Category: 92652-76-1

Chen, Yanchi; Ma, Guobin; Gong, Hegui published their research in Organic Letters on August 3 ,2018. The article was titled 《Copper-Catalyzed Reductive Trifluoromethylation of Alkyl Iodides with Togni’s Reagent》.Electric Literature of C15H19NO3 The article contains the following contents:

This work illustrates a reductive cross-electrophile coupling protocol for trifluoromethylation of alkyl iodides under Cu-catalyzed/Ni-promoted reaction conditions. The use of diboron esters as the terminal reductant allows the effective generation of the alkyl-CF3 products with excellent functional group tolerance and broad substrate scope. A mechanism involving a reaction of alkyl-Cu with Togni’s reagent was proposed. The experimental process involved the reaction of Benzyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate(cas: 92652-76-1Electric Literature of C15H19NO3)

Benzyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate(cas: 92652-76-1) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Electric Literature of C15H19NO3 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《N-Allylnoratropine》 were Nador, K.; Gyorgy, L.; Doda, M. M.. And the article was published in Journal of Medicinal & Pharmaceutical Chemistry in 1961. Related Products of 92652-76-1 The author mentioned the following in the article:

Treatment of N-benzylnortropan-3α-ol HCl salt with O-acetyltropic acid chloride (I) at 85° produced N-benzylnoratropine, m. 115°, hydrogenated in the presence of 10% Pd-C to noratropine (II), m. 114°. II was also prepared by treating nortropan-3α-ol with carbobenzoxy chloride to produce N-carbobenzoxynortropan-3α-ol m. 124°, which treated with I in C5H5N gave N-carbobenzoxynoratropine, m. 113°, and this was subjected to catalytic removal of the carbobenzoxy group. N-allylnoratropine, m. 77°, was prepared by treating excess noratropine with allyl bromide and had a very weak parasympatholytic activity, did not antagonize atropine, had weak adrenolytic and hypotensive activity and had an LD50 500 mg./kg. in mice. The experimental part of the paper was very detailed, including the reaction process of Benzyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate(cas: 92652-76-1Related Products of 92652-76-1)

Benzyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate(cas: 92652-76-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Related Products of 92652-76-1 Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics