Category: 94-02-0

Li, Cheng-Kun; Tao, Ze-Kun; Zhou, Zhi-Hao; Bao, Xiao-Guang; Zhou, Shao-Fang; Zou, Jian-Ping published the artcile< Copper-Catalyzed Oxidative sp3-Carbon Radical Cross-Coupling with Trialkylphosphites Leading to α-Phosphonyl 1,3-Dicarbonyl Compounds>, Quality Control of 94-02-0, the main research area is copper catalyzed oxidative cross coupling alkylphosphite dicarbonyl compound; diketone alpha phosphonyl derivative preparation; ketoester alpha phosphonyl derivative preparation.

A Cu-catalyzed radical Csp3-H/P(OR)3 cross-coupling reaction for the formation of Csp3-P bonds is described. A range of 1,3-dicarbonyl compounds and trialkylphosphites were coupled in this fashion to give the corresponding products in moderate to good yields. This protocol provides direct access to α-phosphonyl 1,3-dicarbonyl compounds

Journal of Organic Chemistry published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Quality Control of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fernandes, Alessandra A. G.; Stivanin, Mateus L.; Jurberg, Igor D. published the artcile< RuCl3/ PPh3 - Catalyzed Direct Conversion of Isoxazol-5-ones to 2,3-Disubstituted Pyridines>, Category: esters-buliding-blocks, the main research area is isoxazolone acrolein ruthenium chloride triphenyl phosphine catalyst decarboxylative heterocyclization; pyridine preparation.

A novel catalytic system employing RuCl3/ PPh3 was described for the preparation of 2,3-disubstituted pyridines starting from 3,4-disubstituted isoxazol-5-ones and acrolein. Mechanistic studies involving 31P NMR, HRMS analyses and control experiments were performed in order to supported key events and intermediates proposed for this transformation.

ChemistrySelect published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Luo, Zhenli; Wan, Shanhong; Pan, Yixiao; Yao, Zhen; Zhang, Xin; Li, Bohan; Li, Jiajie; Xu, Lijin; Fan, Qing-Hua published the artcile< Metal-Free Reductive Amination of Ketones with Amines Using Formic Acid as the Reductant under BF3 · Et2O Catalysis>, Synthetic Route of 94-02-0, the main research area is ketone amine formic acid boron trifluoride etherate reductive amination; alkylamine preparation.

BF3·Et2O was found to effectively catalyze reductive amination of ketones with amines employing formic acid as the reductant under metal-free conditions. This transformation tolerated a broad range of primary and secondary amines and differently decorated ketones, delivering N-alkylated amines in good to excellent yields with high compatibility of functional groups. The synthetic potential of this protocol was demonstrated by its application in the preparation of biol. and pharmaceutically relevant compounds

Asian Journal of Organic Chemistry published new progress about Amines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Synthetic Route of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reddy, Angula Chandra Shekar; Anbarasan, Pazhamalai published the artcile< Rhodium-Catalyzed Rearrangement of S/Se-Ylides for the Synthesis of Substituted Vinylogous Carbonates>, Category: esters-buliding-blocks, the main research area is sulfur seleno vinylogous carbonate preparation chemo regioselective; seleno sulfur ylide oxa sigmatropic rearrangement rhodium catalyst.

An efficient rhodium-catalyzed unprecedented oxa-[2,3]-sigmatropic rearrangement of sulfur ylide derived from α-thioesters/ketones and diazo carbonyl compounds has been accomplished for the synthesis of various sulfur-tethered vinylogous carbonates in good to excellent yields. Important features of the developed reaction include wide functional group tolerance, excellent chemo- and regioselectivity, and efficient rearrangement involving the carbonyl motif. The present reaction also equally works well with α-selenoesters for the synthesis of seleno-containing vinylogous carbonates.

Organic Letters published new progress about Carbonates Role: SPN (Synthetic Preparation), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Winterson, Bethan; Rennigholtz, Tim; Wirth, Thomas published the artcile< Flow electrochemistry: a safe tool for fluorine chemistry>, Category: esters-buliding-blocks, the main research area is fluoro compound preparation; allyl amide electrochem fluorination hypervalent iodine mediated; alc allyl electrochem fluorination hypervalent iodine mediated; carbonyl compound electrochem fluorination hypervalent iodine mediated.

A scalable, versatile and safe electrochem. fluorination protocol was conferred and strategy proceeded through a transient (difluoroiodo)arene, generated by anodic oxidation of an iodoarene mediator. Even the isolation of iodine(III) difluorides was facile since electrolysis was performed in the absence of other reagents. A broad range of hypervalent iodine mediated reactions afforded 5-(fluoromethyl)-aryl-oxazolines [R = Ph, 2-furanyl, 4-MeOC6H4, etc.], ((2,3-difluoropropoxy)methyl)-aromatic compounds [R1 = Ph, 2-MeC6H4, 4-FC6H4, etc.; R2 = H, Me] and some fluoro compounds R3-F [R3 = 1,3-diphenylpropanyl-1,3-dione, 1-phenyl-1-propanone, 3-phenyldihydrofuran-2(3H)-one, etc.] in high yields by coupling the electrolysis step with downstream reactions in flow, surpassing limitations of batch chem. (Difluoroiodo)arenes were toxic and suffered from chem. instability, so the uninterrupted generation and immediate use in flow was highly advantageous. High flow rates facilitated productivities of up to 834 mg h-1 with vastly reduced reaction times. Integration into a fully automated machine and in-line quenching was key in reducing the hazards surrounding the use of hydrofluoric acid.

Chemical Science published new progress about Allylic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dong, Jun; Du, Hongguang; Xu, Jiaxi published the artcile< Regiospecific synthesis of polysubstituted furans with mono- to tricarboxylates from various sulfonium acylmethylides and acetylenic esters>, COA of Formula: C11H12O3, the main research area is polysubstituted furan preparation regioselective; ylide alkyne tandem Michael addition nucleophilic ring opening elimination.

Polysubstituted furans I [R1 = CO2Me, CO2Et; R2 = H, CF3, CO2Me, CO2Et; R3 = H, CO2Me, CO2Et; R4 = Me, Ph, 1-naphthyl, etc.] were prepared in moderate to good yields from sulfur ylides and acetylenic esters. The direct reactions of dimethylsulfonium acylmethylides with acetylenic esters afforded furans I through a tandem sequence of Michael addition, intramol. nucleophilic addition, 4π ring opening, intramol. Michael addition and elimination. The method was extended to synthesize furan-3-carboxylate, -2,4-dicarboxylates, and -2,3,4-tricarboxylates as well. The current method provided a direct and simple strategy in synthesis of structurally diverse polysubstituted furans with mono- to tricarboxylate groups from safe and readily available dimethylsulfonium acylmethylides and different acetylenic esters.

RSC Advances published new progress about Elimination reaction. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, COA of Formula: C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lyons, Demelza J. M.; Dinh, An H.; Ton, Nhan N. H.; Crocker, Reece D.; Mai, Binh Khanh; Nguyen, Thanh Vinh published the artcile< Ring Contraction of Tropylium Ions into Benzenoid Derivatives>, HPLC of Formula: 94-02-0, the main research area is benzenoid preparation; tropylium ion ring contraction.

Authors report a method to convert substituted tropylium ions into benzenoid derivatives

Organic Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, HPLC of Formula: 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Hao-Nan; Cao, Hao-Qiang; Cheung, Chi Wai; Ma, Jun-An published the artcile< Cu-Mediated Expeditious Annulation of Alkyl 3-Aminoacrylates with Aryldiazonium Salts: Access to Alkyl N2-Aryl 1,2,3-Triazole-carboxylates for Druglike Molecular Synthesis>, Synthetic Route of 94-02-0, the main research area is aryldiazonium salt alkyl aminoacrylate preparation copper heterocyclization; alkyl aryltriazole carboxylate preparation.

A Cu-mediated annulation reaction of alkyl 3-aminoacrylates with aryldiazonium salts was described, both of which were readily available substrates. Furthermore, alkyl 2-aminoacrylates were also viable substrates. Diverse alkyl N2-aryl 1,2,3-triazole-carboxylates and their analogs was rapidly prepared under mild conditions. Especially, this protocol allowed one to access several druglike variants of carbonic anhydrase inhibitors and celecoxib.

Organic Letters published new progress about Amino esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Synthetic Route of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Dae Gyu; Huddar, Srigouri; Lim, Semi; Kong, Jiwon; Lee, Yuno; Park, Chul Min; Lee, Seungbeom; Suh, Young-Ger; Kim, Minkyoung; Lee, Kyeong; Lee, Sunkyung; Kim, Sunghoon published the artcile< Allosteric inhibition of the tumor-promoting interaction between exon 2-depleted splice variant of aminoacyl-transfer RNA synthetase-interacting multifunctional protein 2 and heat shock protein 70>, Reference of 94-02-0, the main research area is aminoacyl tRNA synthetase heat shock protein allosteric inhibition.

Although protein-protein interactions (PPIs) have emerged as an attractive therapeutic target space, the identification of chems. that effectively inhibit PPIs remains challenging. Here, we identified through library screening a chem. probe (compound 1) that can inhibit the tumor-promoting interaction between the oncogenic factor exon 2-depleted splice variant of aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2-DX2) and heat shock protein 70 (HSP70). We found that compound 1 binds to the N-terminal subdomain of glutathione S-transferase (GST-N) of AIMP2-DX2, causing a direct steric clash with HSP70 and an intramol. interaction between the N-terminal flexible region and the GST-N of AIMP2-DX2, which induces masking of the HSP70 binding region during mol. dynamics and mutation studies. Compound 1 thus interferes with the AIMP2-DX2 and HSP70 interaction and suppresses the growth of cancer cells that express high levels of AIMP2-DX2 in vitro and in preliminary in vivo experiment This work provides an example showing that allosteric conformational changes induced by chems. can be a way to control pathol. PPIs.

Journal of Pharmacology and Experimental Therapeutics published new progress about Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Reference of 94-02-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bakaraki Turan, Nouha; Zaman, Buse T.; Arvas, Busra; Yolacan, Cigdem; Bakirdere, Sezgin published the artcile< Implementation of a spraying-assisted fine droplet formation-based simultaneous liquid-phase microextraction method for the determination of copper in clove extract samples>, Category: esters-buliding-blocks, the main research area is simultaneous liquid phase microextraction copper clove extract spraying apparatus.

A simultaneous liquid-phase microextraction method was investigated as an alternative to the traditional dispersive liquid-liquid microextraction for the determination of copper. The potential of this approach is based on the simultaneous complexation and extraction process (SCE) using an innovative spraying apparatus forming finer droplets. Method optimization was performed after ensuring the complexation of copper with a novel ligand, namely 8-(1,3-dihydroxy-1-phenylpropan-2-ylimino)methyl)-7-hydroxy-4-phenyl-2H-chromen-2-one ligand with respect to the conventional FAAS system; the detection power of the new developed system (spraying-assisted fine droplet formation-based simultaneous liquid-phase microextraction-slotted quartz tube-flame at. absorption spectrometry, SAFDF-SLPME-SQT-FAAS) was about 33.8. The quantification and detection values were calculated to be 8.7 and 2.6 μg L-1. Recovery studies were tested in clove extract samples. Obtained percent recoveries were between 96.0 and 103.3% highlighting the applicability and the accuracy of the developed method.

Chemical Papers published new progress about Drops. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics