Category: 927-68-4

Application of 927-68-4, The chemical industry reduces the impact on the environment during synthesis 927-68-4, name is 2-Bromoethyl acetate, I believe this compound will play a more active role in future production and life.

Step 14b. 2-(6-Amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)ethyl acetate (Compound 401-38); A mixture of compound 105-38 (3.89 g, 9.41 mmol), Cs2CO3 (3.68 g, 11.3 mmol), 2-bromoethyl acetate (1.89 g, 11.3 mmol) and anhydrous DMF (50 mL) was stirred for 2 h at 50 C. The solvent was removed under high vacuum and the crude purified by column chromatography on silica gel (CH2Cl2/MeOH=60/1) to provide target compound 401-38 as a pale yellow solid (2.95 g, 62.8%): LCMS: 500 [M+1]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromoethyl acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Qian, Changgeng; Cai, Xiong; Gould, Stephen; Zhai, Haixiao; US2008/234297; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 927-68-4, These common heterocyclic compound, 927-68-4, name is 2-Bromoethyl acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of Intermediate 11 (470 mg, 1.50 mmol), 2-bromoethyl acetate (1.00 g, 5.99 mmol) and DBU (913 mg, 6.01 mmol) in DMF (3 ml) was heated under argon at 80QC for 1.5 h. On cooling the reaction mixture was diluted with EtOAc (50 ml) and 1M aqueous HCI (50 ml). The organic layer was separated, washed with water (40 ml) and brine (40 ml), dried (Na2SO4) and evaporated. The crude product was chromatographed on an Isolute Si Il cartridge (20 g) eluting with 50-100% EtOAc in pentane.Yield: 457 mg (63%)LC-MS (Method 1): Rt 3.22 min, m/z 486 [MH+]

Statistics shows that 2-Bromoethyl acetate is playing an increasingly important role. we look forward to future research findings about 927-68-4.

Reference:
Patent; ARGENTA DISCOVERY LIMITED; WO2007/107706; (2007); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 927-68-4, name is 2-Bromoethyl acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 927-68-4, Recommanded Product: 2-Bromoethyl acetate

(R)-7-chloro-N-(piperidin-3 -yl)-4-(trifluoromethyl)benzo[b]thiophene-2-carboxamide (TFA salt, 95 mg, 0.20 mmol), Nal (50 mg, 0.33 mmol), K2C03 (180 mg, 1.30 mmole), 2- bromoethyl acetate (32 uL, 0.29 mmol) and DMF (2 mL) were added into a reaction flask, and stirred at room temperature overnight. The mixture was dissolved in ethyl acetate (20 mL) and water (5 mL). The layers were separated and the aqueous layer was extracted with ethyl acetate (2x). The ethyl acetate layer was concentrated in vacuo and chromatographed on silica gel using hexanes and ethyl acetate to give title compound (50 mg, 0.11 mmol, 56%). ?H NMR (CD3OD, 400 MHz) 8.34 (s, 1H), 7.83 (dd, IN, J 0.4, 8.0 Hz), 7.68 (dd, 1H, J?0.4, 8.0 Hz), 4.50 (m, 2H), 4.38 (m, 1H), 3.73 (m, 1H), 3.56 (m, IH), 3.32 (m, 2H),3.02 (m, 2H), 2.14 (m, 5H), 2.00 (m, 2H), 1.79 (m, 2H). LCMS (ES) 449, 451 (M+H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromoethyl acetate, and friends who are interested can also refer to it.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; ICAHN SCHOOL OF MEDICINE AT MONT SINAI; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; KAMENECKA, Theodore, M.; KENNY, Paul; LINDSTROM, Jon, M.; WANG, Jingyi; JIN, Zhuang; DOEBELIN, Christelle; (95 pag.)WO2016/191366; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 927-68-4,Some common heterocyclic compound, 927-68-4, name is 2-Bromoethyl acetate, molecular formula is C4H7BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 7-1 (200 mg, 0.9 mmol) And sodium hydride (54mg, 1.35mmol) dissolved in 3ml DMF and stirred for 30 minutes, Add 2-bromoethyl acetate (165 mg, 0.99 mmol) in 2 ml of DMF, Stir overnight at room temperature. On the following day, after the reaction was detected by TLC, water was added for extraction. It was washed with saturated brine and dried over anhydrous sodium sulfate. Suction filtration, the filtrate was concentrated under reduced pressure, the crude product was separated by column chromatography, 172 mg of a colorless oil was obtained in a yield of 61%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromoethyl acetate, its application will become more common.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhang Ao; Meng Linghua; Ding Jian; Chen Shulun; Ding Chunyong; Guo Wei; (26 pag.)CN110143955; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

927-68-4, name is 2-Bromoethyl acetate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2-Bromoethyl acetate

To a solution of the product of step 1(143 mg, 0.69 mmol) in DMF (1.5 mL) at 0 C, wasadded NaH (60% suspension in mineral oil, 30 mg, 0.76 mmol). The mixture was stirred for 0.5 h followed and 2-bromoethyl acetate (184 mg, 0.12 mL, 1.1 mmol) was added. The reaction was brought to room temperature and stirred overnight. The mixture was diluted with EtOAc, washed with water and brine, dried over Na2504, and concentrated underreduced pressure. The residue was purified by silica gel column chromatography (0-20% gradient MeOH in CH2C12) to afford the title compound (180 mg, 89%) as a colorless oil.?H NMR (500 MHz, CDC13) oe 1.36 (t, J=7.4 Hz, 3H), 1.89-2.00 (m, 2H), 2.03-2.15 (m, 5H), 2.75-2.82 (m, 2H), 2.89 (t, J=6.3 Hz, 2H), 3.99 (q, J=7.4 Hz, 2H), 5.25 (s, 2H)

