Category: 924-99-2

Al-Saleh, Balkis published the artcileStudies with functionally substituted enamines: the reactivity of enaminals and enamino esters toward naphthoquinone, hydrazonoyl halides, aminoazoles and hippuric acid, Application of Ethyl 3-(dimethylamino)acrylate, the publication is Synthesis (2006), 59-62, database is CAplus.

Whereas enamines react with naphthoquinone to yield naphthofuran (i.e., naphtho[1,2-b]furan) aldehyde and carboxylic acid ester derivatives, enamine ester react with naphthoquinone to yield benzindole derivatives Et 3-(dimethylamino)-2-propenoate reacts with hydrazonoyl halides to yield 3,4-disubstituted pyrazole derivatives On the other hand, and enaminal, 3-(dimethylamino)-2-propenal, failed to react with hydrazonoyl halides, while an enamine ester, Et 3-(anilino)acrylate, afforded a hydrazone derivative on treatment with hydrazonoyl halide. An enamino ester, Et 3-(dimethylamino)-2-propenoate, afforded tri-Et 1,3,5-benzenetricarboxylic acid esters on refluxing in acetic acid.

Synthesis published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Application of Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ma, Cong-Xuan published the artcileDesign, synthesis and structure-activity relationships of novel macrolones: Hybrids of 2-fluoro 9-oxime ketolides and carbamoyl quinolones with highly improved activity against resistant pathogens, Product Details of C7H13NO2, the publication is European Journal of Medicinal Chemistry (2019), 1-20, database is CAplus and MEDLINE.

Constitutively erythromycin-resistant apathogens are more difficult to address than inducible resistant and efflux-resistant strains. Three series of the 4th generation 2-fluoro 9-oxime erythromycin ketolides were synthesized and evaluated. Incorporation of substituted heteroaryl groups, in contrast to previously reported the unsubstituted heteroaryl groups, proved to the beneficial for enhancement of the activities of the 9-propargyl ketolide 8 series and the 9-allyl ketolide 14 series. Structure-activity relationships and mol. modeling indicated that some title compounds may have different binding sites compared to current erythromycins. These findings pave the way for rational design of novel non-telithromycin macrolides that target new binding sites within bacterial ribosomes.

European Journal of Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Product Details of C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gupton, John T. published the artcileReaction of Gold’s reagent with activated methylene groups derived from esters and nitroarenes, Application of Ethyl 3-(dimethylamino)acrylate, the publication is Synthetic Communications (1982), 12(12), 939-46, database is CAplus.

Acetate and malonate esters reacted with Me₂NCH:NCH:N⁺Me₂ Cl^– (I) to yield RC(:CHNMe₂)CO₂Et (R = H, Ph, CO₂Et, cyano). Similarly prepared, from nitrotoluenes and lactones, were II (R = H, Br, Cl, NO₂; R¹ = NO₂, H) and III (R = H, Me). Thus, PhCH₂CO₂Et was treated with I and NaOEt in EtOH to give PhC(:CHNMe₂)CO₂Et.

Synthetic Communications published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Application of Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Larina, Nina A. published the artcileSynthesis and photochromism of a series of new 2-unsubstituted 3-(2-benzylbenzoyl)quinolin-4(1H)-ones, SDS of cas: 924-99-2, the publication is Tetrahedron (2010), 66(42), 8291-8299, database is CAplus.

Synthesis and characterization of a series of new 2-unsubstituted 3-(2-benzylbenzoyl)quinolin-4(1H)-ones is described. In addition to their potential biol. activity, these compounds exhibit photoreversible photochromic properties in anaerobic conditions. Using the 1 and 2D NMR techniques we demonstrated that the coloration occurred owing to the formation of fluorescent 5a,6-dihydrobenzo[b]acridin-(5H)-ones. The photoreaction is stereoselective and the S,R-isomers are the major products (83%) whereas the S,S-isomers are the minor (6%). In addition, the irreversible formation of two oxidation products, 3-(2-benzoylbenzoyl)quinolin-4(1H)-ones, and acridin-12(5H)-one derivatives was observed in the presence of air.

Tetrahedron published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, SDS of cas: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhi, Ying published the artcile4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B, Name: Ethyl 3-(dimethylamino)acrylate, the publication is Bioorganic & Medicinal Chemistry (2014), 22(14), 3670-3683, database is CAplus and MEDLINE.

Protein tyrosine phosphatase 1B is a neg. regulator in the insulin and leptin signaling pathways, and has emerged as an attractive target for the treatment of type 2 diabetes and obesity. However, the essential pharmacophore of charged phosphotyrosine or its mimetic confer low selectivity and poor cell permeability. Starting from the previously reported aryl diketoacid-based PTP1B inhibitors, a drug-like scaffold of 4-quinolone-3-carboxylic acid was introduced for the first time as a novel surrogate of phosphotyrosine. An optimal combination of hydrophobic groups installed at C-6, N-1 and C-3 positions of the quinolone motif afforded potent PTP1B inhibitors with low micromolar IC₅₀ values. These 4-quinolone-3-carboxylate based PTP1B inhibitors displayed a 2-10-fold selectivity over a panel of PTP’s. Furthermore, the bidentate inhibitors of 4-quinolone-3-carboxylic acids conjugated with aryl diketoacid or salicylic acid were cell permeable and enhanced insulin signaling in CHO/hIR cells. The kinetic studies and mol. modeling suggest that the 4-quinolone-3-carboxylates act as competitive inhibitors by binding to the PTP1B active site in the WPD loop closed conformation. Taken together, the study shows that the 4-quinolone-3-carboxylic acid derivatives exhibit improved pharmacol. properties over previously described PTB1B inhibitors and warrant further preclin. studies.

Bioorganic & Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C13H10N2S, Name: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cecchetti, Violetta published the artcilePotent 6-defluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy, Application of Ethyl 3-(dimethylamino)acrylate, the publication is Journal of Medicinal Chemistry (1996), 39(25), 4952-4957, database is CAplus and MEDLINE.

In a furtherance of our SAR study on the C-6 position of quinolone antibacterials, a series of 6-defluoro-8-methylquinolones were synthesized and evaluated for their in vitro antimicrobial activity. As a result of this study, compounds with strong activity against Gram-pos. bacteria, including ciprofloxacin-resistant and methicillin-resistant Staphylococcus aureus, were identified. The best Gram-pos. antibacterial activity was exhibited by piperidinyl derivative which was 17 times more potent than ciprofloxacin and displayed extremely high activity against Streptococcus pneumoniae with an MIC value of ≤0.016 μg/mL. Thus, we have shown that substituent combinations in the quinolone ring, excluding the C-6 fluorine atom, might produce powerful antibacterial agents.

Journal of Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Application of Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cecchetti, Violetta published the artcileStudies on 6-aminoquinolones: Synthesis and antibacterial evaluation of 6-amino-8-methylquinolones., Product Details of C7H13NO2, the publication is Journal of Medicinal Chemistry (1996), 39(2), 436-45, database is CAplus and MEDLINE.

Novel 6-amino-8-methylquinolone derivatives have been synthesized with enhanced antibacterial activity, particularly against Gram-pos. bacteria. The 1,2,3,4-tetrahydroisoquinolinyl derivative (I) showed the highest antibacterial activity with MIC values on Gram-pos. bacteria lower than those of ciprofloxacin, especially against Staphylococcus aureus strains, including those strains which are methicillin- and ciprofloxacin-resistant.

Journal of Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Product Details of C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Abadleh, Mohammed M. published the artcileSynthesis and Biological Activity of Some New N1-(6-fluoro-4-oxoquinolin-8-yl)amidrazones, Safety of Ethyl 3-(dimethylamino)acrylate, the publication is Letters in Organic Chemistry (2014), 11(9), 664-670, database is CAplus.

A selected set of five N1-(6-fluoro-4-oxoquinolin-8-yl)amidrazone-3-carboxylates incorporating piperazines and related congeners has been synthesized by reacting the hydrazonoyl chloride, derived from 8-amino-6-fluoro-4-oxoquinline-3-carboxylate, with the appropriate sec-cyclic amines. Their suggested structures are supported by elemental anal., 1H NMR, 13C NMR and ESI-HRMS spectral data. These novel compounds were screened for their antitumor and antibacterial activity. While no significant antitumor activity was observed, three compounds, e.g. I, have shown moderate in vitro antibacterial activity against Gram pos. bacteria cells. Unlike the others, compound I has also shown to moderately inhibit the growth of Gram neg. bacteria.

Letters in Organic Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Safety of Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Al-Huniti, Mohammed H. published the artcileHeterocycles [h]fused onto 4-oxoquinoline-3-carboxylic acid, Part IV. Convenient synthesis of substituted hexahydro[1,4]thiazepino[2,3-h]quinoline-9-carboxylic acid and its tetrahydroquino[7,8-b]benzothiazepine homolog, Computed Properties of 924-99-2, the publication is Molecules (2007), 12(8), 1558-1568, database is CAplus and MEDLINE.

Substituted [1,4]thiazepino[2,3-h]quinolinecarboxylate I is prepared by PPA-catalyzed thermal lactamization of the resp. 8-amino-7-[(2-carboxyethyl)thio]-1,4-dihydroquinoline-3-carboxylate. The latter synthon is obtained by reduction of the 8-nitro-1,4-dihydroquinoline precursor 8 which, in turn, is made accessible via interaction of 3-mercaptopropionate with 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-1,4-dihydroquinoline-3-carboxylate (II) in the presence of Et₃N. A benzo-homolog of I, namely tetrahydroquino[7,8-b]benzothiazepine-3-carboxylate, is analogously prepared via the reaction of 2-mercaptobenzoate with II, followed by reduction of the resulting 7-[(2-carboxyphenyl)thio]-8-nitro product into the corresponding 8-amino derivative, and subsequent lactamization.

Molecules published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Al-Sinjilawi, Hadeel T. published the artcileSynthesis and antibacterial activity of some novel 4-oxopyrido[2,3-a]phenothiazines, SDS of cas: 924-99-2, the publication is Archiv der Pharmazie (Weinheim, Germany) (2014), 347(11), 861-872, database is CAplus and MEDLINE.

A series of substituted 4-oxopyrido[2,3-a]phenothiazine-3-carboxylic acids I [R = H ; X = H, CH₃, OCH₃, Cl] was prepared via cyclization of 4-oxoquinoline-3-carboxylates II, followed by hydrolysis of the resultant esters I [R = C₂H₅]. Synthesized carboxylic acids I [R = H] were evaluated for their antibacterial activity. Among the tested carboxylic acids, I [R = H ; X = H] was most active against representative Gram-pos. and Gram-neg. bacterial strains and these compounds were also active against Methicillin-resistant Staphylococcus aureus (MRSA) with very low toxicity to the normal cells. Virtual screening using ligand-protein docking modeling predicted that the compounds I [R = H] were potential inhibitors of the topoisomerase IV enzyme and that hydrophobic interactions and hydrogen bonds were the major mol. interactions between these compounds and the residues of the active site of topoisomerase IV.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, SDS of cas: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics