Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 955887-09-9, name is tert-Butyl 4-bromo-2,6-difluorobenzoate, A new synthetic method of this compound is introduced below., Recommanded Product: tert-Butyl 4-bromo-2,6-difluorobenzoate
To tert-butyl 4-bromo-2,6-difluorobenzoate (1.47 g, 5.00 mmol), DMA (10 ml), copper(I) chloride (990 mg, 10.0 mmol), triethylamine (1.74 ml, 12.5 mmol), and TMSN3 (1.32 ml, 10.0 mmol) were added, followed by stirring at 100 C. for 16 hours. To the reaction liquid, water was added, followed by extraction with ethyl acetate (10 ml¡Á3). After concentration under reduced pressure, the residue was purified by reversed-phase HPLC (H2O containing 0.1% TFA/CH3CN system), followed by freeze-drying, to obtain a TFA salt (810 mg, 71%) of the title compound. [1075] MS (ESI) m/z 230 (M+H)+
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; AJINOMOTO CO., LTD.; Ueno, Hirokazu; Yamamoto, Takashi; Takashita, Ryuta; Yokoyama, Ryohei; Sugiura, Toshihiko; Kageyama, Shunsuke; Ando, Ayatoshi; Eda, Hiroyuki; Eviryanti, Agung; Miyazawa, Tomoko; Kirihara, Aya; Tanabe, Itsuya; Nakamura, Tarou; Noguchi, Misato; Shuto, Manami; Sugiki, Masayuki; Dohi, Mizuki; US2015/51395; (2015); A1;,
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