The synthetic route of 927-68-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PTC THERAPEUTICS, INC.; GERASYUTO, Aleksey, I.; ARNOLD, Michael, A.; CHEN, Guangming; KARP, Gary, Mitchell; QI, Hongyan; TURPOFF, Anthony, A.; WANG, Jiashi; WOLL, Matthew, G.; BRANSTROM, Arthur, A.; NARASIMHAN, Jana; DUMBLE, Melissa, L.; HEDRICK, Jean; WEETALL, Maria, L.; (374 pag.)WO2016/109706; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 927-68-4, name is 2-Bromoethyl acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 927-68-4, name: 2-Bromoethyl acetate

After dissolving ethyl imidazole-2-carboxylate (200 mg, 1.43 mmol) in 5 ml of N,N-dimethylformamide and adding cesium carbonate (931 mg, 2.85 mmol) for 0.5 h,Add 2-bromoethyl acetate (385mg, 2.14mmol), warm to 80 for 2h, complete the reaction by TLC, stop the reaction, cool to room temperature, dilute with water,Extract with ethyl acetate (3¡Á20 ml), combine the organic layers, wash with saturated brine, dry over anhydrous sodium sulfate, filter and concentrate to obtain crude product.Purified by column chromatography (PE: EA=3: 1) to give a pale yellow liquid, ie compound1-(2-acetoxyethyl)-1H-imidazole-2-carboxylic acid ethyl ester 26b (300 mg, yield 92.8%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Sichuan University; Li Guobo; Wang Zhenling; (36 pag.)CN111253317; (2020); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 927-68-4, These common heterocyclic compound, 927-68-4, name is 2-Bromoethyl acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Dissolve ethyl imidazole-2-carboxylate (200 mg, 1.43 mmol) in 5 ml of N,N-dimethylformamide, add cesium carbonate (931 mg, 2.85 mmol) and activate for 0.5 h, then add2-bromoethyl acetate(385mg, 2.14mmol), warmed to 80C for 2h, complete reaction by TLC, stop reaction, cooled to room temperature, diluted with water, extracted with ethyl acetate (3¡Á20ml), combined organic layers, washed with saturated brine, anhydrous Dry over sodium sulfate, filter, and concentrate to obtain crude product. Purified by column chromatography (PE:EA=3:1) to give a pale yellow liquid, namely compound 1-(2-acetoxyethyl)-1H-imidazole-2-carboxylic acid ethyl ester 26b (300mg, yield 92.8 %).

The synthetic route of 927-68-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sichuan University; Li Guobo; Wang Zhenling; (40 pag.)CN111187218; (2020); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 927-68-4, A common heterocyclic compound, 927-68-4, name is 2-Bromoethyl acetate, molecular formula is C4H7BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 250 mL flask equipped with magnetic stirring bar, 1-(3-fluoro-2-nitrophenyl)piperazine A-6 (5 g, 22.5 mmol) was added under argon atmosphere and the flask was filled with dry ACN (50 mL). Then, dried K2CO3 (6,0 g, 45 mmol) and 2-bromoethyl acetate (4.45 g, 26.6 mmol) were added, and the reaction mixture was heated to 60 C and stirred for 20h at this temperature. After this time UPLCMS analysis showed no substrate peak. The reaction was cooled to room temperature and solid was filtered. As a result, the product A-2C was obtained as the yellow solid (6.8 g, 99% yield) with 99 % of purity, according to UPLCMS analysis (Method A).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Adamed sp. z o.o.; KOLACZKOWSKI, Marcin; BUCKI, Adam; SNIECIKOWSKA, Joanna; MARCINKOWSKA, Monika; (65 pag.)EP3530651; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

927-68-4, The chemical industry reduces the impact on the environment during synthesis 927-68-4, name is 2-Bromoethyl acetate, I believe this compound will play a more active role in future production and life.

Step D2-azidoethyl acetateN3^0AC [00269] A mixture of 2-bromoethyl acetate (500 muIota, 4.54 mmol) in N,N-dimethylformamide (DMF) (2.0 mL) was treated with sodium azide (295 mg, 4.54 mmol) and then heated to 70 C for 2 hours. The mixture was diluted with water and then extracted with ether. The extracts were washed with water, then brine, dried over sodium sulfate, filtered and concentrated to afford the title compound as a colorless liquid. 1H NMR (400 MHz, CHLOROFORM-d) d = 4.29 – 4.19 (m, 2 H), 3.53 – 3.44 (m, 2 H), 2.1 1 (s, 3 H).

The chemical industry reduces the impact on the environment during synthesis 2-Bromoethyl acetate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; GLAXOSMITHKLINE LLC; DE LA ROSA, Martha Alicia; HAYDAR, Simon, N.; JOHNS, Brian Alvin; VELTHUISEN, Emile Johann; WO2012/102985; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics