Category: 93476-46-1

On April 18, 2016, Kim, Chung Han; Lee, Ju Hyeong published a patent.Application In Synthesis of Ethyl indolizine-1-carboxylate The title of the patent was Aromatic compounds as phosphorescent electroluminescent hosts for organic light emitting devices. And the patent contained the following:

The present invention relates to a novel compound with excellent light emitting ability and an organic electroluminescence device with improved characteristic such as life span, drive voltage, luminous efficiency by including one or more these organic compounds represented by a general chem. formula I, where R1-R2 or R2-R3 or R4-R5 or R6-R7 binds to dot portion of the structure represented by a chem. formula II to form a fused ring, where X1 = O, S, C(Ar1) etc. and R1-11 excluding the one to form the fused ring can be H, halogen, cyano, C1-C40 alkyl etc. and Ar1 = C1-C40 alkyl, C2-C40 alkenyl, C2-C40 alkynyl etc. and R1-11, Ar1 can have substitution groups. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Application In Synthesis of Ethyl indolizine-1-carboxylate

The Article related to organic electroluminescence device host phosphorescent, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Luminescence and other aspects.Application In Synthesis of Ethyl indolizine-1-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Basavaraj, M.; Giles, D.; Das, A. K.; Sakharam, A. G. published an article in 2018, the title of the article was Synthesis and characterization of some novel indolizine derivatives.Quality Control of Ethyl indolizine-1-carboxylate And the article contains the following content:

A novel approach was adopted for the synthesis of Indolizine nucleus. Pyridinium-N-methylides were synthesized by reacting pyridine with different haloacetic acids. Further, the indolizine nucleus were synthesized through 1,3-cycloaddition of pyridinium-N-methylides with electron deficient alkynes or alkenes in presence of MnO2 to give indolizine carboxylates. Later on, derivatives of indolizine were prepared by treating indolizine carboxylates with hydralazine and metformin. Synthesis of indolizine 2-carboxylic acid was achieved, by reacting 2-Me pyridine with Et bromopyruvate. The resulting acid was treated with hydralazine and metformin to form corresponding indolizine derivatives Synthesized compounds were characterized by IR and NMR spectroscopic techniques. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Quality Control of Ethyl indolizine-1-carboxylate

The Article related to indolizinyl carbohydrazide preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of Ethyl indolizine-1-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 2, 2009, Xia, Ji-Bao; Wang, Xue-Qiang; You, Shu-Li published an article.Computed Properties of 93476-46-1 The title of the article was Synthesis of Biindolizines through Highly Regioselective Palladium-Catalyzed C-H Functionalization. And the article contained the following:

Biindolizines were synthesized under mild conditions with excellent regioselectivity in high yields through palladium- catalyzed C-H functionalization of indolizines. Synthesis of a macrocyclic compound was also achieved via intramol. double C-H functionalization. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Computed Properties of 93476-46-1

The Article related to biindolizine regioselective preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Computed Properties of 93476-46-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 20, 2013, Zhao, Baoli; Cheng, Kai; Hu, Liujiang published a patent.COA of Formula: C11H11NO2 The title of the patent was Preparation of arylenealkyne substituted indolizine derivatives as antitumor agents. And the patent contained the following:

This patent supplies chem. structural formula I of title arylenealkyne indolizine derivatives, in which R1 is H or halogen atom, R2 is cyano, COOEt or COOBu, and R3 is C1-C4 alkyl. 3-[2-(4-Chlorophenyl)ethynyl]-1-indolizinecarbonitrile (II) was prepared by reacting 4-chloro-2,2-dibromovinylbenzene and 1-indolizinecarbonitrile in the presence of inorganic alkali and Pd catalyst in N,N-DMF under nitrogen protection at 80-100°C, and separating and purifying. Compound II was prepared and showed IC50 value of 3.2 μm/mL against colon cancer cells. The arylenealkyne substituted indolizine derivatives are applied for producing antineoplastic drug. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).COA of Formula: C11H11NO2

The Article related to indolizine arylenealkyne preparation antitumor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C11H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shen, Chuang; Yang, Yuzhu; Liu, Zhanxiang; Zhang, Yuhong published an article in 2014, the title of the article was Palladium-Catalyzed Direct C-3 Alkynylation of Indolizines with (2,2-Dibromovinyl)arenes.Electric Literature of 93476-46-1 And the article contains the following content:

The direct C-3 alkynylation of indolizines with (2,2-dibromovinyl)arenes in the presence of palladium catalyst has been developed. This novel protocol showed wide substrate scope with respect to both indolizines and dibromoalkenes. Also this method was characterized with high efficiency and good functional group tolerance. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Electric Literature of 93476-46-1

The Article related to alkynylation indolizine dibromovinylarene palladium catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Electric Literature of 93476-46-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 18, 2011, Yang, Yuzhu; Chen, Li; Zhang, Zhaoguo; Zhang, Yuhong published an article.Formula: C11H11NO2 The title of the article was Palladium-Catalyzed Oxidative C-H Bond and C=C Double Bond Cleavage: C-3 Acylation of Indolizines with α,β-Unsaturated Carboxylic Acids. And the article contained the following:

A novel palladium-catalyzed C-3 acylation of indolizines with α,β-unsaturated carboxylic acids via C-H bond and C=C double bond cleavage under oxidative conditions is described. E.g., in presence of PdCl2 and K2CrO4, acylation of indolizine I with cinnamic acid II gave 64% III. The regioselectivity is assisted by the carboxylic group, and the selection of the oxidant is crucial to the reaction. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Formula: C11H11NO2

The Article related to palladium catalyst acylation indolizine unsaturated carboxylic acid, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Formula: C11H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 6, 2022, Tang, Ling; Jiang, Shuangshuang; Huang, Xinmiao; Song, Zhiyong; Wang, Jian-bo; Ma, Ming; Chen, Bo; Ma, Yuanhong published an article.Safety of Ethyl indolizine-1-carboxylate The title of the article was Cascade of C(sp2)-H Addition to Carbonyl and C(sp2)-CN/C(sp2)-H Coupling Enabled by Bronsted Acid: Construction of Benzo[a]carbazole Frameworks. And the article contained the following:

Herein, an unprecedented cascade reaction of C(sp2)-H addition to carbonyl and the C(sp2)-CN/C(sp2)-H coupling of 2-(2-oxo-2-arylethyl)benzonitriles with indoles enabled by com. available TsOH·H2O was reported. The protocol represented the first metal-free C(sp2)-CN/C(sp2)-H coupling, affording a new route for the synthesis of various benzo[a]carbazole derivatives I [R1 = H, 3-OMe, 3-F, etc.; R2 = Ph, 2-MeC6H4, 4-ClC6H4, etc.; R3 = H, Me, Ph; R4 = H, Me, Et; R5 = H, 9-F, 8-Br, etc.] with a broad substrate scope, high yields, and simple conditions. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Safety of Ethyl indolizine-1-carboxylate

The Article related to benzocarbazole preparation, indole benzonitrile cascade addition coupling, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Safety of Ethyl indolizine-1-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Pusu; Liu, Chenxu; Zhang, Wenwen; You, Shuli published an article in 2021, the title of the article was Ir-catalyzed enantioselective Friedel-Crafts type allylic substitution of indolizines.Category: esters-buliding-blocks And the article contains the following content:

Indolizine is an important N-containing heterocyclic nucleus and their derivatives display interesting biol. activities. The development of synthetic methods towards indolizine derivatives has attracted extensive attention. Despite the rapid growth in this area, asym. synthesis of indolizine derivatives has been rarely reported. Ir-catalyzed asym. allylic substitution reaction is an efficient method for the enantioselective construction of C-C or C-X bonds, furnishing terminal olefins bearing a stereogenic center at the allylic position with excellent regio- and enantioselectivities. In this regard, various electron-rich arenes, including indoles, pyrroles, naphthols, have been applied as the nucleophiles via Friedel-Crafts type process in the allylic substitution reactions. As a class of constitutional isomers of indoles, indolizines are now demonstrated as suitable nucleophiles in transition-metal-catalyzed allylic substitution reactions. Herein, an iridium- catalyzed enantioselective allylic substitution of allylic alc. with indolizine is reported. A broad range of 3-allylindolizines were accessed with high yields (83%∼95%) and excellent enantioselectivities (95%∼>99% ee). A general procedure for the asym. allylation of indolizines is described in the following: A flame-dried Schlenk tube was cooled to room temperature and filled with argon. To this flask were added [Ir(cod)Cl]2 (4.0 mg, 0.006 mmol, 3 mol%) and (S)-L1 (12.1 mg, 0.024 mmol, 12 mol%). After the flask was evacuated and refilled with argon for three times, freshly distilled dichloromethane (DCM) (2 mL) were added. After the mixture was stirred for 15 min at room temperature, indolizines (0.2 mmol, 1.0 equivalent), allylic alcs. (0.4 mmol, 2.0 equivalent) and (PhSO2)2 NH (18.0 mg, 0.06 mmol, 30 mol%) were added under argon atm. The reaction mixture was stirred at room temperature and monitored by thin-layer chromatog. (TLC). Once indolizines were consumed, the reaction was diluted with water (5 mL), and the mixture was extracted with EtOAc (10 mL×3). The organic layer was collected, dried over Na2SO4 and then concentrated in vacuo to afford the crude product. This crude material was purified by column chromatog. to afford the product. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Category: esters-buliding-blocks

The Article related to iridium catalyst enantioselective friedel crafts allylic substitution indolizine, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 22, 2022, Ma, Yuanhong; Tang, Ling published a patent.Electric Literature of 93476-46-1 The title of the patent was Preparation of arylcyclo[a]carbazoles and arylcyclo[g]pyridine indoles. And the patent contained the following:

The invention discloses the preparation method of arylcyclo[a]carbazole compounds with general formula I and arylcyclo[g]pyridine indole compounds with general formula II [where R1 = hydrogen, alkyl, substituted aryl, substituted heteroaryl, acyl, alkyl amide, alkyl ether, alkylthio, ester, alkylamino, alkenyl or alkynyl; R2 = alkyl, substituted aryl, substituted heteroaryl or alkyl ether; R3 = hydrogen, alkyl, substituted aryl, substituted heteroaryl, acyl, alkylamide, alkyl ether, alkylthio, ester, alkylamino, alkenyl or alkynyl; R4 = hydrogen, alkyl, substituted aryl or alkynyl heteroaryl or acyl; Ar = substituted aryl or substituted heteroaryl; R5 = alkyl acyl, arylacyl, ester or cyano; R6 = hydrogen, alkyl, substituted aryl, substituted heteroaryl, acyl, alkyl amide, alkyl ether, alkylthio, ester, alkylamino, alkenyl or alkynyl], which has the following advantages: mild reaction conditions, simple operation, wide source of raw materials, high utilization value of products, and is conducive to industrial production For example, 11-methyl-6-phenyl-11H-benzo[a]carbazole was prepared by oxidative cyclization of 1-methyl-1H-indole and 2-(2-oxo-2-phenylethyl)benzonitrile. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Electric Literature of 93476-46-1

The Article related to bronsted acid preparation benzonitrile indolizine indole carbazole oxidative cyclization, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Electric Literature of 93476-46-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Huayou; Liu, Yun; Zhong, Hao; Zhu, Yulan; Wang, Chao; Ji, Min published an article in 2012, the title of the article was Heck-Type Cross-Dehydrogenative Coupling Reactions of Indolizines at the 3-Position with Electron-Deficient Alkenes through Palladium-Catalyzed C-H Activation.Formula: C11H11NO2 And the article contains the following content:

Palladium-catalyzed Heck-type cross-dehydrogenative coupling reactions of indolizines with electron-deficient alkenes gave 3-alkenyl substituted indolizines. E.g., in presence of Pd(OAc)2 as catalyst, Cu(OAc)2 as oxidant, and KHCO3 as base, reaction of indolizine (I) with Et acrylate gave up to 82.3% 3-alkenyl substituted indolizine (II) as the (E)-isomer. The reaction took place at the 3-position through Pd-catalyzed C-H activation. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Formula: C11H11NO2

The Article related to palladium catalyst dehydrogenative coupling reaction indolizine electron deficient alkene, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Formula: C11H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics