Synthetic Route of 945-93-7, A common heterocyclic compound, 945-93-7, name is Ethyl 3-phenylbut-2-enoate, molecular formula is C12H14O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Unsaturated ester (4a-4d) (0.1 mol) was boiled with 5 N NaOH under a reflux condenser for 2-3 h and left to stir at room temperature overnight. The formed carboxylate salt was dissolved in water and diluted HCl was added. The obtained solid product was filtered and crystallized with EtOH-water. (E) -3-Phenylbut-2-enoic acid (3d) [34]: Yield: 15 g, 94%. Mp: 90-92 C, (lit: 90-92 C). 1 H NMR (400 MHz, CDCl3) , delta (ppm): 7.51-7.49 (3H, m), 7.40-7.38 (2H, m), 6.18 (1H, s), 2.61 (3H, s).
The synthetic route of 945-93-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Sari, Sait; Uenalan, Seda; Yilmaz, Mehmet; Turkish Journal of Chemistry; vol. 43; 6; (2019); p. 1656 – 1671;,
Ester – Wikipedia,
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