Extracurricular laboratory: Synthetic route of 952285-52-8

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 952285-52-8, A common heterocyclic compound, 952285-52-8, name is Methyl 4-amino-2,5-difluorobenzoate, molecular formula is C8H7F2NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(Step 1) Synthesis of methyl 2,5-difluoro-4-[(4-nitrophenyl)sulfonylamino]benzoate A 4-nitro benzene sulfonyl chloride (8.9 g, 40.1 mmol) was added to a pyridine solution (30 ml) of methyl 4-amino-2,5-difluoro-benzoate (3.0 g, 16.0 mmol), followed by stirring at 50?C for 18 hours. The resultant mixture was concentrated under reduced pressure, and the residue was slurry washed using acetonitrile to obtain methyl 4-[bis[(4-nitrophenyl)sulfonyl]amino]-2,5-difluoro-benzoate (11.6 g).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; EA Pharma Co., Ltd.; TOKUMASU Munetaka; NOGUCHI Masatsugu; KAWAHIRA Mizuki; IWASAKI Kana; HAYAKAWA Nobuhiko; MIYANAGA Wataru; SAITOU Yuki; YAMAURA Yui; ANDO Ayatoshi; TSURUTA Atsushi; NOGUCHI Misato; (127 pag.)EP3412660; (2018); A1;,
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