Category: 93476-46-1

Bragg, D. R.; Wibberley, D. G. published an article in 1963, the title of the article was Indolizines. II. Preparation from ethyl 2-pyridylacetate and related compounds.SDS of cas: 93476-46-1 And the article contains the following content:

cf. CA 57, 5885e. The preparation of indolizines (I) from Et 2-pyridineacetate and α-halo ketones has been extended to the use of other 2-picolyl derivatives and other α-bromo carbonyl compounds It is now possible to synthesize directly indolizines with ester, acyl, or cyano groups in position 1 or 3. The reaction of α-bromo esters yields 2-hydroxyindolizines. The mechanism of this preparation of indolizines is discussed. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).SDS of cas: 93476-46-1

Ethyl indolizine-1-carboxylate(cas:93476-46-1) belongs to ethers. Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. SDS of cas: 93476-46-1

Referemce:
Ester – Wikipedia,
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On November 12, 2008, You, Shuli; Xia, Jibao published a patent.Computed Properties of 93476-46-1 The title of the patent was A process for preparing 3,3′-biindolizine compounds. And the patent contained the following:

The invention relates to a process for the preparation of 3,3′-biindolizine derivatives I, wherein R1 and R2 are independently H, (un)substituted alkyl, NH2, etc. For instance, the invention compound II was prepared by dimerization of 1-indolizinecarboxylic acid Me ester in the presence of Pd(OAc)2, Cu(OAc)2, and K2CO3. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Computed Properties of 93476-46-1

The Article related to biindolizine preparation dimerization, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Computed Properties of 93476-46-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 20, 2013, Zhao, Baoli; Cheng, Kai; Fan, Shaolou published a patent.COA of Formula: C11H11NO2 The title of the patent was Preparation of indolizine derivatives as antitumor agents. And the patent contained the following:

Title compounds I [wherein R1 = alkyl, thienyl, or (un)substituted phenyl; R2 = CN, C(O)OEt, or C(O)OBu], and their pharmaceutically acceptable salts thereof, were prepared as antitumor agents. Thus, the invention compound I (R1 = 4-OMe-Ph; R2 = CN) was prepared via reaction of 1-indolizinecarbonitrile with 4-methoxybenzaldehyde in 96% yield. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).COA of Formula: C11H11NO2

The Article related to indolizine derivative preparation antitumor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.COA of Formula: C11H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Huayou; Li, Guodong; Gu, Ning; Gu, Min published an article in 2016, the title of the article was Synthesis of 3-unsubstituted indolizines from electron deficient alkenes under transition metal free conditions.HPLC of Formula: 93476-46-1 And the article contains the following content:

3-Unsubstituted indolizine not only exhibits a variety of important biol. activities, but also is a kind of important intermediate in organic synthesis. A transition metal free method for synthesizing 3-unsubstituted indolizines from pyridines, 2-chloroacetic acid and electron deficient alkenes has been invented in this paper. The designed products were obtained via oxidative dehydrogenation and decarboxylation reactions, and 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) was used as an oxidant. This method featured simple procedure, easy available starting materials and transition metal free conditions. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).HPLC of Formula: 93476-46-1

The Article related to indolizine preparation electron deficient alkene dehydroaromatization, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 93476-46-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 22, 2009, You, Shuli; Xia, Jibao published a patent.Computed Properties of 93476-46-1 The title of the patent was Method for synthesizing 3-haloindolizine. And the patent contained the following:

The invention relates to the method for preparation of 3-haloindolizine derivatives of formula I. Compounds of formula I wherein R1 and R2 are independently H, C1-16 alkyl, C3-16 cycloalkyl, amino and derivatives,C1-16 alkoxy, halo, C1-16 alkanoyl, C5-10 heterocyclyl, C5-10 heteroaryl, etc.; are claimed. Compounds of formula I were prepared via halogenation of indolizines with copper halides. The method has the advantages of broad scope of suitable substrates, low cost, mild reaction conditions, easy operation, high efficiency, and high selectivity. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Computed Properties of 93476-46-1

The Article related to indolizine derivative halogenation, haloindolizine derivative preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Computed Properties of 93476-46-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 17, 2009, Yang, Yuzhu; Cheng, Kai; Zhang, Yuhong published an article.Application of 93476-46-1 The title of the article was Highly Regioselective Palladium-Catalyzed Oxidative Coupling of Indolizines and Vinylarenes via C-H Bond Cleavage. And the article contained the following:

A highly regioselective oxidative coupling reaction between indolizines and vinylarenes has been accomplished in the presence of palladium catalysts to give only the branched α-product in high efficiency. The regioselectivity is promoted significantly by bidentate nitrogen ligands. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Application of 93476-46-1

The Article related to regioselective oxidative coupling indolizine vinylarene palladium catalyst, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 93476-46-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 16, 2015, Amaral, Monica F. Z. J.; Baumgartner, Amanda A.; Vessecchi, Ricardo; Clososki, Giuliano C. published an article.Product Details of 93476-46-1 The title of the article was Directed Metalation of 1-Ester-Substituted Indolizines: Base/Electrophile-Controlled Regioselective Functionalization. And the article contained the following:

A variety of C-2 and C-5 difunctionalized indolizines e. g., I, have been prepared through the reaction of 1-ester-substituted indolizines with organometallic bases followed by a reaction with different electrophiles. Metalation takes place under mild conditions allowing the isolation of a number of difunctionalized indolizines in good yields. The regioselectivity of the reaction appears to be governed by the nature of the base and electrophile. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Product Details of 93476-46-1

The Article related to indolizine regioselective synthesis, electrophile indolizine organometallic base metalation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Product Details of 93476-46-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 29, 2010, Barluenga, Jose; Lonzi, Giacomo; Riesgo, Lorena; Lopez, Luis A.; Tomas, Miguel published an article.Related Products of 93476-46-1 The title of the article was Pyridine Activation via Copper(I)-Catalyzed Annulation toward Indolizines. And the article contained the following:

The copper(I)-catalyzed regioselective [3 + 2] cyclization of pyridines toward alkenyldiazoacetates leading to functionalized indolizine derivatives, e.g., I is reported. A broad range of pyridine derivatives (including quinoline and isoquinoline) is compatible with this cyclization reaction. The process represents the first successful example of metal-catalyzed cyclization of a π-deficient heterocyclic system with alkenyldiazo compounds The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Related Products of 93476-46-1

The Article related to indolizine preparation reaction mechanism, pyridine alkenyldiazoacetate cyclization copper catalyst, Heterocyclic Compounds (One Hetero Atom): Other 5-Membered Rings and other aspects.Related Products of 93476-46-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 31, 2012, Xu, Shao-hong published an article.Quality Control of Ethyl indolizine-1-carboxylate The title of the article was Iron-catalysed C-3 functionalization of indolizines via C-H bond cleavage. And the article contained the following:

The synthesis of 3,3′-(arylmethylene)diindolizine with a FeCl3.6H2O catalyst was achieved with excellent efficiency at room temperature Various indolizines were prepared by the reaction with either aromatic or aliphatic aldehydes to produce di- or triheteroarylmethanes. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Quality Control of Ethyl indolizine-1-carboxylate

The Article related to indolizine aldehyde electrophilic substitution carbon hydrogen bond cleavage, arylmethylene diindolizine preparation iron catalyst, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Quality Control of Ethyl indolizine-1-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Baoli published an article in 2012, the title of the article was Pd-Catalyzed C-3 functionalization of indolizines via C-H bond cleavage.Product Details of 93476-46-1 And the article contains the following content:

New transition metal-catalyzed methods for the arylation of indolizines by the direct cleavage of C-H bonds have been developed. A wide range of aryltrifluoroborate salts react with indolizines in the presence of Pd(OAc)2 catalyst and AgOAc oxidant to give the arylated indolizines in high yields. Both electron-donating and electron-withdrawing groups perform smoothly while bromide and chlorine substituents are tolerated. In addition, the indolizines display similar reactivities in the Pd-catalyzed reaction with 3-phenylpropiolic acid to afford the corresponding C-3 alkynylated indolizines. These methods allow the direct functionalization of indolizines in one step. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Product Details of 93476-46-1

The Article related to palladium catalyzed functionalization indolizine carbon hydrogen bond cleavage, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Product Details of 93476-46-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics