Category: 98231-07-3

The discovery and structure-activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: A novel potent antibacterial analog derived from hygromycin A was written by Le, Phuong T.;Brickner, Steven J.;Wade, Sarah K.;Brighty, Katherine;Monahan, Rhonda;Stone, Gregory G.;Girard, Dennis;Finegan, Steve;Duignan, Joan;Schafer, John;Maloney, Meghan;Zaniewski, Richard P.;Connolly, Ann G.;Liras, Jennifer;Bordner, Jon;Samardjiev, Ivan. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Application of 98231-07-3 This article mentions the following:

SAR studies and optimization of various modified Hygromycin A fluoroalkyl ethers, which led to the discovery of the highly potent 4′-(2-cyclopropyl-2-fluoroethyl ether) antibacterial CE-156811 (1) derived from truncation of the ribose ring and difluorination of the Ph found in Hygromycin A, are discussed. In the experiment, the researchers used many compounds, for example, Methyl 3,3-dimethoxycyclobutanecarboxylate (cas: 98231-07-3Application of 98231-07-3).

Methyl 3,3-dimethoxycyclobutanecarboxylate (cas: 98231-07-3) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application of 98231-07-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of methylenecyclobutane analogues of nucleosides with axial chirality and their phosphoralaninates: A new pronucleotide effective against Epstein-Barr virus was written by Wang, Ruifang;Kern, Earl R.;Zemlicka, Jiri. And the article was included in Antiviral Chemistry & Chemotherapy in 2002.COA of Formula: C8H14O4 This article mentions the following:

Methylenecyclobutane analogs of 2′-deoxyadenosine, 2′-deoxyguanosine and 2′-deoxycytidine, and the corresponding phosphoralaninate pronucleotides comprising adenine and guanine bases, were synthesized as potential antiviral agents. Phosphoralaninate of adenine methylenecyclobutane was a potent inhibitor of replication of Epstein-Barr virus (EBV) in Daudi cell culture. Phosphoralaninate of guanine analog was inactive but both pronucleotides were substrates for porcine liver esterase. Adenine methylenecyclobutane analog was deaminated by adenosine deaminase. In the experiment, the researchers used many compounds, for example, Methyl 3,3-dimethoxycyclobutanecarboxylate (cas: 98231-07-3COA of Formula: C8H14O4).

Methyl 3,3-dimethoxycyclobutanecarboxylate (cas: 98231-07-3) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C8H14O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics