Related Products of 957205-72-0,Some common heterocyclic compound, 957205-72-0, name is Methyl 3-methyl-4-(trifluoromethyl)benzoate, molecular formula is C10H9F3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3-Methyl-4-trifluoromethylbenzoic acid methyl ester (0.20 g) was dissolved in THF (10 mL), and lithium borohydride (0.060 g) was added to the solution. The reaction mixture was refluxed with stirring for 3 hours and cooled to room temperature. 1N hydrochloric acid was added to the reaction mixture, followed by extraction thrice, each with ethyl acetate. The extracts were combined and washed with saturated brine, followed by drying over sodium sulfate. Insoluble matter was removed by filtration, and then the filtrate was concentrated. The residue was purified by silica gel column chromatography, whereby the title compound (0.16 g) was yielded. 1H-NMR (CDCl3) delta : 1.72(1H,t,J=5.9Hz), 2.48-2.50(3H,m), 4.73(2H,d,J=5.6Hz), 7.26-7.26(1H,m), 7.29(1H,s), 7.59(1H,d,J=7.8Hz).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-methyl-4-(trifluoromethyl)benzoate, its application will become more common.
Reference:
Patent; Daiichi Sankyo Company, Limited; EP2017263; (2009); A1;,
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