood glucose level in STZ-diabetic mice, and the blood glucose level in the treated normal mice was not altered. The lesions of kidney and liver caused by diabetes have varying degrees of improvement. To complete the study, the researchers used Methyl 3-methylbenzoate (cas: 99-36-5) .

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester. Esters are widespread in nature and are widely used in industry. Several billion kilograms of polyesters are produced industrially annually, important products being polyethylene terephthalate, acrylate esters, and cellulose acetate.Quality Control of Methyl 3-methylbenzoate

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Han;Sun, Yu;Wong, Wee Lin;Cui, Jiajia;Li, Jingyang;You, Xuefu;Yap, Lee Fah;Huang, Yu;Hong, Wei;Yang, Xinyi;Paterson, Ian C.;Wang, Hao published 《The development of a novel transforming growth factor-β (TGF-β) inhibitor that disrupts ligand-receptor interactions》 in 2020. The article was appeared in 《European Journal of Medicinal Chemistry》. They have made some progress in their research.SDS of cas: 99-36-5 The article mentions the following:

Transforming growth factor-β (TGF-β) plays an important role in regulating epithelial to mesenchymal transition (EMT) and the TGF-β signaling pathway is a potential target for therapeutic intervention in the development of many diseases, such as fibrosis and cancer. Most currently available inhibitors of TGF-β signaling function as TGF-β receptor I (TβR-I) kinase inhibitors, however, such kinase inhibitors often lack specificity. In the present study, we targeted the extracellular protein binding domain of the TGF-β receptor II (TβR-II) to interfere with the protein-protein interactions (PPIs) between TGF-β and its receptors. One compound, CJJ300, inhibited TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex. Treatment of A549 cells with CJJ300 resulted in the inhibition of downstream signaling events such as the phosphorylation of key factors along the TGF-β pathway and the induction of EMT markers. Concomitant with these effects, CJJ300 significantly inhibited cell migration. The present study describes for the first time a designed mol. that can regulate TGF-β-induced signaling and EMT by interfering with the PPIs required for the formation of the TGF-β signaling complex. Therefore, CJJ300 can be an important lead compound with which to study TGF-β signaling and to design more potent TGF-β signaling antagonists. And Methyl 3-methylbenzoate (cas: 99-36-5) was used in the research process.

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are common in organic chemistry and biological materials, and often have a pleasant characteristic, fruity odor. This leads to their extensive use in the fragrance and flavor industry. Ester bonds are also found in many polymers.SDS of cas: 99-36-5

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sattenapally, Narsimha;Sharma, Jhanvi;Hou, Yuqing published 《Selective conversion of primary amides to esters promoted by KHSO₄》 in 2018. The article was appeared in 《ARKIVOC (Gainesville, FL, United States)》. They have made some progress in their research.Synthetic Route of C9H10O2 The article mentions the following:

Primary amides, either aliphatic or aromatic, were easily converted to the corresponding esters via reflux in lower primary alcs. in the presence of KHSO₄. Secondary amides led to complicated mixtures under analogous conditions, whereas tertiary amides were inert. Use of iso-Pr alc. resulted in the formation of product at slower rate and lower yield along with side products, whereas, use of tertiary alcs. did not give successful conversion and allyl and benzyl alc. provided complex mixtures And Methyl 3-methylbenzoate (cas: 99-36-5) was used in the research process.

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids.Synthetic Route of C9H10O2 Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Slavchev, Ivaylo;Ward, Jas. S.;Rissanen, Kari;Dobrikov, Georgi M.;Simeonov, Svilen published 《Base-promoted direct amidation of esters: beyond the current scope and practical applications》. The research results were published in《RSC Advances》 in 2022.Reference of Methyl 3-methylbenzoate The article conveys some information:

The base-promoted direct amidation of unactivated esters is among the most useful reactions for amide bond formation in contemporary organic chem. The intensive research in this area has led to the development of a number of new methods to achive this transformation. However, to date, the existing literature is more methodol. and in many instances lacks practical directions. Therefore, the full potential of this transformation is yet to be revealed by broadening the substrate scope. In a search for new practical applications of the amidation reaction, herein a comprehensive study of a number of base-promoted direct amidations that encompass a wide range of amines and esters is presented. Furthermore, authors applied their findings in the synthesis of phosphoramidates and several industrially relevant products. The experimental procedure involved many compounds, such as Methyl 3-methylbenzoate (cas: 99-36-5) .

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids.Reference of Methyl 3-methylbenzoate Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of C9H10O2《Reactions of benzyltriphenylphosphonium salts under photoredox catalysis》 was published in 2021. The authors were Boldt, Andrew M.;Dickinson, Sidney I.;Ramirez, Jonathan R.;Benz-Weeden, Anna M.;Wilson, David S.;Stevenson, Susan M., and the article was included in《Organic & Biomolecular Chemistry》. The author mentioned the following in the article:

The development of benzyltriphenylphosphonium salts RCH₂P⁺(C₆H₅)₃X^– (R = 3-methylphenyl, 4-bromophenyl, 3,5-dimethylphenyl, etc.; X = Cl, Br) as alkyl radical precursors using photoredox catalysis is described. Depending on substituents, the benzylic radicals may couple to form C-C bonds or abstract a hydrogen atom to form C-H bonds. A natural product, brittonin A, was also synthesized using this method. The experimental procedure involved many compounds, such as Methyl 3-methylbenzoate (cas: 99-36-5) .

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids.Synthetic Route of C9H10O2 Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

HPLC of Formula: 99-36-5《Cerium(III) triflate-catalyzed cycloaddition reaction in aqueous conditions to substituted naphthotriazolediones》 was published in 2022. The authors were Li, Ya-Syuan;Liang, Chien-Fu, and the article was included in《Journal of the Chinese Chemical Society (Weinheim, Germany)》. The author mentioned the following in the article:

In this study, the cerium(III) trifluoromethanesulfonate-catalyzed cycloaddition of 1,4-naphthoquinone with functionalized azides in aqueous solutions was used to synthesize naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives Moreover, this method boasts scalability and completes the synthesis of two key biol. compounds This method’s advantages are environmentally friendly reaction conditions, easy applicability in large-scale operations, broad structurally diverse products produced in high yields and the recyclability of catalysts. To complete the study, the researchers used Methyl 3-methylbenzoate (cas: 99-36-5) .

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester. Esters are widespread in nature and are widely used in industry. Several billion kilograms of polyesters are produced industrially annually, important products being polyethylene terephthalate, acrylate esters, and cellulose acetate.HPLC of Formula: 99-36-5

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics